Testagen 20 mg

▎ Testagen Ọdịdị

▎ Testagen Nyocha

Kedu ihe ndabere nyocha nke Testagen?

N'ịmegide ndabere nke ọganihu nkà na ụzụ ọgbara ọhụrụ na nyocha nke biomedical, nchọpụta nke peptides bioactive aghọwo ntụziaka nyocha dị mkpa n'ọhịa. Dị ka peptide sịntetik, Testagen na-ejide ihe nchọpụta pụtara ìhè n'ihi uru ọ bara na usoro cellular, mmeghari anụ ahụ, ụzọ metabolic, na usoro physiological na biochemical ndị ọzọ. N'ịbụ nke ụdị nke peptides bioactive, Testagen mejupụtara

 nke usoro amino acid nke nwere ike imetụta mmekọrịta sel-molecule. Emebere ihe owuwu ya iji ṅomie ma ọ bụ kwado usoro ihe ọmụmụ ihe dị ndụ, si otú a na-egosipụta ikike dị ka isiokwu nyocha na bayoloji molecular, biochemistry, na nyocha nyocha.

Onyonyo 1. Bioregulation usoro nke a multicellular organism. 

Isi mmalite: MDPI ^[1]

Gịnị bụ usoro nke omume nke Testagen?

Ntinye Cell: Nnyocha egosiwo na mgbe etinyere mkpụrụ ndụ HeLa na fluorescein isothiocyanate-labeled Testagen, a na-ahụ fluorescence dị iche na cytoplasm, cell nucleus, na nucleolus, na-egosi na Testagen nwere ikike ịbanye n'ime sel anụmanụ na nuclei ha. Ikike ya ịgafe akpụkpọ ahụ cell na akpụkpọ ahụ nuklia n'ime cell nwere ike jikọta ya na ụfọdụ protein na-ebuga na akpụkpọ ahụ cell ma ọ bụ mmiri mmiri. Mkpụrụ ndụ akpụkpọ ahụ abụghị ihe a na-apụghị imeri emeri; o nwere ọwa na usoro njem. Testagen nwere ike ịbanye na sel site na iso protein ndị a na-ebugharị ma ọ bụ site na usoro endocytosis na-eji mmiri mmiri mee ihe, na-atọ ntọala maka mmetụta ya na-esote ^[2].  

Mmekọrịta dị iche iche na Nucleic Acids: peptides dị iche iche nke sitere na mmalite na-egosipụta mmetụta dị iche iche na fluorescence nke 5,6-carboxyfluorescein-labeled deoxyoligonucleotides na DNA-ethidium bromide complexes. Site n'ịtụle ihe nkwụsị Stern-Volmer, a chọpụtara na Testagen, ma e jiri ya tụnyere peptides ndị ọzọ dị mkpụmkpụ, na-eme ka ogo dị iche iche nke fluorescence na-eme ka ọ bụrụ ihe dị iche iche na-eme ka ọ bụrụ ihe na-eme ka ọ bụrụ ihe na-egbuke egbuke nke a na-akpọ deoxyoligonucleotides, dabere na nhazi mbụ nke peptide. Nke a na-egosiputa mmekọrịta dị n'etiti Testagen na usoro nucleic acid. Mgbe ejikọtara na nucleic acid, Testagen nwere ike ịmata ọdịiche dị n'etiti usoro nucleotide dị iche iche na ọbụna mata ọkwa cytosine methylation ha. Dịka ọmụmaatụ, Testagen na-egosi na ọ na-akacha mma jikọtara ya na deoxyoligonucleotides nwere usoro CAG. Enwere ike nweta njikọ dị otú ahụ kpọmkwem site na mmekọrịta ndị na-abụghị covalent dị ka njikọ hydrogen na mmekọrịta electrostatic n'etiti amino acid residues na Testagen molecule na bases ma ọ bụ phosphate backbones nke nucleic acid. Nkọwapụta a na-enye ohere Testagen ka ọ kọwaa kpọmkwem mpaghara nucleic acid, si otú ahụ na-emetụta usoro dị ka mkpụrụ ndụ ihe nketa ^[2].  

Epigenetic Regulation of Cellular Genetic Functions: N'ihi ikike ya ijikọ kpọmkwem na DNA, mmekọrịta dị na saịtị Testagen na DNA nwere ike ijikwa ọrụ mkpụrụ ndụ ihe nketa cell na ọkwa epigenetic. Usoro epigenetic anaghị agbanwe usoro usoro DNA mana ọ na-emetụta mkpụrụ ndụ ihe nketa site na mgbanwe DNA (dịka ọmụmaatụ, methylation) na mgbanwe histone. Testagen nwere ike jikọta na mpaghara DNA akọwapụtara, na-emetụta usoro chromatin na mpaghara ndị ahụ ma ọ bụ na-eweghachi ihe ndị na-edozi protein epigenetic iji gbanwee ọrụ ntụgharị mkpụrụ ndụ ihe nketa. Usoro dị otú ahụ nke ọrụ mkpụrụ ndụ ihe nketa nwere ike rụọ ọrụ dị oke mkpa na mmalite mmalite nke ndụ na mmalite ndụ, na-enyere ihe ndị dị ndụ aka ịhazi kpọmkwem okwu mkpụrụ ndụ ihe nketa na gburugburu dị iche iche iji mee mgbanwe na mgbanwe na usoro ndụ zuru ezu ^[2]..  

Mmetụta na arụ ọrụ Endocrine na-adịghị ala ala Prostatitis na-adịghị ala ala: Na nyocha ahụike, ọmụmụ banyere ndị ọrịa na-arịa ọrịa prostatitis na-adịghị ala ala (IIIA) achọpụtala na mgbe otu ọnwa nke ọgwụgwọ na-agbanwe agbanwe na usoro gụnyere Testagen (α1-adrenergic blockers + rectal suppositories nwere ndị na-abụghị steroidal anti-inflammatory parameters), mbelata nke ukwuu ọgwụ mgbochi ọrịa na-adịghị ala ala, uteroid prostatic parampat. mkpokọta testosterone mụbara. Nke a na-egosi na Testagen nwere ike ịhazi nguzozi endocrine site na usoro ụfọdụ. Usoro dị mma bụ na Testagen na-emetụta ụzọ mgbaàmà metụtara njikọ testosterone na mkpụrụ ndụ Leydig. Njikọ Testosterone bụ usoro dị mgbagwoju anya nke gụnyere ọtụtụ enzymes na ụmụ irighiri ihe na-egosi. Testagen nwere ike rụọ ọrụ ma ọ bụ gbochie ụzọ mgbaàmà ndị metụtara ya site na ijikọta ndị na-anabata intracellular, si otú ahụ na-akwalite njikọ testosterone, meziwanye ọnọdụ endocrine onye ọrịa, na ibelata mgbaàmà nke prostatitis na-adịghị ala ala ^[3]..  

Kedu ihe bụ ngwa Testagen?  

Ọgwụgwọ Prostatitis na-abụghị nje na-adịghị ala ala: Prostatitis nke na-abụghị nje na-adịghị ala ala (IIIA), na-enwekarị mgbaàmà urinary ala ala, na-emetụta ụdị ndụ ndị ọrịa na-adịghị mma. Testagen na-ekere òkè dị ukwuu n'ịgwọ ọnọdụ ndị dị otú ahụ ^[4] (Niu D, 2023). Ọmụmụ ihe na-eji usoro ọgwụgwọ na-agbanwe agbanwe na-ejikọta α1-adrenergic blockers, rectal suppositories na ndị na-abụghị steroidal anti-inflammatory drugs, na Testagen nwetara nsonaazụ dị ịrịba ama mgbe otu ọnwa gasịrị. Urodynamic paramita emelitere nke ọma, na-egosi ọrụ micturition emelitere yana enyemaka nke mgbaàmà mgbochi mgbochi urinary ala. Ka ọ dị ugbu a, ọkwa mbufụt nke intraprostatic belatara, na-ebelata mmebi anụ ahụ. Nke ka mkpa, serum mkpokọta testosterone mụbara. Testosterone dị oké mkpa maka ịnọgide na-arụ ọrụ nkịtị nke usoro ọmụmụ nwoke, ọrụ mmekọahụ, na n'ozuzu metabolism, na elu ya na-enyere aka melite ọrịa endocrine nke ọrịa ahụ kpatara ^[3]..  

Ntinye Cell na Nucleic Acid Mmekọrịta: Dị ka peptide dị mkpụmkpụ bioactive, Testagen na-egosipụta ihe onwunwe cellular pụrụ iche nke na-etolite ntọala maka ngwa ahụike ya ^[2] (Fedoreyeva LI, 2011). N'ime nnwale cell HeLa, a hụrụ nhụsianya dị ịrịba ama na cytoplasm, nucleus, na nucleolus mgbe ejiri fluorescein isothiocyanate-labeled Testagen, na-egosipụta ike ya ịbanye n'ime sel anụmanụ na nuclei. Nke a na-enye ohere Testagen ịbanye na sel ma soro akụkụ intracellular na-emekọrịta ihe, na-eme ka ọrụ nchịkwa dị n'ime sel.  

Nnyocha achọpụtala na peptides dị mkpụmkpụ bioactive dị iche iche na-enwe mmetụta dị iche iche na fluorescence nke 5,6-carboxyfluorescein-labeled deoxyribooligonucleotides na DNA-ethidium bromide complexes. Fluorescence quenching etoju, nke Stern-Volmer na-agbanwe agbanwe, dịgasị iche iche n'etiti peptides dị mkpụmkpụ dị ka Testagen dabere na usoro ha bụ isi mgbe ha na-emekọrịta ihe na otu-stranded na nke nwere okpukpu abụọ nke akpọrọ deoxyribooligonucleotides, na-egosi mmekọrịta dị iche iche na usoro nucleic acid. Nnyocha ndị ọzọ na-egosi na Testagen na-ejikọta ya na deoxyribooligonucleotides nwere usoro CAG. Ikike a iji jikọta usoro nucleic acid kpọmkwem na-egosi na Testagen nwere ike ịhazi ọrụ mkpụrụ ndụ ihe nketa cell na ọkwa epigenetic site na mmekọrịta DNA dị na saịtị, na-arụ ọrụ dị mkpa na nhazi ọrụ mkpụrụ ndụ ihe nketa. Nke a na-enwe ike ịmalite usoro ọgwụgwọ dabere na usoro mkpụrụ ndụ ihe nketa-dịka ọmụmaatụ, n'ọrịa ndị metụtara mkpụrụ ndụ ihe nketa na-adịghị mma. Ọ bụ ezie na a kọwabeghị ngwa ụlọ ọgwụ ozugbo, nchọpụta usoro na ọkwa cellular na molecular na-arụtụ aka na ngwa ahụike n'ọdịnihu.  

Mmechi  

Na nchịkọta, Testagen egosila ọgwụgwọ ọgwụgwọ n'ịgwọ ọrịa prostatitis na-adịghị ala ala, ebe njirimara ya nke ntinye cell na mmekọrịta nucleic acid na-enye ohere maka ngwa ahụike ka ukwuu. Site na nyocha ọzọ, a na-atụ anya na ọ ga-ekere òkè dị mkpa n'ịgwọ ọrịa na ọgwụgwọ ndị ọzọ.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Onye ode akwụkwọ akụkọ sayensị

Niu, Dun bụ ọkà mmụta a ma ama na ngalaba ọgwụ na sayensị ndụ. Ejikọtara ya na ụlọ ọrụ a ma ama dị ka Mahadum Medical Army na Mahadum South, ọ na-elekwasị anya nyocha ya na Pharmacology & Pharmacy, Cell Biology, Immunology, na Biochemistry & Molecular Biology. Ọzụzụ ndị a dị oke mkpa maka ikpughe usoro ọrịa, ịkwalite mmepe ọgwụ ọhụrụ, na ịkwalite ahụike mmadụ. Na mgbakwunye, Niu, Dun na-eduzi nyocha na Sistemụ Cardiovascular & Cardiology, na-enyocha pathogenesis na ọgwụgwọ nke ọrịa obi. Ọrụ ya na-enye ntọala usoro ihe ọmụma dị ịrịba ama na nduzi bara uru maka nchọpụta ụlọ ọgwụ na ọgwụgwọ nke ọrịa obi, na-egosipụta nkà ya dị omimi na mmetụta dị ukwuu na nchọpụta ahụike .. Niu, Dun ka edepụtara na ntinye aka nke ntụaka [4].

▎ Okwu ndị dị mkpa

[1] Khavinson VK, Popovich IGE, Linkova NS, et al. Iwu Peptide nke nkwupụta mkpụrụ ndụ ihe nketa: Nleba anya usoro[J]. Molecules, 2021,26 (22}, https://www.mdpi.com/1420-3049/26/22/7053

AKỤKWU-ỌMBA = {7053).DOI:10.3390/molecules26227053.

[2] Fedoreyeva LI, Kireev II, Khavinson V, et al. Ntinye nke peptides dị mkpụmkpụ nke akpọrọ fluorescence n'ime oghere dị na sel HeLa yana mmekọrịta kpọmkwem nke peptides na deoxy ribooligonucleotides na DNA[J]. Biochemistry-Moscow, 2011,76 (11): 1210-1219.DOI:10.1134/S0006297911110022.

[3] Rossikhin V, Hoshchenko Y, Osipov P. Ịrụ ọrụ nke testosterone synthesis inductor ngwa 'testagen' na ụkọ androgenic na ndị ọrịa nwere prostatitis na-adịghị ala ala. Nsogbu nke Endocrine Pathology, 2011,36:17-22.DOI:10.21856/j-PEP.2011.2.03.

[4] Niu D, Wu Y, Lian J. Circular RNA ogwu mgbochi ọrịa na ọgwụgwọ [J]. Ntugharị mgbaàmà na ọgwụgwọ ezubere iche, 2023,8. https://api.semanticscholar.org/CorpusID:261662530.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadobeghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.