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▎ Kagrilintide (Kagrilintide) jɔcogo
Sɔrɔyɔrɔ: PubChem |
A kɛcogo: Pyr-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP CAS: 1415456-99-3. Bamako, Mali Formula: C 174H 269N 45O 52S. Bamako, Mali2 MW 4409 g/mol |
▎ Kagrilintide ɲinini
Cagrilintide ka ɲininiw kɛcogo ye mun ye?
Kagrilintidi ye amilini ni kalisitɔni minɛbaga fila ye (DACRA) min dilannen don ka da amilini sigicogo kan. Amilini bɛ bɔ pankreyasi gun β selilɛriw fɛ ani a bɛ baara kɛ ɲɔgɔn fɛ ni insuline ye walasa ka farikoloɲɛnajɛ baara suguya caman kɛ. A bɛ se ka fasa dusukunnata bila mɔgɔ la ani ka dumuni dunta dɔgɔya, kɛrɛnkɛrɛnnenya la ni a bɛ farikolojɔlifɛnw baara minnu bɛ yɔrɔ la min bɛ ɲɛgɛnɛsira kɔfɛ ɲɛgɛnɛsira naaninan da la. Sɔgɔsɔgɔninjɛ taamasiɲɛw bɛ taa ɲɛfɛla la kelennasira nucleus fɛ ani u bɛ se ka lase fana ka taa hipotalamus kɛrɛfɛyɔrɔ la ani nukilila kulu wɛrɛw la lateral parabrachial nucleus fɛ, o bɛ fasa yɔrɔ lawuli ani ka dumuni bali dunni Amilini bɛ se fana ka sukaro homeostasis labɛn ni a bɛ inisɔndiya ni sukaro bɔli bali walasa ka sukaro hakɛ sabati joli la [2] . A kɛcogo dɔw ye nɔ tilennen ye pankreyasi gun α selilɛriw la ani ka glucagon bɔli ɲɛnabɔ cogo tilennen na ni senfagabana taamasiɲɛw ye hipotalamus kɔnɔ. Banabagatɔ minnu farikololabɔli bɛ u la, β selilɛriw tiɲɛni bɛ na ni amilini bɔli dɔgɔyali ye. Amilini bɛ a sen don sukaro homeostasis labɛnni na ni a bɛ kɔnɔbara lankolonya ni sugunɛbilenni bɔli bali dumuni kɔfɛ, o bɛ dɔ bɔ joli la sukaro jiginni na dumuni kɔfɛ. A bɛ se fana ka kɔnɔbara lankolonya bila kɔfɛ, ka kɔnɔbara basigilen bali, ka dumuni sigi waati janya, ani ka joli sukaro jiginni jugumanba bali. Nka, amilini nafama tilancɛ waati surun bɛ dan sigi a tali la kɛnɛyaso la. Hali ni pramlintide bɛ sɔrɔ fura dɛmɛnan ye, a bɛ pikiri saba kɛ tile kɔnɔ, o tɛ nɔgɔya, wa a bɛ na ni sariya labatoli jugu ye [3] . Walasa ka o ko ɲɛnabɔ, Cagrilintide (Cagrilintide) dabɔra. A ɲininiw n’a yiriwali sinsinnen bɛ amilini nafama farikolo baarakɛcogo faamuyali jugu kan, k’a laɲini k’a baarakɛcogo ladege ka sɔrɔ ka fura in sabatili n’a baara kuntaalajan ɲɛ walasa ka kɛnɛyaso magow ɲɛ.
Cagrilintide ye mun ye?
Kagrilintidi ye amilini analozi kura ye min bɛ baara kɛ waati jan kɔnɔ, a seko ka bon, a y’a jira kaban ko a bɛ se ka kɛ a daminɛ na fasa ni farikoloɲɛnajɛ furakɛli la. A kɛra tuluma ye ani a bɛ ni jogo sabatilenw ye ani a bɛ baara kɛ waati jan kɔnɔ [3] . Amilini ni inisɔndiya bɛ bɔ ɲɔgɔn fɛ pankreyasi β selilɛriw fɛ ani a bɛ fasa dusukunnata bila mɔgɔ la ni a bɛ baara kɛ sugunɛ ka homɛostatiki ni diyanye yɔrɔw la. I n’a fɔ analozi, Cagrilintide bɛ se ka o nɔ in ladege, ka fasa bila mɔgɔ la walasa ka dɛmɛ don ka farikolo girinya kunbɛn. O waati kelen na, i n’a fɔ amilini ni kalisitɔni minɛbaga fila (DACRA), a bɛ bɔ amilini kɔkolo la, wa a kɛcogo kɛrɛnkɛrɛnnen don farikoloɲɛnajɛ labɛnni na.
Cagrinlintide ka sigicogo misali
Soso:PubMed [3] Ɲɛjirali dɔw.
Cagrilintide kɛcogo minnu bɛ tali kɛ o la, olu ye mun ye?
Kɛnɛyaso sɛgɛsɛgɛliw la, Cagrilintide ye nɔ ɲumanw sɔrɔ ka ɲɛsin mɔgɔ girinya dɔgɔyali ma. Misali la, santiri caman kɔnɔ, min kɛra k’a sɔrɔ a ma kɛ cogo si la, min kɛra ni mɔgɔ fila ye, min kɛra ni furakisɛ ye, ani min bɛ baara kɛ ni a bɛ tali kɛ ɲɔgɔn na Fasa 2 fura tata hakɛ ɲinini sɛgɛsɛgɛli la, ni i ye a suma ni furakisɛ tali kulu ye, kagrilintidi tata hakɛ kulu kelen-kelen bɛɛ la, girinya dɔgɔyali kɛmɛsarada la ka bɔ a daminɛ na (miligaramu 0,3 - 4,5) (6,0% - 10,8%) ka ca ni furakisɛ ta kulu ta ye (3,0%). Kisɛya dɔgɔyali miligaramu 4,5 kulu la fana ka ca ni liraglutidi miligaramu 3,0 kulu ta ye (10,8% ni 9,0%), o b’a jira ko a bɛ se ka kɛ fɛɛrɛ ɲuman ye farikolo girinya na kunbɛnni Kagrilintidi ka baarakɛcogo tɛ kelen ye nka a bɛ tali kɛ ɲɔgɔn na ni i ye a suma ni GLP-1 minɛbaga agoniste semaglutide ye. Semaglutidi bɛ dumuni~!phoenix_var106_3!~~!phoenix_var106_4!~
Banabagatɔ minnu ka farikoloɲɛnajɛ suguya 2 bɛ u la, Cagrilintide fana ye joli sukaro kunbɛnni seko ɲuman jira. Dɔgɔtɔrɔso ka sɛgɛsɛgɛliw y’a jira ko a sabatili ka ɲi ani a bɛ se ka kɛ fasa ni farikoloɲɛnajɛ suguya 2 furakɛli la. Misali la, banabagatɔw ka kɛnɛyako sɛgɛsɛgɛli la, farikolojidɛsɛ suguya 2 bɛ banabagatɔ minnu na, Cagrilintide ni GLP-1 minɛbaga agoniste semaglutide tali faralen ɲɔgɔn kan, o ye joli sukaro kunbɛncogo ɲuman jira ani ka girinya dɔgɔya Kɔrɔbɔli wɛrɛ fana y’a jira ko a muɲuni ka ɲi ani ni a lakananen don ni a kɛra a kelen na walima ni a ni semaglutide faralen don ɲɔgɔn kan [6] , barisa fura in sabatili bɛ tali kɛ a muɲuni n’a lakanani na kosɛbɛ.
Ka fara o kan, Cagrilintide muɲuna kosɛbɛ kɛnɛyaso sɛgɛsɛgɛliw la. Fasa 2nan fura tata hakɛ ɲinini sɛgɛsɛgɛli la, furakɛli dabila kudayi hakɛ minnu bɛ furakɛli kulu kelen-kelen bɛɛ la, olu tun bɛ ɲɔgɔn ta, a fanba tun bɛ bɔ ko juguw la. Nka, a kɔlɔlɔ minnu ka teli ka sɔrɔ, olu tun ye kɔnɔboli ye ani pikiri kɛyɔrɔ la, wa u fanba tun ka nɔgɔn fo ka se a danma ma. Fasa 1b sɛgɛsɛgɛli la, min kɛra ni mɔgɔw ye, min kɛra ni mɔgɔw ye, Cagrilintide ni semaglutide miligaramu 2,4 furakɛli faralen ɲɔgɔn kan, o fana ye muɲu ni lakana ɲuman jira [7] . Kɔrɔbɔlibaw ni kuntaalajanw ka kan ka kɛ don nataw la walasa ka nin furakɛli faralen in nafa ni a lakanani jateminɛ kosɛbɛ.
Cagrilintide bɛ jigiya kura lase fasa ni farikoloɲɛnajɛ suguya 2 furakɛli ma. A bɛ furakɛli suguya kura di banabagatɔ fasalenw ma, kɛrɛnkɛrɛnnenya la minnu tɛ ɲɛnamaya kɛcogo fɛɛrɛw jaabi ka ɲɛ, wa u ma bɛn bariatric opereli ma. A ka baarakɛcogo kɛrɛnkɛrɛnnen bɛ hakilina kuraw ni fɛɛrɛ kuraw di fasa furakɛli ma, wa a bɛ se ka kɛ ko nafa caman bɛ a la ka tɛmɛ laadala farikolojidɛsɛ furaw kan (D’Ascanio AM, 2024). Cagrilintide ni semaglutide (CagriSema) tali faralen ɲɔgɔn kan, o min ye ɲɛtaa sɔrɔ, o b’a jira ko furakɛli faralen ɲɔgɔn kan min bɛ kɛ ni laɲini caman ye, o ye fɛɛrɛ ɲuman ye min bɛ se ka fasa furakɛli ɲɛ jaabi Nin misali in bɛ misali kura di fasa kunbɛnni ma ani fana a bɛ na ni farikoloɲɛnajɛ ɲɛtaa caman ye banabagatɔw ma minnu ka farikoloɲɛnajɛ suguya 2 bɛ u la.
Kuncɛli la, i n’a fɔ amilini analozi kura min bɛ baara kɛ waati jan kɔnɔ, Cagrilintide bɛ se ka mɔgɔ farikolo girinya dɔgɔya ani ka joli sukaro kunbɛn. A bɛ fasa taamasiɲɛ sira baara ni amilini ka baara ladege ye ani ka farikoloɲɛnajɛ labɛn i n’a fɔ agoniste dual receptor. Kɛnɛyaso sɛgɛsɛgɛliw y’a jira ko Cagrilintide, a kelen walima a ni semaglutide faralen ɲɔgɔn kan, o bɛ se ka farikolo girinya dɔgɔya kosɛbɛ, wa a bɛ muɲu kosɛbɛ. Ka fara o kan, a ye joli sukaro kunbɛnni seko ɲuman fana jira banabagatɔw la minnu ka farikoloɲɛnajɛ suguya 2 bɛ u la, ka furakɛli suguya kura di fasa ni farikoloɲɛnajɛ furakɛli ma, ka furakɛli kɛcogo kɔrɔw fa, kɛrɛnkɛrɛnnenya la banabagatɔw ma minnu tɛ jaabi ɲuman di ɲɛnamaya kɛcogo fɛɛrɛw ma, wa u ma bɛn opereli ma. A furakɛli fɛɛrɛ min bɛ kɛ ni laɲini caman ye, o bɛ hakilina kuraw di farikoloɲɛnajɛ banaw furakɛli ma.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Dɔgɔtɔrɔ DCW Lau ye karamɔgɔ ye Cumming furakɛli kalanso la, Calgary Iniwɛrisite la, Kanada. A ka ɲininiw ɲɛsinnen bɛ kɔnɔboli ni farikoloɲɛnajɛ, furakɛli bɛɛjɛfanga ni kɔnɔna furakɛli, dusukun ni jolisiraw ni dusukunnakow, foroba kɛnɛya, sigida ni baarakɛyɔrɔ kɛnɛya, ani kansɛri furakɛli. A bɛ jɔyɔrɔw fana sɔrɔ Alberta Health Services (AHS) ani Obesity Canada la ani a bɛ baara kɛ Julia McFarlane Metabolism Research Centre la. Dɔgɔtɔrɔ Lau ka dɔnniya ka bon farikoloɲɛnajɛ ni fasa ɲinini siratigɛ la, a ka baara bɔra kalanko gafew kɔnɔ i n’a fɔ Canadian Journal of Metabolism. Dɔgɔtɔrɔ DCW tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [4].
