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▎He aha ka DSIP?
ʻO DSIP ka pōkole o Delta Sleep Inducing Peptide. He neuropeptide endogenous i haku ʻia me ʻeiwa amino acids.
▎ Hoʻolālā DSIP
![]() Puna: PubChem |
Kaʻina: WAGGDASGE Ke Kumu Molekala: C 35H 48N 10O15 Kaumaha Molekala: 848.8g/mol Helu CAS: 62568-57-4 PubChem CID: 3623358 Synonyms:Delta Sleep Inducing Peptide; Emideltide |
▎ DSIP ʻImi
He aha ke kumu noiʻi o DSIP?
I ka makahiki 1970, ua ulu nui ka noiʻi moe, a ua makemake nā ʻepekema e wehewehe i nā mea pohihihi o ka hoʻoponopono moe. I ka makahiki 1977, ua ʻike ʻole ʻo Schönenberg a me kāna hui i ka DSIP i ka wā e aʻo ana i nā hiʻohiʻona moe o nā rapeti. He non-peptide i haku ʻia me ʻeiwa amino acids, i hana ʻia ma ka hypothalamus a me ka pituitary gland. I loko o kēia manawa, ua hana ʻia nā holomua nui i ka ʻepekema peptide. Ua manaʻo ka ʻepekema ʻAmelika ʻo Kastin a me ka ʻepekema Dutch de Wied i ka manaʻo e hiki i nā peptides ke hele i ka pale koko-lolo, e kau ana i ke kumu no ka noiʻi ʻana ma DSIP. Ma hope o nā mea a pau, paʻa paʻa ka lolo e ka pale koko-lolo, a ʻo ka hapa nui o nā mea paʻakikī ke komo. Inā hiki i ka DSIP ke hele i kēia pale, e hoʻopilikia nui ia i kāna hana ma ka ʻōnaehana hoʻoponopono hiamoe o ka lolo.
Ua ʻike ʻia nā haʻawina ma hope mai aia ʻo DSIP ʻaʻole wale ma nā wahi kikoʻī o ka lolo akā i loko o ka ʻōnaehana limbic i nā ʻano manuahi a i hoʻopaʻa ʻia, a me nā ʻano o nā ʻāpana peripheral, nā ʻiʻo, a me nā wai kino. No ka laʻana, i loko o ka pituitary gland, ua hui pū ʻia me nā ʻano peptides a me nā mediators non-peptide e like me ka hormone adrenocorticotropic. I loko o nā ʻōpū huna huna a me ka pancreas, noho pū ia me ka glucagon. Hōʻike kēia māhele laha ʻana he mau hana like ʻole a paʻakikī paha ka DSIP. I ka wā mua, ua manaʻo ʻia ʻo DSIP he peptide hiamoe. Me ka hohonu o ka noiʻi, ua ʻike ʻia ʻaʻole i kaupalena ʻia kona hopena i ke kino i ka hiamoe. Ua hōʻike ʻia kekahi mau haʻawina e pāʻani paha ia i ka pane ʻana i ke koʻikoʻi a me ka ʻike ʻeha, a loaʻa iā ia nā hiʻohiʻona hiki ke hoʻomaha i ka hopohopo a me ka hōʻemi ʻana i ka ʻeha, akā pono e hōʻoia ʻia kēia mau hopena e ka noiʻi hou aku.
He aha ka hana o ka DSIP?
Hoʻoponopono i ka hiamoe a me ka makaʻala
Ka hoʻololi ʻana i ka pōʻai hiamoe a me ka ala ala: Ua hōʻike ʻia kekahi mau haʻawina he hopena koʻikoʻi ko DSIP i ka hiamoe a me ka ala ʻana. No ka laʻana, i loko o kahi noiʻi, ua hoʻopiʻi pinepine ʻia kahi maʻi narcolepsy kāne 35 makahiki me DSIP, a ua loiloi ʻia ma o ka hōʻike pilikino, nā hoʻokolohua hana, nā hoʻāʻo ʻana i ka hiamoe hiamoe, a me ka polysomnography āpau. Ua ʻike ʻia ua hoʻemi ʻo DSIP i ke alapine o ka hoʻouka ʻana i ka hiamoe, hoʻonui i ka hana o ke ao, makaʻala, a me ka hana [1] . Hoʻopili ʻo DSIP i ka pōʻai hiamoe a hoʻonui i ka hiamoe maka wikiwiki (REM). Hōʻike nā hopena i kēia mau hopena ma muli o DSIP e hoʻonui i ka circadian rhythm a me ka ultradian rhythm. Hiki i ka DSIP ke hoʻoikaika i nā hana physiological o ka hoʻomākaukau peripheral e pili ana i ka hoʻomaka ʻana o ka hiamoe.
Hoʻoponopono i ke ʻano o ka hiamoe: ʻAʻole pili wale ʻo DSIP i ka pinepine a me ka lōʻihi o ka hiamoe akā he hopena pū kekahi i ke ʻano moe. Hiki iā ia ke hoʻonui i ka hiamoe REM, e hōʻike ana i kāna kuleana koʻikoʻi i ka hoʻoponopono ʻana i nā pae like ʻole o ka hiamoe.
Nā hopena kino
Nā hopena i ka thermoregulation, ka puʻuwai puʻuwai, ke koko, ka paepae ʻeha, a me ka ʻōnaehana lymphokine: Ma waho aʻe o ka hoʻoulu ʻana i ka hiamoe ma lalo o nā kūlana kikoʻī o nā holoholona, he ʻano hopena physiological ka DSIP. No ka laʻana, hiki i ka DSIP ke hoʻopili i ka thermoregulation, ka puʻuwai puʻuwai, ke koko, ka paepae ʻeha, a me ka ʻōnaehana lymphokine [2] . Aia kēia mau hopena o ka DSIP i ka pōʻaiapuni circadian rhythm, a ʻike ʻia kekahi mau hopena ma mua o nā hōʻailona o ka hiamoe neural a i ʻole ke ʻano. Hōʻike kēia e hiki i ka DSIP ke hoʻomaka i nā hana physiological o ka hoʻomākaukau peripheral ma mua o ka hoʻomaka ʻana o ka hiamoe.
Ka hopena antioxidant
Ua ʻike nā haʻawina ʻo ka hoʻokele subcutaneous o exogenous DSIP (100μg / kg ke kaumaha o ke kino, i hoʻopaʻa ʻia no 5 mau lā) i nā ʻiole o 2 - 24 mau mahina hiki ke pale pono i ka pōʻino oxidative o nā lipids a me ka hōʻiliʻili ʻana o malondialdehyde i loko o nā kiko a me ka plasma o nā ʻiole o nā makahiki like ʻole [4] . He hopena antioxidant ikaika ka DSIP, i loaʻa ma ka hoʻoulu ʻana i nā ʻano hana pale antioxidant endogenous i loko o nā wai intracellular a me intercellular. He hopena koʻikoʻi ka DSIP i nā hana o ka superoxide dismutase, catalase, a me ceruloplasmin, a pili i nā ʻano o nā antioxidants non-enzymatic e like me ka urea a me ka uric acid. Me ka ʻelemakule physiological o nā mea ola, e kāohi ʻia nā mīkini pale antioxidant, ʻoiai hiki i ka DSIP ke hoʻonui i ka hiki o ka ʻōnaehana pale antioxidant endogenous i loko o nā ʻiʻo a me ke koko, ka mea nui ma ka hoʻoulu ʻana i nā ʻāpana o ka ʻōnaehana antioxidant enzymatic, ʻoi loa i ka pae hope o ka ulu ʻana o kēlā me kēia kanaka.
He aha nā mea hoʻohana o DSIP?
Lapaʻau ʻana i ka hiamoe
Ma kahi noiʻi, ua mālama ʻia ka mālama ʻana i ka injection DSIP i nā maʻi maʻi insomnia. Ua hōʻike ʻia nā hopena e hiki ke hoʻomaikaʻi i ka hiamoe ma mua o ka hiamoe ʻana o ka DSIP ma kahi ʻano o 25nmol/kg. Ua hōʻike ʻia ka hoʻoponopono hou ʻana i ka hoʻoponopono ʻana o ka moe ma hope o ʻehā mau lawelawe. ʻO ka hana hou ʻana i ke kakahiaka, me ka hoʻonui ʻana i ka hana o ke ao, ua loaʻa mau ka hopena maikaʻi i ka hiamoe pō, akā ʻaʻole maikaʻi ka hopena o ka dosing ʻelua i kēlā me kēia lā. I nā hihia o ka insomnia i hoʻokumu ʻia e nā maʻi lolo kūlohelohe, ua pane maikaʻi nā kiʻekiʻe o DSIP [1].
Lapaʻau ʻana i ka narcolepsy
Ua hoʻopaʻa pinepine ʻia kahi maʻi narcolepsy kāne 35 makahiki me DSIP i kahi noiʻi. Ua loiloi ʻia nā hopena o ka DSIP ma ka ʻala a me ka hiamoe ma o ka hōʻike pilikino, nā hoʻokolohua hana, nā hoʻāʻo ʻana o ka hiamoe hiamoe nui, a me ka polysomnography āpau. Ua hōʻike nā hualoaʻa ua hoʻemi ka DSIP i ke alapine o ka hoʻouka ʻana i ka hiamoe, hoʻonui i ka hana o ke ao, makaʻala, a me ka hana. Hoʻopili ʻo DSIP i ka manawa hiamoe a hoʻonui i ka hiamoe REM. Hōʻike nā hopena noiʻi e pili ana kēia mau hopena i ka DSIP e hoʻoikaika ana i ka circadian rhythm a me ka ultradian rhythm [1].
Hoʻomaʻamaʻa i ka waiʻona a me ka opiate withdrawal syndromes
Nā hopena lapaʻau lapaʻau: Ma muli o nā hopena o nā noiʻi holoholona, ʻo ia hoʻi, ʻo ka hoʻokomo pololei ʻana i ka morphine, ka waiʻona, pentobarbital, a me DSIP i loko o ka bulboreticular formation-midbrain-thalamus recruitment system hiki ke hoʻoulu i ka hiamoe lohi a me ka nui o nā nalu spindle, a hiki ke hoʻohuli ʻia kēia hopena e ka naloxone. Ua manaʻo ʻia he hana agonistic ka DSIP ma nā mea loaʻa opioid a he waiwai paha i ka mālama ʻana i nā maʻi withdrawal [3]. Ma hope o ka hoʻohana ʻana i ka DSIP intravenous no ka mālama ʻana i nā maʻi maʻi maʻi 107 me ka waiʻona (n = 47) a i ʻole opiate (n = 60) nā hōʻailona withdrawal, ua hōʻike ʻia nā loiloi lapaʻau a nā kauka a me nā kahu hānai he 97% a me 87% o ka opiate a me ka mea inu waiʻona, i kēlā me kēia, ua nalowale ko lākou mau hōʻailona a me nā hōʻailona. Ua loaʻa i ka poʻe addict opiate nā hōʻailona lapaʻau lōʻihi loa a koi hou aku i nā injections DSIP [3].
ʻO wai nā mea maʻi hiki iā DSIP ke hāʻawi i nā hopena adjuvant?
ʻO nā maʻi me nā maʻi moe: hiki i ka DSIP ke hoʻoulu a hoʻoponopono i ka hiamoe. No nā poʻe maʻi me ka insomnia, me ka poʻe pilikia e hiamoe, hiamoe māmā, a maʻalahi ke ala ala, hiki ke kōkua i ka hoʻomaikaʻi ʻana i ka maikaʻi o ka hiamoe, hoʻolōʻihi i ka manawa hiamoe, a kōkua iā lākou e hiamoe wikiwiki a mālama i ka hiamoe paʻa. Eia kekahi, no ka poʻe i hoʻopilikia ʻia ka puʻupuʻu hiamoe ma muli o ka jet lag, ka hana hoʻololi, a me nā mea ʻē aʻe, hiki i ka DSIP ke kōkua i ka hoʻoponopono ʻana i ka pōʻai hiamoe a hoʻihoʻi i kahi ʻano hiamoe maʻamau.
ʻO nā maʻi me nā maʻi ʻōnaehana nerve: ʻO kekahi mau maʻi ʻōnaehana nerve e like me ka maʻi Parkinson a me ka maʻi Alzheimer e hele pū ʻia me nā maʻi hiamoe a me nā hana aʻalolo ʻē aʻe. Ma waho aʻe o ka hoʻomaikaʻi ʻana i ka hiamoe, hiki i ka DSIP ke loaʻa i kekahi hopena pale i nā cell nerve, e kōkua ana i ka hoʻomaha ʻana i kekahi mau hōʻailona o nā maʻi ʻōnaehana nerve a hoʻomaikaʻi i ka maikaʻi o ke ola o nā maʻi. No ka laʻana, i nā maʻi maʻi o Parkinson, hiki i ka hoʻomaikaʻi ʻana i ka hiamoe ke kōkua i ka hōʻemi ʻana i ka luhi o ka lā a me nā pilikia neʻe.
ʻO nā maʻi me nā maʻi e pili ana i ke koʻikoʻi: ʻO ka poʻe i lalo o ke koʻikoʻi lōʻihi, e like me nā poʻe maʻi me nā maʻi noʻonoʻo a noʻonoʻo e like me nā maʻi hopohopo a me ke kaumaha, loaʻa pinepine nā pilikia hiamoe a ʻo ko lākou kino i ke ʻano o ke kaumaha mau. Hiki i ka DSIP ke hoʻoponopono i ke koʻikoʻi o ke kino ma o ka hoʻoponopono ʻana i ka hiamoe, kōkua i ka hoʻomaha ʻana i nā hōʻailona o ka naʻau e like me ka hopohopo a me ke kaumaha a me ka hoʻomaikaʻi ʻana i ke kūlana holoʻokoʻa o nā maʻi. I ka manawa like, no kekahi mau maʻi hana kino i hoʻokumu ʻia e ke koʻikoʻi, e like me nā maʻi digestive a me ka emi ʻana o ka hana immune, hiki i ka DSIP ke pāʻani i kekahi hana hoʻomaikaʻi adjuvant ma o ka hoʻomaikaʻi ʻana i ka hiamoe a me ka hoʻoponopono ʻana i ka pane o ke kaumaha.
I ka hopena, he koʻikoʻi ko DSIP i ke kahua o ka hoʻoponopono moe. Hiki iā ia ke hoʻomaikaʻi maikaʻi i ka maikaʻi o ka hiamoe o nā maʻi insomnia a hoʻonui i ko lākou manawa hiamoe. No nā poʻe maʻi narcolepsy, hiki iā ia ke hōʻemi i ke alapine o ka hiamoe a hoʻomaikaʻi i ka hana o ke ao a me ka makaʻala.
No ka mea kakau
ʻO nā mea i ʻōlelo ʻia ma luna nei ua noiʻi ʻia, hoʻoponopono ʻia a hōʻuluʻulu ʻia e Cocer Peptides.
Mea kākau moʻolelo ʻepekema
He kanaka noiʻi koʻikoʻi ʻo Schneider-Helmert D ma ke kahua o nā maʻi moe a me nā lāʻau lapaʻau pili. ua pili kāna hana me nā ʻoihana hanohano like ʻole ʻo Kirschgarten pain clin, pain clin, pain clin kirschgarten, med ctr mariastein, university of amsterdam, psychiatrie klinik kanton aargau, kantonsspital aarau ag (ksa), psychiat clin, psychiat klin konigsfelden kpsychiat, psychiat klin konigsfelden kpsychiat rt aargau. ʻO kāna noiʻi e kālele nui ana i nā neurosciences & neurology, psychiatry, general & internal medicine, pharmacology & pharmacy, and psychology. ua hāʻawi nui ʻo ia i ka ʻike a me ka mālama ʻana i ka insomnia a me nā maʻi ʻē aʻe e pili ana i ka hiamoe, me ka hoihoi nui i nā hopena o ka dsip (delta-sleep-inducing-peptide) i ka hiamoe kanaka.
Ua ʻimi kāna mau haʻawina i nā waiwai psychophysiological multifunctional o ka dsip ma mua o kāna kuleana i ka hoʻoulu ʻana i ka hiamoe kūlohelohe, me kona hopena i ka hiamoe o ke kanaka a me kona hiki ke hoʻomaikaʻi i ka maikaʻi o ka hiamoe i nā insomniacs. Eia kekahi, ua noiʻi ʻo ia i nā ʻano kumu a me nā ʻano o ka wakefulness ma waena o nā mea maʻamau a me nā insomniacs, a me ka manaʻo o ka insomnia asymptomatic. ua paʻi ʻia kāna hana ma nā puke moʻolelo hoʻonaʻauao like ʻole, me ka 'sleep,' 'eur neurol,' 'experientia,' a me 'neuropsychobiology,' i waena o kekahi. Ua helu ʻia ʻo Schneider-Helmert D ma ka ʻōlelo kuhikuhi [1].
▎ Nā ʻōlelo pili
[1] Schneider-Helmert D. Nā hopena o DSIP ma ka narcolepsy[J]. European Neurology, 1984,23(5):353-357.DOI:10.1159/000115713.
[2] Yehuda S, Carasso RL DSIP—He mea hana no ka noiʻi ʻana i ke ʻano hana hoʻomaka hiamoe - he loiloi [J]. International Journal of Neuroscience, 1988,38(3-4):345-353.DOI:10.3109/00207458808990695.
[3] ʻO Dick P, Costa C, Fayolle K, et al. ʻO DSIP i ka mālama ʻana i nā syndromes withdrawal mai ka waiʻona a me nā opiates [J]. European Neurology, 1984,23(5):364-371.DOI:10.1159/000115715.
[4] Bondarenko TI, Maiboroda EA, Mikhaleva II, et al. Mechanism of geroprotective action of delta-sleep inducing peptide [J]. Nā holomua ma Gerontology, 2011,1(4):328-339.DOI:10.1134/S2079057011040035.
ʻO nā ʻatikala a me nā ʻike huahana i hāʻawi ʻia ma kēia pūnaewele pūnaewele wale nō no ka hoʻolaha ʻana i ka ʻike a me nā kumu hoʻonaʻauao.
ʻO nā huahana i hāʻawi ʻia ma kēia pūnaewele i manaʻo wale ʻia no ka noiʻi in vitro. Hana ʻia ka noiʻi in vitro (Latin: *i ke aniani*, ʻo ia hoʻi i ka ipu aniani) ma waho o ke kino kanaka. ʻAʻole kēia mau huahana he lāʻau lapaʻau, ʻaʻole i ʻae ʻia e ka US Food and Drug Administration (FDA), a ʻaʻole pono e hoʻohana ʻia no ka pale ʻana, mālama, a hoʻōla paha i kekahi maʻi olakino, maʻi, a i ʻole maʻi. Ua pāpā loa ʻia e ke kānāwai ke hoʻokomo i kēia mau huahana i loko o ke kino kanaka a holoholona paha ma kekahi ʻano.