▎ DSIP Kev Tshawb Fawb
Kev tshawb fawb keeb kwm ntawm DSIP yog dab tsi?
Nyob rau xyoo 1970, muaj kev tshawb fawb txog kev pw tsaug zog, thiab cov kws tshawb fawb tau mob siab rau kev txiav txim siab tsis meej ntawm kev tswj kev pw tsaug zog. Xyoo 1977, Swiss chemist Schönenberg thiab nws pab neeg nrhiav pom DSIP thaum kawm txog kev pw tsaug zog ntawm luav. Nws yog non-peptide uas muaj cuaj amino acids, uas yog tsim nyob rau hauv lub hypothalamus thiab pituitary caj pas. Nyob rau lub sijhawm no, kev ua tiav tseem ceeb tau ua hauv peptide science. Tus kws tshawb fawb Asmeskas Kasstin thiab Dutch tus kws tshawb fawb de Wied tau pom zoo tias peptides tuaj yeem hla cov ntshav-hlwb teeb meem, tso lub hauv paus rau kev tshawb fawb tom ntej ntawm DSIP. Tom qab tag nrho, lub hlwb yog nruj nreem tiv thaiv los ntawm cov ntshav-hlwb barrier, thiab feem ntau cov tshuaj yog ib qho nyuaj rau nkag. Yog tias DSIP tuaj yeem hla qhov teeb meem no, nws yuav cuam tshuam rau nws lub luag haujlwm hauv lub hlwb txoj cai tswj kev pw tsaug zog.
Cov kev tshawb fawb tom qab tau pom tias DSIP muaj nyob tsis tau tsuas yog nyob rau hauv tej cheeb tsam ntawm lub hlwb tab sis kuj nyob rau hauv lub limbic system nyob rau hauv cov ntaub ntawv dawb los yog khi, nrog rau ntau yam peripheral kab mob, cov ntaub so ntswg, thiab lub cev kua. Piv txwv li, nyob rau hauv lub caj pas pituitary, nws yog co-localized nrog ntau yam peptides thiab non-peptide mediators xws li adrenocorticotropic hormone. Hauv cov kab mob hauv plab hnyuv thiab lub txiav, nws coexist nrog glucagon. Qhov kev faib tawm thoob plaws no qhia tau tias DSIP yuav muaj ntau yam haujlwm thiab nyuaj. Thaum pib, DSIP tau suav tias yog pw tsaug zog peptide. Nrog rau kev tshawb fawb tob tob, nws tau pom tias nws qhov cuam tshuam rau lub cev tsis txwv rau kev pw tsaug zog. Qee cov kev tshawb fawb tau pom tias nws tuaj yeem ua lub luag haujlwm hauv kev ntxhov siab thiab kev xav ntawm qhov mob, thiab muaj peev xwm ua tau zoo ntawm kev txo kev ntxhov siab thiab txo qhov mob, tab sis cov teebmeem no tseem yuav tsum tau tshawb xyuas los ntawm kev tshawb fawb ntxiv.
Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm DSIP?
Kev cai ntawm kev pw tsaug zog thiab wakefulness
Kev cuam tshuam rau lub voj voog pw tsaug zog thiab wakefulness: Ntau cov kev tshawb fawb tau pom tias DSIP muaj cov kev cai tseem ceeb ntawm kev pw tsaug zog thiab wakefulness. Piv txwv li, nyob rau hauv ib txoj kev tshawb no, ib tug txiv neej 35-xyoo-laus narcolepsy tus neeg mob tau rov txhaj tshuaj nrog DSIP, thiab tau soj ntsuam los ntawm tus kheej-daim ntawv qhia, kev ntsuam xyuas kev ua tau zoo, ntau yam kev ntsuam xyuas pw tsaug zog latency, thiab txhua hmo polysomnography. Nws tau pom tias DSIP txo qhov zaus ntawm kev pw tsaug zog tawm tsam, nce kev ua haujlwm nruab hnub, kev ceeb toom, thiab kev ua haujlwm [1] . DSIP compressed lub voj voog pw tsaug zog thiab txhim kho qhov muag nrawm (REM) pw tsaug zog. Cov txiaj ntsig tau qhia tias cov teebmeem no yog vim DSIP txhim kho lub circadian atherosclerosis thiab ultradian atherosclerosis. DSIP tuaj yeem txhawb nqa cov txheej txheem physiological ntawm kev npaj peripheral ntsig txog kev pw tsaug zog.
Kev tswj cov qauv kev pw tsaug zog: DSIP tsis tsuas yog cuam tshuam qhov zaus thiab lub sijhawm ntawm kev pw tsaug zog, tab sis kuj tseem cuam tshuam rau cov qauv pw tsaug zog. Nws tuaj yeem txhim kho REM pw tsaug zog, qhia txog nws lub luag haujlwm tseem ceeb hauv kev tswj hwm ntau theem ntawm kev pw tsaug zog.
Physiological teebmeem
Kev cuam tshuam ntawm thermoregulation, lub plawv dhia, ntshav siab, qhov pib mob, thiab lymphokine system: Ntxiv nrog rau kev txhawb nqa kev pw tsaug zog nyob rau hauv cov xwm txheej tshwj xeeb hauv cov tsiaj, DSIP muaj ntau yam teebmeem ntawm lub cev. Piv txwv li, DSIP tuaj yeem cuam tshuam rau thermoregulation, lub plawv dhia, ntshav siab, qhov pib mob, thiab lymphokine system [2] . Cov teebmeem ntawm DSIP no nyob ntawm lub voj voog circadian atherosclerosis, thiab qee qhov teebmeem tshwm sim ua ntej cov tsos mob ntawm neural lossis kev coj cwj pwm pw tsaug zog. Qhov no qhia tau hais tias DSIP tuaj yeem pib lub physiological mechanisms ntawm peripheral npaj ua ntej pw tsaug zog.
Antioxidant nyhuv
Cov kev tshawb fawb tau pom tias kev txhaj tshuaj subcutaneous ntawm exogenous DSIP (100μg / kg lub cev hnyav, txhaj rau 5 hnub sib law liag) hauv cov nas muaj hnub nyoog 2 - 24 lub hlis tuaj yeem tiv thaiv oxidative kev puas tsuaj ntawm lipids thiab tsub zuj zuj ntawm malondialdehyde hauv cov ntaub so ntswg thiab cov ntshav ntawm cov nas sib txawv . DSIP muaj cov nyhuv antioxidant muaj zog, uas yog ua tiav los ntawm kev ua kom muaj ntau yam endogenous antioxidant tiv thaiv mechanisms hauv cov kua dej hauv nruab nrog cev. DSIP muaj cov nyhuv stimulating rau cov dej num ntawm superoxide dismutase, catalase, thiab ceruloplasmin, thiab cuam tshuam cov concentrations ntawm non-enzymatic antioxidants xws li urea thiab uric acid. Nrog rau lub cev kev laus ntawm cov kab mob, cov tshuaj tiv thaiv antioxidant yuav raug cuam tshuam, thaum DSIP tuaj yeem ua rau muaj peev xwm ntawm endogenous antioxidant tiv thaiv kab mob hauv cov ntaub so ntswg thiab ntshav, feem ntau los ntawm kev txhawb nqa cov khoom ntawm cov enzymatic antioxidant system, tshwj xeeb tshaj yog nyob rau theem tom qab ntawm tus neeg txoj kev loj hlob.
Cov ntawv thov ntawm DSIP yog dab tsi?
Kev kho mob ntawm insomnia
Hauv kev tshawb nrhiav, DSIP kev txhaj tshuaj tau ua rau cov neeg mob insomnia. Cov txiaj ntsig tau pom tias ib qho kev txhaj tshuaj ntawm DSIP ntawm ib koob ntawm 25nmol / kg lub cev hnyav ua ntej pw tsaug zog tuaj yeem txhim kho kev pw tsaug zog. Kev tswj hwm rov qab tau pom tias cov qauv pw tsaug zog normalized tom qab plaub kev tswj hwm. Rov qab txhaj tshuaj thaum sawv ntxov, ntxiv rau kev ua haujlwm nruab hnub, tseem muaj kev cuam tshuam zoo rau kev pw tsaug zog hmo ntuj, tab sis cov nyhuv ntawm kev noj ob zaug ib hnub tsis zoo. Nyob rau hauv cov xwm txheej ntawm insomnia los ntawm cov kab mob hauv lub hlwb, cov koob tshuaj ntau ntawm DSIP tau teb zoo [1].
Kev kho mob ntawm narcolepsy
Ib tug txiv neej hnub nyoog 35 xyoo narcolepsy tus neeg mob tau rov txhaj tshuaj nrog DSIP hauv kev tshawb fawb. Cov teebmeem ntawm DSIP ntawm kev pw tsaug zog thiab pw tsaug zog tau soj ntsuam los ntawm kev tshaj tawm tus kheej, kev ntsuas kev ua haujlwm, ntau yam kev ntsuas pw tsaug zog, thiab txhua hmo polysomnography. Cov txiaj ntsig tau pom tias DSIP txo qhov zaus ntawm kev pw tsaug zog tawm tsam, nce kev ua haujlwm nruab hnub, ceeb toom, thiab kev ua haujlwm. DSIP compressed lub sijhawm pw tsaug zog thiab txhim kho REM pw tsaug zog. Cov txiaj ntsig ntawm kev tshawb fawb qhia tias cov teebmeem no yog vim DSIP hais txog lub circadian atherosclerosis thiab ultradian atherosclerosis [1].
Kev kho mob cawv thiab opiate tshem tawm syndromes
Cov teebmeem kev kho mob: Raws li cov txiaj ntsig ntawm kev tshawb fawb tsiaj, uas yog, kev txhaj tshuaj ncaj qha ntawm morphine, cawv, pentobarbital, thiab DSIP rau hauv bulboreticular formation-midbrain-thalamus recruitment system tuaj yeem ua rau qeeb-yoj pw tsaug zog thiab ntau tus spindle nthwv dej, thiab cov nyhuv no tuaj yeem thim rov qab los ntawm naloxone. Nws tau kwv yees tias DSIP muaj agonistic ua haujlwm ntawm opioid receptors thiab tej zaum yuav muaj txiaj ntsig hauv kev kho mob ntawm kev tshem tawm cov mob [3]. Tom qab txhaj tshuaj DSIP rau kev kho mob ntawm 107 tus neeg mob hauv tsev kho mob nrog cawv (n = 47) lossis opiate (n = 60) cov tsos mob tshem tawm, kev soj ntsuam kev soj ntsuam los ntawm cov kws kho mob thiab cov kws saib xyuas neeg mob pom tau tias 97% thiab 87% ntawm cov neeg mob opiate thiab cawv, raws li, muaj lawv cov tsos mob thiab cov tsos mob ntawm DSIP zoo dua, thiab cov tsos mob zoo dua li kev tswj xyuas DSIP. kuj qeeb. Cov neeg quav yeeb quav tshuaj muaj cov tsos mob tshwm sim ntev dua thiab yuav tsum tau txhaj tshuaj DSIP ntau dua [3].
Cov neeg mob twg tuaj yeem DSIP muab cov teebmeem ntxiv rau?
Cov neeg mob pw tsaug zog tsis zoo: DSIP tuaj yeem txhawb thiab tswj kev pw tsaug zog. Rau cov neeg mob insomnia, suav nrog cov neeg uas nyuaj rau pw tsaug zog, pw tsaug zog, thiab yooj yim waking li, nws yuav pab tau kom pw tsaug zog zoo, ncua sij hawm pw tsaug zog, thiab pab lawv tsaug zog sai dua thiab tswj kom muaj zog pw tsaug zog. Tsis tas li ntawd, rau cov neeg uas nws txoj kev pw tsaug zog raug cuam tshuam vim lub dav hlau lag luam, ua haujlwm ua haujlwm, thiab lwm yam, DSIP kuj tseem tuaj yeem pab kho lub voj voog pw tsaug zog thiab rov ua kom zoo li qub.
Cov neeg mob uas muaj kab mob hauv lub paj hlwb: Qee cov kab mob hauv lub paj hlwb xws li Parkinson's disease thiab Alzheimer's disease feem ntau nrog kev pw tsaug zog tsis zoo thiab cov paj hlwb tsis zoo. Ntxiv rau kev txhim kho kev pw tsaug zog, DSIP kuj tseem tuaj yeem muaj qee yam kev tiv thaiv ntawm cov paj hlwb, pab txo qee cov tsos mob ntawm cov kab mob paj hlwb thiab txhim kho lub neej zoo ntawm cov neeg mob. Piv txwv li, hauv cov neeg mob Parkinson tus kab mob, kev txhim kho kev pw tsaug zog tuaj yeem pab txo qis kev qaug zog nruab hnub thiab kev txav mus los.
Cov neeg mob uas muaj cov kab mob ntsig txog kev ntxhov siab: Cov neeg uas muaj kev ntxhov siab ntev, xws li cov neeg mob uas muaj kev puas siab puas ntsws thiab kev puas siab puas ntsws xws li kev ntxhov siab thiab kev nyuaj siab, feem ntau muaj teeb meem pw tsaug zog thiab lawv lub cev nyob rau hauv lub xeev ntawm kev ntxhov siab. DSIP tuaj yeem tswj hwm lub cev qhov kev ntxhov siab los ntawm kev tswj kev pw tsaug zog, pab daws cov tsos mob xws li kev ntxhov siab thiab kev nyuaj siab thiab txhim kho tag nrho lub xeev ntawm cov neeg mob. Nyob rau tib lub sijhawm, rau qee qhov kev ua haujlwm tsis zoo ntawm lub cev los ntawm kev ntxhov siab, xws li digestive disorders thiab txo lub cev tsis muaj zog, DSIP kuj tseem tuaj yeem ua lub luag haujlwm txhim kho qee yam los ntawm kev txhim kho kev pw tsaug zog thiab tswj cov lus teb kev ntxhov siab.
Hauv kev xaus, DSIP ua lub luag haujlwm tseem ceeb hauv kev tswj kev pw tsaug zog. Nws tuaj yeem txhim kho kev pw tsaug zog zoo ntawm cov neeg mob insomnia thiab txuas ntxiv lawv lub sijhawm pw tsaug zog. Rau cov neeg mob narcolepsy, nws tuaj yeem txo qhov zaus ntawm kev pw tsaug zog tawm tsam thiab txhim kho kev ua haujlwm nruab hnub thiab kev ceeb toom.
Hais Txog Tus Sau
Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.
Scientific Journal Author
Schneider-Helmert D yog tus kws tshawb fawb tseem ceeb hauv kev pw tsaug zog thiab kev kho mob ntsig txog. nws txoj haujlwm tau cuam tshuam nrog ntau lub tsev kawm muaj koob npe xws li tsev kho mob kirschgarten mob, mob clin, mob clin kirschgarten, med ctr mariastein, tsev kawm qib siab amsterdam, psychiatrie klinik kanton aargau, kantonsspital aarau ag (ksa), psychiat clin, psychiatschiat klin, aargau, thiab psychiat klin rt aargau. nws txoj kev tshawb fawb feem ntau tsom rau neurosciences & neurology, psychiatry, general & internal tshuaj, pharmacology & chaw muag tshuaj, thiab psychology. nws tau ua haujlwm tseem ceeb rau kev nkag siab thiab kev kho mob ntawm insomnia thiab lwm yam kev pw tsaug zog, nrog rau kev txaus siab tshwj xeeb rau cov teebmeem ntawm dsip (delta-pw tsaug zog-inducing-peptide) ntawm tib neeg pw tsaug zog.
Nws cov kev tshawb fawb tau tshawb fawb txog ntau yam kev puas siab puas ntsws ntawm dsip dhau ntawm nws lub luag haujlwm hauv kev ua kom pw tsaug zog ntuj, suav nrog nws txoj kev cuam tshuam rau tib neeg pw tsaug zog thiab nws lub peev xwm los txhim kho kev pw tsaug zog zoo hauv insomniacs. Tsis tas li ntawd, nws tau tshawb xyuas lub ntsiab lus thiab lub hom phiaj kev ntsuas ntawm wakefulness ntawm ib txwm thiab insomniacs, nrog rau lub tswv yim ntawm asymptomatic insomnia. nws cov hauj lwm tau luam tawm nyob rau hauv ntau yam kev kawm phau ntawv journal, xws li 'pw,' 'eur neurol,' 'experientia,' thiab 'neuropsychobiology,' ntawm lwm tus. Schneider-Helmert D tau teev nyob rau hauv cov ntaub ntawv siv [1].
