▎ DSIP Risach
Wetin na di risach bakgrɔn fɔ DSIP?
Insay di ia 1970, bɔku pipul dɛn bin de du risach bɔt slip, ɛn sayɛnsman dɛn bin rili want fɔ no di sikrit dɛn we de sho aw pɔsin kin slip fayn. Insay 1977, wan Swizaland kemist we nem Schönenberg ɛn in tim bin aksidɛntli fɛn DSIP we dɛn bin de stɔdi aw rɔbish kin slip. na nכn pεptida we kכmכp fכ nayn amino asid dεm, we de prodyuz na di haypothalamus εn pituitary gland. insay dis tεm, dεn bin mek big big bכku bכku tin dεm na pεptida sayns. Wan Amɛrikin sayɛnsman we nem Kastin ɛn wan Dɔch sayɛnsman we nem de Wied bin tɔk bɔt di we aw pipul dɛn kin tink se peptide dɛn kin krɔs di blɔd ɛn bren barɛri, ɛn dis bin mek di fawndeshɔn fɔ di risach we dɛn go du afta dat bɔt DSIP. Afta ɔl, di blɔd ɛn bren barɛri de protɛkt di bren tayt tayt wan, ɛn bɔku pan di tin dɛn nɔ kin izi fɔ go insay. if DSIP kin kכros dis barεri, i go rili afekt in rol insay di bren in slip rεguleshכn mεkanism.
stכdi dεm we dεn du afta dat dεn sho se DSIP nכ de nכmכ na spεsifi k εria dεm na di bren bכt i de insay di limbik sistεm insay fri כ bכnd fכm dεm, εn bak insay difrεn pεrifεral כgan dεm, tisu dεm, εn bכdi fכluid dεm. fכ egzampl, insay di pituitary gland, i de kכ-lokal wit difrεn pεptida dεm εn nכn pεptida mεdiate dεm lεk adrenocorticotropic homon. insay di intestinal sekretri sεl dεm εn di pankrias, i de kכgεst wit glukagon. Dis distribyushɔn we de ɔlsay de sho se DSIP kin gɛt difrɛn ɛn kɔmpleks wok dɛn. Fɔs, dɛn bin de tek DSIP as slip peptide. We dɛn dɔn dip dip pan di risach, dɛn dɔn si se di impak we i gɛt pan di bɔdi nɔto jɔs fɔ slip. Sɔm stɔdi dɔn sho se i kin ple wan rol pan di strɛs rispɔns ɛn di pen we pɔsin kin fil, ɛn i gɛt di kayn tin dɛn we kin mek pɔsin nɔ wɔri ɛn ridyus pen, bɔt dɛn ifɛkt ya stil nid fɔ chɛk bay mɔ risach.
Wetin na di mɛkanism fɔ akshɔn fɔ DSIP?
Rigyuleshɔn fɔ slip ɛn wek
Influεns di slip εn wek saykl: כl di stכdi dεm dεn sho se DSIP gεt sכm sכm rεgεdyushכn ifekt pan slip εn wek. Fɔ ɛgzampul, insay wan stɔdi, dɛn bin injɛkt wan man we ol 35 ia we gɛt narkolepsi wit DSIP bɔku tɛm, ɛn dɛn bin evalyu am tru sɛlf-ripɔt, pefɔmɛns tɛst, bɔku tɛm slip latɛns tɛst, ɛn ɔl-nayt polysomnography. Dɛn bin fain se DSIP de ridyus di frɛkuɛns fɔ slip atak, inkrisayz di de aktiviti, alert, ɛn pefɔmɛns [1] . DSIP kכmprεs di slip saykl εn εnhans rεpid ay muvmεnt (REM) slip. di risal dεm sho se dεn ifekt dεm ya de bi fכ DSIP we de εnhans di sirkadian ritm εn ultradian ritm. DSIP kin promuot di fisiolכjik mεkanism dεm fכ pεrifεral prεparashכn we riliyt to slip onset.
rεgεl di slip strכkchכ: DSIP nכ de כnli afekt di frεkuεns εn di tεm we i de slip bכt i de afekt di slip strכkchכ. i kin mek REM slip bכku, we de sho se i imכtant rol fכ rεgεl difrεn stej dεm fכ slip.
Di ifɛkt dɛn we pɔsin kin gɛt na in bɔdi
di ifekt dεm pan tεmכrεgulεshכn, hat rεt, bכdi prεshכn, pen thrεshold, εn di limfokin sistεm: Apat frכm we i de mek dεn slip כnda spεshal kכndishכn dεm na animal, DSIP gεt difrεn fysiolojikal ifekt dεm. fכ egzampl, DSIP kin afekt tεmכrεgulεshכn, hat rεt, bכdi prεshכn, pen thrεshold, εn di limfokin sistεm [2] . dis ifekt dεm we DSIP de gi dipכnt pan di sirkadian ritm saykl, εn sכm ifekt dεm de apin bifo di sayn dεm fכ nyural כ bihayvכral slip. dis sho se DSIP kin initiate di fisiolכjik mεkanism dεm fכ pεrifεral prεparashכn bifo slip bigin.
Antiɔksidant ifɛkt
stכdi dεm dεn fכnshכn se sכbkutan injεkshכn fכ εksojen DSIP (100μg/kg bכdi wet, injεkt fכ 5 kכnsekyutiv de) insay rat dεm we ol 2 - 24 mכnt kin ifektivli prεvεnt di כksidεtiv damej fכ lipid dεm εn di akyumyuleshכn fכ malondialdehyde insay di tisu εn plasma fכ rat dεm we difrεn ej [4] . DSIP gεt pawaful antioksidant ifekt, we dεn kin achy bay we dεn de aktibכt difrεn εndojεnik antioksidant protεkshכn mεkanism dεm insay intasεlulyar εn intasεlulyar fכluid dεm. DSIP gεt stimulating ifekt pan di aktiviti dεm fכ supεrכksayd dismutase, katalaz, εn sεruloplasmin, εn i de afekt di kכnsantreshכn fכ nכn-εnzym antioksidant dεm lεk yuria εn yurik asid. wit di fysiolojikal ol ej fכ di כganism dεm, di antioksidant protεkshכn mεkanism dεm go inhεbit, we DSIP kin inkrεs di abiliti fכ di εndojεnik antioksidant protεkshכn sistεm insay tisu dεm εn bכdi, mεntal wan bay we i de stimul di kכmכpכnεnt dεm fכ di εnzym antioksidant sistεm, spεshal wan insay di leta stej fכ di wan wan divεlכpmεnt.
Wetin na di aplikeshɔn dɛn fɔ DSIP?
Tritmɛnt fɔ pɔsin we nɔ ebul fɔ slip
Insay wan stɔdi, dɛn bin du DSIP injɛkshɔn tritmɛnt pan pipul dɛn we nɔ de slip. di risal sho se wan singl injεkshכn fכ DSIP pan wan doz 25nmol/kg bכdi wet bifo slip kin impruv slip. Ripit administreshכn sho se di slip strכkchכ nכmal afta fכ administreshכn. Ripit injεkshכn na mכnin, apat frכm inkrεs pan de aktiviti, stil bin gεt strכng pכsitiv impak pan nayt slip, bכt di ifekt fכ tu tεm de doz nכ bin gud. pan kes dεm we dεn nכ de slip we dεn kכz fכ כrganik bren sik, hεy dכz fכ DSIP bin rεspכnd fayn [1] ..
Tritmɛnt fɔ sik we dɛn kɔl narkolepsi
Wan 35 ia ol man we gɛt narkɔlepsi, dɛn bin injɛkt DSIP bɔku tɛm insay wan stɔdi. Di ifekt dεm we DSIP gεt pan wek εn slip bin evaluate tru sεlf-rεpכt, pεrformεns tεst, mכltipכl slip latεns tεst, εn כl-nayt polysomnography. Di risal sho se DSIP ridyus di frɛkuɛns fɔ slip atak, inkrisayz di de aktiviti, alert, ɛn pefɔmɛns. DSIP bin kɔmprɛs di slip tɛm ɛn ɛp fɔ mek REM slip bɛtɛ. di stכdi rizulεt dεn sho se dεn ifekt ya de bi fכ DSIP we de εnfaz di sirkadian ritm εn di ultradian ritm [1]..
Tritmɛnt fɔ di sik dɛn we pɔsin kin gɛt we i de lɛf fɔ drink rɔm ɛn di opiate
di klinik tritmεnt ifekt dεm: Bays pan di risכlt dεm fכ animal stכdi dεm, dat na, di dayrekt injεkshכn fכ mכfin, alkol, pεntobarbital, εn DSIP insay di bulboreticular fכmeshכn-midbren-thalamus rikrutmεnt sistεm kin indyuz slo-wev slip εn big nכmba כf spindl wev dεm, εn dis ifekt kin rivεs bay naloxone. i spεkul se DSIP gεt agonistik aktiviti pan opioid rεsεpכta dεm εn i kin valyu fכ di tritmεnt fכ witdraw sεndrכm[3]. Afta intravenɔs injɛkshɔn fɔ DSIP fɔ di tritmɛnt fɔ 107 ɔspitul pasɛnt dɛn wit rɔm (n = 47) ɔ opiate (n = 60) witdraw simptom, di klinik ɛvalueshɔn dɛn we dɔktɔ ɛn nɔs dɛn du sho se 97% ɛn 87% pan opiate ɛn alkol adikshɔn, rispɛktvɔli, bin gɛt dɛn klinik simptom ɛn sayn dɛn we dɔn lɔs ɔ signifyant impruv afta DSIP administreshɔn, ɛn di rilif fɔ di wɔri simptom dɛn bin rili slo. Di wan dɛn we gɛt opiate adikshɔn bin gɛt klinik simptom dɛn we bin de las fɔ lɔng tɛm ɛn dɛn bin nid fɔ gɛt mɔ DSIP injɛkshɔn [3]..
Us pasɛnt dɛn DSIP kin gi adjuvant ifɛkt fɔ?
Di wan dɛn we gɛt prɔblɛm wit slip: DSIP kin mek pɔsin slip ɛn rigul. Fɔ di wan dɛn we nɔ de slip, ivin di wan dɛn we nɔ kin izi fɔ slip, we nɔ kin slip fayn, ɛn we kin wek izi wan, i kin ɛp fɔ mek dɛn slip fayn, fɔ mek dɛn slip lɔng, ɛn ɛp dɛn fɔ slip kwik ɛn fɔ mek dɛn kɔntinyu fɔ slip fayn. Apat frɔm dat, fɔ pipul dɛm we dɛn slip ritm dɔn ambɔg bikɔs ɔf jet lag, shift wok, ɛn ɔda tin dɛm, DSIP kin ɛp bak fɔ ajɔst di slip saykl ɛn fɔ mek dɛn slip fayn bak.
Pɔsin wae gɛt dis sik na dɛn nervɔs sistɛm: Sɔm nervɔs sistɛm sik lɛk Pakinsin sik ɛn Alzaima sik kin kam wit di prɔblɛm wae dɛn kin gɛt fɔ slip ɛn nɔr de woke fayn fayn wan. Apat frɔm we i kin mek pɔsin slip fayn, DSIP kin gɛt sɔm prɔtɛktiv ifɛkt bak pan di nɛv sɛl dɛn, we kin ɛp fɔ pul sɔm sayn dɛn we de sho se dɛn gɛt sik dɛn na di nervɔs sistɛm ɛn fɔ mek di sikman dɛn gɛt bɛtɛ layf. Fɔ ɛgzampul, pan di wan dɛn we gɛt Pakinsin sik, if dɛn slip fayn, dat kin ɛp fɔ mek dɛn nɔ taya na di de ɛn dɛn nɔ kin ebul fɔ muv.
Di wan dɛm wae gɛt dis sik wae gɛt fɔ du wit strɛs: Pipul dɛm wae gɛt strɛs fɔ lɔng tɛm, lɛk pipul dɛm wae gɛt dis maynia sik wae gɛt dis maynia sik lɛk wae dɛn kin wɔri ɛn pwɛl hat, bɔrku tɛm kin gɛt prɔblɛm wit slip ɛn dɛn bɔdi kin gɛt strɛs we nɔr de dɔn. DSIP kin rεgεl di bכdi in strεs rεspכns bay we i de rεgεl slip, εp fכ rεliv di imכshכnal simptom dεm lεk wae yu de wɔri εn pwεl hat εn i de impruv di כvala stet fכ di sik pipul dεm. pan di sem tεm, fכ sכm fכshal fכnshכn dizכrd dεm we strεs de kכz, lεk dijestiv dizכrd εn di dεkrεshכn fכ di imyun fכnshכn, DSIP kin ple wan sכm adjuvant improvement rol bak bay we i de impruv slip εn rεgεl di strεs rεspכns.
fכ kכnklud, DSIP de ple wan imכtant rol insay di fil fכ slip rεgulεshכn. I kin fayn fɔ mek di wan dɛn we nɔ de slip fayn fɔ slip fayn ɛn i kin mek dɛn slip lɔng. Fɔ di wan dɛn we gɛt narkolepsi, i kin mek dɛn nɔ gɛt bɔku atak we dɛn kin slip ɛn i kin mek dɛn ebul fɔ du tin dɛn we dɛn kin du na di de ɛn fɔ wach.
Bɔt di pɔsin we rayt di buk
Di tin dɛm we wi dɔn tɔk bɔt ɔp na ɔl di risach, ɛdit ɛn kɔmpilayt na Cocer Peptides.
Sayɛns Jɔnal Author
Schneider-Helmert D na wan bigman we de stɔdi bɔt di prɔblɛm dɛn we kin mek pɔsin slip ɛn di tritmɛnt dɛn we gɛt fɔ du wit am. in wok dɔn gɛt fɔ du wit difrɛn prestij institiushɔn dɛn lɛk kirschgarten pen clin, pen clin, pen clin kirschgarten, med ctr mariastein, yunivasiti ɔf amstadam, saykiatrie klinik kanton aargau, kantonsspital aarau ag (ksa), saykayat klinik, saykayat klin konigsfelden, saykayat klin kt aargau, ɛn saykayat klin rt aargau we de na di wɔl. in risach de fכs fכs pan nyurosayns & nyurolכji, saykayatri, jεnarכl & intanεt mεdisin, famakכlכji & famasi, εn saykכlכji. i dɔn mek big kɔntribyushɔn fɔ ɔndastand ɛn trit inshɔmnia ɛn ɔda prɔblɛm dɛn we gɛt fɔ du wit slip, wit patikyula intres pan di ifɛkt dɛn we dsip (delta-sleep-inducing-peptide) gɛt pan mɔtalman slip.
In stכdi dεn dכn εksplכr di mכltifunshכnal saykofysiolojikal prכpati dεm fכ dsip biyכn in rol fכ indyuz nεchכral slip, inklud in inflכεns pan disturb hכman slip εn in pכtεnshal fכ impruv slip kwaliti in insכmnia. apat frכm dat, i dכn invεstigat di sכbjεktiv εn כbjεktiv mεzhɔ dεm fכ wek bitwin nכmal εn insכmnia dεm, εn bak di kכnsεpt fכ asymptomatic insomnia. in wok dɔn de na difrɛn akademik jɔnal dɛm, we inklud 'slip,' 'eur neurol,' 'experientia,' ɛn 'neuropsychobiology,' ɛn ɔda wan dɛm. Schneider-Helmert D de list insay di rεfrεns fכ saytεshכn [1].
