|
1kits (10Vials) .
| Agbɔsɔsɔ: | |
|---|---|
▎ Bpc 157 Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: GEPPPGKPADDAGLV Molekyulãwo ƒe Mɔfiame: C 62H 98N 16O22 Molekyulã ƒe Kpekpeme: 1419.5g/mol CAS ƒe xexlẽdzesi: 137525-51-0 PubChem ƒe CID: 9941957 Nya siwo sɔ kple wo nɔewo: Bepecin |
▎ Bpc 157 Numekuku
Nukae nye numekuku ƒe megbenyawo le Bpc 157 me?
Bpc 157 nye peptide si me amino acid 15 le eye wònye ŋutilã takpɔnu (Bpc) si ŋu woke ɖo heɖe ɖe vovo tso amegbetɔ ƒe dɔgbo me tsi me ƒe ɖoɖo ƒe akpa aɖe. Nusiwo gbɔna nye numekuku ƒe megbenya siwo ku ɖe Bpc 157 ŋu:
Ahɔhɔ̃-dɔgbo ƒe Akpa kple Bpc 157:
Ahɔhɔ̃ kple dɔgbo ƒe kadodoa lɔ peptidergic tsitsinuwɔnuwo ɖe eme. Le wo dome la, dɔgbo me pentadecapeptide si li ke Bpc 157 nye atike si tsia abi nu si nye peptidergic si le dedie eye wòwɔa dɔ nyuie le dɔgbo ƒe dɔléle si xɔa dzo ƒe dodokpɔwo me eye wole dodokpɔ wɔm fifia ɖe dɔgbo ƒe dɔléle si nye multiple sclerosis ŋu. Enɔa amegbetɔ ƒe dɔgbo me tsi me le dzɔdzɔme nu [1] . Bpc 157 ate ŋu awɔ dɔ abe Robert lãmenugbagbeviwo takpɔkpɔ ƒe domenɔla yeye ene, akpɔ gome le dɔgboa ƒe ʋukawo ƒe blibonyenye me léle ɖe asi me aɖi ƒe ŋusẽkpɔɖeamedzi aɖeke manɔmee.
Ekpɔ dzidzedze le dɔgbo ƒe dɔlélewo, aɖuɖɔtoedɔ, aklã kple dɔgbo ƒe abiwo dada me, kpakple lãkusi kple abi vovovowo dada me. Eʋãa Egr-1 domenyiŋusẽfianu, NAB2, FAK-paxillin, kple JAK-2 mɔwo hã [1] .Ne wodo Bpc 157 ɖe gota la, wokpɔa titina ƒe ŋusẽkpɔɖeamedzi nyui siwo sɔ le gɔmedzedzea me, vevietɔ tɔtrɔ siwo vaa serotonin ƒe dodo me le ahɔhɔ̃a ƒe akpa aɖewo (vevietɔ nigrostriatal nuto). Bpc 157 ɖɔa serotonergic kple dopaminergic systems ɖo, eye wòkpɔa ŋusẽ nyui ɖe nuwɔna ƒe kuxi vovovo siwo dzɔna le ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe ʋuʋu/gblẽƒe tɔxɛ ta.
Tsɔ kpe ɖe eŋu la, ahɔhɔ̃mekawo takpɔnu le Bpc 157 ŋu, abe somatosensory ahɔhɔ̃mekawo takpɔkpɔ, gotagome lãmekawo ƒe gbugbɔgadzɔ dodo ɖe ŋgɔ, tsitretsitsi ɖe ŋgɔyiyi ƒe ɖoɖoa ŋu le ahɔhɔ̃ ƒe abi si me nuveviwɔame le megbe, mɔxexe ɖe axonal kple neuronal necrosis, demyelination, kple cyst ƒe wɔwɔ nu le sisiblisi siwo ƒe aklã ƒe tete kpe ɖe caudal paralysis ŋu, kple caudal dɔwɔwɔ gbugbɔgaɖoanyi [1] . .
Akpa Si Wowɔna Le Dɔgbo Me Lãmenugbagbeviwo Takpɔkpɔ Kple Ŋutinuwo Takpɔkpɔ Me:
Bpc 157 le vevie ŋutɔ abe domenɔla si ate ŋu anye Robert ƒe dɔgbo me lãmenugbagbeviwo takpɔkpɔ/lãmenugbagbevi siwo trɔna ɖe nɔnɔmewo ŋu takpɔkpɔ kple ŋutinuwo takpɔkpɔ ene, kpakple domenɔla yeye na Selye ƒe nuteɖeamedzi ƒe ŋuɖoɖo. Bpc 157 kpɔa ƒodo me lãmenugbagbeviwo ta eye wòléa dɔgboa ƒe blibonyenye me ɖe asi tso nu vovovo siwo gblẽa nu le ame ŋu me.
Ate ŋu axe mɔ ɖe aha kple atike siwo me steroid mele o siwo tsia dɔgboa nu ƒe ŋusẽkpɔɖeamedzi gbegblẽ nu ɖe dɔgboa ƒe lãkusi kple lãkusi bubuwo (abe ŋutigbalẽ, aklã, dɔgbo, dzi, kple ahɔhɔ̃ ene) dzi, eye woate ŋu azãe le abidada me. Tsɔ kpe ɖe eŋu la, Bpc 157 ate ŋu atsi dɔgbo ƒe lãmenugbagbeviwo ƒe gbegblẽ hã nu, akpɔ ʋuka bubuwo ta, akpɔ ŋusẽ nyui ɖe ʋukawo dzi, agbugbɔ ʋu ƒe sisi ƒe blibonyenye aɖo kabakaba, eye wòatsi tumor cachexia, lãmekawo ƒe gbegblẽ, kple pro-inflammatory/cachectic cytokines ƒe dzidziɖedzi nu [2]. .
Akpa si Atikewɔwɔ Wɔna le Ʋukawo ƒe Ʋuʋu Me:
Le numekuku le superior mesenteric artery kple vein occlusion le rats me la, Bpc 157 ate ŋu ana collateral mɔwo nawɔ dɔ kabakaba, siwo dometɔ aɖewoe nye superior mesenteric vein-inferior anterior pancreaticoduodenal vein-superior anterior pancreaticoduodenal vein-pyloric vein-portal vein pathway, mɔ bubu siwo yia inferior vena cava to titina colic me vein kple inferior mesenteric vein, kpakple inferior anterior pancreaticoduodenal artery kple inferior mesenteric artery.
Bpc 157 ate ŋu atsi superior sagittal sinus, portal vein, kple inferior vena cava hypertension, aortic hypotension, venous kple arterial thrombosis si yia edzi le nuto siwo le gota kple titina, aɖe ŋutinu geɖe ƒe abi, abi siwo le dzi, lãkusi, aklã, ayiku, dɔgbo ƒe mɔnu, vevietɔ le ahɔhɔ̃ me, kple oxidative stress le lãmenugbagbeviwo me dzi akpɔtɔ [3] ..
Akpa si Budd-Chiari Dɔléle Wɔna: Le Budd-Chiari ƒe dɔléle ƒe kpɔɖeŋu (suprahepatic vena cava ƒe ʋuʋu) ŋuti numekuku me le sisiblisiwo me la, Bpc 157 ate ŋu awɔ mɔ siwo to ʋuka si le anyime-azygos vein (hemiazygos vein)-vena cava si le etame kple portacaval shunt, si tsi tre ɖe portal vein kple inferior ŋu kabakaba vena cava ʋusɔgbɔdɔ, aortic hypotension, eye wòɖea ʋuka me ʋu ƒe sisi, electrocardiogram ƒe dɔlélewo, kple abi siwo le aklã kple dɔgbo me dzi kpɔtɔna. Le ligation me la, nitric oxide kple malondialdehyde ƒe agbɔsɔsɔ le aklã me gakpɔtɔ le lãmesẽ ƒe asixɔxɔ si sɔ me, eye serum enzymes ƒe dzidziɖedzi hã dzi ɖena kpɔtɔna ŋutɔ [4]..
Akpa Si Ate Ŋu Awɔ le Atikewɔwɔ me le COVID-19 me:
Wobua COVID-19 be enye ʋumenugbagbeviɣidɔ kple ʋukawo ƒe dɔléle si koŋ tɔa ŋku lãmenugbagbevi siwo le lãmenugbagbeviwo me le ɖoɖo nu, si ate ŋu ahe ʋuka siwo le titina ƒe dɔmawɔmawɔ nyuie vɛ, si ahe kuxiwo kple ŋutinu geɖe ƒe dɔmawɔmawɔ nyuie vɛ. Bpc 157 nye peptide si tsi tre ɖe dɔdzẽ ŋu, lãmenugbagbeviwo takpɔkpɔ, kple lãmenugbagbeviwo takpɔkpɔ ƒe ŋusẽkpɔɖeamedzi le ŋutinu vovovo siwo le lã ƒomevi vovovowo me. Ate ŋu ana endothelial nitric oxide synthase, si do ƒome kple nitric oxide ƒe dodo, lãmenugbagbeviwo ɖɔɖɔɖo, kple ʋukawo ƒe ɖoɖowɔwɔ ƒe nɔnɔmewo nawɔ dɔ, ana ʋukawo ƒe blibonyenye kple dɔlélenutsiŋutete ƒe dɔwɔwɔ nanyo ɖe edzi, aɖe dɔlélea ƒe nɔnɔme si doa alɔ dɔlélea dzi akpɔtɔ, eye wòaɖe dɔlélea ƒe sesẽ dzi akpɔtɔ. Eyata ele vevie ŋutɔ be woaƒo nu tso eƒe ŋutete ŋu abe mɔxexeɖedɔléle nu kple atikewɔwɔ kpeɖeŋutɔ ene [5] (Deek SA, 2022).
Nuka koŋue nye Bpc 157 ƒe dɔwɔwɔ le ahɔhɔ̃ kple dɔgbo ƒe axis me?
Ahɔhɔ̃ kple dɔgbo ƒe axis nye kadodomɔnu sesẽ aɖe si to mɔ eve dzi si me kadodo si le lãmekawo kple dɔgbo ƒe dɔwɔwɔ dome le, eye Bpc 157 wɔa akpa vevi aɖe le eme, vevietɔ le go etɔ̃ me: Gbã la, abe domenɔla si kpɔa lãmenugbagbeviwo ta ene la, Bpc 157 ate ŋu akpɔ gome le dɔgboa ƒe lãkusi ƒe blibonyenye me léle ɖe asi me. Esi wònye domenɔla yeye na Robert lãmenugbagbeviwo takpɔkpɔ si me aɖi aɖeke mele o ta la, eléa dɔgboa ƒe ŋutilã ƒe dɔwɔwɔ si sɔ me ɖe asi to dɔgbo ƒe lãmenugbagbeviwo takpɔkpɔ me, si wɔnɛ be wòkpɔa ŋusẽ ɖe ahɔhɔ̃ kple dɔgbo ƒe axis ƒe dadasɔ dzi. Evelia, ewɔa ɖoɖo ɖe ahɔhɔ̃mekawo ƒe dɔwɔwɔ ŋu. Bpc 157 ate ŋu aɖɔ serotonergic kple dopaminergic ɖoɖowo ɖo. Ne wodo Bpc 157 ɖe gota la, serotonin ƒe dodo le ahɔhɔ̃a ƒe akpa aɖewo koŋ (vevietɔ nigrostriatal nuto me) atrɔ, si ahe titina ƒe ŋusẽkpɔɖeamedzi nyuiwo vɛ. Gawu la, ate ŋu akpɔ ŋusẽ ɖe nuwɔna ƒe kuxi vovovo siwo dzɔna le ahɔhɔ̃mekawo ƒe dɔwɔwɔ/nusi gblẽ le ahɔhɔ̃mekawo ƒe dɔwɔwɔ ŋu koŋ ta la dzi wòaɖe vi. Le kpɔɖeŋu me, eɖɔa serotonergic kple dopaminergic systems ɖo be wòana nuwɔna me kuxi siwo ahɔhɔ̃mekawo ƒe dɔwɔwɔ si mesɔ o hena vɛ la nanyo ɖe edzi. Etɔ̃lia, ekpɔa ahɔhɔ̃mekawo ta. Bpc 157 ate ŋu akpɔ somatosensory ahɔhɔ̃mekawo ta, ado ahɔhɔ̃mekawo ƒe agbetsitsi kple dɔwɔwɔ ƒe hayahaya ɖe ŋgɔ ne lãmekawo xɔ abi, ado lãmeka siwo le gota ƒe gbugbɔgadzɔ ɖe ŋgɔ, eye wòana lãmekawo ƒe ʋuʋu ƒe dɔwɔwɔ nagaɖo anyi, si aɖe ahɔhɔ̃mekawo ƒe abi si dzɔna dziŋɔ dzi akpɔtɔ. Le kpɔɖeŋu me [1] ..
Nuka koŋue nye Bpc 157 ƒe dɔwɔwɔ le lãmekawo ƒe dɔlélewo dada me?
Bpc 157 ɖe mɔnu geɖe siwo ate ŋu awɔ dɔ le lãmekawo ƒe dɔlélewo dada me fia. Le ahɔhɔ̃mekawo ƒe ʋusɔgbɔdɔ ƒe kpɔɖeŋu me la, Bpc 157 tsia ʋusɔgbɔdɔ si akpa eve ƒe carotid ʋuka siwo bɔ ƒe ƒoƒo hena vɛ nu nyuie to ahɔhɔ̃mekawo takpɔkpɔ kple domenyiŋusẽfianu tɔxɛwo ƒe ɖeɖefia dzi kpɔkpɔ me. Ate ŋu akpɔ nusiwo gblẽna le ahɔhɔ̃mekawo ŋu atraɖii le sisiblisiwo me gbɔ, evɔ wòana ŋkuɖoɖonudzi, lãmekawo ƒe dɔwɔwɔ, kple nuwɔwɔ aduadu ƒe ŋutete siwo tɔtɔ nanyo ɖe edzi. Ekpɔa ŋusẽ ɖe ahɔhɔ̃mekawo ƒe gbegblẽ si ʋumenugbagbeviɣidɔ hena vɛ dzi tẽ eye wòdoa alɔ domenyiŋusẽfianu tɔxɛwo ƒe ɖeɖefia le hippocampal lãmenugbagbeviwo me hã. Ate ŋu ado ahɔhɔ̃mekawo ƒe agbetsitsi kple woƒe dɔwɔwɔ ƒe hayahaya ɖe ŋgɔ to domenyiŋusẽfianu tɔxɛ aɖewo ƒe ɖeɖefia dzi kpɔkpɔ me [6] . .
Dzadzraɖomɔnu siwo kpɔ dzidzedze hena BPC 157 nana ƒe kpɔɖeŋuwo; woka nya ta be mɔwo katã, le nutoa me kple esiwo le ɖoɖo nu, ƒe dɔyɔyɔ me tsonu nyuiwo
Dzɔtsoƒe:PubMed [7] .
Le tagbɔdɔléle gome la, Bpc 157 ɖɔa ƒomedodo si le nitric oxide ƒe ɖoɖoa kple dopamine ƒe ɖoɖoa dome ɖo eye wòtsia dopamine ƒe ɖoɖoa ƒe masɔmasɔ vovovowo nu, si wɔnɛ be tagbɔdɔléle ƒe dzesiwo nyona ɖe edzi. Ate ŋu akpɔ ƒomedodo sesẽ si le nitric oxide ƒe ɖoɖoa kple amphetamine, apomorphine, MK-801, kple methylphenidate zazã atraɖii dome gbɔ, si ɖee fia be ate ŋu ana tagbɔdɔléle ƒe dzesiwo nanyo ɖe edzi to nitric oxide ƒe ɖoɖoa kple dopamine ɖoɖoa ƒe dɔwɔwɔwo dzi kpɔkpɔ me. Ateŋu atsi dopamine ƒe ɖoɖoa ƒe dɔmawɔmawɔ nyuie hã nu, siwo dometɔ aɖewoe nye dopamine ƒe dɔlékuixɔla ƒe mɔxexe, dɔlékuixɔla ƒe dɔwɔwɔ fũu akpa ƒe dzɔdzɔ, xɔla ƒe dɔwɔwɔ, asiɖeɖe le eŋu fũ, nigrostriatal ƒe gbegblẽ, kple vesicular ƒe vɔvɔ, kple bubuawo .
Tsɔ kpe ɖe eŋu la, abe lãmenugbagbeviwo takpɔnu domenɔla ƒomevi yeye ene la, Bpc 157 ɖɔa serotonergic kple dopaminergic ɖoɖowo ɖo, ekpɔa ŋusẽ nyui ɖe nuwɔna ƒe kuxiwo dzi, eye to eƒe ahɔhɔ̃mekawo takpɔnu dzi la, ekpɔa somatosensory ahɔhɔ̃mekawo ta, edoa lãmeka siwo le gota ƒe gbugbɔgadzɔ ɖe ŋgɔ, etsia ahɔhɔ̃ ƒe abi si gblẽa nu le ame ŋu ƒe ŋgɔyiyi nu, eye wògbugbɔa caudal ƒe dɔwɔwɔ ɖoa anyi. Ate ŋu awɔ dɔ abe domenɔla yeye si kpɔa lãmenugbagbeviwo ta ene, akpɔ gome le dɔgboa ƒe lãkusi ƒe blibonyenye me léle ɖe asi me, eye wòakpɔ ŋusẽ si mele tẽ o ɖe lãmekawo ƒe dɔlélewo dzi le atikewɔwɔ me. Ate ŋu aɖɔ serotonergic kple dopaminergic systems hã ɖo, akpɔ ŋusẽ nyui ɖe nuwɔna ƒe kuxi vovovo siwo dzɔna le ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe ʋuʋu/gblẽ nu le eŋu koŋ (si gbɔ eme) ta, eye le ɣeyiɣi ma ke me la, akpɔ ahɔhɔ̃mekawo takpɔkpɔ ƒe ŋusẽkpɔɖeamedziwo, abe somatosensory ahɔhɔ̃mekawo takpɔkpɔ, gotagome lãmekawo ƒe gbugbɔgadzɔ dodo ɖe ŋgɔ, tsitretsitsi ɖe ahɔhɔ̃ si gblẽa nu le ame ŋu ƒe abixɔxɔ ŋu, tsitretsitsi ɖe axonal kple neuronal necrosis, demyelination, kple cyst formation ŋu le sisiblisi siwo ŋu aklã ƒe dɔwɔwɔ le me, kple caudal dɔwɔwɔ gbugbɔgaɖoanyi [1] . .
Nukae nye Nusɔsrɔ̃ siwo do ƒome kple Bpc 157?
Abe COVID-19 ƒe Atikewɔwɔ ene:
Le ƒe 2019 ƒe nuwuwu la, coronavirus dɔléle 2019 (COVID-19) he dɔvɔ̃ gã aɖe vɛ le xexeame katã. Numekukuwo ɖee fia be COVID-19 nye ʋuka me dɔléle si tsoa ʋukawo me kple ʋukawo me ƒe akpa gãtɔ si tɔa ŋku lãmenugbagbevi siwo le lãmekawo me le ɖoɖo nu, si ate ŋu ana ʋukawo ƒe dɔwɔwɔ natɔtɔ [5] . Dɔnɔ siwo ŋu COVID-19 le ate ŋu axɔ ŋutinu geɖe ƒe dɔmawɔmawɔ nyuie abe acute respiratory distress syndrome, dzitodzito me kuxiwo, aklã ƒe abixɔxɔ, kple lãmekawo ƒe abixɔxɔ. Numekulawo nɔ te ɖe lãwo ƒe kpɔɖeŋu ŋuti nyatakakawo dzi ƒo nu tso akpa si Bpc 157 wɔna abe atike yeye ene le COVID-19 ƒe dɔdamɔnu dzi kpɔkpɔ nyuie wu me. Bpc 157 nye peptide si ɖea dɔlékuiwutike, lãmenugbagbeviwo takpɔkpɔ, kple lãmenugbagbeviwo takpɔkpɔ ƒe ŋusẽkpɔɖeamedzi fiana le ŋutinu vovovo siwo le lã ƒomevi vovovowo me. Bpc 157 naa endothelial nitric oxide synthase (eNOS), si do ƒome kple nitric oxide (NO) ƒe dodo, lãmenugbagbeviwo ɖɔɖɔɖo, kple ʋukawo ƒe ɖoɖowɔwɔ ƒe nɔnɔmewo wɔa dɔ, eye ate ŋu ana ʋukawo ƒe blibonyenye kple dɔlélenutsiŋutete ƒe dɔwɔwɔ nanyo ɖe edzi, aɖe dɔlélea ƒe nɔnɔme si doa alɔ dɔlélea dzi akpɔtɔ, eye wòaɖe dɔlélea ƒe sesẽ dzi akpɔtɔ. Eyata ele vevie ŋutɔ be míaƒo nu tso ŋutete si le eŋu abe mɔxexeɖedɔléle nu kple atikewɔwɔ ƒe mɔnu si akpe ɖe ame ŋu ene ŋu.
Lãmetsiŋusẽ ƒe Lãmetsi Falɛfalɛwo ƒe Dɔyɔyɔ Kabakaba:
Wowɔ ŋkuléle ɖe akpa si Bpc 157 wɔna le lãmeka falɛfalɛwo ƒe abi dada me ŋu [7] .Fifia la, dodokpɔ siwo katã ku ɖe Bpc 157 ŋu ɖee fia be le abi ƒomevi vovovowo gome (siwo dometɔ aɖewoe nye abi siwo dzɔna le lãmeka falɛfalɛwo me kple abi siwo woxɔna le lãmeka falɛfalɛ vovovowo me), Bpc 157 kpɔa ŋusẽ nyui kple dɔyɔyɔ kabakaba si nɔa anyi ɖaa. Gake vaseɖe fifia la, wowɔ numekuku akpa gãtɔ le lãkle suewo ƒe kpɔɖeŋuwo ŋu, eye womeɖo kpe Bpc 157 ƒe dɔwɔwɔ dzi le amegbetɔwo ŋu o. Ke hã, edze ƒã be ŋutete gã aɖe le Bpc 157 ŋu eye wole mɔ kpɔm be ava zu atikewɔmɔnu si woatsɔ ada abi siwo me ʋukawo mesɔ gbɔ ɖo o kple esiwo me lãmenugbagbeviwo mesɔ gbɔ ɖo o (abe lãkusiwo kple lãkusiwo ene) ƒe abixɔxɔ le mɔ si me womezãa nu geɖe le o nu alo abe kpeɖeŋutɔ ene hena hayahaya le eƒe ŋgɔyiyi bubuwo megbe. Tsɔ kpe ɖe eŋu la, ƒunukpeƒeŋusẽ ƒe abixɔxɔ ƒe kpɔɖeŋua ɖee fia be menye ɖeko Bpc 157 kpɔa ŋusẽ nyui ɖe abi siwo tso nuveviwɔame tẽ gbɔ ko o, ke ekpɔa ŋusẽ nyui ɖe abi siwo woxɔna le ɖoɖo nu siwo dometɔ aɖewoe nye hyperkalemia kple hypermagnesemia hã dzi.
Mɔ̃a ƒe Dɔwɔwɔ Nyuitɔ Le Akɔta ƒe Abixɔxɔ megbe:
Numekulawo zã sisiblisi ƒe kpɔɖeŋu si ŋu wotrɔ asi le nyuie tsɔ ɖee fia be dɔgbo me pentadecapeptide Bpc 157 si li ke ate ŋu ana aklã ƒe abixɔxɔ nanyo ɖe edzi [8] . Numekuku siwo wowɔ va yi ɖee fia be Bpc 157 ate ŋu atsi peripheral (sciatic nerve) nerve transection/anastomosis me tsonuwo nu eye wòana lãmekawo ƒe dɔyɔyɔ, ahɔhɔ̃ ƒe nuveviwɔame, kple tagbɔdɔ vovovowo nanyo ɖe edzi. Wozã Bpc 157 abe peptide si tsia abi nu ene le dɔgbo ƒe dɔléle si me dɔdzẽ le dodokpɔwo kple dɔgbo ƒe dɔléle si nye multiple sclerosis dodokpɔwo me. Le numekuku aɖe me la, wodo Bpc 157 (200 alo 2μg/kg) alo dze si sɔ (5ml/kg) ɖe dɔgbo me zi ɖeka le sisiblisiwo me le abixɔxɔ le aklã me megbe. Sisi siwo katã xɔ abi la ɖe ŋgɔyiyi si yi edzi fia le Bpc 157 zazã vɔ megbe, eye asike ƒe dɔwɔwɔ nyuie wu le kɔdzi le kɔdzi eye womewɔa wo ɖokui lãɖeɖe ƒe nuwɔna aɖeke o; wokpɔ ʋuʋudedi ƒe kuxia gbɔ le ŋkeke 15 lia dzi; le nusuekpɔmɔ̃ te (adze egɔme tso ŋkeke 7 lia dzi) la, wotsi vacuoles kple axonal ƒe bu le nu ɣia me, edema le nu ɣia me, kple motor neurons ƒe bu le Bpc 157 rats me, kpakple axons gã siwo me myelinated le ƒe xexlẽme dzi ɖeɖe kpɔtɔ le rat caudal nerve me nu le akpa gãtɔ me. Electromyogram ƒe nuŋlɔɖiwo ɖee fia be motor unit ƒe ŋutetewo dzi ɖe kpɔtɔ ŋutɔ le asike ƒe lãmekawo me. Tsɔ kpe ɖe eŋu la, numekulawo gawɔ dodokpɔ bubu. Wodo Bpc 157 ŋkeke 4 le abi si woxɔ le aklã me megbe, eye wona Bpc 157 (10μg/kg, 0.16μg/mL, 12ml/rat/ŋkeke) to tsinono me kwasiɖa 4, gake tsinono koe na ƒuƒoƒo si me wokpɔa wo gbɔ le. Nusiwo do tso eme ɖee fia be sisiblisi siwo wotsɔ Bpc 157 da dɔe la ɖe ŋgɔyiyi gã aɖe fia eye woyi edzi haya vaseɖe esime wohaya keŋkeŋ.
Tsitretsitsi ɖe Akɔta ƒe Malikemanɔmanɔ ŋu:
Be woahe aklã ƒe malikenyenye vɛ le sisiblisiwo me la, numekulawo lé fɔ ɖe akpa eve ƒe facetectomy ŋu eye wodzro atikewɔwɔ me viɖe siwo ate ŋu anɔ dɔgboa me pentadecapeptide Bpc 157 si li ke si le tsinono me ŋu [9] .Le numekuku siwo wowɔ va yi me la, wokpɔe be Bpc 157 nana aklã ƒe abixɔxɔ, lãmeka siwo le gota ƒe abixɔxɔ, ahɔhɔ̃ ƒe abixɔxɔ, kple vovovowo nyona ɖe edzi ahɔhɔ̃medɔlélewo. Le numekuku sia me la, woɖe L3-L4 facetectomy bliboe na sisiblisiwo, eye le dɔwɔwɔ nɛ vɔ megbe la, wona Bpc 157 (10ng/kg, 0.16ng/mL, 12ml/rat/day) alo tsinono ko wo. Wowɔ keklẽŋusẽ ƒe dodokpɔwo le kwasiɖa 1 kple kwasiɖa 8. Emetsonuwo ɖee fia be le kwasiɖa 1 me la, womekpɔ nɔnɔme madeamedzi aɖeke si dze ƒã le sisiblisi siwo le ƒuƒoƒo si me wokpɔa wo gbɔ le kple Bpc 157 ƒuƒoƒoa me le yameʋu aɖeke me o, edze abe womekpɔ ŋusẽ ɖe akɔta ƒe lãkusi dome ƒe teƒea dzi o ene, ahɔhɔ̃mekawo ƒe ʋuƒo si le amekoko ƒe ɖoɖo nu keke vie, eye sisiblisi siwo le ƒuƒoƒo si noa Bpc 157 me la ƒe a ƒu ƒe kpekpeme bliboa si lolo wu. Le kwasiɖa 8 lia me la, womekpɔ nɔnɔme madeamedzi aɖeke si dze ƒã le ƒuƒoƒo eveawo ƒe sisiblisiwo ŋu le yameʋu aɖeke me o, womekpɔ ŋusẽ ɖe akɔtaƒuwo dome disk ƒe teƒea dzi o, ahɔhɔ̃mekawo ƒe ʋuƒo si le amekoko ƒe ɖoƒea keke vie, ƒumelã siwo le Bpc 157 ƒuƒoƒoa me ƒe ƒuwo ƒe kpekpeme lolo ŋutɔ, eye callus ƒe wɔwɔme gbogbo aɖe menɔ anyi le ɖoɖo si wowɔ le vome si woate ŋu akpɔ le ƒuƒoƒo si me wokpɔa wo gbɔ le me o. Tsɔ kpe ɖe eŋu la, sisiblisi siwo le ƒuƒoƒo si me wokpɔa wo gbɔ le la ɖee fia be woƒe lãmekawo ƒe dɔwɔwɔ gblẽ si dze ƒã le abixɔxɔ ƒe dɔwɔwɔ vɔ megbe teti, gake sisiblisi siwo le Bpc 157 nono ƒe ƒuƒoƒoa me tsi tre ɖe lãmekawo ƒe dɔmawɔmawɔ nyuie sia ŋu keŋkeŋ.
Le nyataƒoƒo me la, asixɔxɔ vevitɔ si le Bpc 157 ŋu le eƒe domenyiŋusẽfianu kple ɖoɖo geɖe ƒe ɖoɖowɔwɔ ƒe nɔnɔmewo me, si naa egbɔkpɔnu yeyewo na dɔdzẽ si mexɔa dɔlékui o, lãmenugbagbeviwo ƒe gbɔdzɔgbɔdzɔ, kple ahɔhɔ̃mekawo ƒe tagbɔdɔlélewo. Le kamedefefe ƒe nuveviwɔame gome la, ate ŋu ana lãmekawo abe lãmekawo, lãkusiwo, kple lãkusiwo ene naɖɔ ɖo kabakaba ahagbugbɔ wo awɔ yeyee, ana ɣeyiɣi si woatsɔ ahaya la nanɔ kpuie, eye wòakpɔ ŋusẽ nyui ɖe nuveviwɔame sesẽwo dzi le atikewɔwɔ me. Le dzobibi dada me la, Bpc 157 ate ŋu ana lãmenugbagbevi siwo le lãkusi me ƒe nugbagbeŋusẽwo abe dzidziɖedzi, ʋuʋu, kple ʋukawo ƒe wɔwɔme ene nanyo ɖe edzi ŋutɔ, si ana abi siwo wofiã la dzadzraɖo kabakaba. Tsɔ kpe ɖe eŋu la, ekpɔa dɔgboa ta, ate ŋu ado dɔgbo ƒe abiwo ƒe dɔyɔyɔ ɖe ŋgɔ, eye wòaxe mɔ ɖe dɔgbo ƒe dɔlélewo nu ahaɖe wo dzi akpɔtɔ. Bpc 157 hã ɖea ŋutete fiana le ahɔhɔ̃mekawo takpɔkpɔ me, ekpɔa lãmekawo ta to mɔnuwo abe dɔdzẽ ƒe ŋuɖoɖo dzi ɖeɖe kpɔtɔ kple apoptosis ƒe mɔxexe ɖe enu ene me. Ekpɔa ŋusẽ ɖe amegbetɔ ƒe ŋutinuwo abe dɔgbo, aklã, kple dzi ene hã ta, si ɖe eƒe nugbagbeŋusẽ ƒe ŋusẽkpɔɖeamedzi gbogboawo fia abe peptide si wɔa dɔ geɖe ene.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Predrag Sikiricis nye agbalẽnyala si do ƒome kple suku geɖe, siwo dometɔ aɖewoe nye Zagreb Yunivɛsiti, Sarajevo Yunivɛsiti, Sch Med, J. J. Strossmayer Osijek Yunivɛsiti, kple Rudjer Boskovic Nusrɔ̃ƒe. Eƒe numekukuwo ku ɖe nusɔsrɔ̃ geɖe ŋu abe Atikeŋutinunya & Atikeŋutinunya, Nu gbagbewo ƒe Dzɔdzɔmeŋusẽŋununya & Molecular Biology, Gastroenterology & Hepatology, Physiology, kple Cell Biology.
Sikiric ƒe ƒuƒoƒoa wɔ numekuku geɖe tso BPC157 ƒe lãmenugbagbeviwo takpɔkpɔ ƒe ŋusẽkpɔɖeamedzi le ŋutinu kple lãkusi vovovowo me ŋu, eye akpa si wòwɔna le ahɔhɔ̃mekawo ƒe abixɔxɔ kple dɔgbo ƒe abi me hã le eme. Eƒe gomenɔamesiwo hã le BPC, si nye atike si wɔa dɔ le atikewo me, si me edzadzraɖomɔnu kple atikewɔwɔ ƒe dɔwɔwɔ hã le.Sikiric Pis nye ame si ŋu wodea bubui le agbalẽnyalawo dome, eye eƒe numekukua do dɔ siwo me wòkpɔ gome le la ɖe ŋgɔ ŋutɔ.Sikiric Pis listed in the reference of citation [1].
