1 khoom (10Vials)
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▎ Bpc 157 Txheej txheem cej luam
Bpc 157 yog ib qho hluavtaws peptide tsim los ntawm 15 amino acids, tseem hu ua 'Lub cev tiv thaiv Compound 157'. Nws tau pib cais tawm los ntawm cov proteins hauv cov kua txiv hmab txiv ntoo thiab tom qab ntawd cov khoom sib xyaw ua ke. Bpc 157 muaj ntau yam kev ua ub no, suav nrog kev txhawb nqa qhov txhab zoo, tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv kab mob, thiab tshuaj tiv thaiv antioxidant, thiab lwm yam.
Hais txog kev txhawb nqa qhov txhab zoo, Bpc 157 tuaj yeem ua kom cov txheej txheem kho cov ntaub so ntswg xws li tawv nqaij, leeg, thiab ligaments. Nws qhia tau hais tias muaj txiaj ntsig tshwj xeeb hauv kev kho mob ntawm qhov txhab. Nws txhawb nqa angiogenesis thiab cov ntaub so ntswg rov tsim dua los ntawm kev txhim kho kev ua haujlwm lom neeg ntawm cov hlwb endothelial, xws li kev loj hlob, kev tsiv teb tsaws, thiab kev tsim tubule. Hais txog kev tiv thaiv neuroprotection, Bpc 157 tuaj yeem muaj kev cuam tshuam zoo rau hauv nruab nrab lub paj hlwb los ntawm kev tswj cov neurotransmitters xws li serotonin thiab dopamine, uas pab txhim kho cov teeb meem xws li plab zom mov, malabsorption, thiab kev tiv thaiv kab mob qis.
Bpc 157 kuj muaj cov tshuaj tiv thaiv kab mob thiab tiv thaiv kab mob. Nws tuaj yeem tswj tau qhov kev ncaj ncees ntawm lub plab hnyuv mucosa, tiv thaiv cov kab mob thiab co toxins los ntawm kev nkag mus thiab ua rau cov hnyuv. Tsis tas li ntawd, nws plays lub luag haujlwm tseem ceeb hauv kev tiv thaiv daim siab. Nws tuaj yeem tiv thaiv kev loj hlob ntawm tes, tiv thaiv cov qauv ntawm daim siab hlwb, tswj cov qib enzyme ib txwm, txo qis cytokines, thiab tiv thaiv daim siab fibrosis.
Piv nrog rau lwm yam tshuaj, qhov zoo ntawm Bpc 157 yog nyob rau hauv nws tsis muaj toxicity tseem ceeb los yog kev phiv, thiab nws muaj kev ruaj ntseg zoo thiab kam rau ua nyob rau hauv ntau yam tsiaj qauv. Nws tsis tsuas yog muaj qhov tshwj xeeb zoo hauv kev kho cov kab mob hauv plab, tab sis kuj tseem tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev txhawb nqa cov ntaub so ntswg kho, txhim kho lub hlwb kev noj qab haus huv, thiab tiv thaiv kev laus.
▎ Bpc 157 Qauv
Source: PubChem |
Sequence: GEPPPGKPADDAGLV Molecular Formula: C 62H 98N 16O22 Molecular Luj: 1419.5g/mol CAS Nr .: 137525-51-0 PubChem CID: 9941957 Synonyms: Bepecin |
▎ Bpc 157 Kev Tshawb Fawb
Dab tsi yog qhov kev tshawb fawb keeb kwm ntawm Bpc 157?
Bpc 157 yog peptide muaj li ntawm 15 amino acids thiab yog ib feem ntawm cov kab ke ntawm lub cev tiv thaiv compound (Bpc) nrhiav pom thiab cais los ntawm tib neeg lub plab kua txiv. Cov hauv qab no yog qhov kev tshawb fawb keeb kwm ntsig txog Bpc 157:
Lub hlwb-Gut Axis thiab Bpc 157:
Lub paj hlwb kev sib cuam tshuam cuam tshuam nrog kev loj hlob ntawm peptidergic. Ntawm lawv, qhov ruaj khov pentadecapeptide Bpc 157 yog ib qho tshuaj tiv thaiv kab mob peptidergic uas muaj kev nyab xeeb thiab siv tau zoo hauv kev sim kab mob plab hnyuv thiab tam sim no tab tom sim rau ntau yam sclerosis. Nws ib txwm muaj nyob hauv tib neeg cov kua txiv hmab txiv ntoo [1] . Bpc 157 tuaj yeem ua tus neeg nruab nrab tshiab ntawm Robert cell tiv thaiv, koom nrog kev tswj xyuas kev ncaj ncees ntawm lub plab hnyuv mucosa yam tsis muaj tshuaj lom.
Nws tau ua tiav zoo hauv kev kho cov kab mob hauv plab, mob plab, mob siab thiab mob pancreatic, nrog rau kev kho mob ntawm ntau yam ntaub so ntswg thiab qhov txhab. Nws kuj txhawb nqa Egr-1 noob, NAB2, FAK-paxillin, thiab JAK-2 txoj hauv kev [1] .Thaum Bpc 157 raug tswj hwm peripherally, cov txiaj ntsig zoo hauv nruab nrab tau pib pom, tshwj xeeb tshaj yog cov kev hloov pauv hauv serotonin tso tawm hauv qee thaj chaw ntawm lub hlwb (tsuas yog thaj tsam nigrostria). Bpc 157 tswj cov kab ke serotonergic thiab dopaminergic, muaj txiaj ntsig zoo rau ntau yam kev coj cwj pwm tsis zoo uas tshwm sim vim qhov tshwj xeeb stimulation / kev puas tsuaj ntawm cov neurotransmitter system.
Tsis tas li ntawd, Bpc 157 muaj cov teebmeem neuroprotective, xws li tiv thaiv somatosensory neurons, txhawb peripheral paj hlwb regeneration, counteracting cov txheej txheem tom qab raug mob hlwb, tiv thaiv axonal thiab neuronal necrosis, demyelination, thiab cyst tsim nyob rau hauv nas nrog spinal qaum compression accompaning 1. .
Lub luag haujlwm hauv Kev Tiv Thaiv Kab Mob plab thiab kev tiv thaiv lub cev:
Bpc 157 yog qhov tseem ceeb tshaj plaws raws li tus neeg tuaj yeem ua tau ntawm Robert's gastric cell tiv thaiv / adaptive cell tiv thaiv thiab tiv thaiv lub cev, nrog rau tus neeg kho mob tshiab ntawm Selye cov lus teb kev ntxhov siab. Bpc 157 tiv thaiv lub plab zom mov thiab tswj kev ncaj ncees ntawm lub plab tiv thaiv ntau yam teeb meem.
Nws tuaj yeem tiv thaiv qhov tsis zoo ntawm cawv thiab tshuaj tsis-steroidal tshuaj tiv thaiv kab mob ntawm lub plab epithelium thiab lwm yam epithelium (xws li daim tawv nqaij, daim siab, txiav, lub plawv, thiab lub hlwb), thiab muaj peev xwm siv tau rau hauv qhov txhab kho. Tsis tas li ntawd, Bpc 157 tseem tuaj yeem tiv thaiv kev puas tsuaj hauv plab endothelial, tiv thaiv lwm cov vascular endothelia, muaj kev cuam tshuam zoo rau cov hlab ntsha, ua kom cov ntshav ntws sai sai, thiab tiv thaiv qog nqaij hlav cachexia, nqaij nkim, thiab nce pro-inflammatory / cachectic cytokines [2] .
Lub luag haujlwm Therapeutic hauv Vascular Occlusion:
Nyob rau hauv txoj kev tshawb fawb ntawm superior mesenteric hlab ntsha thiab cov hlab ntsha occlusion nyob rau hauv nas, Bpc 157 tuaj yeem ua kom sai sai rau txoj hauv kev, nrog rau cov kab mob mesenteric leeg-inferior anterior pancreaticoduodenal vein-superior anterior pancreaticoduodenal vein-pyloric vein txoj kev, Vena cava los ntawm nruab nrab colic leeg thiab inferior mesenteric leeg, nrog rau cov inferior pancreaticoduodenal hlab ntsha thiab inferior mesenteric hlab ntsha.
Bpc 157 tuaj yeem tiv thaiv kev ua haujlwm zoo tshaj sagittal sinus, portal vein, thiab inferior vena cava hypertension, aortic hypotension, venous thiab arterial thrombosis nyob rau hauv peripheral thiab central cheeb tsam, alleviate multi-organ lesions, lesions nyob rau hauv lub plawv, ntsws, daim siab, ob lub raum, mob plab, tshwj xeeb tshaj yog oxidative cov ntaub so ntswg ..
Lub luag haujlwm hauv Budd-Chiari Syndrome: Hauv kev tshawb fawb ntawm Budd-Chiari syndrome qauv (occlusion ntawm suprahepatic vena cava) hauv nas, Bpc 157 tuaj yeem tsim txoj hauv kev nrawm nrawm ntawm cov kab mob tsis zoo vena cava-azygos vein (hemiazygos vein)-shovunactorac vein, vena cavunactorac. thiab inferior vena cava hypertension, aortic hypotension, thiab alleviate thrombosis, electrocardiogram disorders, thiab lesions nyob rau hauv daim siab thiab gastrointestinal ib ntsuj av. Thaum lub sij hawm ligation, cov qib ntawm nitric oxide thiab malondialdehyde nyob rau hauv daim siab nyob twj ywm nyob rau hauv lub cev noj qab haus huv tus nqi ntau, thiab qhov nce nyob rau hauv cov enzymes hauv cov ntshav kuj tseem txo tau [4].
Lub luag haujlwm kho mob muaj peev xwm hauv COVID-19:
COVID-19 yog suav tias yog kab mob thrombotic thiab vascular feem ntau tsom rau cov kab mob endothelial, uas tuaj yeem ua rau lub hauv paus vascular tsis ua haujlwm, ua rau muaj teeb meem thiab ntau lub cev tsis ua haujlwm. Bpc 157 yog peptide uas muaj cov tshuaj tiv thaiv kab mob, cytoprotective, thiab endothelial tiv thaiv los ntawm cov kab mob sib txawv ntawm ntau hom. Nws tuaj yeem ua rau endothelial nitric oxide synthase, uas muaj feem xyuam rau kev tso tawm nitric oxide, kho cov ntaub so ntswg, thiab kev tswj cov hlab ntsha, txhim kho vascular kev ncaj ncees thiab kev tiv thaiv kab mob, txo cov kev mob tshwm sim, thiab txo qhov mob hnyav. Yog li ntawd, nws yog ib qho tseem ceeb los tham txog nws lub peev xwm raws li kev tiv thaiv thiab kev kho mob ntxiv [5] (Deek SA, 2022).
Dab tsi yog qhov tshwj xeeb ntawm kev ua ntawm Bpc 157 nyob rau hauv lub hlwb-plab axis?
Lub hlwb-lub plab axis yog ib qho kev sib txuas lus ob txoj hauv kev uas muaj kev cuam tshuam ntawm cov hlab ntsha thiab lub plab zom mov, thiab Bpc 157 plays lub luag haujlwm tseem ceeb hauv nws, feem ntau hauv peb yam: Ua ntej, ua tus kws kho mob cytoprotective, Bpc 157 tuaj yeem koom nrog kev tswj hwm kev noj qab haus huv. Raws li tus kws kho mob tshiab ntawm Robert cell tiv thaiv yam tsis muaj tshuaj lom, nws tswj cov kev ua haujlwm physiological ntawm lub plab zom mov los ntawm kev tiv thaiv kab mob plab, yog li cuam tshuam rau qhov sib npaug ntawm lub hlwb-lub plab axis. Qhov thib ob, nws tswj cov kab mob neurotransmitter. Bpc 157 tuaj yeem tswj cov kab ke serotonergic thiab dopaminergic. Thaum Bpc 157 raug tswj hwm los ntawm peripheral, tso tawm serotonin hauv cov hlwb tshwj xeeb (feem ntau yog thaj tsam nigrostriatal) yuav hloov, ua rau muaj txiaj ntsig zoo hauv nruab nrab. Ntxiv mus, nws tuaj yeem muaj txiaj ntsig cuam tshuam rau ntau yam kev coj cwj pwm tsis zoo uas tshwm sim vim qhov tshwj xeeb stimulation / kev puas tsuaj ntawm neurotransmitter system. Piv txwv li, nws tswj cov serotonergic thiab dopaminergic systems los txhim kho kev coj cwj pwm teeb meem tshwm sim los ntawm txawv txav neurotransmitter systems. Thib peb, nws muaj cov teebmeem neuroprotective. Bpc 157 tuaj yeem tiv thaiv somatosensory neurons, txhawb nqa neuron ciaj sia thiab ua haujlwm rov qab thaum muaj paj hlwb raug mob, txhawb kev tsim cov paj hlwb peripheral, thiab kho cov paj hlwb ua haujlwm, txo cov kev raug mob ntawm lub hlwb. Piv txwv li, nyob rau hauv cov ntaub ntawv ntawm tus txha caj qaum compression nyob rau hauv nas nrog caudal tuag tes tuag taw, axonal thiab neuronal necrosis, demyelination, thiab cyst tsim, Bpc 157 tuaj yeem khaws cia caudal muaj nuj nqi thiab txo qhov kev puas tsuaj rau hauv nruab nrog cev xws li lub paj hlwb thiab lub plab zom mov tshwm sim los ntawm kev siv tshuaj ntau dhau ntawm lub cev, lossis kev tiv thaiv ib txwm muaj ..
Dab tsi yog qhov tshwj xeeb ntawm Bpc 157 hauv kev kho mob hauv nruab nrab paj hlwb?
Bpc 157 tau qhia ntau lub peev xwm los kho cov kab mob hauv lub paj hlwb. Nyob rau hauv tus qauv ntawm cerebral ischemic stroke, Bpc 157 zoo tiv thaiv cov hlab ntsha ntawm ob sab ntawm cov hlab ntsha carotid clamping los ntawm kev tiv thaiv cov neurons thiab txhawb cov kev qhia tshwj xeeb. Nws tuaj yeem hais txog qhov kev puas tsuaj tsis tu ncua rau lub hlwb neurons hauv nas, thaum txhim kho kev nco, lub cev muaj zog, thiab kev sib koom tes. Nws muaj kev tiv thaiv ncaj qha rau cov neuronal puas tsuaj los ntawm ischemic stroke thiab kuj txhawb kev qhia ntawm cov noob tshwj xeeb hauv cov ntaub so ntswg hippocampal. Nws tuaj yeem txhawb txoj kev ciaj sia thiab kev ua haujlwm rov qab los ntawm cov neurons los ntawm kev tswj cov kev qhia ntawm cov noob tshwj xeeb [6] .

Piv txwv ntawm kev tswj hwm kev ua tiav rau kev xa khoom ntawm BPC 157; txhua txoj hauv kev, hauv zos thiab cov txheej txheem, tau tshaj tawm tias muaj txiaj ntsig zoo
Source: PubMed [7]
Rau schizophrenia, Bpc 157 tswj kev sib raug zoo ntawm nitric oxide system thiab dopamine system thiab tiv thaiv ntau yam txawv txav ntawm dopamine system, yog li txhim kho cov tsos mob ntawm tus mob schizophrenia. Nws tuaj yeem hais txog kev sib raug zoo ntawm nitric oxide system thiab amphetamine, apomorphine, MK-801, thiab kev tswj hwm methylphenidate ntev, qhia tias nws tuaj yeem txhim kho cov tsos mob ntawm tus mob schizophrenia los ntawm kev tswj cov haujlwm ntawm nitric oxide system thiab dopamine system. Nws kuj tseem tuaj yeem tiv thaiv ntau yam kev txawv txav ntawm dopamine system, suav nrog dopamine receptor blockade, kev txhim kho ntawm receptor hypersensitivity, receptor activation, tso tawm ntau dhau, kev puas tsuaj nigrostriatal, thiab vesicular depletion, thiab lwm yam. Nws muaj ntau yam kev tswj xyuas cov teebmeem ntawm dopamine system thiab pab rov qab ua haujlwm tshuav nyiaj li cas ntawm cov neeg mob dopamine [6]. .
Tsis tas li ntawd, raws li hom tshiab ntawm cytoprotective mediator, Bpc 157 tswj cov kab mob serotonergic thiab dopaminergic, muaj txiaj ntsig zoo rau kev coj tus cwj pwm tsis zoo, thiab los ntawm nws cov txiaj ntsig neuroprotective, tiv thaiv somatosensory neurons, txhawb nqa peripheral paj hlwb rov tsim dua tshiab, tiv thaiv kev ua haujlwm ntawm lub hlwb, thiab rov ua haujlwm ntawm lub hlwb. Nws tuaj yeem ua raws li hom tshiab ntawm cytoprotective mediator, koom nrog tswj kev ncaj ncees ntawm lub plab hnyuv mucosa, thiab muaj kev cuam tshuam tsis ncaj ncees rau cov kab mob hauv nruab nrog cev. Nws tseem tuaj yeem tswj hwm cov kab ke serotonergic thiab dopaminergic, muaj txiaj ntsig zoo rau ntau yam kev coj cwj pwm tsis zoo uas tshwm sim vim qhov tshwj xeeb (ntau) stimulation / kev puas tsuaj ntawm neurotransmitter system, thiab tib lub sijhawm muaj cov teebmeem neuroprotective, xws li kev tiv thaiv somatosensory neurons, txhawb kev tawm tsam peripheral paj hlwb regeneration, axonal thiab neuronal necrosis, demyelination, thiab cyst tsim nyob rau hauv nas nrog tus txha caj qaum compression, thiab rov ua haujlwm caudal [1] .
Dab tsi yog Kev Tshawb Fawb Txog Bpc 157?
Raws li Kev Kho Mob Muaj Peev Xwm rau COVID-19:
Thaum kawg ntawm 2019, tus kab mob coronavirus 2019 (COVID-19) ua rau muaj kev sib kis loj thoob ntiaj teb. Kev tshawb fawb qhia tias COVID-19 feem ntau yog kab mob thrombotic thiab vascular kab mob tsom rau cov kab mob endothelial, uas tuaj yeem ua rau muaj kev cuam tshuam ntawm kev ua haujlwm hauv plawv plawv [5] . Cov neeg mob uas muaj tus kab mob COVID-19 tuaj yeem tsim muaj ntau lub cev tsis ua haujlwm xws li mob ua pa nyuaj, mob plawv, mob siab, thiab raug mob paj hlwb. Raws li cov ntaub ntawv tus qauv tsiaj, cov kws tshawb fawb tau sib tham txog lub luag haujlwm ntawm Bpc 157 yog cov tshuaj tshiab hauv kev txhim kho kev tswj hwm ntawm COVID-19. Bpc 157 yog peptide uas nthuav tawm cov tshuaj tiv thaiv kab mob, cytoprotective, thiab endothelial tiv thaiv cov teebmeem hauv cov kabmob sib txawv ntawm ntau hom. Bpc 157 activates endothelial nitric oxide synthase (eNOS), uas muaj feem xyuam rau nitric oxide (NO) tso tawm, kho cov ntaub so ntswg, thiab vascular regulation zog, thiab tuaj yeem txhim kho vascular kev ncaj ncees thiab kev tiv thaiv kab mob, txo cov pro-inflammatory xeev, thiab txo qhov hnyav ntawm tus kab mob. Yog li ntawd, nws yog ib qho tseem ceeb heev los tham txog nws lub peev xwm raws li kev tiv thaiv thiab kev kho mob ntxiv.
Accelerating Kho ntawm Musculoskeletal Mos Tissue:
Kev tshuaj xyuas tau ua tiav ntawm lub luag haujlwm ntawm Bpc 157 hauv kev kho mob ntawm cov nqaij mos raug mob [7] .Tam sim no, tag nrho cov kev sim kawm Bpc 157 tau pom tias rau ntau hom kev raug mob (xws li kev raug mob ntawm lub cev thiab ntau yam kev raug mob ntawm cov nqaij mos), Bpc 157 muaj qhov zoo sib xws thiab kho tau sai. Txawm li cas los xij, txog niaj hnub no, feem ntau ntawm cov kev tshawb fawb tau ua rau cov qauv nas me, thiab qhov ua tau zoo ntawm Bpc 157 tsis tau lees paub rau tib neeg. Txawm li cas los xij, Bpc 157 kom meej meej muaj peev xwm zoo thiab xav tias yuav dhau los ua txoj kev kho mob rau kev kho mob ntawm cov hlab ntsha thiab cov nqaij mos uas tsis muaj cellular (xws li cov leeg thiab ligaments) raug mob los yog ua ib qho ntxiv rau kev rov qab los tom qab kev loj hlob ntxiv. Tsis tas li ntawd, cov qauv kev raug mob ntawm pob txha pob txha qhia tau hais tias Bpc 157 tsis yog tsuas yog muaj txiaj ntsig zoo rau kev raug mob los ntawm kev raug mob ncaj qha tab sis kuj rau kev raug mob xws li hyperkalemia thiab hypermagnesemia.
Txhim kho lub cev muaj zog ua haujlwm tom qab txha caj qaum raug mob:
Cov kws tshawb fawb tau siv tus qauv nas uas tsim tau zoo los ua kom pom tias qhov ruaj khov ntawm lub plab pentadecapeptide Bpc 157 tuaj yeem txhim kho tus txha caj qaum [8] . Cov kev tshawb fawb yav dhau los tau pom tias Bpc 157 tuaj yeem cuam tshuam qhov tshwm sim ntawm peripheral (sciatic paj) paj hlwb transection / anastomosis thiab txhim kho paj hlwb, mob hlwb, thiab ntau yam encephalopathies. Bpc 157 tau siv los ua tshuaj tiv thaiv kab mob peptide hauv kev sim kab mob plab hnyuv thiab ntau yam kev sim sclerosis. Hauv ib txoj kev tshawb fawb, nas tau txais ib qho kev txhaj tshuaj intraperitoneal ntawm Bpc 157 (200 lossis 2μg / kg) lossis ib txwm saline (5ml / kg) tom qab raug mob qaum qaum. Txhua tus nas raug mob tau pom kev txhim kho tas li tom qab Bpc 157 kev kho mob, nrog kev kho mob zoo dua qub thiab tsis muaj tus cwj pwm ntawm tus kheej; qhov teeb meem spasm tau daws nyob rau hnub 15; Nyob rau hauv lub tshuab ntsuas (pib txij hnub 7th), vacuoles thiab axonal poob nyob rau hauv cov teeb meem dawb, edema hauv cov teeb meem grey, thiab poob ntawm lub cev muaj zog neurons hauv Bpc 157 nas, nrog rau kev txo qis ntawm cov myelinated axons loj hauv nas caudal paj hlwb, feem ntau counteracted. Electromyogram kaw tau pom qhov txo qis hauv lub cev muaj zog hauv cov leeg nqaij. Tsis tas li ntawd, cov kws tshawb fawb kuj tau ua lwm yam kev sim. Bpc 157 tau muab 4 hnub tom qab raug mob qaum, thiab Bpc 157 (10μg / kg, 0.16μg / mL, 12ml / nas / hnub) tau muab los ntawm cov dej haus rau 4 lub lis piam, thaum pawg tswj hwm tau txais cov dej haus xwb. Cov txiaj ntsig tau pom tias cov nas tau kho nrog Bpc 157 tau pom tias muaj kev txhim kho zoo thiab txuas ntxiv mus kom txog thaum rov ua tiav.
Counteracting Spinal Instability:
Txhawm rau ua kom tus txha caj qaum tsis ruaj khov hauv cov nas, cov kws tshawb fawb tau tsom mus rau ob sab facetectomy thiab tshawb nrhiav cov txiaj ntsig kho tau zoo ntawm lub plab zom mov ruaj khov pentadecapeptide Bpc 157 hauv cov dej haus [9] .In yav dhau los kev tshawb fawb, Bpc 157 tau pom tias txhim kho qaum qaum kev raug mob, peripheral paj hlwb raug mob, hlwb encephapath, thiab ntau yam. Hauv txoj kev tshawb no, nas tau txais kev ua tiav ob sab L3-L4 facetectomy, thiab tom qab ua haujlwm, lawv tau muab Bpc 157 (10ng / kg, 0.16ng / mL, 12ml / nas / hnub) lossis tsuas yog haus dej. Kev ntsuam xyuas hluav taws xob tau ua nyob rau lub lim tiam 1 thiab lub lim tiam 8. Cov txiaj ntsig tau pom tias nyob rau lub lim tiam 1, tsis muaj qhov pom tseeb deformity tau pom hauv cov nas ntawm pawg tswj hwm thiab Bpc 157 pawg hauv ib lub dav hlau, qhov chaw intervertebral disc zoo li tsis muaj kev cuam tshuam, neural foramen ntawm qib phais tau nthuav dav me ntsis, thiab Bpc den 157 pawg nas. Nyob rau lub lim tiam 8, tsis muaj qhov pom tseeb deformity tau pom nyob rau hauv cov nas ntawm ob pawg hauv ib lub dav hlau, qhov chaw intervertebral disc tsis muaj kev cuam tshuam, neural foramen ntawm qib phais tau nthuav dav me ntsis, cov nas hauv Bpc 157 pawg muaj cov pob txha loj dua, thiab tsis muaj qhov loj ntawm callus tsim nyob rau hauv cov qauv random. Tsis tas li ntawd, cov nas nyob rau hauv pawg tswj tau pom tias muaj kev cuam tshuam lub cev muaj zog tam sim ntawd tom qab raug mob induction, thaum cov nas nyob rau hauv pawg Bpc 157 haus tau tag nrho counteracted no lub cev muaj zog.
Hauv kev xaus, tus nqi tseem ceeb ntawm Bpc 157 nyob rau hauv nws cov endogenous thiab multi-system tswj cov yam ntxwv, muab cov kev daws teeb meem tshiab rau refractory o, cov ntaub so ntswg tsis xws luag, thiab cov kab mob neuropsychiatric. Hauv kev ua kis las kis las, nws tuaj yeem nrawm kho thiab rov tsim cov ntaub so ntswg xws li cov leeg, leeg, thiab ligaments, txo lub sijhawm rov qab los, thiab muaj txiaj ntsig zoo rau kev raug mob hnyav. Hauv kev kho mob kub hnyiab, Bpc 157 tuaj yeem txhim kho kev ua haujlwm lom neeg ntawm cov hlwb endothelial xws li kev loj hlob, kev tsiv teb tsaws, thiab tubule tsim, yog li ua kom kho qhov mob kub hnyiab. Tsis tas li ntawd, nws muaj kev tiv thaiv kab mob hauv lub plab, tuaj yeem txhawb kev kho mob ntawm plab hnyuv, thiab tiv thaiv thiab txo cov kab mob hauv plab. Bpc 157 kuj qhia tau hais tias muaj peev xwm nyob rau hauv neuroprotection, tiv thaiv lub paj hlwb los ntawm cov txheej txheem xws li txo cov inflammatory teb thiab inhibiting apoptosis. Nws kuj muaj kev tiv thaiv zoo rau tib neeg lub cev xws li pancreas, siab, thiab lub plawv, ua kom pom nws ntau yam ntawm cov teebmeem lom neeg raws li kev ua haujlwm ntau yam peptide.
Hais Txog Tus Sau
Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.
Scientific Journal Author
Predrag Sikiricis tus kws tshawb fawb koom nrog ntau lub tsev kawm ntawv, suav nrog University of Zagreb, University of Sarajevo, Sch Med, University of JJ Strossmayer Osijek, thiab Rudjer Boskovic Institute. Nws txoj kev tshawb fawb nthuav dav ntau yam kev qhuab qhia xws li Pharmacology & Pharmacy, Biochemistry & Molecular Biology, Gastroenterology & Hepatology, Physiology, thiab Cell Biology.
Sikiric pab pawg tau tshawb fawb ntau txog cov teebmeem cytoprotective ntawm BPC157 hauv ntau yam kabmob thiab cov ntaub so ntswg, suav nrog nws lub luag haujlwm hauv kev raug mob neural thiab mob plab hnyuv. Nws kuj tuav patents rau txoj kev loj hlob ntawm BPC, ib tug pharmacologically active tshuaj, nrog rau nws cov kev npaj thiab kev kho mob daim ntawv thov.Sikiric Pis ib tug hwm daim duab nyob rau hauv academia, thiab nws cov kev tshawb fawb tau loj hlob mus rau hauv lub teb uas nws koom nrog.
▎ Cov Lus Qhia Tseem Ceeb
[1] Sikiric P, Seiwerth S, Rucman R, et al. Brain-gut Axis thiab Pentadecapeptide BPC 157: Theoretical and Practical Implications [J]. Tam sim no Neuropharmacology, 2016,14(8): 857-865.DOI: 10.2174/1570159X 13666160502 153022.
[2] Sikiric P, Hahm K, Blagaic AB, et al. Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection / Adaptive Cytoprotection / Organoprotection, thiab Selye's Stress Coping Response: Progress, Achievements, and the Future [J]. Lub plab thiab lub siab, 2020, 14(2): 153-167.DOI: 10.5009/gnl18490.
[3] Knezevic M, Gojkovic S, Krezic I, et al. Ua haujlwm Superior Mesenteric Artery thiab Vein. Kev kho mob nrog Stable Gastric Pentadecapeptide BPC 157 [J]. Biomedicines, 2021,9(7).DOI:10.3390/biomedicines9070792.
[4] Gojkovic S, Krezic I, Vrdoljak B, et al. Pentadecapeptide BPC 157 daws suprahepatic occlusion ntawm inferior caval leeg, Budd-Chiari syndrome qauv hauv nas.[J]. World Journal of Gastrointestinal Pathphysiology, 2020,11(1):1-19.DOI:10.4291/wjgp.v11.i1.1.
[5] Deek S A. BPC 157 raws li Kev Kho Mob Muaj Peev Xwm rau COVID-19[J]. Medical Hypotheses, 2022,158.DOI:10.1016/j.mehy.2021.110736.
[6] Vukojevic J, Milavic M, Perovic D, et al. Pentadecapeptide BPC 157 thiab lub hauv paus paj hlwb [J]. Neural Regeneration Research, 2022,17(3):482.DOI:10.4103/1673-5374.320969.
[7] Gwyer D, Wragg NM, Wilson S. Cell thiab Tissue Research, 2019,377(2):153-159.DOI:10.1007/s00441-019-03016-8.
[8] Perovic D, Krezic I, Dokuzovic S, et al. Stable Gastric Pentadecapeptide BPC 157 Rov qab ua haujlwm lub cev muaj zog tom qab Rat Spinal Cord Injury [J]. Faseb Journal, 2019, 33.https://doi.org/10.1096/fasebj.2019.33.1_supplement.822.5.
[9] Dokuzovic S, Bebek I, Perovic D, et al. Spinal Instability nyob rau hauv nas Counteracted los ntawm Pentadecapeptide BPC 157 [J]. Faseb Journal, 2019, 33.https://doi.org/10.1096/fasebj.2019.33.1_supplement.822.3.
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.