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▎ Bpc 157 Imiterere
Inkomoko: PubChem |
Urukurikirane: GEPPPGKPADDAGLV Inzira ya molekulari: C 62H 98N 16O.22 Uburemere bwa molekuline: 1419.5g / mol Numero ya CAS: 137525-51-0 PubChem CID: 9941957 Synonyme: Bepecin |
▎ Bpc 157 Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na Bpc 157?
Bpc 157 ni peptide igizwe na acide 15 ya amine kandi iri murwego rwikurikiranya ryumubiri urinda umubiri (Bpc) yavumbuwe kandi itandukanijwe numutobe wigifu. Ibikurikira nubushakashatsi bujyanye na Bpc 157:
Ubwonko-Gut Axis na Bpc 157:
Imikoranire yubwonko-amara ikubiyemo ibintu bikura peptidergic. Muri byo, pentadecapeptide ya gastricique ihamye Bpc 157 ni imiti igabanya ubukana peptidergic ifite umutekano kandi ikora neza mugupima indwara zifata amara kandi kuri ubu irimo gukorerwa ibizamini bya sclerose nyinshi. Mubisanzwe bibaho mumitobe yigifu [1] . Bpc 157 irashobora gukora nkumuhuza mushya wo kurinda selile ya Robert, akagira uruhare mukubungabunga ubusugire bwimitsi ya gastrointestinal nta ngaruka z'uburozi.
Yageze ku ntsinzi mu kuvura indwara zo mu gifu, parontontitis, umwijima na pancreatic lesion, ndetse no gukiza ingirangingo zitandukanye n'ibikomere. Itera kandi inzira ya Egr-1, NAB2, FAK-paxillin, na JAK-2 inzira . Bpc 157 igenga sisitemu ya serotonergique na dopaminergique, ikagira ingaruka nziza kubibazo bitandukanye byimyitwarire ibaho bitewe no gukanguka / kwangirika kwa sisitemu ya neurotransmitter.
Byongeye kandi, Bpc 157 igira ingaruka za neuroprotective, nko kurinda neuron ya somatosensory, guteza imbere imitsi ya nervice ya periferique, kurwanya inzira yiterambere nyuma yo gukomeretsa ubwonko bwubwonko, kwirinda necrosis ya axonal na neuronal, demyelination, hamwe na cyst mu mbeba hamwe no kwikuramo umugongo hamwe no kumugara wa caudal [1] .
Uruhare mu Kurinda Ingirabuzimafatizo no Kurinda Urwego:
Bpc 157 ifite akamaro kanini nkumuhuza ushobora gukingira ingirabuzimafatizo ya Robert kurinda / kurinda ingirabuzimafatizo no kurinda ingingo, ndetse numuhuza mushya wibibazo bya Selye. Bpc 157 irinda ingirabuzimafatizo kandi ikomeza ubusugire bwigifu kubintu bitandukanye byangiza.
Irashobora gukumira ingaruka mbi ziterwa n'inzoga hamwe n'imiti itari steroidal anti-inflammatory kuri epitelium gastrici na epiteliya (nk'uruhu, umwijima, pancreas, umutima, n'ubwonko), kandi ifite uburyo bushoboka bwo gukiza ibikomere. Byongeye kandi, Bpc 157 irashobora kandi kurwanya kwangirika kwa gastric endoteliyale, kurinda izindi endoteliya yimitsi, bigira ingaruka nziza kumitsi yamaraso, kongera kubaka ubunyangamugayo bwamaraso, no kurwanya cachexia yibibyimba, guta imitsi, no kongera cytokine itera inflammatory / cachectic [2] .
Uruhare rwo kuvura mu mitsi y'amaraso:
Mu bushakashatsi bwerekeye imiyoboro ihanitse ya mesenteric arterière hamwe no gufunga imitsi mu mbeba, Bpc 157 irashobora gukora byihuse inzira zingwate, harimo na mesenteric vein-inferior anterior pancreaticoduodenal vein-superior pancreaticoduodenal vein-pyloric vein-portal vein inzira, inzira zinyuranye zerekeza mumyanya yo hasi ya vena na veva. imiyoboro y'imbere ya pancreaticoduodenal na arteri ya mesenteric arteri.
Bpc 157 irashobora kurwanya sinus isumba izindi, imitsi ya portal, hamwe na hypertension ya vena cava yo hasi, hypotension ya aortic, trombose igenda itera imbere hamwe no hagati, kugabanya ibikomere byingingo nyinshi, ibikomere mumutima, ibihaha, umwijima, impyiko, mubice byubwonko, hamwe na oxydeide.
Uruhare muri Syndrome ya Bud-Chiari: Mu bushakashatsi bwakozwe ku cyitegererezo cya syndrome ya Bud-Chiari (occlusion ya suprahepatic vena cava) mu mbeba, Bpc 157 irashobora kwihuta kunyura mu nzira nyabagendwa ya vena cava-azygos yo hepfo (hemiazygos vein) -superior vena cava na portacaval vena vena vena hypotension, no kugabanya trombose, indwara ya electrocardiogram, hamwe nibisebe byumwijima na gastrointestinal. Mu gihe cyo kuburana, urugero rwa aside nitide na malondialdehyde mu mwijima biguma mu gipimo gisanzwe cy’agaciro keza, kandi kwiyongera kwa enzymes za serumu nabyo byagabanutse cyane [4].
Uruhare rushoboka rwo kuvura muri COVID-19:
COVID-19 ifatwa nkindwara ya trombotique nu mitsi itwara cyane cyane yibasira selile ya endoteliyale sisitemu, ishobora gutera imikorere mibi yimitsi yo hagati, bigatera ibibazo no kunanirwa kwingingo nyinshi. Bpc 157 ni peptide ifite anti-inflammatory, cytoprotective, na endoteliyale ikingira sisitemu zitandukanye zingingo zitandukanye. Irashobora gukora synthase ya nitric okiside ya endoteliyale, ifitanye isano no kurekura aside nitide, gusana ingirangingo, hamwe nuburyo bwo kugenzura imitsi, kunoza ubunyangamugayo bwimitsi hamwe nubudahangarwa bw'umubiri, kugabanya imiterere-yumuriro, no kugabanya ubukana bwindwara. Niyo mpamvu, ni ngombwa kuganira ku bushobozi bwayo nk'uburyo bwo gukumira no kunganirana [5] (Deek SA, 2022).
Nubuhe buryo bwihariye bwibikorwa bya Bpc 157 muburyo bwubwonko-amara?
Ubwonko-amara ni uburyo bukomeye bwo gutumanaho muburyo bubiri burimo imikoranire hagati yimitsi yumutima nuyoboro wigifu, kandi Bpc 157 igira uruhare runini muri yo, cyane cyane mubice bitatu: Icya mbere, nkumuhuza wa cytoprotective, Bpc 157 irashobora kugira uruhare mukubungabunga ubusugire bwa mucosa gastrointestinal. Nkumuhuza mushya wo kurinda selile ya Robert nta ngaruka zuburozi, ikomeza imikorere isanzwe yumubiri wumubyimba wigifu urinda ingirabuzimafatizo, bityo bikagira ingaruka kuburinganire bwubwonko-bwonko. Icya kabiri, igenga sisitemu ya neurotransmitter. Bpc 157 irashobora kugenga sisitemu ya serotonergique na dopaminergique. Iyo Bpc 157 itanzwe muburyo butandukanye, kurekura serotonine mubice byubwonko bwihariye (cyane cyane akarere ka nigrostriatal) bizahinduka, bitange ingaruka zingirakamaro hagati. Byongeye kandi, irashobora kugira ingaruka nziza kubibazo bitandukanye byimyitwarire ibaho bitewe no gukangura / kwangirika kwa sisitemu ya neurotransmitter. Kurugero, igenga sisitemu ya serotonergique na dopaminergique kugirango itezimbere ibibazo byimyitwarire iterwa na sisitemu idasanzwe ya neurotransmitter. Icya gatatu, ifite ingaruka za neuroprotective. Bpc 157 irashobora kurinda neuron ya somatosensory, igatera ubuzima bwa neuron no gukira kwimikorere mugihe habaye imvune yimitsi, igatera imitekerereze ya periferique, kandi igasubiza imikorere yimitsi, bikagabanya ibikomere byubwonko. Kurugero, kubijyanye no kwikuramo uruti rwumugongo ku mbeba ziherekejwe na paralise caudal, necrosis ya axonal na neuronal necrosis, demyelination, hamwe na cyst, Bpc 157 irashobora gukiza imikorere ya caudal no kugabanya kwangirika kwingingo nka sisitemu ya nervice na gastrointestinal iterwa no kunywa ibiyobyabwenge cyangwa encephalopathie, birinda imikorere isanzwe yumubiri [1].
Ni ubuhe buryo bwihariye bwa Bpc 157 mu kuvura indwara zifata imitsi yo hagati?
Bpc 157 yerekanye uburyo bwinshi bushoboka mukuvura indwara zifata imitsi yo hagati. Muburyo bwubwonko bwubwonko bwubwonko, Bpc 157 irwanya neza ubwonko buterwa nubwonko busanzwe bwa karotide yimitsi ikingira kurinda neuron no gushyigikira imvugo yihariye. Irashobora gukemura ibibazo byangirika byubwonko bwubwonko bwimbeba, mugihe byongera ubushobozi bwo kwibuka, moteri, hamwe nubushobozi bwo guhuza. Ifite ingaruka zitaziguye zo kwangiza imitsi iterwa na stroke ischemic kandi inashyigikira imvugo ya genes yihariye mumyanya ya hippocampal. Irashobora guteza imbere kubaho no gukira kwa neuron muguhindura imiterere ya genes zihariye [6] .
Ingero zuburyo bwiza bwo kuyobora bwo gutanga BPC 157; inzira zose, zaho na sisitemu, byavuzwe ko bifite ibisubizo byiza byo gukiza
Inkomoko: Byatangajwe [7]
Kuri schizofrenia, Bpc 157 igenga isano iri hagati ya sisitemu ya nitric oxyde na sisitemu ya dopamine ikanarwanya ibintu bitandukanye bidasanzwe bya sisitemu ya dopamine, bityo bikazamura ibimenyetso bya sizizofreniya. Irashobora gukemura umubano utoroshye hagati ya sisitemu ya nitric na amphetamine, apomorphine, MK-801, hamwe nubuyobozi bwa methylphenidate idakira, byerekana ko ishobora kunoza ibimenyetso bya sizizofreniya muguhuza imikorere ya sisitemu ya nitide na sisitemu ya dopamine. Irashobora kandi kurwanya ibintu bidasanzwe bidasanzwe bya sisitemu ya dopamine, harimo gukumira reseptor ya dopamine, iterambere rya reseptor hypersensitivite, gukora reseptor, kurekura bikabije, kwangirika kwa nigrostriatal, hamwe no kugabanuka kwa viticular, nibindi . .
Byongeye kandi, nkubwoko bushya bwumuhuza wa cytoprotective, Bpc 157 igenga sisitemu ya serotonergique na dopaminergique, igira ingaruka nziza kumyitwarire yimyitwarire, kandi binyuze mumikorere yayo ya neuroprotective, ikarinda neuron ya somatosensory, igatera imitekerereze mibi yubwonko bwubwonko, ikanagarura imikorere yubwonko bwubwonko. Irashobora gukora nk'ubwoko bushya bw'umuhuza wa cytoprotective, ikagira uruhare mu kubungabunga ubusugire bwa mucosa gastrointestinal, kandi ikagira ingaruka zitaziguye zo kuvura indwara zifata ubwonko bwo hagati. Irashobora kandi kugenga sisitemu ya serotonergique na dopaminergique, igira ingaruka nziza kumyitwarire itandukanye yimyitwarire ibaho bitewe no gukurura / kwangirika / kwangirika kwa sisitemu ya neurotransmitter, kandi mugihe kimwe ikagira ingaruka za neuroprotective, nko kurinda neuron ya somatosensory, guteza imbere imitekerereze ya neurone, no kurwanya ubwonko bwubwonko, no kurwanya ubwonko bwubwonko, imbeba hamwe no kwikuramo umugongo, no kugarura imikorere ya caudal [1] .
Ni ubuhe bushakashatsi bujyanye na Bpc 157?
Nkumuti ushobora kuvura COVID-19:
Mu mpera za 2019, indwara ya coronavirus 2019 (COVID-19) yateje icyorezo kinini ku isi. Ubushakashatsi bwerekana ko COVID-19 ahanini ari indwara ya trombotique n’amaraso yibasira ingirabuzimafatizo ya endoteliyale, ishobora gutera ihungabana ry'imikorere y'amaraso yo hagati [5] . Abarwayi bafite COVID-19 barashobora kunanirwa ningingo nyinshi nka syndrome de santrale ikabije yubuhumekero, ibibazo byumutima nimiyoboro y'amaraso, gukomeretsa umwijima, no gukomeretsa imitsi. Hashingiwe ku makuru y’icyitegererezo cy’inyamaswa, abashakashatsi baganiriye ku ruhare rwa Bpc 157 nk'umuti mushya mu kunoza imiyoborere y’amavuriro ya COVID-19. Bpc 157 ni peptide yerekana anti-inflammatory, cytoprotective, na endoteliyale ikingira sisitemu zitandukanye zingingo zitandukanye. Bpc 157 ikora synthase ya nitric okiside ya endoteliyale (eNOS), ifitanye isano no kurekura nitide (OYA), gusana ingirangingo, hamwe no kugenzura imiyoboro y'amaraso, kandi irashobora kunoza ubunyangamugayo bwimitsi hamwe nubudahangarwa bw'umubiri, kugabanya imiterere itera indwara, no kugabanya ubukana bw'indwara. Kubwibyo, ni ngombwa cyane kuganira kubushobozi bwayo nkuburyo bwo kuvura no gukumira.
Kwihutisha gukira kwa musculoskeletal Tissue yoroshye:
Isuzuma ryakozwe ku ruhare rwa Bpc 157 mu kuvura ibikomere byoroheje [7] .Ubu kandi, ubushakashatsi bwose bwakozwe kuri Bpc 157 bwerekanye ko ku bwoko butandukanye bw’imvune (harimo ibikomere by’ihungabana ndetse na sisitemu ndetse n’imvune zinyuranye zoroshye), Bpc 157 igira ingaruka nziza kandi yihuse yo gukira. Nyamara, kugeza ubu, ubushakashatsi bwinshi bwakorewe ku ngero ntoya y’imbeba, kandi ingaruka za Bpc 157 ntizigeze zemezwa mu bantu. Nubwo bimeze bityo ariko, Bpc 157 biragaragara ko ifite imbaraga nyinshi kandi byitezwe ko izahinduka uburyo bwo kuvura uburyo bwo kuvura ibikomere byoroheje-vasculaire na selile nkeya (nka tendons na ligaments) cyangwa nkibishobora gukira nyuma yiterambere. Byongeye kandi, uburyo bwo gukomeretsa imitsi ya skeletale bwerekana ko Bpc 157 itagira ingaruka nziza gusa kubikomere byatewe nihungabana ritaziguye ahubwo binagira no gukomeretsa sisitemu harimo hyperkalemia na hypermagnesemia.
Kunoza imikorere ya moteri nyuma yo gukomeretsa umugongo:
Abashakashatsi bakoresheje urugero rwimbeba rwateguwe neza kugirango berekane ko pentadecapeptide ya gastrica ihamye Bpc 157 ishobora kunoza imvune yumugongo [8] . Ubushakashatsi bwibanze bwerekanye ko Bpc 157 ishobora kurwanya ingaruka ziterwa na periferique (sciatic nervée) nervice / anastomose no kunoza imitsi, ihahamuka ryubwonko, hamwe na encephalopathies zitandukanye. Bpc 157 yakoreshejwe nka peptide irwanya ibisebe mugupima indwara zifata amara no kugerageza sclerose nyinshi. Mu bushakashatsi bumwe, imbeba zabonye inshinge imwe ya intraperitoneal ya Bpc 157 (200 cyangwa 2μg / kg) cyangwa umunyu usanzwe (5ml / kg) nyuma yo gukomeretsa umugongo. Imbeba zose zakomeretse zerekanye iterambere rihoraho nyuma yo kuvurwa kwa Bpc 157, hamwe nibikorwa byiza bya moteri yumurizo wamavuriro kandi nta myitwarire yo kwikebagura; ikibazo cya spasm cyakemutse kumunsi wa 15; munsi ya microscope (guhera kumunsi wa 7), vacuole nigihombo cya axon mubintu byera, edema mubintu byumukara, no gutakaza neurone ya moteri muri Bpc imbeba 157, ndetse no kugabanuka kwumubare munini wa axe nini ya myeline mumitsi ya caudal nervice, yarwanyijwe cyane. Ibyuma bya elegitoroniki byerekana ko byagabanutse cyane mubushobozi bwa moteri mumitsi yumurizo. Byongeye kandi, abashakashatsi bakoze ubundi bushakashatsi. Bpc 157 yatanzwe nyuma yiminsi 4 nyuma yimvune yumugongo, naho Bpc 157 (10μg / kg, 0.16μg / mL, 12ml / imbeba / kumunsi) yatanzwe binyuze mumazi yo kunywa mugihe cibyumweru 4, mugihe itsinda ryabashinzwe kwakira amazi yo kunywa gusa. Ibisubizo byerekanaga ko imbeba zavuwe na Bpc 157 zagaragaje iterambere ryinshi kandi zikomeza gukira kugeza zimaze gukira.
Kurwanya ihungabana ryumugongo:
Kugira ngo imbeba zidahungabana mu mbeba, abashakashatsi bibanze ku miterere y’ibihugu byombi banashakisha inyungu zishobora kuvurwa ziterwa na gastric pentadecapeptide Bpc 157 ihamye mu mazi yo kunywa [9] .Mu bushakashatsi bwabanje, Bpc 157 yerekanye ko izamura imvune y’umugongo, ibikomere by’imitsi ya peripheri, ihahamuka ry’ubwonko, ndetse na encephalopathies zitandukanye. Muri ubu bushakashatsi, imbeba zabonye ibice byombi bya L3-L4, hanyuma nyuma yo kubagwa, bahabwa Bpc 157 (10ng / kg, 0.16ng / mL, 12ml / imbeba / umunsi) cyangwa amazi yo kunywa gusa. Isuzuma rya radiologiya ryakozwe ku cyumweru cya 1 nicyumweru cya 8. Ibisubizo byerekanye ko ku cyumweru cya 1, nta bugaragara bwagaragaye bwagaragaye mu mbeba z’itsinda rishinzwe kugenzura no mu itsinda rya Bpc 157 mu ndege iyo ari yo yose, umwanya wa disikuru hagati y’imbere wasaga nkaho utagize ingaruka, abashinzwe imitsi y’imitsi yo mu rwego rwo kubaga bariyongereyeho gato, kandi imbeba zo mu itsinda rya Bpc 157 zari zifite ubwinshi bw’amagufwa. Ku cyumweru cya 8, nta bumuga bugaragara bwagaragaye mu mbeba z’amatsinda yombi mu ndege iyo ari yo yose, umwanya wa disikuru hagati ya interineti ntiwagize ingaruka, abashinzwe imitsi y’imitsi ku rwego rwo kubaga baragutse gato, imbeba zo mu itsinda rya Bpc 157 zari zifite ubwinshi bw’amagufwa, kandi habuze ikibazo kinini cyo guhamagarwa mu buryo butunguranye bugaragara mu itsinda rishinzwe kugenzura. Byongeye kandi, imbeba zo mu itsinda ryagenzuye zerekanye ubumuga bugaragara bwa moteri nyuma yo gukomeretsa, mu gihe imbeba zo mu itsinda ry’ibinyobwa Bpc 157 zarwanyije burundu ubwo bumuga bwa moteri.
Mu gusoza, agaciro kingenzi ka Bpc 157 gashingiye kumiterere yacyo ya endogenous na sisitemu nyinshi, itanga ibisubizo bishya byo gutwika imitsi, inenge, nindwara zo mu mutwe. Mu rwego rwo guhahamuka kwa siporo, irashobora kwihutisha gusana no kuvugurura ingirangingo nk'imitsi, imitsi, na ligaments, bigabanya igihe cyo gukira, kandi bigira ingaruka nziza zo kuvura ihahamuka rikabije. Mu kuvura ibicanwa, Bpc 157 irashobora kuzamura cyane imikorere yibinyabuzima ya selile endoteliyale nko gukwirakwira, kwimuka, no kwibumbira hamwe, bityo byihutisha gusana ibikomere byahiye. Byongeye kandi, igira ingaruka zo gukingira inzira yigifu, irashobora guteza imbere gukira ibisebe byo munda, no kwirinda no kugabanya indwara zifata igifu. Bpc 157 irerekana kandi ubushobozi muri neuroprotection, kurinda sisitemu yimitsi ikoresheje uburyo nko kugabanya ibisubizo byumuriro no kubuza apoptose. Ifite kandi ingaruka zo gukingira ingingo z'umuntu nka pancreas, umwijima, n'umutima, byerekana ingaruka zitandukanye z’ibinyabuzima nka peptide ikora.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Predrag Sikiricis intiti ifatanije n’ibigo byinshi by’amasomo, harimo kaminuza ya Zagreb, kaminuza ya Sarajevo, Sch Med, kaminuza ya JJ Strossmayer Osijek, n’ikigo cya Rudjer Boskovic. Ubushakashatsi bwe bukubiyemo amasomo menshi nka Pharmacology & Farumasi, Biochemie & Molecular Biology, Gastroenterology & Hepatology, Physiology, na Biologiya Cell.
Itsinda rya Sikiric ryakoze ubushakashatsi bwimbitse ku ngaruka za cytoprotective ya BPC157 mu ngingo no mu ngingo zitandukanye, harimo n'uruhare rwayo mu gukomeretsa imitsi ndetse n'ibisebe byo mu gifu. Afite kandi patenti zo guteza imbere BPC, imiti ikora imiti, harimo uburyo bwo kuyitegura ndetse nuburyo bwo kuvura.Sikiric Pis umuntu wubahwa muri kaminuza, kandi ubushakashatsi bwe bwateje imbere cyane imirima arimo. Pis Sikiric Pis yanditse kurutonde rwavuzwe [1].
