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1kits (Ebipipa 10) .
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▎ Bpc 157 Enzimba
Ensibuko: PubChem |
Omutendera: GEPPPGKPADDAGLV Ensengekera ya molekyu: C 62H 98N 16O22 Obuzito bwa molekyu: 1419.5g/mol Ennamba ya CAS: 137525-51-0 PubChem CID: 9941957. Enkola y’okukuuma eddagala lino Ebigambo ebifaanagana: Bepecin |
▎ Bpc 157 Okunoonyereza
Ensibuko y’okunoonyereza eya Bpc 157 eri etya?
Bpc 157 ye peptide erimu amino acids 15 era kitundu ku nsengekera y’ekirungo ekikuuma omubiri (Bpc) ekyazuulibwa era ne kyawulwa okuva mu mubisi gw’omu lubuto lw’omuntu. Wammanga ye nsonga y’okunoonyereza ekwata ku Bpc 157:
Ekisenge ky’obwongo-ekyenda ne Bpc 157:
Enkolagana y’obwongo n’ekyenda erimu ensonga z’okukula eza peptidergic. Mu bino, eddagala eriyitibwa stable gastric pentadecapeptide Bpc 157 ddagala eriziyiza amabwa peptidergic nga teririna bulabe era nga likola bulungi mu kugezesebwa kw’endwadde z’ekyenda ezizimba era mu kiseera kino ligenda mu kugezesebwa ku bulwadde bwa multiple sclerosis. Mu butonde kiri mu mubisi gw’omu lubuto lw’omuntu [1] . Bpc 157 eyinza okukola nga omutabaganya omupya ow’okukuuma obutoffaali bwa Robert, okwetaba mu kukuuma obulungi bw’omubiri gw’omu lubuto awatali butwa.
Efunye obuwanguzi mu kujjanjaba endwadde z’omu lubuto, obulwadde bw’amanyo, ebiwundu by’ekibumba n’olubuto, wamu n’okuwonya ebitundu n’ebiwundu eby’enjawulo. Era kisitula amakubo g’obuzaale bwa Egr-1, NAB2, FAK-paxillin, ne JAK-2 [1] .Bpc 157 bw’eweebwa mu ngeri ey’okumpi, ebikolwa eby’omugaso eby’omu makkati ebikwatagana bisooka kulabibwa, naddala enkyukakyuka mu kufulumya serotonin mu bitundu ebimu eby’obwongo (okusinga ekitundu kya nigrostriatal). Bpc 157 etereeza enkola za serotonergic ne dopaminergic, nga erina eky’omugaso ku buzibu obw’enjawulo obw’enneeyisa obubaawo olw’okusikirizibwa okwetongodde/okwonooneka kw’enkola y’obusimu obutambuza obusimu.
Okugatta ku ekyo, Bpc 157 erina ebikolwa eby’okukuuma obusimu, gamba ng’okukuuma obusimu obuyitibwa somatosensory neurons, okutumbula okuddamu okukola kw’obusimu obw’okumpi, okuziyiza enkola y’okukulaakulana oluvannyuma lw’okulumwa obwongo mu ngeri ey’ekikangabwa, okuziyiza okufa kw’obusimu n’obusimu obuyitibwa axonal ne neuronal necrosis, demyelination, n’okutondebwa kw’ekizimba mu nvunza ezirina okunyigirizibwa kw’omugongo nga kuwerekerwako okusannyalala kw’omugongo, n’okuzzaawo enkola y’omugongo [1] . .
Omulimu mu Kukuuma obutoffaali bw’omu lubuto n’okukuuma ebitundu by’omubiri:
Bpc 157 ya makulu mangi ng’omutabaganya asoboka ow’okukuuma obutoffaali bw’olubuto bwa Robert/okukuuma obutoffaali obutuukagana n’okukuuma ebitundu by’omubiri, awamu n’omutabaganya omupya ow’okuddamu kwa Selye ku situleesi. Bpc 157 ekuuma obutoffaali bw’olubuto n’okukuuma obulungi bw’olubuto okuva ku bintu eby’obulabe eby’enjawulo.
Kiyinza okuziyiza ebikosa omwenge n’eddagala eriziyiza okuzimba eritali lya steroid ku bitundu by’olubuto n’ebitundu ebirala (nga olususu, ekibumba, olubuto, omutima, n’obwongo), era kiyinza okukozesebwa mu kuwonya ebiwundu. Okugatta ku ekyo, Bpc 157 era esobola okuziyiza okwonooneka kw’endothelial y’olubuto, okukuuma endothelia z’emisuwa endala, okuba n’akakwate akalungi ku misuwa, okuddamu okuzimba amangu obulungi bw’okutambula kw’omusaayi, n’okulwanyisa cachexia y’ebizimba, okusaasaana kw’ebinywa, n’okweyongera kwa pro-inflammatory/cachectic cytokines [2]. .
Omulimu gw’obujjanjabi mu kuzibikira emisuwa:
Mu kunoonyereza ku misuwa egy’okungulu egy’omu lubuto n’okuzibikira kw’emisuwa mu nvunza, Bpc 157 esobola okukola amangu amakubo ag’omusingo, omuli n’omusuwa ogw’omu lubuto ogw’okungulu-omusuwa ogw’omu maaso ogw’omu maaso-omusuwa ogw’omu maaso ogw’omusuwa-omusuwa ogw’omu maaso-omusuwa ogw’omu maaso-omusuwa ogw’omu maaso, amakubo amalala agagenda mu musuwa ogw’omunda ogwa cava okuyita mu colic eya wakati omusuwa n’omusuwa ogw’omu lubuto ogwa wansi, awamu n’omusuwa ogw’omu maaso ogw’omu lubuto n’omusuwa ogw’omu lubuto ogwa wansi.
Bpc 157 esobola okuziyiza puleesa eya superior sagittal sinus, portal vein, ne inferior vena cava hypertension, aortic hypotension, progressive venous and arterial thrombosis mu bitundu eby’okumpi n’eby’omu makkati, okukendeeza ku biwundu by’ebitundu ebingi, ebiwundu mu mutima, amawuggwe, ekibumba, ensigo, mu nkola y’olubuto naddala mu bwongo, ne oxidative stress mu bitundu by’omubiri [3] ..
Omulimu mu Budd-Chiari Syndrome: Mu kunoonyereza ku Budd-Chiari syndrome model (occlusion of the suprahepatic vena cava) mu nvunza, Bpc 157 esobola okukola amangu amakubo agayita mu musuwa ogwa wansi-omusuwa gwa azygos (hemiazygos vein)-superior vena cava ne portacaval shunt, counteract portal vein ne inferior vena cava puleesa, puleesa y’omusuwa, n’okukendeeza ku thrombosis, obuzibu mu electrocardiogram, n’ebiwundu mu kibumba n’omu lubuto. Mu kiseera ky’okusiba, emiwendo gya nitric oxide ne malondialdehyde mu kibumba gisigala mu muwendo gwa bulijjo ogw’obulamu, era okweyongera kw’enziyiza z’omusaayi nakyo kikendeera nnyo [4]..
Omulimu oguyinza okujjanjaba mu COVID-19:
COVID-19 etwalibwa ng’obulwadde obuva ku thrombotic n’emisuwa okusinga nga bugenderera obutoffaali obukola endothelial cells, ekiyinza okuvaako emisuwa egy’omu makkati obutakola bulungi, ekivaako obuzibu n’okulemererwa kw’ebitundu by’omubiri ebingi. Bpc 157 ye peptide erimu ebikolwa ebiziyiza okuzimba, okukuuma obutoffaali, n’okukuuma endothelial mu nkola z’ebitundu eby’enjawulo eby’ebika eby’enjawulo. Kiyinza okukola endothelial nitric oxide synthase, ekikwatagana n’okufulumya nitric oxide, okuddaabiriza ebitundu, n’eby’obugagga by’okulungamya emisuwa, okulongoosa obulungi bw’emisuwa n’okuddamu kw’abaserikale b’omubiri, okukendeeza ku mbeera y’okuzimba, n’okukendeeza ku buzibu bw’obulwadde. N’olwekyo, kikulu nnyo okukubaganya ebirowoozo ku busobozi bwayo ng’enkola y’obujjanjabi ey’okuziyiza n’okugatta [5] (Deek SA, 2022).
Enkola ki entongole ey’okukola kwa Bpc 157 mu kisenge ky’obwongo-ekyenda?
Ekisiki ky’obwongo n’ekyenda nkola ya mpuliziganya enzibu ey’engeri bbiri erimu enkolagana wakati w’enkola y’obusimu n’enkola y’olubuto, era Bpc 157 ekola kinene mu kyo, okusinga mu bintu bisatu: Ekisooka, ng’omutabaganya akuuma obutoffaali, Bpc 157 esobola okwetaba mu kukuuma obulungi bw’omubiri gw’omu lubuto. Nga omutabaganya omupya ow’okukuuma obutoffaali bwa Robert awatali butwa, ekuuma omulimu ogwa bulijjo ogw’omubiri ogw’enkola y’omu lubuto ng’ekuuma obutoffaali bw’omu lubuto, bwe kityo ne kikosa bbalansi y’ekisenge ky’obwongo n’ekyenda. Ekyokubiri, kitereeza enkola y’obusimu obutambuza obusimu. Bpc 157 esobola okulungamya enkola ya serotonergic ne dopaminergic. Bpc 157 bw’eweebwa mu ngeri ey’okumpi, okufuluma kwa serotonin mu bitundu by’obwongo ebitongole (okusinga ekitundu kya nigrostriatal) kujja kukyuka, okuvaamu ebikolwa eby’omugaso eby’omu makkati. Ekirala, kiyinza okukosa mu ngeri ey’omugaso obuzibu obw’enjawulo obw’enneeyisa obubaawo olw’okusikirizibwa/okwonooneka okwetongodde kw’enkola y’obusimu obutambuza obusimu. Okugeza, etereeza enkola ya serotonergic ne dopaminergic okulongoosa ebizibu by’enneeyisa ebiva ku nkola z’obusimu ezitambuza obusimu ezitali za bulijjo. Ekyokusatu, kirina ebikolwa eby’okukuuma obusimu. Bpc 157 esobola okukuuma obusimu obuyitibwa somatosensory neurons, okutumbula obulamu bw’obusimu n’okuddamu okukola mu mbeera y’obusimu obulumwa, okutumbula okuddamu okukola kw’obusimu obw’okumpi, n’okuzzaawo enkola y’okutambuza obusimu, okukendeeza ku buvune bw’obwongo obuva ku buvune. Okugeza, mu mbeera y’okunyigirizibwa kw’omugongo mu nvunza nga kuwerekerwako okusannyalala kw’omugongo, okufa kw’omugongo n’obusimu obuyitibwa axonal ne neuronal necrosis, demyelination, n’okutondebwa kw’ebizimba, Bpc 157 esobola okutaasa enkola y’omugongo n’okukendeeza ku kwonooneka kw’ebitundu ng’obusimu n’enkola y’omu lubuto olw’okukozesa eddagala erisukkiridde oba obulwadde bw’obwongo, okukuuma emirimu egya bulijjo egy’omubiri [1] ..
Enkola ki entongole eya Bpc 157 mu kujjanjaba endwadde z’obusimu obw’omu makkati?
Bpc 157 eraze enkola eziwera eziyinza okukolebwa mu kujjanjaba endwadde z’obusimu obw’omu makkati. Mu model ya cerebral ischemic stroke, Bpc 157 eziyiza bulungi stroke ereetebwa bilateral common carotid artery clamping nga ekuuma obusimu obuyitibwa neurons n’okuwagira specific gene expression. Kiyinza okukola ku kwonooneka okutambula obutasalako ku busimu bw’obwongo mu nvunza, ate nga kirongoosa obusobozi bw’okujjukira, enkola y’emirimu, n’okukwatagana okutaataaganyizibwa. Kirina ekikolwa eky’obukuumi obutereevu ku kwonooneka kw’obusimu obuva ku ischemic stroke era era kiwagira okwolesebwa kw’obuzaale obw’enjawulo mu bitundu by’omubiri ebiyitibwa hippocampal tissue. Kiyinza okutumbula obulamu n’okuddamu okukola kw’obusimu obuyitibwa neurons nga kitereeza okwolesebwa kw’obuzaale obw’enjawulo [6] . .
Eby’okulabirako by’enkola z’okugaba obulungi okugaba BPC 157; amakubo gonna, ag’omu kitundu n’ag’enkola, gabadde gategeezeddwa nti galina ebivaamu ebirungi mu kuwona
Ensibuko:PubMed [7] .
Ku bulwadde bw’okutabuka emitwe, Bpc 157 etereeza enkolagana wakati w’enkola ya nitric oxide n’enkola ya dopamine era n’eziyiza ebitali bya bulijjo eby’enkola ya dopamine, bwe kityo n’etereeza obubonero bw’obulwadde bw’okutabuka emitwe. Kiyinza okukola ku nkolagana enzibu wakati w’enkola ya nitric oxide n’okuweebwa amphetamine, apomorphine, MK-801, n’okuweebwa methylphenidate okumala ebbanga, ekiraga nti kiyinza okulongoosa obubonero bw’obulwadde bw’okutabuka emitwe nga kitereeza emirimu gy’enkola ya nitric oxide n’enkola ya dopamine. Era esobola okuziyiza obutali bwa bulijjo obw’enkola ya dopamine, omuli okuzibikira dopamine receptor, okukula kw’okuwulikika ennyo kw’ebikwata, okukola kw’ebikwata, okufulumya okuyitiridde, okwonooneka kw’obusimu obuyitibwa nigrostriatal, n’okukendeera kw’emisuwa, n’ebirala Kirina ebikolwa bingi eby’okulungamya ku nkola ya dopamine era kiyamba okuzzaawo bbalansi y’emirimu gy’enkola ya dopamine mu balwadde ba schizophrenia [6] . .
Okugatta ku ekyo, ng’ekika ekipya eky’omutabaganya w’okukuuma obutoffaali, Bpc 157 etereeza enkola za serotonergic ne dopaminergic, erina akakwate ak’omugaso ku buzibu bw’enneeyisa, era okuyita mu nkola yaayo ey’okukuuma obusimu, ekuuma obusimu obuyitibwa somatosensory neurons, etumbula okuddamu okukola kw’obusimu obw’okumpi, eziyiza okukulaakulana kw’obuvune bw’obwongo obuva ku buvune, n’okuzzaawo enkola y’omumwa. Kiyinza okukola ng’ekika ekipya eky’omutabaganya w’okukuuma obutoffaali, okwetaba mu kukuuma obulungi bw’omubiri gw’omu lubuto, era n’okuba n’ekikolwa eky’obujjanjabi ekitali butereevu ku ndwadde z’obusimu obw’omu makkati. Era esobola okulung’amya enkola za serotonergic ne dopaminergic, okuba n’omugaso ku buzibu obw’enjawulo obw’enneeyisa obubeerawo olw’okusikirizibwa/okwonooneka okw’enjawulo (okuyitiridde) kw’enkola y’obusimu, era mu kiseera kye kimu n’ebikolwa eby’okukuuma obusimu, gamba ng’okukuuma obusimu obuyitibwa somatosensory neurons, okutumbula okukulaakulana kw’obusimu obw’okumpi, okulwanyisa okutambula kw’obwongo obulumwa obuvune, okuziyiza axonal ne neuronal necrosis, demyelination, n’okutondebwa kw’ekizimba mu nvunza ezirina okunyigirizibwa kw’omugongo, n’okuzzaawo enkola y’omugongo [1]. .
Biki Ebinoonyereza Ebikwatagana ne Bpc 157?
Nga Obujjanjabi Obuyinza Okulwala COVID-19:
Ku nkomerero ya 2019, obulwadde bwa coronavirus 2019 (COVID-19) bwaleetawo ssenyiga omunene mu nsi yonna. Okunoonyereza kulaga nti COVID-19 okusinga bulwadde bwa thrombotic ne vascular disease obugenderera systemic endothelial cells, ekiyinza okuvaako okutaataaganyizibwa kw’emirimu gy’emisuwa egy’omu makkati [5] . Abalwadde ba COVID-19 bayinza okufuna okulemererwa kw’ebitundu by’omubiri ebingi nga acute respiratory distress syndrome, obuzibu bw’emisuwa, okulumwa ekibumba, n’okulumwa obusimu. Okusinziira ku biwandiiko ebikwata ku nkola y’ebisolo, abanoonyereza boogedde ku mulimu gwa Bpc 157 ng’eddagala eppya mu kulongoosa enzirukanya y’obujjanjabi bwa COVID-19. Bpc 157 ye peptide eraga ebikolwa ebiziyiza okuzimba, okukuuma obutoffaali, n’okukuuma endothelial mu nkola z’ebitundu eby’enjawulo eby’ebika eby’enjawulo. Bpc 157 ekola endothelial nitric oxide synthase (eNOS), ekwatagana n’okufulumya nitric oxide (NO), okuddaabiriza ebitundu, n’eby’obugagga by’okulungamya emisuwa, era esobola okulongoosa obulungi bw’emisuwa n’okuddamu kw’abaserikale b’omubiri, okukendeeza ku mbeera y’okuzimba, n’okukendeeza ku buzibu bw’obulwadde. N’olwekyo, kya makulu nnyo okukubaganya ebirowoozo ku busobozi bwayo ng’enkola y’obujjanjabi ey’okuziyiza n’okuyamba.
Okwanguya okuwona kw’ebitundu ebigonvu eby’ebinywa n’amagumba:
Okwekenenya kukoleddwa ku kifo kya Bpc 157 mu kujjanjaba obuvune bw’ebitundu ebigonvu [7] .Mu kiseera kino, okugezesa kwonna okunoonyereza ku Bpc 157 kulaga nti ku bika by’obuvune eby’enjawulo (nga mw’otwalidde n’obuvune obw’ekikangabwa n’obw’enkola n’obuvune obw’enjawulo obw’ebitundu ebigonvu), Bpc 157 erina ekikolwa ekirungi ekitakyukakyuka era eky’okuwonya amangu. Wabula n’okutuusa kati, okunoonyereza okusinga kukoleddwa ku bikolwa by’ebiwuka ebitono, era obulungi bwa Bpc 157 tebunnakakasibwa mu bantu. Wadde kiri kityo, Bpc 157 kyeyoleka bulungi nti erina obusobozi bungi era esuubirwa okufuuka enkola y’obujjanjabi ey’obujjanjabi obw’okukuuma obuvune bw’ebitundu ebigonvu eby’emisuwa emitono n’eby’obutoffaali obutono (nga emisuwa n’emisuwa) oba ng’ekiyamba okuwona oluvannyuma lw’okwongera okukula. Okugatta ku ekyo, enkola y’obuvune mu binywa by’amagumba eraga nti Bpc 157 tekoma ku kukola mugaso ku buvune obuva ku buvune obutereevu wabula n’obuvune obw’enkola omuli hyperkalemia ne hypermagnesemia.
Okulongoosa Enkola y’Emirimu (Motor Function) oluvannyuma lw’Obuvune ku Mugongo:
Abanoonyereza bakozesezza enkola y’envunza eyategekebwa obulungi okulaga nti ekirungo ekinywevu eky’omu lubuto ekiyitibwa pentadecapeptide Bpc 157 kisobola okulongoosa obuvune bw’omugongo [8] . Okunoonyereza okwakolebwa emabegako kwalaga nti Bpc 157 esobola okuziyiza ebiva mu kusala obusimu obw’okumpi (sciatic nerve) transection/anastomosis n’okulongoosa okuwona kw’obusimu, okulumwa obwongo, n’obulwadde obw’enjawulo obw’obwongo. Bpc 157 ebadde ekozesebwa nga anti-ulcer peptide mu kugezesebwa kw’endwadde z’ekyenda ezizimba n’okugezesa obulwadde bwa multiple sclerosis. Mu kunoonyereza okumu, envunza zaafuna empiso emu mu lubuto eya Bpc 157 (200 oba 2μg/kg) oba omunnyo ogwa bulijjo (5ml/kg) oluvannyuma lw’okulumwa omugongo. Envunza zonna ezaalumizibwa zalaga okulongoosa okutambula obutasalako oluvannyuma lw’okujjanjabwa Bpc 157, nga zirina enkola y’enkola y’omukira mu bujjanjabi ennungi ennyo era nga tezirina nneeyisa ya kwesalako; ekizibu ky’okusannyalala kyagonjoolwa ku lunaku olw’ekkumi n’ettaano; wansi wa microscope (okutandika okuva ku lunaku olw’omusanvu), okufiirwa kwa vacuoles n’obusimu obuyitibwa axonal mu kintu ekyeru, edema mu kintu enzirugavu, n’okufiirwa kw’obusimu obukola emirimu mu nvunza za Bpc 157, awamu n’okukendeera kw’omuwendo gw’obusimu obunene obwa myelinated mu busimu bw’omumwa gw’envunza, okusinga byaziyizibwa. Electromyogram recordings zalaga okukendeera okw’amaanyi mu motor unit potentials mu binywa by’omukira. Okugatta ku ekyo, abanoonyereza nabo baakola okugezesa okulala. Bpc 157 yaweebwa oluvannyuma lw’ennaku 4 oluvannyuma lw’okulumwa omugongo, ate Bpc 157 (10μg/kg, 0.16μg/mL, 12ml/rat/day) yaweebwa okuyita mu mazzi ag’okunywa okumala wiiki 4, ate ekibinja ekifuga kyafuna amazzi gokka ag’okunywa. Ebyavudde mu kunoonyereza biraga nti envunza ezajjanjabwa ne Bpc 157 zaalaze okulongoosa okunene era ne zigenda mu maaso n’okuwona okutuusa lwe zaawona ddala.
Okulwanyisa Obutabeera mu ntebenkevu mu Mugongo:
Okuleetera omugongo obutabeera mu ntebenkevu mu nvunza, abanoonyereza essira baalitadde ku kusala facetectomy ku njuyi zombi ne banoonyereza ku migaso egisoboka mu bujjanjabi egya stable gastric pentadecapeptide Bpc 157 mu mazzi ag’okunywa [9] .Mu kunoonyereza okwakolebwa emabegako, Bpc 157 eragiddwa okulongoosa obuvune bw’omugongo, obuvune bw’obusimu obw’okumpi, okulumwa obwongo, n’eby’enjawulo obulwadde bw’obwongo. Mu kunoonyereza kuno, envunza zaafuna okulongoosebwa okujjuvu okwa L3-L4 facetectomy, era oluvannyuma lw’okulongoosebwa, zaweebwa Bpc 157 (10ng/kg, 0.16ng/mL, 12ml/rat/day) oba amazzi gokka ag’okunywa. Radiological evaluations were performed at week 1 and week 8. Ebivuddemu biraga nti mu wiiki 1, tewali bulema bwa maanyi bwalabibwa mu nvunza z’ekibinja ekifuga n’ekibinja kya Bpc 157 mu nnyonyi yonna, ekifo kya intervertebral disc kyalabika nga tekikoseddwa, neural foramen ku ddaala ly’okulongoosebwa kyagaziwa katono, ate envunza mu kibinja ekyali kinywa Bpc 157 zaali n’ obuzito bw’amagumba okutwalira awamu obusingako. Ku wiiki 8, tewali bulema bwa maanyi bwalabibwa mu nvunza z’ebibinja byombi mu nnyonyi yonna, ekifo kya disiki wakati w’omugongo tekyali kikoseddwa, ekituli ky’obusimu ku ddaala ly’okulongoosa kyali kigaziyiziddwa katono, envunza mu kibinja kya Bpc 157 zaali zirina density y’amagumba esingako nnyo, era waaliwo obutaba na bungi bwa callus formation mu nkola ey’ekifuulannenge erabika mu kibinja ekifuga. Okugatta ku ekyo, envunza mu kibinja ekifuga zalaga obuzibu obweyoleka mu nkola y’emirimu amangu ddala oluvannyuma lw’okuyingiza obuvune, ate envunza mu kibinja ekyali kinywa Bpc 157 zaaziyiza ddala okukosebwa kuno okw’enkola y’emirimu.
Mu kumaliriza, omuwendo omukulu ogwa Bpc 157 guli mu mpisa zaayo ez’okulungamya ez’omunda n’enkola nnyingi, okuwa eby’okugonjoola ebiyiiya ku kuzimba okuziyiza, obulema mu bitundu by’omubiri, n’endwadde z’obusimu bw’omutwe. Mu kitundu ky’obuvune mu mizannyo, esobola okwanguya okuddaabiriza n’okuzza obuggya ebitundu by’omubiri ng’ebinywa, emisuwa, n’emisuwa, okukendeeza ku budde bw’okuwona, era kikola bulungi mu bujjanjabi ku buvune obw’amaanyi. Mu kujjanjaba okwokya, Bpc 157 esobola okutumbula ennyo emirimu gy’ebiramu egy’obutoffaali bw’omubiri (endothelial cells) ng’okukula, okusenguka, n’okutondebwa kw’obutoffaali obuyitibwa tubule, bwe kityo ne kyanguya okuddaabiriza ebiwundu eby’okwokya. Okugatta ku ekyo, erina obukuumi ku nkola y’omu lubuto, esobola okutumbula okuwona amabwa mu lubuto, n’okuziyiza n’okukendeeza ku ndwadde z’omu lubuto. Bpc 157 era eraga obusobozi mu kukuuma obusimu, okukuuma enkola y’obusimu okuyita mu nkola nga okukendeeza ku kuddamu kw’okuzimba n’okuziyiza apoptosis. Era erina ekikolwa eky’obukuumi ku bitundu by’omuntu nga pancreas, ekibumba, n’omutima, nga kiraga ebikolwa byayo eby’enjawulo eby’ebiramu nga peptide ekola emirimu mingi.
Ebikwata ku Muwandiisi
Ebintu ebyogeddwako waggulu byonna binoonyerezeddwako, birongooseddwa era ne bikung’aanyizibwa kkampuni ya Cocer Peptides.
Omuwandiisi wa Scientific Journal
Predrag Sikiricis mukenkufu eyeegattira mu matendekero g’ebyenjigiriza agatali gamu, omuli Yunivasite y’e Zagreb, Yunivasite y’e Sarajevo, Sch Med, Yunivasite ya JJ Strossmayer Osijek, ne Rudjer Boskovic Institute. Okunoonyereza kwe kukwata ku bintu ebiwerako nga Pharmacology & Pharmacy, Biochemistry & Molecular Biology, Gastroenterology & Hepatology, Physiology, ne Cell Biology.
Ttiimu ya Sikiric ekoze okunoonyereza okunene ku ngeri BPC157 gy’ekuuma obutoffaali mu bitundu by’omubiri n’ebitundu eby’enjawulo omuli omulimu gwayo mu buvune bw’obusimu n’amabwa mu lubuto. Era alina patent z’okukola BPC, ekirungo ekikola eddagala, omuli enkola z’okukiteekateeka n’okukikozesa mu bujjanjabi.Sikiric Pis omuntu ow’ekitiibwa mu by’ensoma, era okunoonyereza kwe kukulaakulanye nnyo ennimiro z’akwatibwako Sikiric Pis listed in the reference of citation [1].
