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1 pahu (10 Vials)
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▎ Epitalon Hoʻolālā
Puna: PubChem |
Sequence: Ala-Glu-Asp-Gly Hui Molekala: C 14H 22N 4O9 Kaumaha Molekala: 390.35 g/mol Helu CAS: 307297-39-8 PubChem CID: 219042 Synonyms: Epithalon |
▎ Epitalon Research
He aha ke kumu noiʻi o Epitalon?
I ka makahiki 1980, ua ʻike mua kahi hui o nā mea noiʻi Lūkini i alakaʻi ʻia e Vladimir Khavinson iā Epitalon1 [1] . ʻO ka Epitalon kahi peptide pōkole synthetic i haku ʻia me ʻehā amino acids: alanine, glutamic acid, aspartic acid, a me glycine. Hoʻokumu ʻia kona synthesis ma ka peptide epithalamion kūlohelohe i lawe ʻia mai ka ʻili pineal. Manaʻo ʻia he hopena antioxidant ka Epitalon e like me ka melatonin a loaʻa paha ka pōmaikaʻi o ka hoʻonui ʻana i ke ola [2] . Ua ʻike nā mea noiʻi hiki iā Epitalon ke hoʻoulu i ka hana o ka telomerase. ʻO Telomerase kahi enzyme e hiki ke pale a hoʻonui i nā telomeres ma nā wēlau o nā chromosomes. E like me ka makahiki o ka poʻe, pōkole nā telomeres, e pili ana i nā maʻi pili makahiki a me ka pōkole o ke ola. Ma ka hoʻoulu ʻana i ka hana telomerase, hiki i ka Epitalon ke kōkua i ka hoʻonui ʻana i nā telomeres, a laila e hoʻolohi i ke kaʻina hana ʻelemakule a pale i nā maʻi pili i ka ʻelemakule [1] . Ua hōʻike kekahi mau haʻawina e pili ana paha ʻo Epitalon i ka hoʻoponopono ʻana i ka hōʻike ʻana o nā genes CCL11 a me HMGB1 a hana ma ke ʻano he mea hoʻoikaika i ka hōʻike ʻana o kēia mau genes. I ka manawa like, hiki i ka dipeptide vilon (Lys-Glu) a me ka tetrapeptide Epitalon (Ala-Glu-Asp-Gly) ke hoʻokō i kā lākou hopena anti-aging ma ke kāohi ʻana i kēia mau genes. ʻO ka hui pū, ʻike ʻia ʻo Epitalon a me vilon e hoʻoponopono i ka hōʻike gene a me ka synthesis protein, e hāpai ana i ka emi ʻana o ka make a me ka lohi i ka hoʻomohala pathological i ka poʻe ʻelemakule [3] . I kēia manawa, ʻo ka noiʻi ʻana ma Epitalon ka mea nui i ka pae hoʻokolohua holoholona, a ʻaʻole i hoʻoholo piha ʻia kona hopena lōʻihi a palekana i nā kānaka. ʻOiai ua loaʻa i kekahi mau haʻawina holoholona nā hopena hoʻoikaika, e like me nā rodents, pili ʻo Epitalon me kahi ola lōʻihi a me ke olakino maikaʻi, ʻo ka hoʻohana ʻana o kēia mau hopena i nā kānaka e koi hou aku i ka noiʻi [1].
He aha ke ʻano o ka hana a Epitalon ma ke kahua o ka anti-aging?
E ho'ēmi ana i ka pae o nā ʻano oxygen reactive:
He kuleana koʻikoʻi nā ʻano oxygen reactive (ROS) i ke kaʻina hana ʻelemakule o nā oocytes. ʻO ka nui o ka ROS e hoʻopōʻino i nā oocytes, e pili ana i ko lākou maikaʻi a me ka hiki ke ulu. Ua hōʻike nā haʻawina e hiki i ka Epitalon ke hoʻemi i ka helu o ka ʻāpana cytoplasmic o nā oocytes i hoʻokumu ʻia e ka ʻelemakule a me ka ʻike o nā ʻano oxygen reactive intracellular [2] . Ma ke ʻano he antioxidant, hiki i ka Epitalon ke hoʻokaʻawale i ka ROS intracellular a hoʻemi i kona pōʻino i nā oocytes. Ma ke ʻano kikoʻī, hiki ke hoʻokō ʻia ma kēia mau ala ʻelua: ʻO ka mua, ʻohi pololei i ka ROS. Hiki i ka Epitalon ke hoʻololi pololei me ROS a hoʻololi iā ia i mea ʻino ʻole. ʻO ka lua, hoʻonui i ka hana o nā enzyme antioxidant. Hiki i ka Epitalon ke hoʻoulu i ka hana o nā enzymes antioxidant intracellular, e like me superoxide dismutase (SOD), catalase (CAT), etc. Hiki i kēia mau enzymes ke kōkua i ka scavenge ROS a mālama i ke kaulike redox intracellular.
Hoʻomaikaʻi i ka hana mitochondrial:
He kuleana koʻikoʻi ka Mitochondria i ka metabolism ikehu a me ke ola ola o nā oocytes. E like me ka makahiki oocytes, e emi mālie ana ka hana mitochondrial, i hōʻike ʻia ma ke ʻano he emi ʻana o ka hiki o ka membrane mitochondrial a me ka hōʻemi ʻana i ka helu kope o ka DNA mitochondrial. Hiki i ka Epitalon ke hoʻonui i ka pono o ka membrane mitochondrial a me ka helu kope o ka DNA mitochondrial [2] . Kōkua kēia i ka hoʻonui ʻana i ka ikehu o nā oocytes a mālama i nā hana physiological maʻamau o nā cell. Hiki ke komo i ka hana kiko'ī o ka hana: ʻO ka mea mua, e hoʻonui i ka hiki o ka membrane mitochondrial. He mea koʻikoʻi ka mālama ʻana i ka membrane mitochondrial no ka hana maʻamau o ka mitochondria. Hiki i ka Epitalon ke hoʻonui i ka pono o ka membrane mitochondrial ma o ka hoʻoponopono ʻana i nā kahawai ion a i ʻole ka lawe ʻana i nā protein i ka membrane mitochondrial, e hoʻonui ana i ka mana hana o ka mitochondria. ʻO ka lua, hoʻonui i ka helu kope o ka DNA mitochondrial. ʻO ka hoʻonui ʻana i ka helu kope o ka DNA mitochondrial hiki ke hoʻomaikaʻi i ka hiki synthesis o mitochondria a hāʻawi i ka ikehu hou no nā cell. Hiki i ka Epitalon ke hoʻonui i ka helu kope o ka DNA mitochondrial ma o ka hoʻolaha ʻana i ka replication o ka DNA mitochondrial a i ʻole ka hōʻemi ʻana i kona degradation.
E hōʻemi ana i ka morphology spindle abnormal a me ka exocytosis abnormal o nā granules cortical:
I ka wā o ka ʻelemakule o nā oocytes, e hoʻonui ʻia nā lakio o ka morphology spindle abnormal a me ka exocytosis abnormal o cortical granules, e hoʻopilikia i ka hoʻoulu ʻana a me ka hiki ke hoʻomohala embryonic o nā oocytes. Hiki i ka Epitalon ke hoʻemi i nā lakio o ka morphology spindle abnormal a me ka exocytosis abnormal o nā granules cortical [2] . ʻO kēia paha ma muli o ka hopena hoʻoponopono o Epitalon i ka paʻa o ka cytoskeleton a me ka membrane cell: ʻO ka mea mua, hoʻopaʻa i ka ʻōnaehana spindle. He hale koʻikoʻi ka spindle i ke kaʻina o ka mahele cell, a ʻo kona ʻano ʻano ʻano e alakaʻi i ka hoʻokaʻawale chromosome maʻamau a pili i ka ulu ʻana o nā oocytes. Hiki i ka Epitalon ke hoʻopaʻa i ka ʻōnaehana spindle ma ka hoʻoponopono ʻana i ka polymerization a me ka depolymerization o ka tubulin, e hōʻemi ana i ka hiki ʻana mai o ka morphology abnormal. ʻO ka lua, mālama i ka paʻa o nā granules cortical. He kuleana koʻikoʻi ka cortical granules i ka hana fertilization o nā oocytes. Hiki i ka Epitalon ke mālama i ka paʻa o nā granules cortical ma ka hoʻoponopono ʻana i ka permeability o ka membrane cell a i ʻole ka hōʻailona calcium ion, e hōʻemi ana i ka hiki ʻana o ka exocytosis maʻamau.
E hōʻemi ana i nā hōʻailona apoptosis:
I ka wā ʻelemakule o nā oocytes, e hoʻonui ʻia nā hōʻailona apoptosis, e alakaʻi ana i ka make cell. Hiki i ka Epitalon ke ho'ēmi i ka maikaʻi o ka Annexin V staining a me ka fluorescence intensity o γH2AX i loko o vitro aged oocytes [2] . Hōʻike kēia i hiki iā Epitalon ke hoʻemi i ka apoptosis o nā oocytes. Hiki i ka mīkini kiko'ī ke komo: ʻO ka mua, ke kāohi ʻana i ke ala hōʻailona apoptosis. Hiki i ka Epitalon ke kaohi i ka lawe ʻana i nā hōʻailona apoptosis ma o ka hoʻoponopono ʻana i nā protein kī ma ke ala hōʻailona apoptosis, e like me nā protein ʻohana Bcl-2 a me nā protein ʻohana caspase, a e hōʻemi i ka make cell. ʻO ka lua, mālama i ke kūpaʻa genomic. ʻO γH2AX kekahi o nā hōʻailona o ka pōʻino DNA. Hiki i ka Epitalon ke mālama i ke kūpaʻa genomic ma ka hōʻemi ʻana i ka pōʻino DNA a me ka hōʻemi ʻana i nā hōʻailona apoptosis.
Ua mālama ʻo Epitalon i ka pololei spindle maʻamau a me ka hāʻawi ʻana i nā CG.
Puna:PubMed [2]
He aha ke ʻano kikoʻī o ka hana a Epitalon i ka mālama ʻana i nā maʻi neurodegenerative?
Hoʻoponopono i ka hana immune:
Ua hōʻike nā haʻawina e hiki i ka Epitalon ke hoʻopilikia i ka pane ʻana o nā ʻiole ma lalo o nā kūlana koʻikoʻi. I ke alo o ka immune-stimulating rotational stress a immunosuppressive combined stress, hiki i ka Epitalon ke hoʻonui i ka hana proliferation o nā thymocytes [4] . ʻO ia ka mea hiki ke hoʻoikaika ʻo Epitalon i ke kūʻē ʻana o ke kino i nā maʻi neurodegenerative ma o ka hoʻoponopono ʻana i ka ʻōnaehana pale. ʻO ka hoʻonui ʻana o nā thymocytes e pili kokoke ana i ka hana o ka ʻōnaehana pale, a he mea nui ka ʻōnaehana pale i ka hanana a me ka ulu ʻana o nā maʻi neurodegenerative. No ka laʻana, pili paha kekahi mau maʻi neurodegenerative i ka hoʻoulu ʻana a i ʻole ka hana ʻole o ka ʻōnaehana pale. ʻO ka hopena hoʻolaha o Epitalon i ka hoʻonui ʻana o nā thymocytes hiki ke kōkua i ka mālama ʻana i ke kaulike o ka ʻōnaehana pale, a laila e hoʻēmi i nā hōʻailona o nā maʻi neurodegenerative.
Ka hopena ma ke ala transduction hōʻailona:
He hopena hoʻoponopono ko Epitalon ma ke ala transduction hōʻailona interleukin-1β (IL-1β). Ma keʻano kiko'ī, hiki i ka Epitalon ke hoʻonui i ka hopena synergistic o IL-1β a hoʻopili i ka hana o ka enzyme kī ma ke ala transduction hōʻailona ceramide ma ka cerebral cortex membrane,ʻo ia hoʻi ka membrane neutral sphingomyelinase (nSMase) [4] . ʻO IL-1β kahi cytokine koʻikoʻi i komo i nā ʻano hana physiological a me nā pathological. I nā maʻi neurodegenerative, hiki i ka hōʻike maʻamau o IL-1β ke alakaʻi i ka neuroinflammation a me ka pōʻino neuronal. Ma ka hoʻoponopono ʻana i ke ala transduction hōʻailona IL-1β, hiki i ka Epitalon ke hōʻemi i ka neuroinflammation a pale i nā neurons mai ka pōʻino. Eia kekahi, pili pū nā loli i ka hana o nSMase i nā maʻi neurodegenerative. ʻO ka hoʻoponopono o ka hana o nSMase e Epitalon hiki ke kōkua i ka mālama ʻana i ka hana maʻamau o nā pūnaʻi nerve. Eia nō naʻe, ʻo ka noiʻi o kēia manawa e pili ana iā Epitalon i ka mālama ʻana i nā maʻi neurodegenerative aia nō i ka pae mua, a pono e noiʻi hou e hōʻoia i kona pono a me ka palekana.
Ka holomua noiʻi o Epitalon
Ka hopena i ka maikaʻi o nā oocytes
Hoʻopaneʻe i ka ʻelemakule o nā oocytes:
Ua ʻike ʻia nā haʻawina hoʻokolohua in vitro hiki iā Epitalon ke hoʻemi i ke kiʻekiʻe o ka intracellular reactive oxygen species (ROS) i loko o nā oocytes ʻiole kahiko ma hope o ka ovulation. I ka wā lōʻihi, e emi mālie ka ulu ʻana o nā oocytes ma hope o ka ovulation in vivo a i ʻole in vitro. Ma ke ʻano he peptide pōkole synthetic, hana like ʻo Epitalon me ka melatonin a he antioxidant pono, hiki ke loaʻa ka pōmaikaʻi o ka hoʻonui ʻana i ke ola. ʻO ka hoʻomaʻamaʻa ʻana me Epitalon i hoʻemi nui i ka pinepine o nā hemahema spindle a me ka hāʻawi ʻole ʻana o nā granules cortical i nā hola 12 a me 24 mau hola o ka ʻelemakule, a ma ka manawa like hoʻonui i ka hiki ke mitochondrial membrane a me ka helu kope o ka mitochondrial DNA, a laila e hōʻemi ana i ka apoptosis o nā oocytes i nā hola 24 o in vitro aging. Hōʻike kēia mau hopena e hiki iā Epitalon ke hoʻopaneʻe i ke kaʻina hana kahiko o nā oocytes in vitro ma o ka hoʻoponopono ʻana i ka hana mitochondrial a me nā pae ROS [2].
Hoʻomaikaʻi i ka maikaʻi o nā oocytes:
ʻO ka hoʻohui ʻana i ka 0.1 mM o Epitalon i ka moʻomeheu in vitro hiki ke hōʻemi i ka helu o ka cytoplasmic fragmentation i ka parthenogenetic activation o oocytes i hoʻokumu ʻia e ka in vitro aging ma hope o ka ovulation, e hoʻemi i nā lakio o ka morphology spindle abnormal a me ka exocytosis abnormal o cortical granules, e hoʻonui i ka hiki o ka membrane mitochondrial a me ka helu kope o ka DNA a me ka helu kope o ka mitochondrial. ka ikaika o ka fluorescence o γH2AX i loko o nā oocytes makahiki in vitro. Hōʻike kēia i hiki iā Epitalon ke hoʻomaikaʻi i ka maʻi o nā organelles i ka wā o ke kaʻina hana ʻelemakule in vitro o nā oocytes a hoʻomaikaʻi i ka maikaʻi o nā oocytes (Xue Yue).
ʻO ka hopena i ka hoʻokaʻawale ʻana o nā pūnana nerve
Ua ʻike nā haʻawina e hiki i ka AEDG peptide (Epitalon) ke hoʻonui i ka synthesis o nā hōʻailona hoʻokaʻawale neurogenic i loko o ke kanaka gingival mesenchymal stem cell, e like me Nestin, GAP43, β Tubulin III, a me Doublecortin. Hōʻike nā ʻano hoʻohālike molekula e pili pono ana ʻo Epitalon i nā histones H1 / 6 a me H1 / 3, ʻo ia paha kekahi o nā hana e hoʻonui ai i ka transcription o kēia mau neuronal differentiation genes [5].
ʻO ka hopena hoʻoponopono i ka ʻōnaehana nerve
Hoʻoponopono i ka hana neuronal:
Ma o ka noiʻi ʻana i nā ʻiole, ua ʻike ʻia ʻo intranasal infusion o Epitalon (2 ng) hiki ke hoʻoikaika nui i ka hana neural o ka cerebral cortex o nā ʻiole i loko o kekahi mau minuke, a ua hoʻonui ʻia ke kī ʻana o nā neurons e 2 - 2.5 manawa [6] . Ma kekahi mau hoʻopaʻa ʻana, ua ʻike pū ʻia nā pane paʻakikī i loaʻa i kekahi mau pae. ʻO ka piʻi ʻana o ka hana kuʻuna o nā neurons e Epitalon ke kumu o ke kiʻekiʻe kiʻekiʻe o nā ʻāpana hana mua a me ke komo ʻana o nā cell silent mua. ʻO ka liʻiliʻi o ka pae mua o ka hana a Epitalon hiki ke wehewehe ʻia e ka hopena pololei o kēia peptide ma nā cell o ka cortex motor.
Ka hopena pale pilikia:
He hopena koʻikoʻi ko Epitalon i nā ʻiole i ʻike ʻia i nā kūlana koʻikoʻi like ʻole. Ua hōʻike ʻia nā hoʻokolohua e hoʻonui ʻo Epitalon i ka hana proliferation o nā thymocytes. Inā hoʻonui ʻia ma lalo o ke koʻikoʻi rotational immune-stimulating a i ʻole ke kāohi ʻia ma lalo o ke koʻikoʻi hui pū ʻana o ka immunosuppressive, hiki iā Epitalon ke hana i kahi kuleana hoʻoponopono (Vladimir Kh Khavinson, 2002). I ka manawa like, hiki i ka Epitalon ke hoʻonui i ka hopena synergistic o interleukin-1β (IL-1β) a he hopena i nā loli i ka hana o sphingomyelinase (nSMase) i loko o ka membrane cortex cerebral i hoʻoulu ʻia e ke kaumaha. Hōʻike kēia he hopena pale koʻikoʻi ʻo Epitalon ma ke kiʻekiʻe o ka transduction hōʻailona IL-1β ma ke ala sphingomyelin a ma ke kiʻekiʻe o ka hoʻonui ʻana o ka thymocyte target i nā ʻiʻo nerve.
ʻO ka hopena i ka hana endocrine o nā primates ʻole kanaka:
I nā monkey rhesus kahiko, hiki i ka Epitalon ke hoʻemi i ka pae basal o ka glucose a me ka insulin a hoʻonui i ka pae basal melatonin i ka pō. I ka manawa like, hiki i ka Epitalon ke hoʻemi i ka wahi ma lalo o ke kaʻe pane pane o ka glucose plasma, hoʻonui i ka 'nalo' o ka glucose, a hoʻomaʻamaʻa i nā kinetics insulin plasma i pane i ka hoʻokele glucose. Hōʻike kēia ʻo Epitalon kahi mea hoʻohiki no ka hoʻihoʻi ʻana i ka maʻi endocrine pili i ka makahiki i nā primates [7].
ʻO ka hoʻohana pono ʻana o Epitalon i ka mālama ʻana i nā maʻi ʻōnaehana nerve
ʻO ka maʻi o Alzheimer: ʻO ka maʻi Alzheimer kahi maʻi neurodegenerative maʻamau, ʻike nui ʻia e ka emi ʻana o ka hana cognitive a me ka nalowale hoʻomanaʻo. Hōʻike ka noiʻi o kēia manawa e pili ana ka maʻi o Alzheimer i ka ʻokoʻa neurogenic impaired. Ke emi nei ka heluna o nā pūnaewele neural i loko o ka lolo o nā maʻi maʻi o Alzheimer, a ua pāpā ʻia hoʻi ko lākou ʻokoʻa. Hiki i ka Epitalon ke hoʻoikaika i ka hoʻonui ʻana a me ka hoʻokaʻawale ʻana o nā cell stem neural, hoʻonui i ka helu o nā neurons, a hoʻomaikaʻi i ka hana cognitive o nā maʻi maʻi o Alzheimer. Eia kekahi, hiki i ka Epitalon ke hoʻoponopono i ka hoʻokuʻu ʻana o nā neurotransmitters, e hoʻomaikaʻi i ka hoʻomanaʻo a me ke aʻo ʻana o nā maʻi maʻi o Alzheimer [8].
ʻO ka maʻi o Parkinson: ʻO ka maʻi o Parkinson he maʻi neurodegenerative i hōʻike nui ʻia e nā maʻi kaʻa. ʻO kāna hiʻohiʻona pathological nui ka nalowale o nā neurons dopaminergic i ka substantia nigra. ʻO nā ala lapaʻau o kēia manawa e hoʻomaha nui i nā hōʻailona ma o ka hoʻonui ʻana i ka dopamine a i ʻole ke kāohi ʻana i ka hoʻohaʻahaʻa ʻana o dopamine, akā ʻaʻole hiki i kēia mau ala ke hoʻōki i ka piʻi ʻana o ka maʻi. ʻO ka hoʻololi ʻana i ke ʻano o ka neural stem cell kahi ala lapaʻau kūpono, akā ʻo ke kumu a me ka hiki ke hoʻokaʻawale ʻia o nā cell stem neural kahi pilikia. Hiki i ka Epitalon ke hoʻoikaika i ka hoʻonui a me ka hoʻokaʻawale ʻana o nā pūnaewele neural stem, hoʻonui i ka nui o nā neurons dopaminergic, a hoʻomaikaʻi i ka hana kaʻa o nā maʻi maʻi o Parkinson [8].
ʻO ka hahau ʻana a me ka ʻeha lolo: ʻO ka hahau ʻana he maʻi cerebrovascular maʻamau, a ʻo kāna hopena nui ʻo ka make ʻana o nā neurons a me ka maʻi neurological. Hiki i ka ʻeha lolo ke alakaʻi i ka nalowale o nā neurons a me ka hana ʻole. He kuleana koʻikoʻi nā pūnaewele neural stem i ka hoʻoponopono ʻana a me ka hana hou ʻana ma hope o ka hahau ʻana a me ka hōʻeha lolo. Hiki i ka Epitalon ke hoʻoikaika i ka hoʻonui a me ka hoʻokaʻawale ʻana o nā pūnaewele neural stem, hoʻonui i ka helu o nā neurons, a hoʻomaikaʻi i ka hana neurological o nā maʻi maʻi ʻeha a me ka lolo [8].
I ka hopena, ma ke ʻano he tetrapeptide synthetic, ʻo ke kumu anti-aging mechanical o Epitalon aia i ka hoʻoulu ʻana i ka hōʻike ʻana o ka telomerase reverse transcriptase subunit (TERT), e hoʻolōʻihi i ka lōʻihi o nā telomeres a me ka mālama ʻana i ka hana telomerase, a laila e komo i ke kaʻina kumu o ka ʻelemakule cellular. Aia kona koʻikoʻi i ka ʻike mua ʻana o ka hana anti-kahiko mai ka manaʻo o ka telomere biology, ka haki ʻana i ka palena o nā antioxidants kuʻuna e hoʻopaʻa wale i nā radical manuahi, a hāʻawi i kahi pahuhopu hou no ka hoʻopaneʻe ʻana i nā maʻi pili makahiki e like me ka maʻi Alzheimer a me nā maʻi cardiovascular. ʻOiai ʻo kona palekana no ka wā lōʻihi (ʻoi aku ka pilikia o ka maʻi kanesa) pono e hōʻoia ʻia i nā hoʻokolohua lapaʻau pae III, e like me ka noiʻi a me ka hoʻomohala ʻana o ka lāʻau anti-aging ʻano telomerase activator-type mua, hōʻailona ia i kahi holomua kipi i ka wā ʻelemakule mai ka hoʻomaikaʻi ʻana i nā hōʻailona a hiki i ka hoʻoponopono ʻana i ka molecular mechanism a manaʻo ʻia e hāpai i ka hoʻonui ʻana i ke ola olakino kanaka.
No ka mea kakau
ʻO nā mea i ʻōlelo ʻia ma luna nei ua noiʻi ʻia, hoʻoponopono ʻia a hōʻuluʻulu ʻia e Cocer Peptides.
ʻO ka mea kākau moʻolelo ʻepekema ʻo Vladimir Khavinson he mea noiʻi biogerontologist Lūkini kaulana a me ka mea noiʻi bioregulator peptide. ʻO ia ka Luna Hoʻokele o ka St. Petersburg Institute of Bioregulation and Gerontology a he lālā o ka Russian Academy of Medical Sciences. Ua hāʻawi koʻikoʻi ʻo Khavinson i ka ʻimi noiʻi ʻelemakule a ua kākau i nā puke he nui i loko o nā puke pai kaulana e like me 'Molecular Biology of Aging' a me 'Journal of Anti-Aging Medicine'. Kuhi nui kāna hana i ka hoʻomohala ʻana a me ka hoʻohana ʻana i nā bioregulators peptide e hakakā i nā maʻi pili makahiki a hoʻomaikaʻi i ke olakino. He mea koʻikoʻi ka noiʻi a Khavinson ma ke kahua o ka gerontology, e hāʻawi ana i nā ʻike hou a me nā ala lapaʻau no ka ʻelemakule olakino. Ua helu ʻia ʻo Vladimir Khavinson ma ka ʻōlelo kuhikuhi [5].
