MOTS-c miligaramu 20

▎ MOTS-c Jatebɔcogo

▎ MOTS-c Sɛgɛsɛgɛli

MOTS-c ka ɲininiw kɛcogo ye mun ye?

MOTS-c ka ɲininiw kɔkankow bɔra sɛgɛsɛgɛliw la minnu kɛra mitokondriyaw ADN jɔyɔrɔ kan farikoloɲɛnajɛ kɛnɛya ni kɔrɔya la. Mitokondriyaw ka baara faamuyali bonyalen kɔfɛ, a jirala ko mitokondriyaw tɛ fanga sɛnɛyɔrɔ dɔrɔn ye, nka u bɛ u sen don fana selilɛriw ka kumaɲɔgɔnya ni taamasiɲɛw cili la. Ni AMPK sira bɛ baara kɛ, u sen bɛ sukaro ni tulumafɛnw sɛnɛcogo la, minnu ni farikoloɲɛnajɛ banaw bɛ tali kɛ ɲɔgɔn na kosɛbɛ i n’a fɔ sukarodunbana ni fasa, wa u bɛ layidu ta i n’a fɔ furakɛli laɲini kura ye nin bana ninnu na. Ni an y’a jateminɛ ko jɛɲɔgɔnya bɛ mitokondriyaw ka baara ni bana suguya caman cɛ, MOTS-c fana kɛra cogoyaw la i n’a fɔ sugunɛbilenni basigilen B ani kɔnɔbara kansɛri. Sɛgɛsɛgɛliw y’a jira ko a bɛ se ka jɔyɔrɔba ta banakisɛw sɔrɔli taabolo la. Farikoloɲɛnajɛ bɛ MOTS-c labɛnni n’a jirali sabati hadamaden farikolo la, o bɛ farikolo yɔrɔw labɛncogo ɲɛ, farikolo baarakɛcogo ɲuman, ani farikolo baara bɛɛ lajɛlen, ka daliluw di farikoloɲɛnajɛw kan minnu sinsinnen bɛ kɔrɔya kɛlɛli fɛɛrɛw kan ani ka MOTS-c ɲininiw bonya.

MOTS-c ka baarakɛcogo ye mun ye?

AICAR-AMPK taamasiɲɛw sira baarakɛcogo: 

MOTS-c b’a farikolo baara kɛ fɔlɔ ni AICAR-AMPK taamasiɲɛw sira baara ye. A bɛ folate-méthionine (folate-méthionine) sɛgɛsɛgɛli tiɲɛ farikolokisɛw kɔnɔ, o la, a bɛ AICAR-AMPK taamasiɲɛw sira baara. Misali la, farikoloɲɛnajɛw la i n’a fɔ inisɔndiya sabatili ani fasa kunbɛnni, o sira in baarakɛli jɔyɔrɔ ka bon kosɛbɛ. Ni MOTS-c ye nin sira in baara, a bɛ se ka selilɛriw ka fanga sɛnɛcogo ɲɛnabɔ, ka selilɛriw ka sukaro tali ni a baaracogo ɲɛ, o la, a bɛ se ka farikolojɔli kɛcogo ɲɛnabɔ farikolo la ^[1,2]..

Jɛɲɔgɔnya minnu bɛ kɛ ni taamasiɲɛw sira kɛrɛnkɛrɛnnenw ni jamu ye: 

Farikolo yɔrɔw la, MOTS-c bɛ jɛɲɔgɔnya kɛ ni taamasiɲɛw cili ni sɛbɛnnikɛlan 3 (STAT3) ye a ka YIFY yɔrɔ ka Src-homologous 2 (SH2) sirili motif fɛ, o bɛ STAT3 ka sɛbɛnni baara dɔgɔya ani ka miyɔtubuw jɔli bonya. Sɔgɔsɔgɔninjɛ la, MOTS-c bɛ fogonfogon tiɲɛni, funu ani oksidan degun nɔgɔya, a kɛtɔ ka dɔ fara nukilila facteur E2-related factor (Nrf2) hakɛ kan ani ka a nukilila jiginni sabati, o la, a bɛ mitokondriyaw ka baara lakana. Ka fara o kan, MOTS-c bɛ farikolo baara suguya caman kɛ ni a bɛ jamu jiracogo ɲɛnabɔ i n’a fɔ GLUT4, STAT3, ani IL-10 ^{[3] .}.

Farikoloɲɛnajɛ siraw labɛnni: 

MOTS-c bɛ a sen don farikoloɲɛnajɛ kɛcogo nafama suguya caman labɛnni na, i n’a fɔ sukaro sɛnɛcogo, tulumafɛnw sɛnɛcogo, ani kolo sɛnɛcogo, otokirini ni parakirini fɛɛrɛw fɛ. Sukaro sɛnɛcogo la, a bɛ inisɔndiya sabati ani ka joli sukaro hakɛ labɛn; tulumafɛnw sɛnɛcogo la, a bɛ dɔ fara tulumafɛnw sɛnɛcogo kan, ka tulumafɛnw falenni sabati, ani ka fasa ni tulumafɛnw falenfalenbaliya bali; kolotugudaw la, a bɛ kolotugudaw caya, ka danfara don u ni ɲɔgɔn cɛ, ani ka kolotugudaw bɔli bali, ka kolotugudaw falenfalenni ni kolotugudaw labɛn kokura ^[4,.

Jaa 1 MOTS-c ka baarakɛcogo n’a baarakɛcogo ^{[6] .}.

MOTS-c ka baarakɛcogo n’a baarakɛcogo ye mun ye?

MOTS-c ka baarakɛcogo

Labɛnni nɔ minnu bɛ sɔrɔ farikoloɲɛnajɛ la: 

MOTS-c bɛ se ka sukaro ni tulumafɛnw sɛnɛcogo ɲɛ farikolo la. Sukaro sɛnɛcogo la, a bɛ dɔ bɔ inisɔndiya la, ka dɛmɛ don ka sukarodunbana suguya 2 bali, ani ka sukaro tali ni a baaracogo ɲuman sabati selilɛriw fɛ. Tumuw falenni na, a bɛ dɔ fara tulumafɛnw sɛnɛcogo kan, ka tulumafɛnw falenni sabati, o la, a bɛ tulumafɛnw sɛnɛcogo ɲɛnabɔ, ka fasa bali, ani tulumafɛnw falenfalenbaliya minnu bɛ tali kɛ o la. A bɛ dɔ bɔ fana sugunɛbilenni na min tɛ dɔlɔ ye ani ka sugunɛbilenniw falenfalencogo ɲɛnabɔ ^{[2] .}.

A bɛ nɔ minnu bila selilɛriw ka baara la: 

A bɛ mitokondriyaw ka baara sabati ani ka farikolokisɛw tanga tiɲɛni ma. Misali la, sɔgɔsɔgɔninjɛ min bɛ sɔrɔ fiɲɛ fɛ, a bɛ dɔ bɔ mitokondriyaw tiɲɛni na fogonfogon la, a bɛ dɔ bɔ farikolokisɛw ka apoptose la, ani ka selilɛriw ka baara kɛcogo ɲuman sabati. Pankreyasi selilɛriw la, MOTS-c bɛ nɔ bila insuline ni glucagon bɔli ni u jirali la, ka pankreyasi selilɛriw farikolo labɛn, ani fana a bɛ nɔ bila selilɛriw ka ɲɛnamaya ni apoptose la ^[4,.

A bɛ nɔ minnu bila farikolo ni kolotugudaw la: 

Farikolo la, MOTS-c bɛ farikolo ɲɛfɛla selilɛriw danfara sabati, ka dɔ fara miyɔtubuw dilanni kan, ani ka farikolokisɛw tanga tiɲɛni ma min bɛ sɔrɔ interleukin-6 (IL-6) fɛ, o bɛ se ka farikolojidɛsɛ bali. Kolow siratigɛ la, a bɛ kolotugudaw caya, u ka danfara ani u ka fɛnɲɛnamafagalanw sɔrɔli sabati, a bɛ kolotugudaw sɔrɔli bali, ka kolotugudaw ka farikoloɲɛnajɛ balansi sabati, ani ka koloci bila kɔfɛ ^[1,.

Banakisɛfagalanw ni farikolo tangalanw: 

MOTS-c bɛ dɔ bɔ farikolo funu basigilen jaabiw la ani ka farikolo tangalanw ka baara ɲɛnabɔ. Funu dimi misaliw la, MOTS-c bɛ dimi caya kojugu nɔgɔya, ka funufɛnw bɔli dɔgɔya, ani ka glial selilɛriw ni senfagabana baara bali, o bɛ funu kɛlɛli ni dimi madali nɔ ^jira.

MOTS-c ka baarakɛcogo

A bɛ nɔ minnu bila farikoloɲɛnajɛ banaw la: 

MOTS-c ka sariyasunba nɔ minnu bɛ sukaro ni tulumafɛnw sɛnɛcogo la, olu b’a kɛ furakɛli laɲini kura ye farikoloɲɛnajɛ banaw la i n’a fɔ sukarodunbana suguya 2, fasa, ani sugunɛbilenni min tɛ dɔlɔ ^ye.

Farikolo ni kolotugudaw banaw kunbɛnni ni u furakɛli: 

A nɔ ɲuman minnu bɛ farikolo ni kolotugudaw la, olu bɛ se ka kɛ ka farikolojidɛsɛbanaw ni kolotugudaw bali ani k’u furakɛ i n’a fɔ koloci. Banabagatɔ minnu farikolojidɛsɛ bɛ u la, a bɛ se ka farikolo baara ɲɛ ka taa a fɛ ni farikolo yɔrɔw danfara sabatili ye ani ka farikolokisɛw ka apoptose bali; Banabagatɔ minnu koloci bɛ u la, a bɛ se ka kolotugudaw labɛn, ka dɔ fara koloci kan, ka koloci bali ani k’a furakɛ ^[1,5]..

Fiɲɛdimi tiɲɛni lakanani: 

Sɛgɛsɛgɛliw la minnu kɛra sɔgɔsɔgɔninjɛ kan, MOTS-c ye a jira ko a bɛ mɔgɔ tanga fogonfogon tiɲɛni ma. A bɛ se ka kɛ radiyofurakɛli waati la walasa ka farikolo yɔrɔw lakana minnu ka ɲi, ka farikolo yɔrɔw tiɲɛni dɔgɔya fiɲɛ fɛ, ani ka kɛnɛyaji furakɛli nafa bonya ^{[2] .}.

Funubanaw furakɛli : 1 . 

Ka da a ka banakisɛfagalanw kan, MOTS-c bɛ se ka kɛ ka funubanaw furakɛ i n’a fɔ funubana, o bɛ sira kura di o bana suguw furakɛli ^ma.

Kuncɛli

I n’a fɔ pepitiri min bɛ bɔ mitokondriyaw la, MOTS-c bɛ se ka taamasiɲɛw siraw baara walasa ka sukaro ni tulumafɛnw sɛnɛcogo ɲɛnabɔ, ka inisɔndiya kunbɛncogo ɲɛ, ani ka farikoloɲɛnajɛ banaw farati dɔgɔya a bɛ se fana ka farikolo ni kolo baara sabati, ka farikolojidɛsɛ ni koloci bali; ani a bɛ ni funu kɛlɛli ni selilɛri lakanani baara ye, a jɔyɔrɔ ka bon fiɲɛ tiɲɛni lakanani na ani funubanaw furakɛli la.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Wan, Yanmin ni tɔnba tɔgɔba suguya caman bɛ ɲɔgɔn na, i n’a fɔ dɔgɔtɔrɔsow, ɲininikɛyɔrɔw, iniwɛrisitew, ani baarakɛda minnu bɛ i n’a fɔ Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, wdfl A ka ɲininiw nafa ka bon kosɛbɛ, a ɲɛsinnen bɛ fɔlɔ kalansenw ma minnu ye Immunology Science & Technology, Virology, ani Materials Science ye Chimie (Simi) ka dɔnniya. Immunology Science & Technology siratigɛ la, a bɛ sɛgɛsɛgɛli kɛ farikolo tangacogo fɛɛrɛw n’a baarakɛcogo kan. A ka Virology ɲininiw ɲɛsinnen bɛ banakisɛw cogoyaw, a jɛnsɛnni ani a kunbɛnni ma. Fɛnɲɛnɛmako dɔnniya Simi siratigɛ la, a cɛsirilen don fɛnw nafaw yiriwali la ani chimie baarakɛcogo kura la, o b’a kɛ mɔgɔ kɛrɛnkɛrɛnnen ye min ye ɲininiw kɛ kosɛbɛ kalanko siratigɛ la. Wan, Yanmin tɔgɔ sɛbɛnnen bɛ citation (citation) ka ɲɛfɔli kɔnɔ [6].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] García-Benlloch S, Revert-Ros F, Blesa JR, ani a ɲɔgɔnnaw. MOTS-c bɛ farikolo yɔrɔw danfara sabati in vitro[J]. Pepitidiw, 2022,155:170840.DOI:10.1016/j.pɛtidiw.2022.170840.

[2] Zhang Y, Huang J, Zhang Y, ani a ɲɔgɔnnaw. Peptide MOTS-c min bɛ bɔ mitokondriyaw la, o bɛ sɔgɔsɔgɔninjɛ nɔgɔya ni Nrf2 ye[J]. Oksidanw, 2024,13.

[3] Wang Z, Yang L, Xu L, ani mɔgɔ wɛrɛw. MOTS-c cɛmancɛ ni a lamini fɛɛrɛ bɛ dimi juguya dɔgɔya sosow ka dimi funu modɛli la[J]. Hakilila-sɛgɛsɛgɛli, 2024,46(2):165-177.DOI:10.1080/01616412.2023.2258584.

[4] Bień J, Pruszyńska-Oszmałek E, Kołodziejski P, ani a ɲɔgɔnnaw. MOTS-c bɛ pankreyasi alfa ni beta selilɛri baarakɛcogo ɲɛnabɔ in vitro[J]. Histochimie ani selilɛri ɲɛnamaya, 2024,161(6):449-460.DOI:10.1007/s00418-024-02274-0.

[5] Yi X, Hu G, Yang Y, ani mɔgɔ wɛrɛw. MOTS-c jɔyɔrɔ kolotugudaw labɛnni na[J]. Dancɛw farikoloɲɛnajɛ la, 2023,14:1149120.DOI:10.3389/fphys.2023.1149120.

[6] Wan W, Zhang L, Lin Y, ani mɔgɔ wɛrɛw. Mitokondriyaw ka pepitiri MOTS-c: a nɔw ni a kɛcogo minnu bɛ tali kɛ degun, farikoloɲɛnajɛ ani kɔrɔya la[J]. Bamanankan bamanankan furakɛli gafe, 2023,21(1):36.DOI:10.1186/s12967-023-03885-2.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.