MOTS-c 20 mg

▎ MOTS-c Qauv

▎ MOTS-c Kev Tshawb Fawb

Kev tshawb fawb keeb kwm ntawm MOTS-c yog dab tsi?

Kev tshawb fawb keeb kwm yav dhau los ntawm MOTS-c tau pib los ntawm kev tshawb nrhiav rau lub luag haujlwm ntawm mitochondrial DNA hauv metabolic noj qab haus huv thiab kev laus. Raws li kev nkag siab ntawm mitochondrial kev ua haujlwm tob zuj zus, nws tau pom tias mitochondria tsis yog lub hauv paus ntawm lub zog metabolism, tab sis kuj koom nrog hauv kev sib txuas lus ntawm tes thiab cov teeb liab. Los ntawm kev ua kom txoj hauv kev AMPK, lawv koom nrog hauv cov piam thaj thiab lipid metabolism, cuam tshuam nrog cov kab mob metabolic xws li ntshav qab zib thiab rog rog, thiab tuav cov lus cog tseg raws li cov hom phiaj kho tshiab rau cov mob no. Muab kev koom tes ntawm mitochondrial muaj nuj nqi thiab ntau yam kab mob, MOTS-c kuj tau siv rau hauv cov xwm txheej xws li mob siab B thiab mob qog noj ntshav ntawm zes qe menyuam. Kev tshawb fawb qhia tias nws tuaj yeem ua lub luag haujlwm tseem ceeb hauv cov txheej txheem kis kab mob. Kev tawm dag zog txhawb kev sib txuas thiab kev qhia ntawm MOTS-c hauv tib neeg lub cev, yog li txhim kho cov leeg nqaij metabolism, kev ua haujlwm ntawm lub cev, thiab tag nrho lub cev ua haujlwm, muab pov thawj rau kev tawm dag zog raws li kev tiv thaiv kev laus thiab nthuav dav ntawm MOTS-c kev tshawb fawb.

Lub mechanism ntawm kev txiav txim ntawm MOTS-c yog dab tsi?

Ua kom lub AICAR-AMPK signaling txoj kev: 

MOTS-c feem ntau exerts nws physiological functions los ntawm activating AICAR-AMPK signaling txoj kev. Nws cuam tshuam lub voj voog folate-methionine hauv cov hlwb, yog li ua rau AICAR-AMPK teeb liab txoj hauv kev. Piv txwv li, hauv cov txheej txheem physiological xws li kev txhim kho insulin tsis kam thiab tiv thaiv kev rog, kev ua kom txoj hauv kev no ua lub luag haujlwm tseem ceeb. Los ntawm kev ua kom txoj hauv kev no, MOTS-c tuaj yeem tswj hwm cellular zog metabolism, txhim kho cellular uptake thiab siv cov piam thaj, yog li tswj cov txheej txheem metabolic homeostasis ^[1,2].

Kev cuam tshuam nrog cov kev taw qhia tshwj xeeb thiab cov noob: 

Hauv cov leeg nqaij, MOTS-c cuam tshuam nrog cov teeb liab transduction thiab transcription activator 3 (STAT3) los ntawm nws cov YIFY domain's putative Src-homologous 2 (SH2) binding motif, txo STAT3's transcriptional activator thiab txhim kho myotube tsim. Nyob rau hauv hluav taws xob pneumonitis, MOTS-c alleviates lub ntsws cov ntaub so ntswg puas, o, thiab oxidative kev nyuaj siab los ntawm kev ua kom muaj zog nuclear E2-txog yam zoo (Nrf2) ntau ntau thiab txhawb nws cov kev hloov pauv nuclear, yog li tiv thaiv mitochondrial muaj nuj nqi. Tsis tas li ntawd, MOTS-c ua haujlwm ntau yam kev ua haujlwm ntawm lub cev los ntawm kev tswj cov kev qhia ntawm cov noob xws li GLUT4, STAT3, thiab IL-10 ^[3].

Kev tswj cov txheej txheem metabolic: 

MOTS-c koom nrog kev tswj hwm ntawm ntau yam txheej txheem metabolic tseem ceeb, suav nrog cov piam thaj metabolism, lipid metabolism, thiab cov pob txha metabolism, los ntawm autocrine thiab paracrine mechanisms. Hauv cov metabolism hauv qabzib, nws txhim kho insulin tsis kam thiab tswj cov ntshav qabzib; nyob rau hauv lipid metabolism, nws tsub kom xim av rog thermogenesis, txhawb cov rog dawb browning, thiab tiv thaiv rog rog thiab lipid metabolism teeb meem; Nyob rau hauv cov pob txha metabolism, nws txhawb osteoblast proliferation, sib txawv, thiab mineralization, inhibits osteoclast tiam, thiab tswj cov pob txha metabolism thiab pob txha remodeling ^[4,5].

Daim duab 1 Mechanism thiab kev ua haujlwm ntawm MOTS-c ^[6].

Dab tsi yog cov haujlwm thiab kev siv ntawm MOTS-c?

Kev ua haujlwm ntawm MOTS-c

Regulatory cuam tshuam rau cov metabolism hauv: 

MOTS-c tuaj yeem txhim kho cov piam thaj thiab lipid metabolism hauv lub cev. Hauv cov metabolism hauv qabzib, nws txo qis insulin tsis kam, pab tiv thaiv kab mob ntshav qab zib hom 2, thiab txhim kho cellular uptake thiab kev siv cov piam thaj. Nyob rau hauv lipid metabolism, nws nce xim av rog thermogenesis, txhawb lub browning ntawm cov rog dawb, yog li tswj lipid metabolism, tiv thaiv rog rog, thiab cuam tshuam nrog lipid metabolism. Nws kuj txo qhov tshwm sim ntawm cov kab mob uas tsis yog-alcoholic fatty siab kab mob thiab tswj cov kab mob siab lipid metabolism ^[2].

Cov teebmeem ntawm cellular function: 

Nws txhawb kev ua haujlwm mitochondrial thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj. Piv txwv li, nyob rau hauv hluav taws xob-induced pneumonia, nws txo mitochondrial puas nyob rau hauv lub ntsws epithelial hlwb, txo cell apoptosis, thiab tswj ib txwm cellular muaj nuj nqi. Hauv cov kab mob pancreatic, MOTS-c cuam tshuam rau kev tso tawm thiab kev qhia ntawm insulin thiab glucagon, tswj cov kab mob pancreatic cell physiology, thiab tseem cuam tshuam rau cellular viability thiab apoptosis ^[4,5].

Kev cuam tshuam rau cov leeg thiab pob txha: 

Hauv cov nqaij, MOTS-c txhawb nqa cov leeg nqaij progenitor cell sib txawv, nce myotube tsim, thiab tiv thaiv cov leeg hlwb los ntawm interleukin-6 (IL-6)-vim kev puas tsuaj, muaj peev xwm tiv thaiv cov leeg nqaij atrophy. Hais txog cov pob txha, nws txhawb txoj kev loj hlob, sib txawv, thiab mineralization ntawm osteoblasts, inhibits osteoclast tsim, tswj cov pob txha metabolic tshuav nyiaj li cas, thiab pab ncua osteoporosis ^[1,5].

Anti-inflammatory thiab immunomodulatory teebmeem: 

MOTS-c txo cov kab mob ua rau mob ntev thiab tswj kev tiv thaiv kab mob. Hauv cov qauv mob inflammatory, MOTS-c alleviates mob hypersensitivity, txo qhov tso tawm ntawm inflammatory yam, thiab inhibits lub activation ntawm glial hlwb thiab neurons, qhia anti-inflammatory thiab mob-relieving teebmeem ^[3].

Kev siv ntawm MOTS-c

Kev cuam tshuam rau cov kab mob metabolic: 

MOTS-c cov kev tswj xyuas cov txiaj ntsig ntawm cov piam thaj thiab lipid metabolism ua rau nws yog lub hom phiaj kho mob tshiab rau cov kab mob metabolic xws li hom 2 mob ntshav qab zib, rog rog, thiab tsis muaj dej cawv fatty siab kab mob ^[2].

Kev Tiv Thaiv thiab Kev Kho Mob Musculoskeletal Disease: 

Nws cov txiaj ntsig zoo ntawm cov leeg thiab cov pob txha tuaj yeem siv los tiv thaiv thiab kho cov leeg nqaij atrophy-txog kab mob thiab kab mob pob txha xws li pob txha. Rau cov neeg mob uas muaj cov leeg nqaij atrophy, nws tuaj yeem txhim kho cov leeg nqaij los ntawm kev txhawb nqa cov leeg nqaij sib txawv thiab inhibiting leeg nqaij apoptosis; Rau cov neeg mob osteoporosis, nws tuaj yeem tswj cov pob txha metabolic tshuav, ua kom cov pob txha ceev, thiab tiv thaiv thiab kho pob txha ^[1,5].

Kev tiv thaiv hluav taws xob puas tsuaj: 

Hauv kev tshawb fawb txog hluav taws xob pneumonitis, MOTS-c tau qhia txog kev tiv thaiv lub ntsws tawg. Nws tuaj yeem siv thaum siv xov tooj cua los tiv thaiv cov ntaub so ntswg ib txwm, txo cov ntaub so ntswg puas tsuaj, thiab txhim kho kev siv hluav taws xob zoo ^[2].

Kev kho mob ntawm cov kab mob inflammatory: 

Raws li nws cov tshuaj tiv thaiv kab mob, MOTS-c tuaj yeem siv los kho cov kab mob inflammatory xws li mob inflammatory, muab cov lus qhia tshiab rau kev kho mob ntawm cov mob no ^[3].

Xaus

Raws li mitochondrial-derived peptide, MOTS-c tuaj yeem ua kom muaj kev taw qhia los tswj cov piam thaj thiab lipid metabolism, txhim kho insulin tsis kam, thiab txo cov kev pheej hmoo ntawm cov kab mob metabolic; nws tuaj yeem tswj cov leeg nqaij thiab pob txha ua haujlwm, tiv thaiv cov leeg nqaij atrophy thiab osteoporosis; thiab nws muaj cov tshuaj tiv thaiv kab mob thiab kev tiv thaiv ntawm tes, ua lub luag haujlwm hauv kev tiv thaiv hluav taws xob tiv thaiv thiab kho cov kab mob inflammatory.

Hais Txog Tus Sau

Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.

Scientific Journal Author

Wan, Yanmin koom nrog ntau lub koom haum muaj koob npe, suav nrog tsev kho mob, chaw tshawb fawb, tsev kawm qib siab, thiab cov lag luam xws li Linping Hosp Integrated Tradit Suav & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, thiab lwm yam. Nws txoj kev tshawb fawb tau nthuav dav, feem ntau tsom mus rau cov kev kawm qib siab & Technology, Immunology. Hauv thaj tsam ntawm Immunology Science & Technology, nws delves rau hauv cov txheej txheem thiab kev siv ntawm lub cev tiv thaiv kab mob. Nws Virology tshawb fawb chaw nyob ntawm tus kab mob kis, kis, thiab kev tiv thaiv. Nyob rau hauv lub domain of Materials Science Chemistry, nws tau cog lus rau kev txhim kho cov khoom vaj khoom tsev thiab kev siv tshiab ntawm chemistry, ua rau nws muaj txiaj ntsig zoo nrog kev tshawb fawb tseem ceeb hauv cov haujlwm kev kawm. Wan, Yanmin tau teev nyob rau hauv cov ntaub ntawv siv [6].

▎ Cov Lus Qhia Tseem Ceeb

[1] García-Benlloch S, Revert-Ros F, Blesa JR, et al. MOTS-c txhawb cov leeg sib txawv hauv vitro[J]. Peptides, 2022,155:170840.DOI:10.1016/j.peptides.2022.170840.

[2] Zhang J, Zhang Y, et al. Mitochondrial-Derived Peptide MOTS-c Alleviates Radiation Pneumonitis ntawm Nrf2-Dependent Mechanism[J]. Antioxidants, 2024, 13.

[3] Wang Z, Yang L, Xu L, et al. Central thiab peripheral mechanism ntawm MOTS-c attenuates mob hypersensitivity nyob rau hauv cov nas qauv ntawm inflammatory mob [J]. Neurological Research, 2024,46(2):165-177.DOI:10.1080/01616412.2023.2258584.

[4] Bień J, Pruszyńska-Oszmałek E, Kołodziejski P, et al. MOTS-c tswj pancreatic alpha thiab beta cell ua haujlwm hauv vitro [J]. Histochemistry thiab Cell Biology, 2024,161(6):449-460.DOI:10.1007/s00418-024-02274-0.

[5] Yi X, Hu G, Yang Y, et al. Lub luag haujlwm ntawm MOTS-c hauv kev tswj cov pob txha metabolism [J]. Frontiers hauv Physiology, 2023, 14: 1149120.DOI: 10.3389/fphys.2023.1149120.

[6] Lin W, Zhang Y, et al. Mitochondria-derived peptide MOTS-c: cov teebmeem thiab cov txheej txheem ntsig txog kev ntxhov siab, metabolism thiab kev laus [J]. Phau ntawv Journal of Translational Medicine, 2023,21(1):36.DOI:10.1186/s12967-023-03885-2.

Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.  

Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.