MOTS-c 20mg

▎ Enzimba ya MOTS-c

▎ MOTS-c Okunoonyereza

Ensibuko y’okunoonyereza eya MOTS-c eri etya?

Ensibuko y’okunoonyereza eya MOTS-c yasibuka mu kunoonyereza ku kifo kya DNA ya mitochondrial mu bulamu bw’enkyukakyuka y’emmere n’okukaddiwa. Nga okutegeera enkola ya mitochondria kweyongera, kyazuulibwa nti mitochondria si kifo kyokka eky’okukyusakyusa amaanyi wabula era zeetaba mu mpuliziganya y’obutoffaali n’okukyusa obubonero. Nga zikola ekkubo lya AMPK, zeenyigira mu nkyukakyuka ya glucose ne lipid, ezikwatagana ennyo n’endwadde z’enkyukakyuka mu mubiri nga sukaali n’omugejjo, era zisuubiza ng’ebigendererwa ebipya eby’obujjanjabi eri embeera zino. Okusinziira ku kakwate akaliwo wakati w’enkola ya mitochondria n’endwadde ez’enjawulo, MOTS-c era ebadde ekozesebwa mu mbeera nga chronic hepatitis B ne kookolo w’enkwaso. Okunoonyereza kulaga nti kiyinza okukola kinene mu nkola z’okukwatibwa akawuka. Dduyiro atumbula okusengejja n’okwolesebwa kwa MOTS-c mu mubiri gw’omuntu, bwe kityo n’alongoosa enkyukakyuka y’ebinywa, okukola kw’omubiri, n’enkola y’omubiri okutwalira awamu, n’awa obujulizi ku bukodyo obuziyiza okukaddiwa obusinziira ku dduyiro n’okugaziya obuwanvu bw’okunoonyereza kwa MOTS-c.

Enkola y’okukola kwa MOTS-c eri etya?

Okukola kw’ekkubo ly’obubonero bwa AICAR-AMPK: 

MOTS-c okusinga ekola emirimu gyayo egy’omubiri ng’ekola ekkubo ly’obubonero erya AICAR-AMPK. Kitaataaganya enzirukanya ya folate-methionine mu butoffaali, bwe kityo ne kikola ekkubo ly’obubonero erya AICAR-AMPK. Okugeza, mu nkola z’omubiri nga okulongoosa obuziyiza bwa insulini n’okuziyiza omugejjo, okukola ekkubo lino kikola kinene. Nga ekola ekkubo lino, MOTS-c esobola okulungamya enkyukakyuka y’amasoboza g’obutoffaali, okutumbula okutwalibwa kw’obutoffaali n’okukozesa glucose, bwe kityo n’etereeza enkola y’okukyusakyusa emmere y’omubiri (systemic metabolic homeostasis) ^[1,2]..

Enkolagana n’amakubo ag’obubonero ag’enjawulo n’obuzaale: 

Mu butoffaali bw’ebinywa, MOTS-c ekwatagana ne signal transduction ne transcription activator 3 (STAT3) okuyita mu YIFY domain’s putative Src-homologous 2 (SH2) binding motif yaayo, okukendeeza ku STAT3’s transcriptional activity n’okutumbula okutondebwa kwa myotube. Mu bulwadde bwa radiation pneumonitis, MOTS-c ekendeeza ku kwonooneka kw’ebitundu by’amawuggwe, okuzimba, n’okunyigirizibwa okw’okwokya (oxidative stress) ng’eyongera ku miwendo gya nuclear factor E2-related factor (Nrf2) n’okutumbula okukyusakyusa kwayo okwa nuclear, bwe kityo n’ekuuma enkola ya mitochondria. Okugatta ku ekyo, MOTS-c ekola emirimu egy’enjawulo egy’omubiri nga etereeza okwolesebwa kw’obuzaale nga GLUT4, STAT3, ne IL-10 ^[3]..

Okulungamya amakubo g’enkyukakyuka mu mubiri: 

MOTS-c yeetaba mu kulungamya enkola ez’enjawulo enkulu ez’enkyukakyuka mu mubiri, omuli enkyukakyuka ya glucose, enkyukakyuka y’amasavu, n’okukyusakyusa amagumba, okuyita mu nkola za autocrine ne paracrine. Mu nkyukakyuka ya glucose, alongoosa obuziyiza bwa insulini n’okutereeza emiwendo gya glucose mu musaayi; mu nkyukakyuka y’amasavu, kyongera ku thermogenesis y’amasavu ga kitaka, kitumbula amasavu amazungu okufuuka kitaka, era kiziyiza omugejjo n’obuzibu mu nkyukakyuka y’amasavu; mu nkyukakyuka y’amagumba, kitumbula okukula kw’amagumba, okwawukana, n’okufuuka eby’obutonde, kiziyiza okutondebwa kw’amagumba, era kitereeza enkyukakyuka y’amagumba n’okuddamu okukola kw’amagumba ^[4,5]..

Ekifaananyi 1 Enkola n’enkola ya MOTS-c ^[6]..

Emirimu ki n’enkozesa ya MOTS-c?

Emirimu gya MOTS-c

Ebikosa okulungamya ku nkyukakyuka y’emmere: 

MOTS-c esobola okulongoosa enkyukakyuka ya glucose ne lipid mu mubiri. Mu nkyukakyuka ya glucose, kikendeeza ku buziyiza bwa insulini, kiyamba okuziyiza sukaali ow’ekika eky’okubiri, era kiyamba obutoffaali okutwala n’okukozesa obulungi glucose. Mu nkyukakyuka y’amasavu, kyongera ku thermogenesis y’amasavu ga kitaka, kitumbula okufuuka kitaka kw’amasavu amazungu, bwe kityo ne kitereeza enkyukakyuka y’amasavu, ne kiziyiza omugejjo, n’obuzibu obukwatagana mu nkyukakyuka y’amasavu. Era kikendeeza ku bulwadde bw’ekibumba ekirimu amasavu agatali ga mwenge era kitereeza enkyukakyuka y’amasavu mu kibumba ^[2]..

Ebikosa enkola y’obutoffaali: 

Kitumbula enkola ya mitochondria era kikuuma obutoffaali obutakwonooneka. Okugeza, mu kifuba ekiva ku masanyalaze, kikendeeza ku kwonooneka kwa mitochondria mu butoffaali bw’amawuggwe, kikendeeza ku kufa kw’obutoffaali, era kikuuma enkola y’obutoffaali eya bulijjo. Mu butoffaali bw’olubuto, MOTS-c ekwata ku kufulumya n’okwolesebwa kwa insulini ne glucagon, okulungamya enkola y’obutoffaali bw’olubuto, era era ekosa obulamu bw’obutoffaali n’okufa ^[4,5]..

Ebikosa ebinywa n’amagumba: 

Mu binywa, MOTS-c etumbula okwawukana kw’obutoffaali obusibuka mu binywa, eyongera ku kutondebwa kwa myotube, era ekuuma obutoffaali bw’ebinywa okuva ku kwonooneka okuva mu interleukin-6 (IL-6), ekiyinza okuziyiza okukendeera kw’ebinywa. Mu nsonga z’amagumba, kitumbula okukula, okwawukana, n’okufuuka eby’obutonde mu bitundu by’amagumba, kiziyiza okutondebwa kw’amagumba, kikuuma bbalansi y’enkyukakyuka y’amagumba, era kiyamba okulwawo okuzimba amagumba ^[1,5]..

Ebikolwa ebiziyiza okuzimba n’okukendeeza ku busimu obuziyiza endwadde: 

MOTS-c ekendeeza ku systemic chronic inflammatory responses era etereeza enkola y’abaserikale b’omubiri. Mu bikolwa by’obulumi bw’okuzimba, MOTS-c ekendeeza ku bulumi obuyitiridde, ekendeeza ku kufulumya ensonga ezizimba, era eziyiza okukola kw’obutoffaali bwa glial n’obusimu obuyitibwa neurons, okulaga ebikolwa eby’okulwanyisa okuzimba n’okukendeeza obulumi ^[3]..

Enkozesa ya MOTS-c

Ebikosa endwadde z’enkyukakyuka mu mubiri: 

MOTS-c’s regulatory effects on glucose and lipid metabolism zigifuula ekigendererwa ekipya eky’obujjanjabi eri endwadde z’enkyukakyuka mu mubiri nga sukaali ow’ekika eky’okubiri, omugejjo, n’obulwadde bw’ekibumba obw’amasavu obutali bwa mwenge ^[2]..

Okuziyiza n’okujjanjaba endwadde z’ebinywa n’amagumba: 

Ebirungi by’ekola ku binywa n’amagumba bisobola okukozesebwa okuziyiza n’okujjanjaba endwadde ezeekuusa ku kukendeera kw’ebinywa n’endwadde z’amagumba ng’okuzimba amagumba. Ku balwadde abalina okuzimba ebinywa, kiyinza okulongoosa enkola y’ebinywa nga kitumbula okwawukana kw’obutoffaali bw’ebinywa n’okuziyiza okufa kw’obutoffaali bw’ebinywa; Ku balwadde abalina obulwadde bw’amagumba, busobola okutereeza bbalansi y’enkyukakyuka y’amagumba, okwongera ku density y’amagumba, n’okuziyiza n’okujjanjaba obulwadde bw’amagumba ^[1,5]..

Obukuumi bw’okwonooneka kw’obusannyalazo: 

Mu kunoonyereza ku bulwadde bw’ekifuba obuva ku masanyalaze, MOTS-c eraga nti ekola bulungi ku kwonooneka kw’obusannyalazo bw’amawuggwe. Kiyinza okukozesebwa mu kiseera ky’obujjanjabi obw’amasannyalaze okukuuma ebitundu ebya bulijjo, okukendeeza ku kwonooneka kw’ebitundu ebiva ku masanyalaze, n’okutumbula obulungi bw’obujjanjabi obw’amasannyalaze ^{[2] .}.

Obujjanjabi bw’endwadde ezizimba: 

Okusinziira ku buzibu bwayo obuziyiza okuzimba, MOTS-c esobola okukozesebwa okujjanjaba endwadde ezizimba ng’obulumi obuzimba, okuwa endagiriro empya ez’okujjanjaba embeera ng’ezo ^[3]..

Mu bufunzi

Nga peptide evudde mu mitochondrial, MOTS-c esobola okukola amakubo agalaga obubonero okulungamya enkyukakyuka ya glucose ne lipid, okulongoosa obuziyiza bwa insulini, n’okukendeeza ku bulabe bw’endwadde z’enkyukakyuka mu mubiri; era esobola okukuuma ebinywa n’amagumba okukola, okuziyiza ebinywa okuzimba n’okuzimba amagumba; era erina emirimu gy’okulwanyisa okuzimba n’okukuuma obutoffaali, ekola kinene mu kukuuma okwonooneka kw’obusannyalazo n’okujjanjaba endwadde ezizimba.

Ebikwata ku Muwandiisi

Ebintu ebyogeddwako waggulu byonna binoonyerezeddwako, birongooseddwa era ne bikung’aanyizibwa kkampuni ya Cocer Peptides.

Omuwandiisi wa Scientific Journal

Wan, Yanmin akwatagana n’ebibiina eby’ekitiibwa eby’enjawulo, omuli amalwaliro, ebifo eby’okunoonyereza, amatendekero, n’ebitongole nga Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, n’ebirala Eby’obutonde (Chemistry). Mu kisaawe kya Immunology Science & Technology, agenda mu maaso n’okunoonyereza ku nkola n’enkozesa y’abaserikale b’omubiri. Okunoonyereza kwe mu Virology kwesigamye ku mpisa z’akawuka, okusaasaana, n’okuziyiza. Mu kitundu kya Materials Science Chemistry, yeewaddeyo okutumbula eby’obugagga by’ebintu n’okukozesa enkola ya kemiko mu ngeri ey’obuyiiya, ekimufuula omuntu ow’amaanyi ng’afunye obuwanguzi obw’amaanyi mu kunoonyereza mu by’ensoma ebikwatagana. Wan, Yanmin awandiikiddwa mu kiwandiiko ekijuliziddwa [6].

▎ Ebiwandiiko Ebikwatagana

[1] García-Benlloch S, Revert-Ros F, Blesa JR, n’abalala. MOTS-c etumbula okwawukana kw’ebinywa mu vitro[J]. Peptides, 2022,155:170840.DOI:10.1016/j.peptides.2022.170840.

[2] Zhang Y, Huang J, Zhang Y, n’abalala. Peptide MOTS-c evudde mu mitochondrial ekendeeza ku bulwadde bw’ekifuba obuva ku masanyalaze ng’eyita mu nkola eyeesigama ku Nrf2[J]. Ebirungo ebiziyiza obuwuka obuleeta obulwadde, 2024,13.

[3] Wang Z, Yang L, Xu L, n’abalala. Enkola y’omu makkati n’ey’okumpi eya MOTS-c ekendeeza ku bulumi obuyitiridde mu nkola y’ebibe ey’obulumi obuzimba[J]. Okunoonyereza ku busimu, 2024, 46 (2): 165-177.DOI: 10.1080 / 01616412.2023.2258584.

[4] Bień J, Pruszyńska-Oszmałek E, Kołodziejski P, n’abalala. MOTS-c etereeza emirimu gy’obutoffaali bw’olubuto alpha ne beta mu vitro[J]. Histochemistry n'ebiramu by'obutoffaali, 2024,161 (6): 449-460.DOI: 10.1007 / s00418-024-02274-0.

[5] Yi X, Hu G, Yang Y, n’abalala. Omulimu gwa MOTS-c mu kulungamya enkyukakyuka y’amagumba[J]. Ensalo mu by’omubiri, 2023,14:1149120.DOI:10.3389/fphys.2023.1149120.

[6] Wan W, Zhang L, Lin Y, n’abalala. Mitochondria-derived peptide MOTS-c: ebikolwa n’enkola ezikwatagana ne situleesi, enkyukakyuka mu mubiri n’okukaddiwa[J]. Journal of Eddagala ly'okuvvuunula, 2023,21 (1): 36.DOI: 10.1186 / s12967-023-03885-2.

EBINTU BYONNNA N’AMAWULIRE GW’EBINTU EBIweereddwa KU MUTINDO GUNO BIKOZESEBWA KU KUSASANYA AMAWULIRE N’EBIKOLWA BY’OKUSOMESA.  

Ebintu ebiweereddwa ku mukutu guno bigendereddwamu kunoonyereza mu kisenge (in vitro research) byokka. Okunoonyereza mu vitro (Olulattini: *mu ndabirwamu*, ekitegeeza mu bikozesebwa mu ndabirwamu) kukolebwa ebweru w’omubiri gw’omuntu. Ebintu bino si bya ddagala, tebikkiriziddwa kitongole kya Amerika ekivunaanyizibwa ku by’emmere n’eddagala (FDA), era tebirina kukozesebwa kuziyiza, kujjanjaba oba kuwonya mbeera yonna ya bujjanjabi, bulwadde oba bulwadde. Kikugirwa nnyo mu mateeka okuyingiza ebintu bino mu mubiri gw’omuntu oba ebisolo mu ngeri yonna.