MOTS-c 20mg

▎ MOTS-c Tsarin

▎ MOTS-c Bincike

Menene asalin bincike na MOTS-c?

Binciken bincike na MOTS-c ya samo asali ne daga bincike kan rawar mitochondrial DNA a cikin lafiyar rayuwa da tsufa. Yayin da fahimtar aikin mitochondrial ya zurfafa, an gano cewa mitochondria ba kawai cibiyar makamashi ba ne amma kuma suna shiga cikin sadarwar salula da watsa sigina. Ta hanyar kunna hanyar AMPK, suna shiga cikin glucose da metabolism na lipid, suna da alaƙa da cututtukan rayuwa kamar su ciwon sukari da kiba, kuma suna ɗaukar alƙawarin azaman sabbin maƙasudin warkewa na waɗannan yanayi. Idan aka ba da haɗin kai tsakanin aikin mitochondrial da cututtuka daban-daban, MOTS-c kuma an yi amfani da shi a cikin yanayi irin su hepatitis B na kullum da ciwon daji na ovarian. Bincike ya nuna yana iya taka muhimmiyar rawa a cikin hanyoyin kamuwa da cuta. Motsa jiki yana inganta haɓakawa da kuma bayyana MOTS-c a cikin jikin mutum, don haka inganta ƙwayar tsoka, aikin jiki, da kuma aikin jiki gaba ɗaya, yana ba da shaida ga dabarun rigakafin tsufa na motsa jiki da kuma fadada iyakokin bincike na MOTS-c.

Menene tsarin aikin MOTS-c?

Kunna hanyar siginar AICAR-AMPK: 

MOTS-c da farko yana aiwatar da ayyukan ilimin lissafin jiki ta hanyar kunna hanyar siginar AICAR-AMPK. Yana rushe zagayowar folate-methionine a cikin sel, ta haka yana kunna hanyar siginar AICAR-AMPK. Misali, a cikin tsarin ilimin halittar jiki kamar inganta juriya na insulin da hana kiba, kunna wannan hanyar yana taka muhimmiyar rawa. Ta hanyar kunna wannan hanyar, MOTS-c na iya daidaita tsarin makamashin salula, haɓaka ɗaukar salula da amfani da glucose, ta haka ne ke daidaita tsarin homeostasis na rayuwa ^[1,2].

Ma'amala tare da takamaiman hanyoyin sigina da kwayoyin halitta: 

A cikin ƙwayoyin tsoka, MOTS-c yana hulɗa tare da siginar siginar da mai kunnawa 3 (STAT3) ta hanyar YIFY yanki na sa Src-homologous 2 (SH2) mai ɗaure motif, rage aikin rubutun STAT3 da haɓaka haɓakar myotube. A cikin cutar pneumonitis na radiation, MOTS-c yana rage lalacewar nama na huhu, kumburi, da damuwa na oxidative ta hanyar haɓaka matakan factor factor E2-related factor (Nrf2) da kuma inganta yanayin motsi na nukiliya, don haka kare aikin mitochondrial. Bugu da ƙari, MOTS-c yana aiwatar da ayyuka daban-daban na ilimin lissafi ta hanyar daidaita maganganun kwayoyin halitta kamar GLUT4, STAT3, da IL-10 ^[3].

Tsarin hanyoyin metabolism: 

MOTS-c yana shiga cikin tsari na matakai daban-daban masu mahimmanci na rayuwa, ciki har da metabolism na glucose, metabolism na lipid, da metabolism na kashi, ta hanyar hanyoyin autocrine da paracrine. A cikin metabolism na glucose, yana inganta juriya na insulin kuma yana daidaita matakan glucose na jini; a cikin metabolism na lipid, yana haɓaka thermogenesis mai launin ruwan kasa, yana haɓaka launin fata mai launin fata, kuma yana hana kiba da rikicewar metabolism na lipid; a cikin metabolism na kashi, yana inganta haɓakar osteoblast, bambance-bambance, da ma'adinai, yana hana tsararrun osteoclast, kuma yana daidaita ƙasusuwan kashi da gyaran kashi ^[4,5]..

Hoto 1 Injiniyanci da aikin MOTS-c ^[6].

Menene ayyuka da aikace-aikacen MOTS-c?

Ayyukan MOTS-c

Abubuwan da aka tsara akan metabolism: 

MOTS-c na iya inganta glucose da metabolism na lipid a cikin jiki. A cikin metabolism na glucose, yana rage juriya na insulin, yana taimakawa hana nau'in ciwon sukari na 2, kuma yana haɓaka ɗaukar salula da ingantaccen amfani da glucose. A cikin lipid metabolism, yana ƙara launin ruwan kasa thermogenesis mai launin ruwan kasa, yana haɓaka launin fata mai launin fata, ta haka yana daidaita metabolism na lipid, yana hana kiba, da rikice-rikice na rayuwa mai alaƙa. Hakanan yana rage yawan cututtukan hanta mai kitse mara-giya kuma yana daidaita metabolism na lipid na hanta ^[2].

Tasiri kan aikin salula: 

Yana inganta aikin mitochondrial kuma yana kare sel daga lalacewa. Alal misali, a cikin ciwon huhu da ke haifar da radiation, yana rage lalacewar mitochondrial a cikin huhu epithelial cell, yana rage apoptosis cell, kuma yana kula da aikin salula na al'ada. A cikin sel na pancreatic, MOTS-c yana rinjayar ɓoyewa da bayyanar insulin da glucagon, yana daidaita ilimin ilimin halittar jini na pancreatic, kuma yana rinjayar iyawar salula da apoptosis ^[4,5]..

Tasiri akan tsokoki da kasusuwa: 

A cikin tsokoki, MOTS-c yana haɓaka bambance-bambancen ƙwayoyin tsoka na ƙwayoyin tsoka, yana haɓaka haɓakar myotube, kuma yana kare ƙwayoyin tsoka daga lalatawar interleukin-6 (IL-6), mai yuwuwar hana atrophy na tsoka. Dangane da kasusuwa, yana haɓaka haɓakawa, bambance-bambance, da ma'adinai na osteoblasts, yana hana haɓakar osteoclast, yana kula da ma'auni na ƙasusuwa, kuma yana taimakawa jinkirta osteoporosis ^[1,5]..

Anti-mai kumburi da immunomodulatory effects: 

MOTS-c yana rage amsawar kumburin ƙwayar cuta na yau da kullun kuma yana daidaita aikin rigakafi. A cikin nau'o'in ciwon kumburi, MOTS-c yana rage jin zafi da rashin jin daɗi, yana rage sakin abubuwan da ke haifar da kumburi, kuma yana hana kunna ƙwayoyin glial da ƙananan ƙwayoyin cuta, yana nuna alamun cututtuka da cututtuka na ciwo ^[3].

Aikace-aikace na MOTS-c

Tasiri kan cututtuka na metabolism: 

Abubuwan da aka tsara na MOTS-c akan glucose da metabolism na lipid sun sa ya zama sabon maƙasudin warkewa don cututtukan rayuwa kamar nau'in ciwon sukari na 2, kiba, da cututtukan hanta mara-giya ^[2].

Rigakafi da Maganin Cututtukan Musculoskeletal: 

Ana iya amfani da ingantaccen tasirinsa akan tsokoki da ƙasusuwa don hanawa da kuma magance cututtukan da ke da alaƙa da ciwon tsoka da cututtukan kwarangwal kamar osteoporosis. Ga marasa lafiya tare da atrophy na tsoka, zai iya inganta aikin tsoka ta hanyar inganta bambance-bambancen ƙwayar tsoka da kuma hana apoptosis na ƙwayar tsoka; Ga marasa lafiya tare da osteoporosis, zai iya daidaita ma'auni na rayuwa na kashi, ƙara yawan kashi, da kuma hanawa da magance osteoporosis ^[1,5].

Kariyar lalata radiyo: 

A cikin nazarin kan radiation pneumonitis, MOTS-c ya nuna alamun kariya daga lalacewar huhu. Ana iya amfani da shi yayin aikin rediyo don kare kyallen takarda na yau da kullun, rage lalacewar nama da ke haifar da radiation, da haɓaka ingancin aikin rediyo ^[2].

Maganin cututtuka masu kumburi: 

Dangane da tasirin anti-mai kumburi, MOTS-c za a iya amfani dashi don magance cututtuka masu kumburi irin su ciwo mai kumburi, samar da sababbin hanyoyin magance irin waɗannan yanayi ^[3].

Kammalawa

A matsayin peptide na mitochondrial, MOTS-c na iya kunna hanyoyin sigina don daidaita glucose da lipid metabolism, inganta juriya na insulin, da rage haɗarin cututtukan cututtuka; yana kuma iya kula da aikin tsoka da kashi, hana atrophy na tsoka da osteoporosis; kuma tana da ayyukan kariya da ƙwayoyin cuta da ƙwayoyin cuta, suna taka rawa wajen kariya daga lalacewar radiation da kuma magance cututtukan kumburi.

Game da Marubuci

Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.

Mawallafin Jaridar Kimiyya

Wan, Yanmin yana da alaƙa da ƙungiyoyi masu daraja iri-iri, ciki har da asibitoci, cibiyoyin bincike, jami'o'i, da masana'antu irin su Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, da dai sauransu. Bukatun bincikensa suna da yawa, da farko yana mai da hankali kan nau'ikan nau'ikan ilimin Immunology Science & Technology, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry da Chemistry. A fagen Kimiyya da Fasaha na Immunology, ya shiga cikin hanyoyin da aikace-aikacen tsarin rigakafi. Cibiyar bincikensa ta Virology ta dogara ne akan halayen ƙwayoyin cuta, watsawa, da rigakafi. A cikin fannin Chemistry na Materials Science Chemistry, ya himmatu wajen haɓaka kaddarorin kayan aiki da sabbin aikace-aikacen sinadarai, yana mai da shi sanannen mutum wanda ya sami nasarorin bincike a fagagen ilimi masu dacewa. Wan, Yanmin an jera a cikin ma'anar ambato [6].

▎ Abubuwan da suka dace

[1] García-Benlloch S, Revert-Ros F, Blesa JR, et al. MOTS-c yana haɓaka bambancin tsoka a cikin vitro [J]. Peptides, 2022,155:170840.DOI:10.1016/j.peptides.2022.170840.

[2] Zhang Y, Huang J, Zhang Y, et al. The Mitochondrial-Derived Peptide MOTS-c Yana Rage Radiation Pneumonitis ta hanyar Nrf2-Dependent Mechanism[J]. Antioxidants, 2024,13.

[3] Wang Z, Yang L, Xu L, et al. Tsarin tsakiya da na gefe na MOTS-c yana rage jin daɗin jin zafi a cikin ƙirar mice na ciwon kumburi [J]. Binciken Neurological, 2024,46 (2): 165-177.DOI: 10.1080/01616412.2023.2258584.

[4] Bień J, Pruszyńska-Oszmałek E, Kołodziejski P, et al. MOTS-c yana daidaita ayyukan alpha na pancreatic da ayyukan ƙwayoyin beta a cikin vitro [J]. Tarihi da Halittar Halitta, 2024,161(6):449-460.DOI:10.1007/s00418-024-02274-0.

[5] Yi X, Hu G, Yang Y, et al. Matsayin MOTS-c a cikin ka'idar metabolism na kashi [J]. Iyaka a cikin Ilimin Halitta, 2023,14:1149120.DOI:10.3389/fphys.2023.1149120.

[6] Wan W, Zhang L, Lin Y, et al. Mitochondria-derived peptide MOTS-c: sakamako da hanyoyin da suka danganci danniya, metabolism da tsufa [J]. Jaridar Magungunan Fassara, 2023,21 (1): 36.DOI: 10.1186/s12967-023-03885-2.

DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.  

Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.