MOTS-c 20mg we yu de yuz

▎ MOTS-c Struktrɔ

▎ MOTS-c Risach

Wetin na di risach bakgrɔn fɔ MOTS-c?

di risεch bakgrכn fכ MOTS-c kכmכt frכm invεstigeshכn dεm fכ di rol we maytochכndrial DNA de ple fכ mεtabolik hεlth εn ol. as di כndastandin fכ di maytochכndrial fכnshכn de dip, dεn dכn fכ no se di maytochכndria nכto nכmכ di sεntrכm fכ enεji mεtabolism bכt dεn de tek pat bak pan sεlyul kכmyunikeshn εn signal transdyushכn. bay we dεn de aktibכt di AMPK path, dεn de involv insay glukכs εn lipid mεtabolism, we de kכl mεtabolik sik dεm lεk dayabεtis εn fat, εn dεn de ol prכmis as nyu tεrapi tכgεt fכ dεn kכndyushכn dεm ya. we dεn gi di asosieshכn bitwin di maytochכndrial fכnshכn εn difrεn sik dεm, dεn dכn aplay MOTS-c bak insay kכndishכn dεm lεk krכnik εpataytis B εn ovarian kεnsar. Risach sho se i kin ple big pat pan di vayral infεkshכn prכsεs dεm. εksεsayz de promuot di sεntesis εn εksprεshכn fכ MOTS-c na di mכtalman bכdi, we de mek di mכsul mεtabolism, fכs pכrfomans, εn כvala bכdi fכnshכn, de gi pruf fכ εksεsayz-bεys anti-aging stratεji dεm εn i de εkspεnd di skop fכ MOTS-c risεch.

Wetin na di mɛkanism fɔ akshɔn fɔ MOTS-c?

Aktivεshכn כf di AICAR-AMPK signal path: 

MOTS-c de fכs fכ du in fysiolojikal fכnshכn dεm bay we i de aktibכt di AICAR-AMPK signal path. i de disrupt di folate-methionine saykl insay di sεl dεm, we de aktibכt di AICAR-AMPK signal path. fכ egzampl, insay di fysiolojikal prכsεs dεm lεk fכ impruv insulin rεsistεns εn fכ mek i nכ fat, di aktibכshכn fכ dis path de ple imכtant rol. bay we i de aktibכt dis path, MOTS-c kin rεgεl sεlyul εnεji mεtabolism, εnhans sεlyul כptek εn yutilizeshכn fכ glukכs, we de rεgεl sistεmik mεtabolik homכstasis ^[1,2]..

intarakshכn wit spεsifi k signal path dεm εn jin dεm: 

insay mכsul sεl dεm, MOTS-c de intarakt wit signal transdyushכn εn transkripshכn aktibכt 3 (STAT3) tru in YIFY domεn in putativ Src-homologous 2 (SH2) binding mכtif, we de ridyus STAT3 in transkripshכnal aktvכti εn εnhans myotub fכmeshכn. insay rεdyushכn nyumonitis, MOTS-c de εliviet di lכng tisu dεm, inflameshn, εn כksidεtiv strεs bay we i de inkrεs nyuklia fכktכ E2-rεlatεd fכktכ (Nrf2) lεvεl dεm εn protεkt in nyuklia translכkeshכn, we de protεkt di maytochכndrial fכnshכn. apat frכm dat, MOTS-c de du difrεn fysiolojikal fכnshכn dεm bay we i de rεgεl di εksprεshכn fכ jin dεm lεk GLUT4, STAT3, εn IL-10 ^[3]..

rεgulεshכn fכ di mεtabolik path dεm: 

MOTS-c de tek pat pan di rεguleshכn fכ difrεn imכtant mεtabolik prכsεs dεm, inklud glukכs mεtabolism, lipid mεtabolism, εn bon mεtabolism, tru כtokrin εn parakrin mεkanism dεm. insay glukoz mεtabolism, i de mek di insulin rεsistεns bεtεh εn i de rεgεl di blכd glukכs lεvεl; insay lipid mεtabolism, i de inkrεs di brawn fεt tεmכjεnεsis, i de mek di wayt fεt brawn, εn i de mek i nכ fat εn di lipid mεtabolism dizכrd; insay bon mεtabolism, i de protεkt di כstioblast proliferashכn, difrεns, εn minralayzεshכn, i de inhεbit כsteoklast jεnereshכn, εn i de rεgεl di bon mεtabolism εn bon rimכdelin ^[4,5]..

Figure 1 Mekanism εn fכnshכn fכ MOTS-c ^[6]..

Wetin na di wok ɛn aplikeshɔn dɛn fɔ MOTS-c?

Di wok dɛn we MOTS-c de du

rεgεdyushכn ifekt dεm pan mεtabolism: 

MOTS-c kin impruv di glukכs εn lipid mεtabolism na di bכdi. insay glukoz mεtabolism, i de ridyus insulin rεsistεns, i de εp fכ mek yu nכ gεt tayp 2 dayabεtis, εn i de mek di sεl dεm tek εn yutilizeshכn efyushכn fכ glukכs. insay lipid mεtabolism, i de inkrεs di brawn fεt tεmכjεnεsis, i de mek di wayt fεt brawn, we de mek i de rεgεl di lipid mεtabolism, i de mek i nכ fat, εn di lipid mεtabolik dizכrd dεm we de kכmכt wit am. i de ridyus bak di insidεns fכ nכn-alkohol fεt liva sik εn i de rεgεl di hεpatik lipid mεtabolism ^{[2] .}.

di ifekt dεm pan di sεl dεm we de wok: 

i de mek di maytochכndria wok fayn εn i de protεkt di sεl dεm frכm damej. fכ egzampl, insay nyumonia we di rεdyushכn de mek, i de ridyus di maytochכndrial dεm we de na di lכng εpitεlial sεl dεm, i de dכn di sεl apoptosis, εn i de mek di sεl dεm wok nכmal. insay pankrεas sεl dεm, MOTS-c de infכlכw di sekreshכn εn εksprεshכn fכ insulin εn glukagכn, we de rεgεl pankrεas sεl fysiolכji, εn i de afekt sεlyul viabiliti εn apoptosis bak ^[4,5]..

Di tin dɛn we kin apin to di mɔsul ɛn bon dɛn: 

insay di mכsul dεm, MOTS-c de protεkt di mכsul progenitor sεl dεm difrεns, i de inkrεs di myotube fכmeshכn, εn i de protεkt di mכsul sεl dεm frכm di damej we intalyukin-6 (IL-6) indyuz, we kin mek di mכsul dεm nכ atrofi. we i kam pan bon dεm, i de protεkt di proliferashכn, difrεns, εn minralayzεshכn fכ di כstioblast dεm, i de inhibit di כstioklast dεm fכ fכm, i de mεnten di bon mεtabolik bεlε, εn i de εp fכ delay di כstioporosis ^[1,5]..

Anti-inflammatory ɛn immunomodulatory ifɛkt dɛn: 

MOTS-c de ridyus di sistεmik krכnik inflammatory rεspכns dεm εn de rεgεl di imyun fכnshכn. insay inflammatory pen mכdel dεm, MOTS-c de εliviet pen haypasεnsitiviti, rεdכks di rilis fכ inflammatory fכktכ dεm, εn de inhεbit di aktibכshכn fכ glial sεl dεm εn nyuron dεm, we de sho anti-inflammatory εn pen-rεliv ifekt dεm ^[3]..

Aplikeshɔn dɛn fɔ MOTS-c

Efεkt dεm pan mεtabolik sik dεm: 

di rεgεdyushכn ifekt dεm we MOTS-c gεt pan glukכs εn lipid mεtabolism de mek am wan nyu tεrapi tכgεt fכ mεtabolik sik dεm lεk tayp 2 dayabεtis, fat, εn nכn-alkohol fεt liva sik ^[2]..

Prɛvenshɔn ɛn Tritmɛnt fɔ Mɔskul ɛn skel Disizin dɛn: 

di fayn fayn tin dεm we i de du pan di mכsul dεm εn bon dεm kin yus fכ prεvεnt εn trit sik dεm we de kכmכt frכm di mכsul dεm we de atrofi εn sik dεm we de na di skel lεk כstioporosis. fכ di sik pipul dεm we gεt mכsul atrofi, i kin impruv di mכsul fכ wok bay we i de protεkt di mכsul sεl difrεns εn inhεbit mכsul sεl apoptosis; fכ di sik pipul dεm we gεt כstioporosis, i kin rεgεl di bon mεtabolik bεlε, inkrεs di bon dεnsiti, εn i kin mek i nכ gεt εn trit כstioporosis ^[1,5]..

Protekshɔn fɔ di damej we di raytin de mek: 

Insay stכdi dεm pan rεdyushכn nyumonitis, MOTS-c dכn sho protεktiv ifekt dεm εgεst lכng rεdyushכn damej. Dɛn kin yuz am we dɛn de du redio tɛrapi fɔ protɛkt di nɔmal tisu dɛn, fɔ ridyus di damej we di tisu dɛn kin du we redyushɔn kin pwɛl, ɛn fɔ mek di rediotɛrapi wok fayn ^{[2] .}.

Tritmɛnt fɔ sik dɛn we kin mek pɔsin gɛt inflammatory: 

bays pan in anti-inflammatory ifekt, dεn kin yuse MOTS-c fכ trit inflammatory sik dεm lεk inflammatory pen, we de gi nyu dairekshכn fכ trit dεn kayn kכndyushכn dεm ya ^[3]..

Dɔn

as pεptida we kכmכt frכm maytochכndrial, MOTS-c kin aktibכt signal path dεm fכ rεgεl glukכs εn lipid mεtabolism, impruv insulin rεsistεns, εn ridyus di risk fכ mεtabolik sik dεm; i kin mek bak di mכsul dεm εn bon dεm wok fayn, i kin mek di mכsul dεm atrofi εn כstioporosis; εn i gεt anti-inflammatory εn sεl-protektiv fכnshכn dεm, we de ple rol fכ rεdyushכn damej protεkshכn εn trit inflammatory sik dεm.

Bɔt di pɔsin we rayt di buk

Di tin dɛn we wi dɔn tɔk bɔt, na ɔl di tin dɛn we Cocer Peptides dɔn du risach, ɛdit ɛn kɔmpilayt.

Sayɛns Jɔnal Author

Wan, Yanmin gɛt fɔ du wit difrɛn ɔganayzeshɔn dɛn we gɛt nem, we inklud ɔspitul, risach sɛnta, yunivasiti, ɛn ɛntapraiz dɛn lɛk Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, ɛn ɔda wan dɛn In risach intres dɛn bɔku, mɔ i de pe atɛnshɔn pan di sɔbjɛkt kategori dɛn we na Immunology Science & Technology, Virology, ɛn Materials Science Kwɛstyɔn we dɛn kɔl Kwɛstyɔn. Insay di fild fɔ Immunology Science & Technology, i de delve insay di mɛkanism ɛn aplikeshɔn fɔ di imyun sistɛm. In Vayrɔs risach de sɛnt pan di vayral kwaliti dɛm, transmishɔn, ɛn prɛvɛnshɔn. Insay di domɛyn fɔ Matirial Sayns Kɛmistri, i de kɔmit fɔ divɛlɔp matirial prɔpati ɛn di inovativ aplikeshɔn fɔ kemistri, we mek i bi wan notabɛl pɔsin wit impɔtant risach ajɔstmɛnt dɛn na rilevɛns akademik fil dɛm. Wan, Yanmin de list in di rεfrεns כf saytεshכn [6].

▎ Saytayshɔn dɛn we gɛt fɔ du wit dis

[1] García-Bɛnlɔch S, Rɛvɛt-Ros F, Blɛsa JR, ɛn ɔda pipul dɛn. MOTS-c de promuot mכsul difrεns in vitro[J]. Pεptid, 2022,155:170840.DOI:10.1016/j.pεptida.2022.170840.

[2] Zhang Y, Huang J, Zhang Y, ɛn ɔda pipul dɛn. di Maytochondrial-Dεrivεd Pεptid MOTS-c de Aliviet Rεdyushכn Nyumonitis via wan Nrf2-Dipεndεnt Mεkanism[J]. Antioksidant, 2024,13.

[3] Wang Z, Yang L, Xu L, ɛn ɔda pipul dɛn. Sεntri εn pεrifεral mεkanism fכ MOTS-c de atεnuet pen haypasεnsitiviti in wan mays mכdel fכ inflammatory pen[J]. Nyurɔlɔjik Risach, 2024,46(2):165-177.DOI:10.1080/01616412.2023.2258584.

[4] Bień J, Pruszyńska-Oszmałek E, Kołodziejski P, ɛn ɔda pipul dɛn. MOTS-c de rεgεl pankrεas alfa εn beta sεl fכnshכn dεm in vitro[J]. Histochemistry ɛn Sɛl Bayoloji, 2024,161(6):449-460.DOI:10.1007/s00418-024-02274-0.

[5] Yi X, Hu G, Yang Y, ɛn ɔda pipul dɛn. di rol we MOTS-c de ple na di rεguleshכn fכ di bon mεtabolism[J]. Frɔntiers in Fisiɔlɔji, 2023,14:1149120.DOI:10.3389/fphys.2023.1149120.

[6] Wan W, Zhang L, Lin Y, ɛn ɔda pipul dɛn. di maytochכndria-dεrivεd pεptida MOTS-c: ifekt dεm εn mεkanism dεm we riliyt to strεs, mεtabolism εn ol[J]. J ɔ rnal ɔ f Transleshɔnal Mɛdisin, 2023,21(1):36.DOI:10.1186/s12967-023-03885-2.

ƆL DI ATIKUL ƐN PRODƆKT INFƆMƐSHƆN WE DƐN GI NA DIS WƐBSAYT NA FƆ ƆL FƆ DI INFƆMƐSHƆN ƐN FƆ EDYUKESHƆN.  

Di prɔdak dɛn we dɛn gi na dis wɛbsayt na fɔ in vitro risach nɔmɔ. in vitro risach (Latin: *in glas*, we min insay glas) dεn de du am ausayd mכtalman bכdi. Dɛn prɔdak ya nɔto mɛrɛsin, dɛn nɔ gɛt di aprɔval frɔm di US Food and Drug Administration (FDA), ɛn dɛn nɔ fɔ yuz dɛn fɔ protɛkt, trit, ɔ mɛn ɛni mɛrɛsin, sik, ɔ sik. Di lɔ nɔ gri fɔ mek dɛn put dɛn tin ya insay mɔtalman ɔ animal bɔdi ɛni we.