MOTS-c 20mg

▎ MOTS-c Ọdịdị

▎ MOTS-c Nnyocha

Kedu ihe ndabere nyocha nke MOTS-c?

Nchọpụta nyocha nke MOTS-c sitere na nyocha banyere ọrụ mitochondrial DNA na ahụike metabolic na ịka nká. Ka nghota nke ọrụ mitochondrial na-abawanyewanye, a chọpụtara na mitochondria abụghị naanị ebe etiti metabolism ike kamakwa na-ekere òkè na nkwurịta okwu cellular na ntụgharị mgbaàmà. Site na ịgbalite ụzọ AMPK, ha na-etinye aka na glucose na metabolism lipid, nwere njikọ chiri anya na ọrịa metabolic dị ka ọrịa shuga na oke ibu, ma na-ekwe nkwa dị ka ebumnuche ọgwụgwọ ọhụrụ maka ọnọdụ ndị a. Nyere njikọ dị n'etiti ọrụ mitochondrial na ọrịa dị iche iche, MOTS-c etinyekwara ya na ọnọdụ ndị dị ka ịba ọcha n'anya B na ọrịa cancer ovarian. Nnyocha na-egosi na ọ nwere ike na-ekere òkè dị ukwuu na usoro ọrịa nje. Mmega ahụ na-akwalite njikọ na nkwupụta nke MOTS-c n'ime ahụ mmadụ, si otú ahụ na-emeziwanye metabolism nke anụ ahụ, ịrụ ọrụ anụ ahụ, na ọrụ anụ ahụ dum, na-enye ihe akaebe maka usoro mgbochi ịka nká na-emega ahụ na ịgbasawanye nyocha nke MOTS-c.

Kedu ihe bụ usoro nke MOTS-c?

Mgbalite ụzọ akara AICAR-AMPK: 

MOTS-c na-arụ ọrụ ya nke ọma site n'ịgbalite ụzọ akara AICAR-AMPK. Ọ na-akpaghasị okirikiri folate-methionine n'ime sel, si otú a na-eme ka ụzọ akara AICAR-AMPK rụọ ọrụ. Dịka ọmụmaatụ, na usoro physiological dị ka imeziwanye nguzogide insulin na igbochi oke ibu, ịgbalite ụzọ a na-arụ ọrụ dị mkpa. Site n'ime ka ụzọ a rụọ ọrụ, MOTS-c nwere ike ịhazi metabolism ike cellular, welie nnabata cellular na iji glucose, si otú ahụ na-achịkwa usoro metabolic homeostasis ^[1,2]..

Mmekọrịta na ụzọ mgbama na mkpụrụ ndụ ihe nketa: 

N'ime mkpụrụ ndụ akwara, MOTS-c na-emekọrịta ihe na ntụgharị mgbama na transcription activator 3 (STAT3) site na YIFY ngalaba putative Src-homologous 2 (SH2) binding motif, na-ebelata ọrụ ntụgharị STAT3 na ịkwalite nhazi myotube. Na pneumonitis radieshon, MOTS-c na-ebelata mmebi anụ ahụ nku ume, mbufụt, na nrụgide oxidative site n'ịbawanye ọkwa nke ihe metụtara nuklia E2 (Nrf2) na ịkwalite nsụgharị nuklia ya, si otú ahụ na-echebe ọrụ mitochondrial. Ọzọkwa, MOTS-c na-arụ ọrụ dị iche iche nke anụ ahụ site n'ịchịkwa okwu nke mkpụrụ ndụ ihe nketa dị ka GLUT4, STAT3, na IL-10 ^[3].

Usoro nke usoro metabolic: 

MOTS-c na-ekere òkè na nhazi nke usoro metabolic dị iche iche dị mkpa, gụnyere glucose metabolism, lipid metabolism, na ọkpụkpụ, site na autocrine na paracrine usoro. Na metabolism nke glucose, ọ na-eme ka insulin na-eguzogide ma na-achịkwa ọkwa glucose ọbara; na lipid metabolism, ọ na-abawanye thermogenesis abụba agba aja aja, na-akwalite ọcha abụba browning, na-egbochi oke ibu na lipid metabolism ọrịa; na ọkpụkpụ ọkpụkpụ, ọ na-akwalite mmụba osteoblast, ọdịiche, na mineralization, na-egbochi ọgbọ osteoclast, ma na-achịkwa ọkpụkpụ ọkpụkpụ na ọkpụkpụ ọkpụkpụ ^[4,5]..

Ọgụgụ 1 Mechanism na ọrụ MOTS-c ^[6].

Kedu ọrụ na ngwa MOTS-c?

Ọrụ nke MOTS-c

Mmetụta nke usoro metabolic: 

MOTS-c nwere ike melite glucose na lipid metabolism na ahụ. Na metabolism nke glucose, ọ na-ebelata nguzogide insulin, na-enyere aka igbochi ụdị ọrịa shuga 2, na-eme ka nnabata sel na-arụ ọrụ nke ọma na glucose. Na lipid metabolism, ọ na-abawanye thermogenesis abụba agba aja aja, na-akwalite browning nke abụba ọcha, si otú na-achịkwa lipid metabolism, na-egbochi oke ibu, na metụtara lipid metabolic ọrịa. Ọ na-ebelatakwa ọrịa imeju abụba na-adịghị egbu egbu ma na-achịkwa imeju lipid metabolism ^[2].

Mmetụta na ọrụ cell: 

Ọ na-akwalite ọrụ mitochondrial ma na-echebe mkpụrụ ndụ site na mmebi. Dịka ọmụmaatụ, na oyi baa na-akpata radieshon, ọ na-ebelata mmebi mitochondrial na cell epithelial ngụgụ, na-ebelata apoptosis cell, ma na-ejigide ọrụ cellular nkịtị. N'ime mkpụrụ ndụ pancreatic, MOTS-c na-emetụta nzuzo na ngosipụta nke insulin na glucagon, na-achịkwa physiology cell pancreatic, ma na-emetụtakwa ndụ cell na apoptosis ^[4,5]..

Mmetụta na mọzụlụ na ọkpụkpụ: 

N'ime akwara, MOTS-c na-akwalite ọdịiche nke progenitor cell muscle, na-eme ka e nwee myotube, ma na-echebe mkpụrụ ndụ akwara site na interleukin-6 (IL-6) mebiri emebi, nwere ike igbochi atrophy muscle. N'ihe gbasara ọkpụkpụ, ọ na-akwalite mmụba, ọdịiche, na mineralization nke osteoblasts, na-egbochi nhazi osteoclast, na-eme ka ọkpụkpụ metabolic nguzozi, ma na-enyere aka igbu oge osteoporosis ^[1,5]..

Mmetụta mgbochi mkpali na immunomodulatory: 

MOTS-c na-ebelata mmeghachi omume mkpali na-adịghị ala ala ma na-achịkwa ọrụ mgbochi. Na ụdị ihe mgbu na-egbuke egbuke, MOTS-c na-ebelata ihe mgbu hypersensitivity, na-ebelata ntọhapụ nke ihe ndị na-egbuke egbuke, ma na-egbochi ọrụ nke mkpụrụ ndụ glial na neurons, na-egosipụta mmetụta mgbochi mkpali na nkwụsị mgbu ^[3]..

Ngwa nke MOTS-c

Mmetụta na ọrịa metabolic: 

Mmetụta nchịkwa MOTS-c na glucose na lipid metabolism na-eme ka ọ bụrụ ebumnuche ọgwụgwọ ọhụrụ maka ọrịa metabolic dị ka ụdị ọrịa shuga 2, oke ibu, na ọrịa imeju na-adịghị egbu egbu ^[2].

Mgbochi na Ọgwụgwọ Ọrịa Musculoskeletal: 

Enwere ike iji mmetụta dị mma ya na mọzụlụ na ọkpụkpụ iji gbochie ma na-agwọ ọrịa ndị metụtara atrophy muscle na ọrịa skeletal dị ka osteoporosis. Maka ndị ọrịa nwere atrophy muscle, ọ nwere ike imeziwanye ọrụ ahụ site n'ịkwalite ọdịiche dị n'etiti mkpụrụ ndụ akwara na igbochi apoptosis cell muscle; Maka ndị ọrịa nwere osteoporosis, ọ nwere ike ịhazi nguzozi nke ọkpụkpụ, mee ka ọkpụkpụ ọkpụkpụ dịkwuo elu, ma gbochie ma na-emeso ọkpụkpụ ọkpụkpụ ^[1,5]..

Nchekwa mmebi radieshon: 

N'ime ọmụmụ banyere pneumonitis radieshon, MOTS-c egosila mmetụta nchebe megide mmebi radieshon nku ume. Enwere ike iji ya n'oge ọgwụgwọ redio iji kpuchido anụ ahụ nkịtị, belata mmebi anụ ahụ na-akpata radieshon, ma welie ịdị irè nke ọgwụgwọ redio ^[2].

Ọgwụgwọ ọrịa mkpali: 

Dabere na mmetụta mgbochi ya, MOTS-c nwere ike iji na-agwọ ọrịa ndị na-egbuke egbuke dị ka ihe mgbu na-egbuke egbuke, na-enye ntụziaka ọhụrụ maka ọgwụgwọ nke ọnọdụ ndị dị otú ahụ ^[3].

Mmechi

Dị ka peptide sitere na mitochondrial, MOTS-c nwere ike mee ka ụzọ mgbaàmà rụọ ọrụ iji dozie glucose na lipid metabolism, melite nguzogide insulin, ma belata ihe ize ndụ nke ọrịa metabolic; ọ nwekwara ike ịnọgide na-arụ ọrụ akwara na ọkpụkpụ, gbochie atrophy muscle na osteoporosis; na ọ nwere ọrụ mgbochi mkpali na nchekwa cell, na-ekere òkè na nchebe mmebi radieshon na ọgwụgwọ nke ọrịa na-efe efe.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Onye ode akwụkwọ akụkọ sayensị

Wan, Yanmin na-ejikọta ya na ụlọ ọrụ dị iche iche a ma ama, gụnyere ụlọ ọgwụ, ụlọ ọrụ nyocha, mahadum, na ụlọ ọrụ dị ka Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, wdg. mmasị nyocha ya dị ukwuu, bụ isi na-elekwasị anya na isiokwu nke Immunology Science & Technology, Virology Chemiss, Virology, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry na Immunology. N'ihe gbasara Immunology Science & Technology, ọ na-abanye n'ime usoro na ngwa nke usoro ahụ ji alụso ọrịa ọgụ. Ihe nyocha Virology ya gbadoro ụkwụ na njirimara nje, nnyefe, na mgbochi. N'ime ngalaba nke Materials Science Chemistry, ọ na-agba mbọ na mmepe nke ihe onwunwe na ngwa ọhụrụ nke kemistri, na-eme ka ọ bụrụ onye ama ama nke nwere nnukwu nchọpụta nyocha na ngalaba agụmakwụkwọ dị mkpa. Wan, Yanmin ka edepụtara n'akwụkwọ ntụaka [6].

▎ Okwu ndị dị mkpa

[1] García-Benlloch S, Revert-Ros F, Blesa JR, et al. MOTS-c na-akwalite ọdịiche anụ ahụ na vitro [J]. Peptides, 2022,155:170840.DOI:10.1016/j.peptides.2022.170840.

[2] Zhang Y, Huang J, Zhang Y, et al. Peptide nke sitere na Mitochondrial MOTS-c na-ebelata Pneumonitis Radiation site na Nrf2-Dependent Mechanism[J]. Antioxidants, 2024,13.

[3] Wang Z, Yang L, Xu L, et al. Usoro etiti na nke dịpụrụ adịpụ nke MOTS-c na-ebelata ihe mgbu hypersensitivity na ụdị oke nke mgbu mgbu [J]. Nnyocha nke akwara ozi, 2024,46 (2): 165-177.DOI: 10.1080/01616412.2023.2258584.

[4] Bień J, Pruszyńska-Oszmałek E, Kołodziejski P, et al. MOTS-c na-achịkwa ọrụ alfa pancreatic na beta cell in vitro[J]. Akụkọ ihe mere eme na ihe ọmụmụ ihe ọmụmụ, 2024,161(6):449-460.DOI:10.1007/s00418-024-02274-0.

[5] Yi X, Hu G, Yang Y, et al. Ọrụ MOTS-c na nhazi nke metabolism ọkpụkpụ [J]. Oke na Physiology, 2023,14:1149120.DOI:10.3389/fphys.2023.1149120.

[6] Wan W, Zhang L, Lin Y, et al. Mitochondria-enwetara peptide MOTS-c: mmetụta na usoro metụtara nrụgide, metabolism na ịka nká [J]. Akwụkwọ akụkọ ọgwụ ntụgharị, 2023,21 (1): 36.DOI: 10.1186/s12967-023-03885-2.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.