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1kits （10Ibikoresho）
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▎ MOTS-c Imiterere
Inkomoko: PubChem |
Urukurikirane: MRWQEMGYIFYPRKLR Inzira ya molekulari: C101H152N28O22S2 Uburemere bwa molekuline: 2174.6g / mol Numero ya CAS: 1627580-64-6 CID CID: 146675088 Synonyme: UNII-A5CV6JFB78 |
▎ MOTS-c Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na MOTS-c?
Ubushakashatsi bwakozwe na MOTS-c bwaturutse ku iperereza ku ruhare rwa ADN ya mitochondial mu buzima bwa metabolike no gusaza. Mu gihe gusobanukirwa imikorere ya mitochondial byagendaga byiyongera, byagaragaye ko mitochondriya atari ihuriro ry’ingufu za metabolisme gusa ahubwo inagira uruhare mu itumanaho rya selile no guhererekanya ibimenyetso. Mugukoresha inzira ya AMPK, bagira uruhare muri glucose na lipide metabolism, bifitanye isano rya hafi n'indwara ziterwa na diabete n'umubyibuho ukabije, kandi bagasezerana nk'intego nshya zo kuvura ibi bihe. Urebye isano iri hagati yimikorere ya mitochondrial nindwara zitandukanye, MOTS-c nayo yakoreshejwe mubihe nka hepatite B idakira na kanseri yintanga. Ubushakashatsi bwerekana ko bushobora kugira uruhare runini muburyo bwo kwandura virusi. Imyitozo ngororamubiri iteza imbere guhuza no kwerekana MOTS-c mu mubiri w'umuntu, bityo igahindura imitekerereze y'imitsi, imikorere y'umubiri, ndetse n'imikorere rusange y'umubiri, itanga ibimenyetso byerekana ingamba zishingiye ku myitozo ngororamubiri yo kurwanya gusaza no kwagura ubushakashatsi bwa MOTS-c.
Nubuhe buryo bwo gukora bwa MOTS-c?
Gukora inzira ya AICAR-AMPK yerekana inzira:
MOTS-c ikora cyane cyane imikorere ya physiologique mugukoresha inzira ya AICAR-AMPK yerekana inzira. Ihagarika uruziga rwa folate-methionine muri selile, bityo igakora inzira yerekana ibimenyetso bya AICAR-AMPK. Kurugero, mubikorwa bya physiologique nko kunoza insuline no kwirinda umubyibuho ukabije, gukora iyi nzira bigira uruhare runini. Mugukoresha iyi nzira, MOTS-c irashobora kugenga imbaraga za metabolisme yingirabuzimafatizo, kongera imbaraga za selile no gukoresha glucose, bityo bikagenga homeostasis ya metabolike ya sisitemu [1,2].
Imikoranire ninzira zerekana ibimenyetso na gen:
Mu ngirangingo z'imitsi, MOTS-c ikorana nogukwirakwiza ibimenyetso no kwandukura inyandiko 3 (STAT3) ibinyujije muri YIFY domaine ya Src-homologous 2 (SH2) ihuza motif, kugabanya ibikorwa byo kwanduza STAT3 no kongera imiterere ya myotube. Muri pneumonite yimirasire, MOTS-c igabanya kwangirika kwingirangingo yibihaha, gutwika, hamwe na stress ya okiside mukongera ibintu bya kirimbuzi E2 bifitanye isano na Nrf2 no guteza imbere itumanaho rya kirimbuzi, bityo bikarinda imikorere ya mito-iyambere. Byongeye kandi, MOTS-c ikora imirimo itandukanye yumubiri muguhuza imvugo ya gen nka GLUT4, STAT3, na IL-10 [3].
Kugena inzira ya metabolike:
MOTS-c igira uruhare mugutunganya inzira zinyuranye za metabolika, harimo glucose metabolism, metabolism lipid metabolism, na metabolisme yamagufwa, binyuze muburyo bwa autocrine na paracrine. Muri glucose metabolism, itezimbere insuline kandi igenga urugero rwa glucose yamaraso; muri metabolism ya lipide, byongera ibinure byijimye thermogenez, bigatera ibinure byera, kandi bikarinda umubyibuho ukabije hamwe na lipide metabolism; muri metabolism yo mu magufa, iteza ikwirakwizwa rya osteoblast, gutandukanya, hamwe na minervaliza, ikabuza kubyara osteoclast, kandi ikagenga metabolism yo mu magufa no guhindura amagufwa [4,5].
Igishushanyo 1 Uburyo n'imikorere ya MOTS-c [6].
Nibihe bikorwa nibikorwa bya MOTS-c?
Imikorere ya MOTS-c
Ingaruka zigenga kuri metabolism:
MOTS-c irashobora guteza imbere glucose na lipide metabolism mumubiri. Muri glucose metabolism, igabanya kurwanya insuline, ifasha kwirinda diyabete yo mu bwoko bwa 2, kandi ikongerera gufata selile no gukoresha neza glucose. Muri metabolism ya lipide, byongera ibinure byamavuta ya termogenezi, bigatera umwijima wamavuta yera, bityo bikagenga metabolisme ya lipide, birinda umubyibuho ukabije, hamwe nindwara ziterwa na lipide. Igabanya kandi kwandura indwara zumwijima zidafite inzoga kandi ikagenga metabolism ya hepatike [2].
Ingaruka ku mikorere ya selire:
Itezimbere imikorere ya mitochondrial kandi ikingira selile kwangirika. Kurugero, mumisonga iterwa nimirasire, igabanya kwangirika kwa mitochondial selile selile epithelia selile, igabanya apoptose selile, kandi ikomeza imikorere isanzwe ya selile. Muri selile pancreatic selile, MOTS-c igira uruhare mu gusohora no kwerekana insuline na glucagon, bigenga physiologie selile pancreatic selile, kandi bikagira ingaruka no mubuzima bwa selile na apoptose [4,5].
Ingaruka ku mitsi n'amagufwa:
Mu mitsi, MOTS-c iteza imbere imitsi ya progenitor itandukanya imitsi, ikongera imitsi ya myotube, kandi ikarinda ingirangingo z'imitsi kwangirika kwa interleukin-6 (IL-6), bishobora gukumira imitsi. Ku bijyanye n'amagufa, ateza imbere gukwirakwizwa, gutandukanya, no kugabanuka kwa osteoblasts, bikabuza imiterere ya osteoclast, bikomeza amagufwa ya metabolike, kandi bigafasha gutinda osteoporose [1,5].
Ingaruka zo kurwanya no gukingira indwara:
MOTS-c igabanya ibisubizo bya sisitemu idakira kandi igenga imikorere yumubiri. Muburyo bwububabare bukabije, MOTS-c igabanya ububabare bukabije, igabanya irekurwa ryibintu bitera umuriro, kandi ikabuza gukora ingirabuzimafatizo ya glial na neuron, ikerekana ingaruka zo kurwanya no kugabanya ububabare [3].
Porogaramu ya MOTS-c
Ingaruka ku ndwara ziterwa na metabolike:
Ingaruka za MOTS-c kuri glucose na lipide metabolism ituma iba intego yo kuvura indwara ziterwa na metabolike nka diyabete yo mu bwoko bwa 2, umubyibuho ukabije, n'indwara y'umwijima idafite inzoga [2].
Kwirinda no kuvura Indwara ya Musculoskeletal:
Ingaruka nziza zayo kumitsi n'amagufa birashobora gukoreshwa mukurinda no kuvura indwara ziterwa na atrophyi yimitsi nindwara zifata skelete nka osteoporose. Ku barwayi bafite atrophyie yimitsi, irashobora kunoza imikorere yimitsi iteza imbere ingirabuzimafatizo no guhagarika imitsi ya apoptose; Ku barwayi barwaye ostéoporose, irashobora kugabanya amagufwa yo mu magufa, kongera ubwinshi bw'amagufwa, no kwirinda no kuvura osteoporose [1.5].
Kurinda imirase:
Mu bushakashatsi bwakozwe kuri pneumonite yimirasire, MOTS-c yerekanye ingaruka zo gukingira kwangiza imirasire yibihaha. Irashobora gukoreshwa mugihe cya radiotherapi kugirango irinde ingirangingo zisanzwe, kugabanya kwangirika kwimitsi iterwa nimirasire, no kongera imikorere ya radiotherapi [2].
Kuvura indwara zanduza:
Hashingiwe ku ngaruka zayo zo kurwanya inflammatory, MOTS-c irashobora gukoreshwa mu kuvura indwara zanduza nk'ububabare, zitanga icyerekezo gishya cyo kuvura indwara nk'izi [3].
Umwanzuro
Nka peptide ikomoka kuri mitochondial, MOTS-c irashobora gukora inzira yerekana ibimenyetso kugirango igabanye glucose na lipide metabolism, kunoza insuline, no kugabanya ibyago byindwara ziterwa na metabolike; irashobora kandi gukomeza imikorere yimitsi namagufwa, ikarinda imitsi na osteoporose; kandi ifite ibikorwa byo kurwanya inflammatory no kurinda selile, bigira uruhare mukurinda kwangiza imishwarara no kuvura indwara zanduza.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Wan, Yanmin yifatanije n’imiryango itandukanye izwi cyane, harimo ibitaro, ibigo by’ubushakashatsi, kaminuza, n’inganda nka Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan University University, n'ibindi. Mu rwego rwa Immunology Science & Technology, yinjiye mu buryo no mu gukoresha sisitemu y’umubiri. Ubushakashatsi bwe bwa virusi yibanda kuri virusi, kwanduza, no kwirinda. Mu rwego rwa Material Science Science Chemistry, yiyemeje guteza imbere umutungo wibintu no gukoresha udushya twa chimie, bituma aba umuntu wamamaye ufite ubushakashatsi bugaragara mubikorwa byubumenyi bijyanye. Wan, Yanmin yanditse murutonde rwibisobanuro [6].
