MOTS-c 20mg ƒe dɔwɔwɔ

▎ MOTS-c Dɔwɔɖoɖo

▎ MOTS-c Numekuku

Nukae nye numekuku si wowɔ le MOTS-c ŋu?

Numekuku siwo wowɔ le MOTS-c ŋu la dzɔ tso numekuku siwo wowɔ le akpa si mitochondrial DNA wɔna le lãmenugbagbeviwo ƒe lãmesẽ kple tsitsi me ŋu. Esi mitochondria ƒe dɔwɔwɔ gɔmesese va nɔ sesẽm ɖe edzi la, wokpɔe be menye ɖeko mitochondria nye ŋusẽ ƒe asitɔtrɔ ƒe titina ko o, ke wokpɔa gome le lãmenugbagbeviwo ƒe kadodo kple dzesiwo ƒe tɔtrɔ hã me. To AMPK mɔa ƒe dɔwɔwɔ me la, wokpɔa gome le sukli kple ami ƒe asitɔtrɔ me, si do ƒome kplikplikpli kple lãmenugbagbeviwo ƒe dɔwɔwɔ abe suklidɔ kple lolo akpa ene, eye wodo ŋugbe be wonye atikewɔwɔ ƒe taɖodzinu yeyewo na nɔnɔme siawo. Esi wònye be kadodo le mitochondria ƒe dɔwɔwɔ kple dɔléle vovovowo dome ta la, wozã MOTS-c le nɔnɔmewo abe aklãdɔléle B si nɔa anyi didi kple azigolo me kansa ene hã me. Numekukuwo ɖee fia be ate ŋu awɔ akpa vevi aɖe le dɔlékuiwo ƒe dɔlékuiwo xɔxɔ ƒe ɖoɖowo me. Kamedede doa MOTS-c ƒe wɔwɔme kple eɖeɖefia ɖe ŋgɔ le amegbetɔ ƒe ŋutilã me, si wɔnɛ be lãmekawo ƒe asitɔtrɔ, ŋutilã ƒe dɔwɔwɔ, kple ŋutilã ƒe dɔwɔwɔ bliboa nyona ɖe edzi, si naa kpeɖodzi le kamedede ƒe mɔnu siwo tsia tre ɖe tsitsi ŋu ŋu eye wòkekea MOTS-c ŋuti numekuku ƒe lolome ɖe enu.

Nukae nye MOTS-c ƒe dɔwɔwɔ ƒe mɔnu?

AICAR-AMPK ƒe dzesimɔa ƒe dɔwɔwɔ: 

MOTS-c wɔa eƒe ŋutilãmedɔwo koŋ to AICAR-AMPK dzesimɔa ƒe dɔwɔwɔ me. Egblẽa folate-methionine ƒe tsatsam le lãmenugbagbeviwo me, si wɔnɛ be AICAR-AMPK ƒe dzesimɔa wɔa dɔ. Le kpɔɖeŋu me, le ŋutilã ƒe dɔwɔwɔwo abe insulin ƒe dɔlélenutsiŋutete ƒe nyonyo kple mɔxexe ɖe lolo akpa nu me la, mɔ sia ƒe dɔwɔwɔ wɔa akpa vevi aɖe. To mɔ sia ƒe dɔwɔwɔ me la, MOTS-c ate ​​ŋu aɖɔ lãmenugbagbeviwo ƒe ŋusẽ ƒe asitɔtrɔ ɖo, ana lãmenugbagbeviwo ƒe sukli ƒe xɔxlɔ̃ kple eŋudɔwɔwɔ nanyo ɖe edzi, si ana wòaɖɔ ɖoɖowɔɖi ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe homeostasis ɖo ^[1,2]..

Kadodo kple dzesimɔ kple domenyiŋusẽfianu tɔxɛwo: 

Le lãmekawo me la, MOTS-c wɔa nu kple dzesiwo ƒe tɔtrɔ kple nuŋɔŋlɔ ƒe dɔwɔwɔ 3 (STAT3) to eƒe YIFY domenyiŋusẽfianu ƒe Src-homologous 2 (SH2) binding motif si wosusu be, si ɖea STAT3 ƒe nuŋɔŋlɔ ƒe dɔwɔwɔ dzi kpɔtɔna eye wòdoa myotube ƒe wɔwɔ ɖe ŋgɔ. Le keklẽŋusẽ ƒe aklãdɔléle me la, MOTS-c ɖea lãkusiwo ƒe gbegblẽ, dɔdzẽ, kple oxidative stress dzi kpɔtɔna to nuklia factor E2-related factor (Nrf2) ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ kple eƒe nuklia ƒe ʋuʋu dodo ɖe ŋgɔ me, si wɔnɛ be wòkpɔa mitochondria ƒe dɔwɔwɔ ta. Tsɔ kpe ɖe eŋu la, MOTS-c wɔa ŋutilã ƒe dɔwɔwɔ vovovowo to domenyiŋusẽfianuwo abe GLUT4, STAT3, kple IL-10 ƒe ɖeɖefia dzi kpɔkpɔ me ^[3]..

Lãmetsiŋusẽ ƒe mɔwo dzi kpɔkpɔ: 

MOTS-c kpɔa gome le lãmenugbagbeviwo ƒe dɔwɔwɔ vevi vovovowo dzi kpɔkpɔ me, siwo dometɔ aɖewoe nye sukli ƒe asitɔtrɔ, ami ƒe asitɔtrɔ, kple ƒu ƒe asitɔtrɔ, to autocrine kple paracrine mɔnuwo dzi. Le sukli ƒe asitɔtrɔ me la, enaa insulin ƒe dɔlélenutsiŋutete nyona ɖe edzi eye wònaa sukli ƒe agbɔsɔsɔ le ʋu me nɔa ɖoɖo nu; le ami ƒe asitɔtrɔ me la, enaa ami ɣi ƒe dzoxɔxɔ ƒe dzɔdzɔ dzina ɖe edzi, edoa ami ɣi ƒe blɔ ɖe ŋgɔ, eye wòxea mɔ na lolo akpa kple ami ƒe asitɔtrɔ ƒe kuxiwo; le ƒu ƒe asitɔtrɔ me la, edoa ƒumeŋuɖuiwo ƒe dzidziɖedzi, vovototodedeameme, kple mineralization ɖe ŋgɔ, exea mɔ na ƒumeŋuɖuiwo ƒe dzidzi, eye wòɖɔa ƒu ƒe asitɔtrɔ kple ƒu ƒe tɔtrɔ ɖo ^[4,5]..

Nɔnɔmetata 1 MOTS-c ƒe dɔwɔwɔ kple dɔwɔwɔ ^{[6] .}.

Nukae nye MOTS-c ƒe dɔwɔwɔ kple eƒe dɔwɔwɔ?

Dɔwɔwɔ siwo le MOTS-c

Dɔwɔnawo ƒe ŋusẽkpɔɖeamedzi ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi: 

MOTS-c ate ​​ŋu ana sukli kple ami ƒe asitɔtrɔ le ŋutilã me nanyo ɖe edzi. Le sukli ƒe asitɔtrɔ me la, eɖea insulin ƒe dɔlélenutsiŋutete dzi kpɔtɔna, ekpena ɖe ame ŋu be woaxe mɔ ɖe suklidɔ ƒomevi evelia nu, eye wònaa lãmenugbagbeviwo ƒe sukli ƒe xɔxlɔ̃ kple eŋudɔwɔwɔ nyuie nyona ɖe edzi. Le ami ƒe asitɔtrɔ me la, edzia ami ɣi ƒe dzoxɔxɔ ƒe dzɔdzɔ ɖe edzi, edoa ami ɣi ƒe blɔ ɖe ŋgɔ, si wɔnɛ be ami ƒe asitɔtrɔ le lãme na ame, xea mɔ na lolo akpa, kple ami ƒe asitɔtrɔ ƒe kuxi siwo do ƒome kplii. Eɖea aklãdɔ si me ami mele o ƒe dzɔdzɔ hã dzi kpɔtɔna eye wòɖɔa aklã me ʋumemi ƒe asitɔtrɔ ɖo ^{[2] .}.

Ŋusẽ si wòkpɔna ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi: 

Edoa mitochondria ƒe dɔwɔwɔ ɖe ŋgɔ eye wòkpɔa lãmenugbagbeviwo ta tso nusiwo agblẽ le wo ŋu me. Le kpɔɖeŋu me, le aklãdɔ si keklẽŋusẽ hena vɛ me la, eɖea mitochondria ƒe gbegblẽ le lãkusi me lãmenugbagbeviwo me dzi kpɔtɔna, eɖea lãmenugbagbeviwo ƒe tsɔtsrɔ̃ dzi kpɔtɔna, eye wòléa lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie me ɖe asi. Le dɔgboa ƒe lãmenugbagbeviwo me la, MOTS-c kpɔa ŋusẽ ɖe insulin kple glucagon ƒe dodo kple eɖeɖefia dzi, si kpɔa dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi, eye wòkpɔa ŋusẽ ɖe lãmenugbagbeviwo ƒe agbenɔnɔ kple apoptosis hã dzi ^[4,5]..

Ŋusẽ si wòkpɔna ɖe lãmekawo kple ƒuwo dzi: 

Le lãmekawo me la, MOTS-c doa lãmekawo ƒe lãmenugbagbeviwo ƒe vovototodedeameme ɖe ŋgɔ, enaa myotube ƒe wɔwɔme dzina ɖe edzi, eye wòkpɔa lãmekawo ta tso nusiwo interleukin-6 (IL-6) hena vɛ me, si ate ŋu axe mɔ na lãmekawo ƒe tsɔtsrɔ̃. Le ƒuwo gome la, edoa ƒumeŋuɖuiwo ƒe dzidziɖedzi, vovototodedeameme, kple mineralization ɖe ŋgɔ, exea mɔ na ƒumeŋuɖuiwo ƒe wɔwɔ, ena ƒuwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ da sɔ, eye wòkpena ɖe ƒumeŋuɖui ŋu wòhea ƒumeŋuɖui ɖe megbe ^[1,5]..

Dɔlékuiwutikewo kple dɔlélenutsiŋutete ƒe dɔwɔwɔ: 

MOTS-c ɖea dɔdzẽ ƒe ŋuɖoɖo siwo nɔa anyi didi le ɖoɖo nu dzi kpɔtɔna eye wòɖɔa dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖo. Le vevesese ƒe kpɔɖeŋuwo me la, MOTS-c ɖea vevesese ƒe seselelãme si gbɔ eme dzi kpɔtɔna, eɖea dɔdzẽ ƒe nusiwo dona le lãme na ame dzi kpɔtɔna, eye wòxea mɔ na glial lãmenugbagbeviwo kple ahɔhɔ̃mekawo ƒe dɔwɔwɔ, si ɖea dɔdzẽ kple vevesese dzi ɖeɖe kpɔtɔ ƒe ŋusẽkpɔɖeamedzi fiana ^[3]..

MOTS-c ƒe dɔwɔwɔwo

Dɔ si wòkpɔna ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo dzi: 

MOTS-c ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe sukli kple ami ƒe asitɔtrɔ dzi na wònye atikewɔwɔ ƒe taɖodzinu yeye na lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo abe suklidɔ ƒomevi eve, lolo akpa, kple aklãdɔ si me ami mele o ^{[2] .}.

Mɔxexe Ðe Lãmetsiŋusẽdɔlélewo Nu Kple Wo Dada: 

Woate ŋu azã ŋusẽ nyui si wòkpɔna ɖe lãmekawo kple ƒuwo dzi atsɔ axe mɔ ɖe dɔléle siwo do ƒome kple lãmekawo ƒe tsɔtsrɔ̃ kple ƒunukpeƒetetedɔ abe ƒumeŋuɖui ene nu ahada wo. Le dɔnɔ siwo ƒe lãmekawo me gblẽ gome la, ate ŋu ana lãmekawo ƒe dɔwɔwɔ nanyo ɖe edzi to lãmekawo ƒe lãmenugbagbeviwo ƒe vovototodedeameme dodo ɖe ŋgɔ kple lãmekawo ƒe lãmenugbagbeviwo ƒe tsɔtsrɔ̃ nu; Le dɔnɔ siwo ŋu ƒumeŋuɖui le gome la, ate ŋu ana ƒu ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nada asɔ, ana ƒu ƒe kpekpeme nadzi ɖe edzi, eye wòaxe mɔ ɖe ƒumeŋuɖui nu ahadae ^[1,5]..

Kekeli ƒe nugbegblẽ takpɔkpɔ: 

Le numekuku siwo wowɔ tso keklẽŋusẽ ƒe aklãdɔléle ŋu me la, MOTS-c ɖee fia be ekpɔa ame ta tso keklẽŋusẽ ƒe nugbegblẽ le lãkusi me ŋu. Woate ŋu azãe le keklẽŋusẽdɔdaɣi atsɔ akpɔ lãkusi siwo sɔ ta, aɖe lãkusi siwo keklẽŋusẽ hena vɛ dzi akpɔtɔ, eye wòana keklẽŋusẽdɔdamɔnu nawɔ dɔ nyuie wu ^{[2] .}.

Dɔléle siwo gblẽa nu le ame ŋu ƒe atikewɔwɔ: 

Woate ŋu anɔ te ɖe eƒe dɔlékuiwutikewo dzi azã MOTS-c atsɔ ada dɔdzẽ ƒe dɔlélewo abe dɔdzẽ ƒe vevesese ene, si ana mɔfiame yeyewo le nɔnɔme mawo dada ŋu ^[3]..

Nyanuwuwuw

Abe peptide si wokpɔna tso mitochondria me ene la, MOTS-c ate ​​ŋu ana dzesimɔwo nawɔ dɔ be woaɖɔ sukli kple ami ƒe asitɔtrɔ ɖo, ana insulin ƒe dɔlélenutsiŋutete nanyo ɖe edzi, eye wòaɖe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo ƒe afɔkua dzi akpɔtɔ; ate ŋu alé lãmekawo kple ƒuwo ƒe dɔwɔwɔ hã ɖe te, axe mɔ ɖe lãmekawo ƒe vuvu kple ƒumeŋuɖui nu; eye dɔ siwo tsia dzodzodzoetsitsi nu kple lãmenugbagbeviwo takpɔkpɔ le esi, eye wòwɔa akpa aɖe le keklẽŋusẽ ƒe nugbegblẽ takpɔkpɔ kple dɔdzẽ ƒe dɔlélewo dada me.

Le Agbalẽŋlɔla La Ŋu

Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.

Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla

Wan, Yanmin do ƒome kple habɔbɔ xɔŋkɔ vovovowo, siwo dometɔ aɖewoe nye kɔdziwo, numekuku dɔwɔƒewo, yunivɛsitiwo, kple dɔwɔƒewo abe Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, kple bubuawo Dzɔdzɔmeŋusẽŋununya. Le Dɔlélenutsiŋutete Ŋuti Nunya & Mɔ̃ɖaŋununya ƒe akpa dzi la, eku nu me tsitotsito le dɔlélenutsiŋutete ƒe dɔwɔwɔ kple eŋudɔwɔwɔ ŋu. Eƒe Dɔlékuiŋutinunya ŋuti numekukuwo ku ɖe dɔlékui ƒe nɔnɔmewo, eƒe kaka, kple mɔxexe ɖe enu ŋu. Le Nuwo ƒe Dzɔdzɔmeŋutinunya ƒe Dzɔdzɔmeŋusẽŋununya ƒe akpaa me la, etsɔ eɖokui na be yeado nuwo ƒe nɔnɔmewo ɖe ŋgɔ eye yeazã atikeŋutinunya le mɔ yeyewo nu, si wɔe be wònye ame ɖedzesi aɖe si si numekuku me dzidzedzekpɔkpɔ veviwo le le sukunusɔsrɔ̃ siwo sɔ me. Woŋlɔ Wan, Yanmin ŋkɔ ɖe nyayɔyɔ ƒe numeɖeɖe me [6].

▎ Nyayɔyɔ Siwo Sɔ

[1] García-Benlloch S, Revert-Ros F, Blesa JR, kple ame bubuwo. MOTS-c doa lãmekawo ƒe vovototodedeameme ɖe ŋgɔ le vitro[J]. Peptides, 2022,155:170840.DOI:10.1016/j.peptidewo.2022.170840.

[2] Zhang Y, Huang J, Zhang Y, kple ame bubuwo. Mitochondrial-Derived Peptide MOTS-c Ðea Kekeli ƒe Aklãdɔ Dzi kpɔtɔna To Nrf2-Dɔɖoanyi ƒe Mɔnu dzi[J]. Nusiwo tsia dzoxɔxɔ nu, 2024,13.

[3] Wang Z, Yang L, Xu L, kple ame bubuwo. MOTS-c ƒe titina kple gota gome mɔnu ɖea vevesese ƒe seselelãme si gbɔ eme dzi kpɔtɔna le mice model of inflammatory pain[J]. Ahɔhɔ̃ŋutinunya Ŋuti Numekuku, 2024, 46 (2): 165-177.DOI: 10.1080 / 01616412.2023.2258584.

[4] Bień J, Pruszyńska-Oszmałek E, Kołodziejski P, kple ame bubuwo. MOTS-c ɖɔa dɔgboa ƒe alpha kple beta lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo le vitro[J]. Lãmetsiŋusẽŋutinunya kple Lãmetsiŋusẽŋutinunya, 2024,161 (6): 449-460.DOI: 10.1007 / s00418-024-02274-0.

[5] Yi X, Hu G, Yang Y, kple ame bubuwo. Akpa si MOTS-c wɔna le ƒu ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me[J]. Liƒowo le Dzɔdzɔmeŋusẽŋununya me, 2023, 14: 1149120.DOI: 10.3389 / fphys.2023.1149120.

[6] Wan W, Zhang L, Lin Y, kple ame bubuwo. Mitochondria-derived peptide MOTS-c: ŋusẽkpɔɖeamedzi kple mɔnu siwo ku ɖe nuteɖeamedzi, lãmenugbagbeviwo ƒe dɔwɔwɔ kple tsitsi ŋu[J]. Gbegɔmeɖeɖe ƒe Atikewɔwɔ ƒe Agbalẽ, 2023, 21 (1): 36.DOI: 10.1186 / s12967-023-03885-2.

NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.  

Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.