MOTS-c 20mg

▎ Hoʻolālā MOTS-c

▎ MOTS-c Imi

He aha ke kumu noiʻi o MOTS-c?

ʻO ke kumu noiʻi o MOTS-c i hoʻokumu ʻia mai nā noiʻi i ka hana o ka mitochondrial DNA i ke olakino metabolic a me ka ʻelemakule. I ka hohonu o ka hoʻomaopopo ʻana i ka hana mitochondrial, ua ʻike ʻia ʻaʻole ʻo mitochondria wale nō ke kikowaena o ka metabolism ikehu akā komo pū kekahi i ka kamaʻilio kelepona a me ka hoʻololi ʻana i nā hōʻailona. Ma ka hoʻolalelale ʻana i ke ala AMPK, pili lākou i ka glucose a me ka lipid metabolism, pili loa i nā maʻi metabolic e like me ka maʻi diabetes a me ka momona, a paʻa i ka ʻōlelo hoʻohiki e like me nā pahuhopu therapeutic hou no kēia mau kūlana. Hāʻawi ʻia i ka hui ʻana ma waena o ka hana mitochondrial a me nā maʻi like ʻole, ua hoʻohana ʻia ʻo MOTS-c i nā kūlana e like me ka hepatitis B mau a me ka maʻi maʻi ovarian. Hōʻike ka noiʻi he mea nui paha ia i nā kaʻina hana maʻi viral. Hoʻoikaika ka hoʻoikaika kino i ka synthesis a me ka hōʻike ʻana o MOTS-c i loko o ke kino o ke kanaka, a laila e hoʻomaikaʻi ai i ka metabolism muscle, ka hana kino, a me ka hana kino holoʻokoʻa, e hāʻawi ana i nā hōʻike no nā hoʻolālā anti-aging e pili ana i ka hoʻoikaika kino a me ka hoʻonui ʻana i ke ʻano o ka noiʻi MOTS-c.

He aha ka hana o ka MOTS-c?

Hoʻomaka ʻana o ke ala hōʻailona AICAR-AMPK: 

Hoʻohana mua ʻo MOTS-c i kāna mau hana physiological ma ka hoʻāla ʻana i ke ala hōʻailona AICAR-AMPK. Hoʻopilikia ia i ka pōʻai folate-methionine i loko o nā pūnaewele, a laila hoʻāla i ke ala hōʻailona AICAR-AMPK. No ka laʻana, i nā kaʻina hana physiological e like me ka hoʻomaikaʻi ʻana i ka pale ʻana o ka insulin a me ka pale ʻana i ka momona, ʻo ka hoʻāla ʻana o kēia alahele he mea nui. Ma ka hoʻoulu ʻana i kēia ala, hiki i ka MOTS-c ke hoʻoponopono i ka metabolism ikehu cellular, hoʻonui i ka lawe ʻana o ka cellular a me ka hoʻohana ʻana i ka glucose, a laila e hoʻoponopono ai i ka homeostasis metabolic systemic ^[1,2].

Nā pilina me nā ala hōʻailona kikoʻī a me nā genes: 

I loko o nā puʻupuʻu muscle, hui pū ʻo MOTS-c me ka transduction hōʻailona a me ka transcription activator 3 (STAT3) ma o kāna YIFY domain's putative Src-homologous 2 (SH2) hoʻopaʻa motif, e hōʻemi ana i ka hana transcriptional o STAT3 a me ka hoʻonui ʻana i ka hoʻokumu ʻana o ka myotube. I ka radiation pneumonitis, MOTS-c e ho'ēmi i ka pōʻino o ka pūpū, ka mumū, a me ke koʻikoʻi oxidative ma o ka hoʻonui ʻana i ka helu nuklea E2-related factor (Nrf2) a me ka hoʻolaha ʻana i kāna translocation nuklea, no laila e pale ai i ka hana mitochondrial. Hoʻohui ʻia, hoʻohana ʻo MOTS-c i nā hana physiological like ʻole ma ka hoʻoponopono ʻana i ka hōʻike ʻana o nā genes e like me GLUT4, STAT3, a me IL-10 ^[3].

Hoʻoponopono i nā ala metabolic: 

Hoʻokomo ʻo MOTS-c i ka hoʻoponopono ʻana i nā kaʻina metabolic koʻikoʻi, me ka metabolism glucose, lipid metabolism, a me ka metabolism iwi, ma o ka autocrine a me ka paracrine mechanisms. I loko o ka glucose metabolism, hoʻomaikaʻi ia i ka insulin resistance a hoʻoponopono i nā pae glucose koko; i ka lipid metabolism, hoʻonui ia i ka thermogenesis momona brown, hoʻoikaika i ka momona keʻokeʻo browning, a pale i ka momona a me nā maʻi lipid metabolism; i loko o ka iwi metabolism, hoʻoikaika ia i ka hoʻonui ʻana o ka osteoblast, ka ʻokoʻa, a me ka mineralization, ke kāohi i ka hanauna osteoclast, a hoʻoponopono i ka metabolism iwi a me ka hoʻoponopono hou ʻana o ka iwi ^[4,5].

Kiʻi 1 Mechanism a me ka hana o MOTS-c ^[6].

He aha nā hana a me nā noi o MOTS-c?

Nā hana o MOTS-c

Nā hopena hoʻoponopono i ka metabolism: 

Hiki i ka MOTS-c ke hoʻomaikaʻi i ka glucose a me ka lipid metabolism i ke kino. I loko o ka glucose metabolism, hoʻemi ia i ke kū ʻana o ka insulin, kōkua i ka pale ʻana i ka maʻi maʻi type 2, a hoʻonui i ka lawe ʻana a me ka hoʻohana pono ʻana o ka glucose. I ka lipid metabolism, hoʻonui ia i ka thermogenesis momona brown, hoʻoikaika i ka browning o ka momona keʻokeʻo, a laila hoʻoponopono i ka lipid metabolism, pale i ka momona, a me nā maʻi pili lipid metabolic. Hoʻemi pū ia i ka maʻi o ka maʻi momona momona ʻole a hoʻoponopono i ka metabolism lipid hepatic ^[2].

Nā hopena i ka hana kelepona: 

Hoʻoikaika ia i ka hana mitochondrial a pale i nā pūnaewele mai ka pōʻino. No ka laʻana, i ka maʻi maʻi maʻi radiation, hoʻemi ia i ka pōʻino mitochondrial i loko o nā pūpū epithelial māmā, hoʻemi i ka apoptosis cell, a mālama i ka hana maʻamau. I loko o nā pūnaewele pancreatic, MOTS-c ka hopena i ka huna a me ka hōʻike ʻana o ka insulin a me ka glucagon, ka hoʻoponopono ʻana i ka physiology cell pancreatic, a pili pū kekahi i ka viability cellular a me ka apoptosis ^[4,5].

Nā hopena i nā ʻiʻo a me nā iwi: 

I loko o nā ʻiʻo, hoʻoikaika ʻo MOTS-c i ka hoʻokaʻawale ʻana o nā ʻiʻo progenitor cell, hoʻonui i ka hoʻokumu ʻana o ka myotube, a pale i nā ʻiʻo ʻiʻo mai ka interleukin-6 (IL-6) -induced pōʻino, hiki ke pale i ka atrophy muscle. Ma ka ʻōlelo o nā iwi, hoʻoikaika ia i ka hoʻonui ʻana, ka ʻokoʻa, a me ka mineralization o nā osteoblasts, ke kāohi nei i ka hoʻokumu ʻana o ka osteoclast, mālama i ka pale metabolic iwi, a kōkua i ka lohi ʻana i ka osteoporosis ^[1,5].

Nā hopena anti-inflammatory a me immunomodulatory: 

Hoʻemi ʻo MOTS-c i nā pane inflammatory maʻamau a hoʻoponopono i ka hana immune. I loko o nā hiʻohiʻona ʻeha inflammatory, MOTS-c e hoʻopau i ka hypersensitivity ʻeha, e hoʻemi i ka hoʻokuʻu ʻana o nā mea inflammatory, a ke kāohi i ka hoʻoulu ʻana o nā cell glial a me nā neurons, e hōʻike ana i nā hopena anti-inflammatory a me nā hōʻeha ʻeha ^[3].

Nā noi o MOTS-c

Nā hopena i nā maʻi metabolic: 

ʻO nā hopena hoʻoponopono o MOTS-c i ka glucose a me ka lipid metabolism e lilo ia i mea hoʻomaʻamaʻa hou no nā maʻi metabolic e like me ka maʻi diabetes type 2, ka momona, a me ka maʻi momona momona ʻole ^[2].

Kāohi a mālama ʻana i nā maʻi musculoskeletal: 

Hiki ke hoʻohana ʻia kona hopena maikaʻi i nā ʻiʻo a me nā iwi e pale a mālama i nā maʻi pili i ka atrophy a me nā maʻi iwi e like me ka osteoporosis. No nā poʻe maʻi me ka ʻiʻo atrophy, hiki iā ia ke hoʻomaikaʻi i ka hana o ka ʻiʻo ma o ka hoʻolaha ʻana i ka ʻokoʻa o ka ʻiʻo a me ka pale ʻana i ka apoptosis cell muscle; No nā poʻe maʻi me ka osteoporosis, hiki iā ia ke hoʻoponopono i ka pale metabolic iwi, hoʻonui i ka iwi iwi, a pale a mālama i ka osteoporosis ^[1,5].

Ka pale ʻana i ka pōʻino o ka radiation: 

Ma nā haʻawina e pili ana i ka pneumonitis radiation, ua hōʻike ʻo MOTS-c i nā hopena pale e kūʻē i ka pōʻino o ka māmā. Hiki ke hoʻohana ʻia i ka wā radiotherapy e pale i nā ʻiʻo maʻamau, e hōʻemi i ka pōʻino o ka ʻiʻo i hoʻoiho ʻia e ka radiation, a hoʻonui i ka pono o ka radiotherapy ^[2].

Ka mālama ʻana i nā maʻi ʻeha: 

Ma muli o kāna mau hopena anti-inflammatory, hiki ke hoʻohana ʻia ka MOTS-c e mālama i nā maʻi ʻeha e like me ka ʻeha ʻeha, e hāʻawi ana i nā kuhikuhi hou no ka mālama ʻana i ia mau kūlana ^[3].

Ka hopena

Ma keʻano he peptide i loaʻa i ka mitochondrial, hiki i ka MOTS-c ke ho'āla i nā ala hōʻailona e hoʻoponopono i ka glucose a me ka lipid metabolism, hoʻonui i ka insulin resistance, a ho'ēmi i ka hopena o nā maʻi maʻi; hiki iā ia ke mālama i ka hana ʻiʻo a me ka iwi, pale i ka atrophy muscle a me ka osteoporosis; a loaʻa iā ia nā hana anti-inflammatory a me nā cell-protection, e pāʻani ana i ka pale ʻana i ka pōʻino o ka radiation a me ka mālama ʻana i nā maʻi ʻeha.

No ka mea kakau

ʻO nā mea i ʻōlelo ʻia ma luna nei ua noiʻi ʻia, hoʻoponopono ʻia a hōʻuluʻulu ʻia e Cocer Peptides.

Mea kākau moʻolelo ʻepekema

Ua pili ʻo Wan, Yanmin me nā hui hanohano like ʻole, me nā halemai, nā kikowaena noiʻi, nā kulanui, a me nā ʻoihana e like me Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, etc. Ma ke kahua o Immunology Science & Technology, ʻimi ʻo ia i nā hana a me nā noi o ka ʻōnaehana pale. ʻO kāna noiʻi Virology e pili ana i nā hiʻohiʻona viral, ka lawe ʻana, a me ka pale ʻana. I loko o ke kahua o Materials Science Chemistry, ua kūpaʻa ʻo ia i ka hoʻomohala ʻana i nā waiwai waiwai a me ka hoʻohana hou ʻana o ke kemika, e hoʻolilo iā ia i mea kaulana me nā holomua noiʻi koʻikoʻi ma nā kula kula pili. Ua helu ʻia ʻo Wan, Yanmin ma ka ʻōlelo kuhikuhi [6].

▎ Nā ʻōlelo pili

[1] García-Benlloch S, Revert-Ros F, Blesa JR, et al. Hoʻoikaika ka MOTS-c i ka hoʻokaʻawale ʻana o ka ʻiʻo i loko o ka vitro [J]. Peptides, 2022,155:170840.DOI:10.1016/j.peptides.2022.170840.

[2] Zhang Y, Huang J, Zhang Y, et al. ʻO ka Mitochondrial-Derived Peptide MOTS-c Hoʻopau i ka Radiation Pneumonitis ma o ka Nrf2-Dependent Mechanism[J]. Nā Antioxidants, 2024,13.

[3] Wang Z, Yang L, Xu L, a me al. ʻO ke kikowaena a me ke kikowaena o MOTS-c e hoʻemi i ka hypersensitivity ʻeha i kahi ʻano ʻiole o ka ʻeha ʻeha [J]. ʻImi Neurological, 2024,46(2):165-177.DOI:10.1080/01616412.2023.2258584.

[4] Bień J, Pruszyńska-Oszmałek E, Kołodziejski P, et al. Hoʻoponopono ʻo MOTS-c i ka alpha pancreatic a me ka hana beta cell in vitro [J]. Histochemistry and Cell Biology, 2024,161(6):449-460.DOI:10.1007/s00418-024-02274-0.

[5] Yi X, Hu G, Yang Y, a me al. Ke kuleana o MOTS-c i ka hoʻoponopono ʻana i ka metabolism iwi [J]. Frontiers in Physiology, 2023,14:1149120.DOI:10.3389/fphys.2023.1149120.

[6] Wan W, Zhang L, Lin Y, a me al. ʻO ka peptide i loaʻa i ka mitochondria MOTS-c: nā hopena a me nā hana e pili ana i ke kaumaha, ka metabolism a me ka ʻelemakule [J]. Journal of Translational Medicine, 2023,21(1):36.DOI:10.1186/s12967-023-03885-2.

ʻO nā ʻatikala a me nā ʻike huahana i hāʻawi ʻia ma kēia pūnaewele pūnaewele wale nō no ka hoʻolaha ʻana i ka ʻike a me nā kumu hoʻonaʻauao.  

ʻO nā huahana i hāʻawi ʻia ma kēia pūnaewele i manaʻo wale ʻia no ka noiʻi in vitro. Hana ʻia ka noiʻi in vitro (Latin: *i ke aniani*, ʻo ia hoʻi i ka ipu aniani) ma waho o ke kino kanaka. ʻAʻole kēia mau huahana he lāʻau lapaʻau, ʻaʻole i ʻae ʻia e ka US Food and Drug Administration (FDA), a ʻaʻole pono e hoʻohana ʻia no ka pale ʻana, mālama, a hoʻōla paha i kekahi maʻi olakino, maʻi, a maʻi paha. Ua pāpā loa ʻia e ke kānāwai ke hoʻokomo i kēia mau huahana i loko o ke kino kanaka a holoholona paha ma kekahi ʻano.