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1 kits (10 Vials)
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▎ Bpc 157 Tsarin
Source: PubChem |
Jeri: GEPPPGKPADDAGLV Tsarin kwayoyin halitta: C 62H 98N 16O22 Nauyin Kwayoyin: 1419.5g/mol Lambar CAS: 137525-51-0 Saukewa: 9941957 Synonyms: Bepecin |
▎ Bpc 157 Bincike
Menene asalin bincike na Bpc 157?
Bpc 157 peptide ne wanda ya ƙunshi amino acid 15 kuma yana cikin jerin abubuwan kariya na jiki (Bpc) wanda aka gano kuma ya keɓe daga ruwan ciki na ɗan adam. Mai zuwa shine asalin bincike mai alaƙa da Bpc 157:
Brain-Gut Axis da Bpc 157:
Haɗin gwiwar kwakwalwa-gut ya ƙunshi abubuwan haɓaka peptidergic. Daga cikin su, barga na pentadecapeptide na ciki Bpc 157 magani ne na peptidergic anti-ulcer wanda ke da lafiya kuma yana da tasiri a cikin gwajin cututtukan hanji mai kumburi kuma a halin yanzu yana fuskantar gwaji don mahara sclerosis. A dabi'a yana wanzuwa a cikin ruwan ciki na ɗan adam [1] . Bpc 157 na iya aiki a matsayin sabon mai shiga tsakani na kariyar tantanin halitta Robert, yana shiga cikin kiyaye mutuncin mucosa na ciki ba tare da sakamako mai guba ba.
Ya samu nasara wajen magance cututtuka na gastrointestinal, periodontitis, hanta da raunuka na pancreatic, da kuma warkar da kyallen takarda da raunuka daban-daban. Har ila yau, yana ƙarfafa tsarin Egr-1, NAB2, FAK-paxillin, da JAK-2 hanyoyi [1] .Lokacin da aka gudanar da Bpc 157 a gefe, ana lura da tasirin tsakiya masu dacewa da farko, musamman canje-canje a cikin sakin serotonin a wasu sassan kwakwalwa (mafi yawancin yankin nigrostriatal). Bpc 157 yana daidaita tsarin tsarin serotonergic da dopaminergic, yana da tasiri mai amfani akan cututtuka daban-daban waɗanda ke faruwa saboda ƙayyadaddun haɓakawa / lalata tsarin neurotransmitter.
Bugu da ƙari, Bpc 157 yana da tasirin neuroprotective, irin su kare ƙananan ƙwayoyin cuta na somatosensory, inganta haɓakar jijiya na gefe, magance tsarin ci gaba bayan rauni na kwakwalwar kwakwalwa, hana axonal da neuronal necrosis, demyelination, da cyst samuwar a cikin berayen tare da kashin baya tare da matsawa na caudal caudal, da kuma sake dawo da aiki [1] .
Matsayin da ke cikin Kariyar Kwayoyin Gastric da Kariyar Gaba:
Bpc 157 yana da mahimmanci a matsayin mai yiwuwa mai shiga tsakani na Robert's gastric cell kariyar kariya / kariyar kwayoyin halitta da kariya ga kwayoyin halitta, da kuma sabon mai shiga tsakani na Selye's danniya. Bpc 157 yana kare ƙwayoyin ciki kuma yana kiyaye mutuncin ciki daga abubuwa masu cutarwa daban-daban.
Zai iya hana mummunan tasirin barasa da magungunan anti-inflammatory marasa steroidal akan epithelium na ciki da sauran epithelia (kamar fata, hanta, pancreas, zuciya, da kwakwalwa), kuma yana da aikace-aikace masu yuwuwa don warkar da rauni. Bugu da ƙari, Bpc 157 kuma zai iya magance lalacewar endothelial na ciki, kare sauran endothelia na jijiyoyin jini, yana da tasiri mai kyau a kan jini, da sauri sake gina mutuncin jini, da kuma magance cachexia tumor, zubar da tsoka, da kuma ƙara yawan cytokines pro-inflammatory / cachectic [2] .
Matsayin Therapeutic a cikin Occlusion na jijiyoyin jini:
A cikin binciken babban jijiya na mesenteric da jijiyoyin jijiya a cikin berayen, Bpc 157 na iya hanzarta kunna hanyoyin haɗin gwiwa, gami da mafi girman jijiya-ƙananan jijiya ta gaba-babban jijiya ta pancreaticoduodenal vein-pyloric vein-portal vein hanya a madadin hanyar jijiyoyin jijiya ta tsakiya, da madadin hanyoyin jijiyoyin jijiya. jijiyar mesenteric na kasa, da kuma na baya na gaba na pancreaticoduodenal artery da ƙananan jijiyar mesenteric.
Bpc 157 na iya magance m sagittal sinus, portal vein, da ƙananan vena cava hauhawar jini, aortic hypotension, ci gaba venous da arterial thrombosis a cikin gefe da tsakiya yankunan, rage Multi-gabobin raunuka, raunuka a cikin zuciya, huhu, hanta, kodan, gastrointestinal fili, musamman a cikin oxidative danniya ..
Matsayin da ke cikin Budd-Chiari Syndrome: A cikin binciken samfurin cutar Budd-Chiari (haɓaka na suprahepatic vena cava) a cikin berayen, Bpc 157 na iya hanzarta samar da hanyoyin wucewa na ƙananan vena cava-azygos vein (hemiazygos vein) - mafi girma vena cava, da kuma cava vein cava cava. hauhawar jini, aortic hypotension, da rage thrombosis, electrocardiogram cuta, da raunuka a cikin hanta da gastrointestinal fili. A lokacin ligation, matakan nitric oxide da malondialdehyde a cikin hanta suna kasancewa a cikin kewayon ƙimar lafiya ta al'ada, kuma haɓakar enzymes na jini shima yana raguwa [4].
Rawar Rawar Jiyya a cikin COVID-19:
COVID-19 ana ɗaukarsa azaman cututtukan thrombotic da jijiyoyi waɗanda galibi ke yin niyya ga sel na endothelial, wanda zai iya haifar da tabarbarewar jijiyoyin jini na tsakiya, yana haifar da rikitarwa da gazawar gabobin jiki da yawa. Bpc 157 peptide ne wanda ke da anti-mai kumburi, cytoprotective, da kuma endothelial kariya kariya a cikin daban-daban gabobin tsarin na daban-daban jinsunan. Zai iya kunna endothelial nitric oxide synthase, wanda ke da alaƙa da sakin nitric oxide, gyaran nama, da kaddarorin ka'idoji na jijiyoyin jini, inganta haɓakar ƙwayoyin cuta da amsawar rigakafi, rage yanayin pro-mai kumburi, da rage tsananin cutar. Don haka, yana da mahimmanci a tattauna yuwuwar sa azaman hanyar rigakafi da ƙarin magani [5] (Deek SA, 2022).
Menene takamaiman tsarin aikin Bpc 157 a cikin axis-gut axis?
Kwakwal-gut axis wani hadadden tsarin sadarwa ne na hanyar sadarwa guda biyu wanda ya shafi hulɗar da ke tsakanin tsarin juyayi da gastrointestinal tract, kuma Bpc 157 yana taka muhimmiyar rawa a ciki, musamman a cikin bangarori uku: Na farko, a matsayin mai shiga tsakani na cytoprotective, Bpc 157 na iya shiga cikin kiyaye mutuncin mucosa na ciki. A matsayin sabon mai shiga tsakani na kariyar kwayar halitta ta Robert ba tare da sakamako mai guba ba, yana kula da aikin al'ada na al'ada na tsarin gastrointestinal ta hanyar kare kwayoyin gastrointestinal, ta haka yana rinjayar ma'auni na kwakwalwa-gut axis. Na biyu, yana daidaita tsarin neurotransmitter. Bpc 157 na iya tsara tsarin serotonergic da dopaminergic. Lokacin da ake gudanar da Bpc 157 a gefe, sakin serotonin a cikin takamaiman sassan kwakwalwa (yawancin yankin nigrostriatal) zai canza, yana haifar da tasirin tsakiya masu fa'ida. Bugu da ƙari, yana iya yin tasiri mai amfani ga cututtuka daban-daban waɗanda ke faruwa saboda ƙayyadaddun ƙarfafawa / lalacewa na tsarin neurotransmitter. Misali, yana daidaita tsarin serotonergic da tsarin dopaminergic don haɓaka matsalolin ɗabi'a waɗanda ke haifar da ƙarancin tsarin neurotransmitter. Na uku, yana da tasirin neuroprotective. Bpc 157 na iya kare ƙananan ƙwayoyin cuta na somatosensory, inganta rayuwar neuron da dawo da aiki idan akwai raunin jijiya, inganta farfadowa na jijiyoyi, da mayar da aikin tafiyar da jijiya, rage raunin kwakwalwa. Misali, idan aka yi la’akari da matsewar kashin baya a cikin berayen tare da gurguwar caudal, axonal da neuronal necrosis, demyelination, da samuwar cyst, Bpc 157 na iya ceton aikin caudal kuma ya rage lalacewar gabobin kamar tsarin jijiya da gastrointestinal da ke haifar da wuce gona da iri na miyagun ƙwayoyi ko encephalopathy, yana kare ayyukan yau da kullun na jiki [1].
Menene takamaiman tsarin Bpc 157 a cikin magance cututtuka na tsarin juyayi na tsakiya?
Bpc 157 ya nuna hanyoyin da za a iya amfani da su wajen magance cututtuka na tsarin juyayi na tsakiya. A cikin samfurin bugun jini na ischemic na cerebral, Bpc 157 yadda ya kamata yana magance bugun jini wanda ya haifar da bugun jini na carotid na yau da kullun ta hanyar karewa neurons da goyan bayan takamaiman magana. Zai iya magance ci gaba da lalacewa ga ƙananan ƙwayoyin kwakwalwa a cikin berayen, yayin da inganta ƙwaƙwalwar ƙwaƙwalwa, motsi, da iyawar daidaitawa. Yana da tasirin kariyar kai tsaye akan lalacewar neuronal da ke haifar da bugun jini na ischemic kuma yana goyan bayan bayyanar takamaiman kwayoyin halitta a cikin nama na hippocampal. Yana iya inganta rayuwa da dawo da aikin neurons ta hanyar daidaita maganganun takamaiman kwayoyin halitta [6] .
Misalan hanyoyin gudanarwa masu nasara don isar da BPC 157; duk hanyoyi, na gida da na tsari, an ba da rahoton samun sakamako mai kyau na warkarwa
Source:PubMed [7]
Don schizophrenia, Bpc 157 yana daidaita alaƙar da ke tsakanin tsarin nitric oxide da tsarin dopamine kuma yana magance ɓarna iri-iri na tsarin dopamine, ta haka inganta alamun schizophrenia. Yana iya magance hadaddun dangantaka tsakanin tsarin nitric oxide da amphetamine, apomorphine, MK-801, da kuma tsarin methylphenidate na yau da kullum, yana nuna cewa zai iya inganta bayyanar cututtuka na schizophrenia ta hanyar daidaita ayyukan tsarin nitric oxide da tsarin dopamine. Har ila yau, yana iya magance cututtuka daban-daban na tsarin dopamine, ciki har da toshewar mai karɓa na dopamine, haɓakar haɓakar haɓakar mai karɓa, kunnawa mai karɓa, sakin wuce haddi, lalacewar nigrostriatal, da raguwar vesicular, da dai sauransu . .
Bugu da ƙari, a matsayin sabon nau'in mai shiga tsakani na cytoprotective, Bpc 157 yana daidaita tsarin tsarin serotonergic da dopaminergic, yana da tasiri mai amfani akan cututtuka na dabi'a, kuma ta hanyar tasirin neuroprotective, yana kare ƙananan ƙwayoyin cuta na somatosensory, yana inganta farfadowa na jijiyoyi na gefe, yana hana ci gaba da raunin kwakwalwa mai rauni, da kuma mayar da aikin caudal. Yana iya aiki a matsayin sabon nau'in mai shiga tsakani na cytoprotective, shiga cikin kiyaye mutuncin mucosa na ciki, kuma yana da tasirin warkewa a kaikaice akan cututtuka na tsarin juyayi na tsakiya. Hakanan yana iya daidaita tsarin tsarin serotonergic da dopaminergic, yana da tasiri mai amfani akan rikice-rikicen halaye daban-daban waɗanda ke faruwa saboda ƙayyadaddun ƙayyadaddun haɓakawa / lalacewa na tsarin neurotransmitter, kuma a lokaci guda suna da tasirin neuroprotective, irin su kare jijiyoyi na somatosensory, haɓaka haɓakar jijiya na jijiyoyin jiki, da hana ci gaba da rauni na jijiyoyi. demyelination, da kuma samuwar cyst a cikin berayen tare da matsawa kashin baya, da maido da aikin caudal [1] .
Menene Nazarin da ke da alaƙa da Bpc 157?
A matsayin Jiyya mai yuwuwar COVID-19:
A ƙarshen 2019, cutar coronavirus 2019 (COVID-19) ta haifar da babbar annoba a duniya. Bincike ya nuna cewa COVID-19 galibi cuta ce ta thrombotic da jijiyoyi da ke niyya ga sel endothelial na tsarin, wanda zai iya haifar da rushewar aikin jijiya ta tsakiya [5] . Marasa lafiya tare da COVID-19 na iya haifar da gazawar gabobin jiki da yawa kamar matsanancin ciwon numfashi na numfashi, rikicewar zuciya, raunin hanta, da raunin jijiya. Dangane da bayanan samfurin dabba, masu bincike sun tattauna rawar Bpc 157 a matsayin sabon magani don haɓaka kulawar asibiti na COVID-19. Bpc 157 peptide ne wanda ke nuna anti-mai kumburi, cytoprotective, da kuma endothelial kariya kariya a cikin daban-daban gabobin tsarin na daban-daban jinsunan. Bpc 157 yana kunna endothelial nitric oxide synthase (eNOS), wanda ke da alaƙa da sakin nitric oxide (NO), gyaran gyare-gyaren nama, da kaddarorin ka'idoji na jijiyoyin jini, kuma zai iya inganta daidaituwar jijiyoyin jini da amsawar rigakafi, rage yanayin pro-mai kumburi, da rage tsananin cutar. Sabili da haka, yana da matukar mahimmanci don tattauna yiwuwarsa a matsayin hanyar rigakafin rigakafi da magani.
Gaggauta Warkar da Tushen Nama mai laushi:
An gudanar da bita a kan rawar da Bpc 157 ke yi a cikin maganin raunuka masu laushi [7] . Duk da haka, har zuwa yau, yawancin binciken da aka gudanar a kan ƙananan nau'in rodents, kuma ba a tabbatar da ingancin Bpc 157 a cikin mutane ba. Duk da haka, Bpc 157 a fili yana da babbar dama kuma ana sa ran ya zama hanyar magani don maganin ra'ayin mazan jiya na ƙananan ƙwayoyin cuta da ƙananan ƙwayoyin cuta (irin su tendons da ligaments) raunin da ya faru ko kuma a matsayin mai ba da shawara don sake dawowa bayan ci gaba. Bugu da ƙari, ƙirar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta nuna cewa Bpc 157 ba kawai yana da tasiri mai tasiri akan raunin da ya faru ta hanyar raunin da ya faru ba amma har ma a kan raunin tsarin ciki har da hyperkalemia da hypermagnesemia.
Inganta Ayyukan Mota Bayan Rauni na Kashin Kashin Kaya:
Masu bincike sun yi amfani da samfurin bera da aka tsara don nuna cewa barga na pentadecapeptide Bpc 157 na iya inganta raunin kashin baya [8] . Nazarin da suka gabata sun nuna cewa Bpc 157 na iya magance sakamakon na gefe (sciatic jijiya) transection jijiya / anastomosis da inganta jijiya waraka, kwakwalwa rauni, da kuma daban-daban encephalopathies. An yi amfani da Bpc 157 azaman peptide anti-ulcer a cikin gwajin cututtukan hanji mai kumburi da gwajin sclerosis da yawa. A cikin binciken daya, berayen sun sami allurar intraperitoneal guda ɗaya na Bpc 157 (200 ko 2μg / kg) ko saline na al'ada (5ml / kg) bayan rauni na kashin baya. Duk berayen da suka ji rauni sun nuna ci gaba da ci gaba bayan jiyya na Bpc 157, tare da ingantaccen aikin motsa jiki na wutsiya na asibiti kuma babu halin katse kai; an warware matsalar spasm a rana ta 15; a karkashin na'urar microscope (farawa daga ranar 7th), vacuoles da asarar axonal a cikin fararen kwayoyin halitta, edema a cikin launin toka, da kuma asarar ƙwayoyin mota a cikin berayen Bpc 157, da kuma raguwar adadin manyan myelinated axon a cikin jijiyar caudal na bera, sun fi mayar da hankali. Rikodi na Electromyogram ya nuna raguwa mai yawa a cikin ƙarfin juzu'in motsi a cikin tsokoki na wutsiya. Bugu da kari, masu binciken sun kuma gudanar da wani gwaji. An gudanar da Bpc 157 kwanaki 4 bayan raunin kashin baya, kuma an ba da Bpc 157 (10μg / kg, 0.16μg / mL, 12ml / rat / day) ta hanyar ruwan sha don makonni 4, yayin da ƙungiyar kulawa ta sami ruwan sha kawai. Sakamakon ya nuna cewa berayen da aka bi da su tare da Bpc 157 sun nuna babban ci gaba kuma sun ci gaba da murmurewa har sai sun warke.
Magance Rashin Kwanciyar Hankali:
Don haifar da rashin zaman lafiya na kashin baya a cikin berayen, masu bincike sun mayar da hankali kan facetectomy na biyu kuma sun bincika yiwuwar maganin warkewa na barga na pentadecapeptide Bpc 157 a cikin ruwan sha [9] . A cikin wannan binciken, berayen sun sami cikakkiyar fuskar fuska ta L3-L4, kuma bayan aikin, an ba su Bpc 157 (10ng/kg, 0.16ng/mL, 12ml/rat/ day) ko ruwan sha kawai. An gudanar da kimantawa na rediyo a mako na 1 da mako 8. Sakamakon ya nuna cewa a mako na 1, ba a sami nakasu a fili a cikin berayen na ƙungiyar kulawa da ƙungiyar Bpc 157 a cikin kowane jirgin sama, sararin diski na intervertebral ya yi kama da ba shi da tasiri, ƙananan ƙwayoyin jijiyoyi a matakin aikin tiyata sun dan kara fadada, kuma berayen a cikin rukunin Bpc 15. A mako na 8, babu wata nakasar da aka gani a cikin berayen kungiyoyin biyu a cikin kowane jirgin sama, sararin diski na intervertebral ba shi da tasiri, jijiyar jijiyoyi a matakin aikin tiyata ya dan kara fadada, berayen da ke cikin kungiyar Bpc 157 suna da girman girman kashi, kuma akwai rashin yawan adadin kira a cikin tsarin bazuwar da ake gani a cikin rukunin kulawa. Bugu da ƙari, berayen da ke cikin ƙungiyar kulawa sun nuna rashin lafiyar mota a fili nan da nan bayan shigar da rauni, yayin da berayen a cikin ƙungiyar shan giya na Bpc 157 gaba ɗaya sun magance wannan rashin lafiyar motar.
A ƙarshe, ainihin ƙimar Bpc 157 ya ta'allaka ne a cikin halayensa na endogenous da tsarin tsari da yawa, yana ba da sabbin hanyoyin magance kumburin kumburi, lahani na nama, da cututtukan neuropsychiatric. A cikin fagen fama da raunin wasanni, zai iya hanzarta gyare-gyare da sake farfadowa na kyallen takarda irin su tsokoki, tendons, da ligaments, rage lokacin dawowa, kuma yana da tasiri mai kyau a kan mummunan rauni. A cikin maganin konewa, Bpc 157 na iya haɓaka ayyukan ilimin halitta na ƙwayoyin endothelial kamar haɓakawa, ƙaura, da samuwar tubule, don haka yana hanzarta gyara raunukan ƙonewa. Bugu da ƙari, yana da tasiri mai kariya ga gastrointestinal tract, zai iya inganta warkar da ciwon ciki, da kuma rigakafi da kuma rage cututtuka na ciki. Bpc 157 kuma yana nuna yuwuwar a cikin neuroprotection, kare tsarin jin tsoro ta hanyar hanyoyin da suka shafi rage kumburi da hana apoptosis. Hakanan yana da tasirin kariya akan gabobin ɗan adam kamar su pancreas, hanta, da zuciya, yana nuna fa'idodin tasirin ilimin halitta azaman peptide multifunctional.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Predrag Sikiricis masani mai alaƙa da cibiyoyin ilimi da yawa, gami da Jami'ar Zagreb, Jami'ar Sarajevo, Sch Med, Jami'ar JJ Strossmayer Osijek, da Cibiyar Rudjer Boskovic. Bincikensa ya shafi fannoni da yawa kamar Pharmacology & Pharmacy, Biochemistry & Molecular Biology, Gastroenterology & Hepatology, Physiology, da Cell Biology.
Ƙungiyar Sikiric ta gudanar da bincike mai zurfi game da tasirin cytoprotective na BPC157 a cikin wasu gabobin jiki da kyallen takarda, ciki har da rawar da yake takawa a cikin rauni na jijiyoyi da gyambon ciki. Har ila yau, yana riƙe da haƙƙin mallaka don haɓaka BPC, wani abu mai amfani da magunguna, ciki har da hanyoyin shirye-shiryensa da aikace-aikacen warkewa.Sikiric Pis mutum ne mai daraja a cikin ilimin kimiyya, kuma bincikensa ya ci gaba da bunkasa filayen da yake da shi.
