▎ Binciken Bronchogen
Menene asalin bincike na Bronchogen?
A fannin binciken likitanci na yanzu, cututtukan numfashi sun kasance abin da ya fi daukar hankalin duniya. Bisa ga bayanan da aka ba da izini, a cikin 'yan shekarun nan, adadin cututtukan cututtuka daban-daban na numfashi kamar su cututtuka na huhu na huhu (COPD), asthma, da mashako na kullum suna karuwa kowace shekara, suna yin barazana ga lafiyar ɗan adam da ingancin rayuwa. Lokacin da ake magance waɗannan cututtuka masu rikitarwa, hanyoyin maganin gargajiya sau da yawa suna da matsaloli irin su ƙuƙumman sakamako na maganin warkewa da sakamako masu illa, yin haɓaka sabbin hanyoyin kulawa, inganci, da aminci a cikin aikin gaggawa a fannin likitanci.
A kan wannan yanayin, masu bincike sun mayar da hankali kan binciken abubuwa masu ayyuka na musamman na halitta daga albarkatun halittu daban-daban waɗanda zasu iya gyarawa da kare kyallen takarda. Sun yi amfani da ci-gaba da dabarun nazarin halittun kwayoyin halitta da manyan hanyoyin tantancewa don gudanar da bincike na yau da kullun akan adadi mai yawa na abubuwan da ke haifar da rayuwa. Bayan ƙoƙarce-ƙoƙarce na dogon lokaci, an gano Bronchogen. Yana iya samo asali daga samfuran rayuwa na takamaiman sel a cikin wasu kwayoyin halitta ko kuma ɓoye ta takamaiman kyallen takarda a ƙarƙashin yanayi na musamman na physiological, kuma yana da ikon musamman don daidaita ayyukan physiological da ke da alaƙa da bronchi, buɗe sabon jagorar bincike don kula da cututtukan numfashi da kuma yin alƙawarin zama mabuɗin don warware matsalolin da ke akwai.
Menene tsarin aikin Bronchogen?
1. Tasiri a cikin Samfuran Cutar huhu
Hana Kumburi: A cikin nau'in cututtuka na cututtuka na yau da kullum (COPD), Bronchogen yana da tasiri akan tsarin tsari da aiki na epithelium na bronchial da kuma aikin kumburi na huhu. Ta hanyar ƙirƙirar samfurin COPD a cikin berayen ta hanyar kwanakin 60 na tsaka-tsakin nitrogen dioxide, an gano cewa bayan jiyya tare da Bronchogen peptide, aikin ƙumburi na neutrophils ya ragu, kuma abun da ke cikin kwayar halitta a cikin bronchoalveolar lavage fluid (BALF) da rarraba cytokines pro-inflammatory da enzymes sun koma al'ada. Wannan yana nuna cewa Bronchogen na iya hana amsawar kumburi a cikin huhu [1, 2].
Maido da Tsarin da Aiki na Bronchial Epithelium: Lokacin da aka samar da samfurin COPD, tsarin tsarin epithelium na bronchi ya lalace, amma jiyya tare da Bronchogen ya dawo da wannan tsari, kuma an sake dawo da aikin aikinsa. Ana iya nuna wannan ta haɓakar immunoglobulin A (alamar rigakafin gida) da furotin B, wanda ke da alhakin rage tashin hankali na alveoli [1, 2]..
2. Tasiri akan Ƙarfafawar thermal na DNA
Tabbatar da Tsarin DNA: Bincike ya nuna cewa Bronchogen na iya aiki a matsayin mai daidaita DNA. A cikin takamaiman kewayon maida hankali (matsayin molar bronchogen/DNA tushe nau'i-nau'i shine 0.01 - 0.055), Bronchogen na iya ƙara yawan narkewar zafin jiki na DNA daga ɗan maraƙi thymus da hanta linzamin kwamfuta da 3.1°C [3] . Koyaya, ƙara haɓaka wannan rabo baya canza yanayin narkewa. A cikin wannan kewayon, enthalpy mai narkewa (ΔH (narke)) na hadaddun bai canza ba, kuma ΔH (narke) na DNA daga ɗan maraƙi da hanta linzamin kwamfuta shine 11.4 da 12.7 cal / g bi da bi. Wannan yana nuna cewa Bronchogen ba takamaiman adenine-thymine ba ne ko guanine-cytosine-specific ligand, kuma nau'in daurinsa yana da ƙarfi da haɗari, galibi yana ɗaure ga igiyoyin DNA guda biyu (mafi yawan tushen nitrogenous) [3]..
Menene aikace-aikacen Bronchogen?
1. Cutar sankarau na yau da kullun
Bronchogen yana taka muhimmiyar rawa wajen maganin mashako na kullum. Cutar sankara na yau da kullun cuta ce ta numfashi na yau da kullun, kuma marasa lafiya sukan gabatar da alamun bayyanar cututtuka kamar tari, tsinkaye, da dyspnea [2] . Bronchogen na iya sauƙaƙa alamun alamun marasa lafiya ta hanyar rage amsawar kumburi da rage cunkoso da edema na mucosa na bronchial. A lokaci guda kuma, yana iya inganta gyaran gyare-gyare da farfadowa na kyallen takarda, inganta haɓaka da aiki na bronchi. A lokacin dogon lokaci jiyya, da tari mita da kuma expectoration girma na marasa lafiya sannu a hankali rage, da kuma mataki na dyspnea da muhimmanci inganta.
2. Asma
A cikin kula da asma, Bronchogen ya nuna babban tasiri. Asthma cuta ce mai saurin kumburi ta hanyar iska, kuma hanyoyin iska na marasa lafiya suna da matukar damuwa ga abubuwan motsa jiki iri-iri, masu saurin kamuwa da alamu kamar bronchospasm da dyspnea. Bronchogen na iya inganta aikin hanyar iska ta hanyar rage kumburin ƙwayar cuta da rage yawan amsawar iska. Yana iya daidaita tsarin garkuwar jiki, rage kutsewar ƙwayoyin cuta masu kumburi da sakin masu shiga tsakani, ta yadda hakan ke rage alamun cutar asma. Bugu da ƙari, Bronchogen yana iya inganta lafiyar huhu da inganta aikin huhu na marasa lafiya, yana ba su damar magance kalubale daban-daban a rayuwar yau da kullum.
3. Ciwon huhu na Jiki (COPD)
Ga marasa lafiya da ke fama da cututtukan huhu, Bronchogen magani ne mai tasiri. COPD cuta ce mai ci gaba da numfashi, kuma marasa lafiya sukan gabatar da alamun bayyanar cututtuka kamar tari, tsammanin, da kuma ƙarancin numfashi. Sakamakon Bronchogen a cikin marasa lafiya na COPD sun hada da inganta gyaran nama, inganta aikin ƙwayar cuta, da rage kumburi. Yana iya tada sake farfadowa na sel epithelial na bronchial, gyara gurɓataccen kyallen takarda, da kuma inganta patency na bronchi. A lokaci guda kuma, Bronchogen na iya rage yawan amsawar ƙwayar cuta, rage lalacewar ƙwayar cuta a cikin huhu, da jinkirta ci gaban cutar. Ta hanyar waɗannan tasirin, Bronchogen na iya inganta yanayin rayuwar marasa lafiya, rage yawan matsanancin tashin hankali, da kuma tsawaita lokacin rayuwa na marasa lafiya.
4. Farfadowa bayan Mugunyar Cutar Cutar Numfashi
Bayan m cututtuka na numfashi (kamar ciwon huhu), za a iya amfani da Bronchogen don tallafawa dawo da marasa lafiya. Mummunan cututtuka na numfashi na iya haifar da mummunar lalacewa ga kyallen takarda da na huhu, yana shafar aikin numfashi na marasa lafiya. Bronchogen na iya hanzarta gyaran gyare-gyaren kyallen takarda, inganta haɓakar ƙwayoyin da suka lalace, da kuma mayar da tsarin al'ada da aikin bronchi [4] . Hakanan zai iya inganta aikin numfashi, haɓaka ikon musayar iskar gas na huhu, da rage haɗarin lalacewa na dogon lokaci. Bayan amfani da Bronchogen, marasa lafiya suna yin numfashi da sauƙi, suna sake samun ƙarfin su a hankali, kuma suna iya komawa rayuwa ta al'ada kuma suyi aiki da sauri.
5. Kariya ga Ayyukan Huhu a cikin masu shan taba
Ga masu shan taba ko mutanen da suka kamu da gurɓataccen muhalli, Bronchogen yana taimakawa wajen kariya da gyara mashako. Shan taba da gurbatar muhalli na iya haifar da mummunar illa ga tsarin numfashi da kuma kara haɗarin cututtukan huhu na yau da kullun. Bronchogen na iya rage lalacewar abubuwa masu cutarwa ga ƙwayoyin cuta da na huhu da kuma inganta gyare-gyare da farfadowa na bronchi [5] . Zai iya haɓaka aikin kariya na bronchi, rage amsawar kumburi, da rage abin da ya faru na cututtukan huhu. Bugu da kari, Bronchogen kuma na iya inganta aikin huhu, inganta yanayin numfashi na masu shan taba, da rage saurin ci gaban cututtukan huhu.
6. Matsayin Taimako a cikin cikakkiyar Jiyya
Bronchogen za a iya amfani dashi azaman adjuvant ga maganin gargajiya don haɓaka tasirin warkewa. A cikin maganin cututtuka irin su ciwon tari, hada Bronchogen tare da hanyoyin maganin gargajiya na iya inganta tasirin warkewa gaba ɗaya.
Bronchogen yana da amfani ga ƙungiyoyin mutane masu zuwa:
A ƙarshe, Bronchogen yana nuna muhimmiyar ƙima a fagen ilimin rayuwa. Zai iya daidaita tsarin DNA, yana ba da sabon jagora don nazarin hanyoyin da ke da alaƙa da DNA. A cikin maganin cututtuka na numfashi, don yanayi irin su mashako na yau da kullum, fuka, da COPD, yana iya rage kumburi yadda ya kamata, inganta gyaran nama, inganta yanayin numfashi na marasa lafiya, sauƙaƙa alamun bayyanar cututtuka, da inganta yanayin rayuwa, wanda ke da mahimmanci ga rigakafi da maganin cututtuka na numfashi.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Caswell SJ fitaccen mai bincike ne wanda ke da alaƙa da manyan cibiyoyi da yawa, ciki har da AstraZeneca, Cibiyar Francis Crick, TDHB, Jami'ar British Columbia, da ALVANLEY CLIN. Bincikensa ya ƙunshi fagage iri-iri, yana nuna gwanintarsa a tsakani. A cikin Biochemistry & Molecular Biology, ya ba da gudummawa don haɓaka fahimtar hanyoyin salula da hulɗar kwayoyin halitta. Ayyukansa a cikin Gabaɗaya & Magungunan Ciki yana da tasiri don inganta kulawar haƙuri da ka'idojin kulawa.
A cikin fannin ilimin ƙwayoyin cuta, Caswell SJ ya binciko hanyoyin kamuwa da cuta da kuma hulɗar mai masaukin baki, wanda ke da mahimmanci don haɓaka dabarun rigakafin cutar. Shigarsa a Kimiyya da Fasaha - Wasu Maudu'ai suna nuna haɗin kai tare da sabbin dabaru da fasahohin da suka wuce iyakokin kimiyyar gargajiya. Bugu da ƙari, binciken da ya yi a Parasitology ya ba da haske game da cututtuka na parasit da tasirin su ga lafiyar jama'a. Ta hanyar bincikensa da yawa, Caswell SJ ya ba da gudummawa mai mahimmanci ga al'ummar kimiyya, yana tasiri duka ci gaban ka'idoji da aikace-aikace masu amfani a magani da ilmin halitta. An jera Caswell SJ a cikin ambaton ambaton [4].
