1kits (Ebipipa 10) .
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▎ Bronchogen kye ki?
Bronchogen ye peptide bioregulator erimu amino acids nnya (Ala-Glu-Asp-Leu, AEDL), okusinga ekozesebwa okuwagira n’okuzzaawo emirimu gy’enkola y’okussa naddala ebitundu by’ennyindo n’amawuggwe.
▎ Okunoonyereza ku Bronchogen
Bronchogen y’egenda mu maaso n’okunoonyereza?
Mu kunoonyereza ku by’obusawo okuliwo kati, endwadde z’okussa bulijjo zibadde zitunuulirwa nnyo mu nsi yonna. Okusinziira ku biwandiiko ebirina obuyinza, mu myaka egiyise, emiwendo gy’endwadde ez’enjawulo ez’okussa nga obulwadde bw’amawuggwe obutawona (COPD), asima, n’obulwadde bw’amawuggwe obutawona gibadde gyeyongera buli mwaka, nga giteeka mu matigga ennyo obulamu bw’abantu n’omutindo gw’obulamu. Nga tukola ku ndwadde zino enzibu, enkola z’obujjanjabi ez’ekinnansi zitera okuba n’ebizibu ng’obuzibu bw’okuwonya n’ebizibu ebivaamu, ekifuula okukola enkola empya ez’obujjanjabi, ezikola obulungi, era ezitali za bulabe omulimu ogw’amangu mu kisaawe ky’obusawo.
Mu mbeera eno, abanoonyereza essira balitadde ku kunoonyereza ku bintu ebirina emirimu egy’enjawulo egy’ebiramu okuva mu by’obugagga eby’enjawulo ebisobola okuddaabiriza n’okukuuma ebitundu by’ennyindo. Bakozesezza obukodyo obw’omulembe obw’ebiramu mu molekyu n’enkola z’okukebera mu ngeri ey’amaanyi okukola okunoonyereza okutegekeddwa ku bitundu ebingi ebikola ebiramu. Oluvannyuma lw’okufuba okumala ebbanga eddene nga tasalako, Bronchogen yazuulibwa. Kiyinza okuva mu biva mu nkyukakyuka y’emmere y’obutoffaali obw’enjawulo mu biramu ebimu oba okufulumizibwa ebitundu ebitongole mu mbeera ez’enjawulo ez’omubiri, era kirina obusobozi obw’enjawulo okulung’amya emirimu gy’omubiri egyekuusa ku nnyindo, okuggulawo obulagirizi obupya obw’okunoonyereza ku kujjanjaba endwadde z’okussa era nga kisuubiza okuba ekisumuluzo ky’okumenya ebizibu by’obujjanjabi ebiriwo.
Enkola ya Bronchogen ekola ki?
1. Ebikosa mu bikolwa by’endwadde z’amawuggwe
Okuziyiza okuzimba: Mu nkola y’obulwadde bw’amawuggwe obutawona (COPD), Bronchogen erina ky’ekola ku nsengeka n’enkola y’ekikuta ky’amawuggwe n’emirimu gy’okuzimba amawuggwe. Nga tukola ekifaananyi kya COPD mu nvunza nga bayita mu nnaku 60 ez’okukwatibwa nayitrojeni dayokisayidi mu biseera ebitali bimu, kyazuulibwa nti oluvannyuma lw’okujjanjabwa n’ekirungo kya Bronchogen peptide, emirimu gy’okuzimba egya neutrophils gyakendeera, era ebitonde by’obutoffaali mu mazzi agalongoosebwa mu nnyindo (BALF) n’okusaasaana kwa cytokines ne enzymes eziyamba okuzimba ne bidda mu mbeera eya bulijjo. Kino kiraga nti Bronchogen esobola okuziyiza okuddamu kw’okuzimba mu mawuggwe [1, 2]..
Okuzzaawo Enzimba n’Emirimu gy’Ensimbi: Mu kutondebwawo kw’ekyokulabirako kya COPD, ensengekera y’ekisenge ky’ennyindo yayonooneka, naye obujjanjabi ne Bronchogen bwazzaawo ensengekera eno, era n’emirimu gyayo egy’emirimu gyaddamu. Kino kiyinza okulagibwa olw’okweyongera kwa secretory immunoglobulin A (a local immune marker) ne surfactant protein B, evunaanyizibwa ku kukendeeza ku kunyigirizibwa okw’okungulu kw’ennywanto [1, 2]..
2. Ebikosa okutebenkera kw’ebbugumu lya DNA
Okutebenkeza Ensengekera ya DNA: Okunoonyereza kulaga nti Bronchogen esobola okukola nga ekinyweza DNA. Mu bbanga erigere ery’obungi (omugerageranyo gw’amagulu ga bronchogen/DNA base pairs guli 0.01 - 0.055), Bronchogen esobola okwongera ku bbugumu ly’okusaanuuka kwa DNA okuva mu thymus y’ennyana n’ekibumba ky’ebibe ne 3.1°C [3] . Naye okwongera okwongera ku mugerageranyo guno tekikyusa bbugumu lya kusaanuuka. Mu bbanga lino, entalpi y’okusaanuuka (ΔH (okusaanuuka)) y’ekizibu esigala nga tekyuse, ate ΔH (okusaanuuka) kwa DNA okuva mu thymus y’ennyana n’ekibumba ky’ebibe eri 11.4 ne 12.7 cal/g. Kino kiraga nti Bronchogen si ligand ya adenine-thymine-specific oba guanine-cytosine, era ekika ky’okusiba kwayo kwesiba kwa maanyi era mu butanwa, okusinga okusiba ku miguwa ebbiri egya DNA (okusinga bases za nayitrojeni) [3]..
Ebikozesebwa bya Bronchogen bye biruwa?
1. Obulwadde bwa Bronchitis obutawona
Bronchogen ekola kinene mu kujjanjaba obulwadde bwa bronchitis obutawona. Obulwadde bw’okussa obutawona bulwadde bwa bulijjo mu kussa, era abalwadde batera okweyanjula n’obubonero ng’okusesema, okufulumya omukka, n’okusannyalala [2] . Bronchogen esobola okumalawo obubonero bw’abalwadde ng’ekendeeza ku kuzimba n’okukendeeza ku kuzimba n’okuzimba mu bitundu by’omubiri ebiyitibwa bronchial mucosa. Mu kiseera kye kimu, era esobola okutumbula okuddaabiriza n’okuzza obuggya ebitundu by’ennyindo, okutumbula obugumu n’enkola y’ennyindo. Mu kiseera ky’obujjanjabi obw’ekiseera ekiwanvu, emirundi gy’abalwadde abasesema n’obungi bw’okufulumya amazzi mu kifuba bikendeera mpolampola, era diguli y’okusannyalala etereera nnyo.
2. Obulwadde bwa asima
Mu kuddukanya obulwadde bwa asima, Bronchogen eraga obusobozi bungi. Asima bulwadde obutawona obuzimba emikutu gy’empewo, era emikutu gy’empewo gikwata nnyo ku bintu eby’enjawulo ebizimba, nga gitera okufuna obubonero ng’okuzimba emisuwa n’okusannyalala. Bronchogen esobola okulongoosa enkola y’emikutu gy’empewo ng’ekendeeza ku kuzimba kw’ennyindo n’okukendeeza ku kuddamu okuyitiridde kw’emikutu gy’empewo. Kisobola okulung’amya abaserikale b’omubiri, okukendeeza ku kuyingira kw’obutoffaali obuzimba n’okufulumya ebitabaganya ebizimba, bwe kityo ne kikendeeza ku bubonero bw’abalwadde ba asima. Okugatta ku ekyo, Bronchogen era esobola okutumbula obulamu bw’amawuggwe n’okulongoosa enkola y’amawuggwe g’abalwadde, ne kibasobozesa okugumira obulungi okusoomoozebwa okw’enjawulo mu bulamu obwa bulijjo.
3. Obulwadde bw’amawuggwe obutawona (COPD) .
Ku balwadde abalina obulwadde bw’amawuggwe obutawona, Bronchogen bujjanjabi bulungi. COPD bulwadde bwa kussa obugenda bweyongera, era abalwadde batera okweyanjula n’obubonero ng’okusesema, okufulumya omukka, n’okussa obubi. Ebiva mu Bronchogen mu balwadde ba COPD okusinga mulimu okutumbula okuddaabiriza ebitundu by’omubiri, okulongoosa enkola y’ennyindo, n’okukendeeza ku kuzimba. Kiyinza okusitula okuddamu okuzimba obutoffaali bw’ennyindo, okuddaabiriza ebitundu by’ennyindo ebyonooneddwa, n’okulongoosa okugguka kw’ennyindo. Mu kiseera kye kimu, Bronchogen era esobola okukendeeza ku kuzimba, okukendeeza ku kwonooneka kw’okuzimba mu mawuggwe, n’okulwawo okukula kw’obulwadde. Okuyita mu bikolwa bino, Bronchogen esobola okulongoosa omutindo gw’obulamu bw’abalwadde, okukendeeza ku muwendo gw’okusajjuka okw’amangu, n’okwongera ku bbanga ly’abalwadde abawangaala.
4. Okuwona oluvannyuma lw’obulwadde bw’okussa obw’amangu
Oluvannyuma lw’obulwadde bw’okussa obw’amangu (nga ekifuba), Bronchogen esobola okukozesebwa okuwagira okuwona kw’abalwadde. Yinfekisoni z’okussa ez’amaanyi ziyinza okuleeta okwonooneka okw’amaanyi mu bitundu by’ennyindo n’amawuggwe, ne zikosa enkola y’okussa kw’abalwadde. Bronchogen esobola okwanguya okuddaabiriza ebitundu by’ennyindo, okutumbula okuddamu okukola obutoffaali obwonooneddwa, n’okuzzaawo ensengekera n’enkola ya bulijjo ey’ennyindo [4] . Era esobola okulongoosa enkola y’okussa, okutumbula obusobozi bw’amawuggwe okuwanyisiganya ggaasi, n’okukendeeza ku bulabe bw’okwonooneka okumala ebbanga eddene. Oluvannyuma lw’okukozesa Bronchogen, abalwadde bassa bulungi, baddamu amaanyi mpolampola, era basobola okudda mu bulamu obwa bulijjo ne bakola amangu.
5. Okukuuma Enkola y’Amawuggwe mu Banywa sigala
Ku banywa sigala oba abantu abakwatibwa obucaafu bw’obutonde, Bronchogen eyamba okukuuma n’okuddaabiriza enseke. Okunywa sigala n’obucaafu bw’obutonde bisobola okwonoona ennyo enkola y’okussa n’okwongera ku bulabe bw’endwadde z’amawuggwe ezitawona. Bronchogen esobola okukendeeza ku kwonooneka kw’ebintu eby’obulabe eri ebitundu by’ennyindo n’amawuggwe n’okutumbula okuddaabiriza n’okuddamu okukola kw’ennyindo [5] . Kiyinza okutumbula enkola y’okwekuuma kw’ennyindo, okukendeeza ku kuzimba, n’okukendeeza ku kubeerawo kw’endwadde z’amawuggwe. Okugatta ku ekyo, Bronchogen era esobola okulongoosa enkola y’amawuggwe, okutumbula omutindo gw’okussa kw’abanywa sigala, n’okukendeeza ku nkula y’endwadde z’amawuggwe ezitawona.
6. Omulimu gw’obuyambi mu bujjanjabi obujjuvu
Bronchogen esobola okukozesebwa ng’ekiyamba ku bujjanjabi obw’ekinnansi okutumbula obujjanjabi. Mu kujjanjaba endwadde ng’okusesema, okugatta Bronchogen n’enkola z’obujjanjabi ez’ekinnansi kiyinza okulongoosa okutwalira awamu eddagala eriwonya.
Bronchogen wa mugaso eri ebibinja by’abantu bino wammanga:
Mu kumaliriza, Bronchogen alaga omugaso omukulu mu kisaawe kya ssaayansi w’obulamu. Kisobola okutebenkeza ensengekera ya DNA, ne kiwa obulagirizi obupya obw’okunoonyereza ku nkola ezikwata ku DNA. Mu kujjanjaba endwadde z’okussa, ku mbeera nga obulwadde bw’okussa obutawona, asima, ne COPD, esobola bulungi okukendeeza ku buzimba, okutumbula okuddaabiriza ebitundu by’omubiri, okulongoosa ennyo embeera y’okussa kw’abalwadde, okumalawo obubonero, n’okutumbula omutindo gw’obulamu, ekintu eky’amakulu amangi mu kuziyiza n’okujjanjaba endwadde z’okussa.
Ebikwata ku Muwandiisi
Ebintu ebyogeddwako waggulu byonna binoonyerezeddwako, birongooseddwa era ne bikung’aanyizibwa kkampuni ya Cocer Peptides.
Omuwandiisi wa Scientific Journal
Caswell SJ munoonyereza wa kitiibwa alina akakwate n’ebitongole ebiwerako ebimanyiddwa, omuli AstraZeneca, Francis Crick Institute, TDHB, University of British Columbia, ne ALVANLEY CLIN. Okunoonyereza kwe kukwata ku bintu bingi, nga kino kiraga obukugu bwe mu by’emikono. Mu Biochemistry & Molecular Biology, akoze kinene mu kutumbula okutegeera enkola z’obutoffaali n’enkolagana ya molekyu. Omulimu gwe mu General & Internal Medicine gulina kye gukola ku kulongoosa enkola y’okulabirira abalwadde n’obujjanjabi.
Mu kitundu kya Virology, Caswell SJ anoonyezza enkola z’akawuka n’enkolagana y’abagenyi, ekintu ekikulu ennyo mu kukola enkola z’okulwanyisa akawuka. Okwenyigira kwe mu Science & Technology - Other Topics kiraga nti yeenyigira mu nkola eziyiiya ne tekinologiya ezisukkulumye ku nsalo za ssaayansi ez’ennono. Ekirala, okunoonyereza kwe mu Parasitology kutadde ekitangaala ku ndwadde z’ebiwuka n’engeri gye zikwata ku bulamu bw’abantu. Okuyita mu kunoonyereza kwe okw’enjawulo, Caswell SJ akoze kinene mu kibiina kya ssaayansi, ng’akwata ku nkulaakulana y’enzikiriziganya n’okukozesebwa mu nkola mu busawo n’ebiramu. Caswell SJ awandiikiddwa mu kiwandiiko ekijuliziddwa [4].
▎ Ebiwandiiko Ebikwatagana
[1] Kuzubova N. A., Lebedeva E. S., Dvorakovskaya IV, n’abalala. Modulating Effect of Peptide Therapy ku Morphofunctional State of Bronchial Epithelium mu nvunza ezirina obulwadde bw’amawuggwe obuziyiza[J]. Bulletin y'okugezesa ebiramu n'obusawo, 2015, 159 (5): 685-688.DOI: 10.1007 / s10517-015-3047-x.
[2] Titova O. N., Kuzubova N. A., Lebedeva E. S., n’abalala. Antiinflammatory n’okuzza obuggya ekikolwa ky’obujjanjabi bwa peptide mu muze gw’obulwadde bw’amawuggwe obuziyiza [J]. Ross Fiziol Zh Im I. M. Sechenova, 2017,103 (2): 201-208. https://pubmed.ncbi.nlm.nih.gov/30199201/.
[3] Monaselidze JR, Khavinson VK, Gorgoshidze MZ, n’abalala. Enkola ya peptide bronchogen (Ala-Asp-Glu-Leu) ku DNA thermostability[J]. Bulletin y'okugezesa ebiramu n'obusawo, 2011,150 (3): 375-377.DOI: 10.1007 / s10517-011-1146-x.
[4] Caswell S. J., Thomson A. H., Ashmore S. P., n’abalala. okuwuliziganya okukwekeddwa eri akawuka k’okussa mu kiseera ky’obulwadde bw’amawuggwe obw’amaanyi n’okukola kw’amawuggwe oluvannyuma lw’okuwona[J]. archives of endwadde mu buto, Archives of endwadde mu buto, 1990,65 (9): 946-952.DOI: 10.1136 / adc.65.9.946.
[5] Yoshida M, Kaneko Y, Ishimatsu A, n’abalala. Ebikolwa bya tiotropium ku nkola y’amawuggwe mu banywa sigala mu kiseera kino n’abatanywa ssigala nga balina asima ow’omu nnyindo[J]. Eddagala ly’amawuggwe n’obujjanjabi, 2017,42:7-12.DOI:10.1016/j.pupt.2016.11.004.
EBINTU BYONNNA N’AMAWULIRE GW’EBINTU EBIweereddwa KU MUTINDO GUNO BIKOZESEBWA KU KUSASANYA AMAWULIRE N’EBIKOLWA BY’OKUSOMESA.
Ebintu ebiweereddwa ku mukutu guno bigendereddwamu kunoonyereza mu kisenge (in vitro research) byokka. Okunoonyereza mu vitro (Olulattini: *mu ndabirwamu*, ekitegeeza mu bikozesebwa mu ndabirwamu) kukolebwa ebweru w’omubiri gw’omuntu. Ebintu bino si bya ddagala, tebikkiriziddwa kitongole kya Amerika ekivunaanyizibwa ku by’emmere n’eddagala (FDA), era tebirina kukozesebwa kuziyiza, kujjanjaba oba kuwonya mbeera yonna ya bujjanjabi, bulwadde oba bulwadde. Kikugirwa nnyo mu mateeka okuyingiza ebintu bino mu mubiri gw’omuntu oba ebisolo mu ngeri yonna.