▎ Cort-g Bincike
Menene asalin bincike na Cort-g?
A matsayin tetrapeptide na roba, Cort-g ya samo asali ne daga binciken binciken kimiyya a fannoni da yawa. A fannin kimiyyar kwakwalwa, saboda gazawar cututtukan da ke da nasaba da jijiya irin su cutar Alzheimer da cutar Parkinson, masu bincike sun yi ta neman abubuwan da za su iya kare neurons da inganta gyaran jijiyoyi. An haifi Cort-g a cikin wannan binciken kuma ana tsammanin zai taimaka wajen gyara neuron da rage ci gaban cutar. A cikin bincike na rigakafi, da aka ba da cewa cututtuka na rigakafi suna haifar da cututtuka da yawa, masana kimiyya sun binciko ƙananan ƙwayoyin cuta don tsarin rigakafi.
Cort-g na iya daidaita tsarin garkuwar jiki, tada maganganun interleukin-2, da rage amsawar autoimmune, yana kawo sabbin ra'ayoyi don maganin cututtuka na rigakafi. Tare da yawan cututtukan cututtukan zuciya da na jijiyoyin jini, sakamakon Cort-g akan alamun da suka dace da maganganun kwayar cutar zuciya suna ba da sabon jagora don rigakafi da maganin waɗannan cututtuka. Dangane da yanayin haɓakar sha'awar binciken rigakafin tsufa saboda haɓakar tsufa na yawan jama'a, Cort-g na iya daidaita kwayoyin halitta da sanya DNA kusa da ƙaramin ƙasa, yana ba da gudummawa ga bayyanar tsarin tsufa da samun nasarar tsufa. Bugu da ƙari, tun da gyare-gyaren nama da farfadowa sune mahimmancin mayar da hankali a cikin magani, halaye na Cort-g a cikin inganta farfadowa na kwayar halitta da kuma ƙarfafa farfadowa na jijiyoyi sun bude sabuwar hanya don bincike a wannan filin.
Menene tsarin aikin Cort-g?
1. Tasiri akan Heterochromatin
Samar da Depolymerization na Total Heterochromatin: peptide bioregulator Cort-g na iya haifar da unwinding da deheterochromatization (depolymerization) na jimlar heterochromatin. Ta hanyar amfani da hanyoyin cytogenetic na kwayoyin halitta, irin su calorimetry daban-daban na sikanin, nazarin ayyukan ƙwayoyin ribosomal a cikin tauraron dan adam stalks na chromosome NORs, nazarin polymorphism na centromeric C-heterochromatin a cikin tsarin gefe, da kuma lura da sãɓãwar launukansa na facultative al'adu da kuma lymphocytes. sama, an gano cewa Cort-g yana da tasiri mai mahimmanci akan heterochromatin [1].
Kunna Ribosomal Gene Synthesis: Saboda kunnawar deheterochromatin na tauraron dan adam stalks na chromosomes na kusa, Cort-g yana kunna tsarin hada kwayoyin halittar ribosomal. A lokaci guda kuma, baya haifar da deheterochromatization na heterochromatin na halitta a kusa da centromere, kuma yana fitar da ƙwayoyin da aka hana saboda ƙayyadaddun yankuna na autosomal waɗanda ke samar da FH [1]..
2. Tasiri akan Neurons
Gudanar da Ayyukan Wutar Lantarki na Neurons: An tabbatar da maganin cortexine da cortexine peptides don daidaita ayyukan lantarki na neurons a cikin hanya guda, wato, matsakaicin canza yanayin hutawa, yuwuwar aiki, da mitar motsa jiki, wanda aka fassara a matsayin tasirin kunnawa. Glycine kuma na iya kunna ayyukan neuron, amma zuwa ƙarami. The tetrapeptide Cort-g kuma na iya yin hyperpolarize neurons ta 2-3 mV kuma ya rage ayyukansu na yau da kullun a matakin 0.1-100 μM, yana nuna tasirinsa (neuroprotective). A wani taro na 1000 μM, Cort-g yana lalata ƙananan ƙwayoyin cuta (2-4 mV), kuma ana yin rikodin karuwa a cikin ayyukan motsa jiki. A cikin maida hankali na 10 mM, yana da mahimmanci kuma yana sake jujjuyawar neurons, yana ƙaruwa da yawa, kuma yana hana haɓakar abubuwan aiki [1].
Tasirin Ion Currents: Cort-g kuma yana iya haɓaka girman jinkirin waje na yanzu da 3-5% a taro na 0.1 μM. Bayan gudanar da Cort-g, ba a sami karuwa a cikin amplitude (kunnawa) na tashoshin sodium da calcium na ciki ba. Bayan gudanar da Cort-g a maida hankali na 100 μM da sama, girman waɗannan igiyoyin ruwa sun fara nuna dogaro da kashi-kashi kuma mai iya juyawa. Bayan matakin peptide ya kai 10 mM, hanawa zai iya kaiwa 80-90%. Daga cikinsu, hana hanyoyin sodium ya fi na tashoshi na calcium [1] tsanani..
3. Tasiri akan Bayyanar Halittar Zuciya
Canza Rubutun Cardiac: Ta hanyar nazarin bayanan 15,247 a cikin zukatan ɓangarorin CBA mata na watanni 6 da suka karɓi ci gaba da allurar Cort-g na kwanaki 5, an gano cewa idan aka kwatanta da ƙungiyar kulawa, cDNA microarray hybridization na samfuran zuciya a cikin rukunin gwaji ya nuna cewa adadin adadin 1.5% na jimlar adadin 2.3. clones) ya canza sosai, kuma waɗannan clones sun dace da sanannun kwayoyin halitta 110 na nau'ikan ayyuka daban-daban. Matsakaicin ƙa'ida da ƙa'idodin ƙasa sune +5.42 da -2.86 bi da bi [2].
Kwatanta tare da Sauran Peptides da Hormones: Kwatanta canje-canje a cikin bayanan bayanan zuciya wanda ke haifar da peptides na roba (Cort-g, Vilon, Epitalon) da pineal peptide melatonin yana bayyana takamaiman tasirin Cort-g akan bayyanar cututtukan zuciya [2].
4. Gudunmawa A Wasu Fage
Tasiri kan Ragewar Jijiya Na Jijiya: A cikin mutane, Cort-g yana da tasirin warkewa a fili akan tsari da dawo da aikin jijiyoyi da suka lalace. peptide na roba ne da aka samu ta hanyar haɗin kai wanda ya dogara da nazarin amino acid na shirye-shiryen peptide na cerebral cortex na halitta Cortexin [1].
Matsayi a cikin Hip Osteoarthritis: Wasu bincike sun nuna cewa an yi amfani da alluran corticosteroid na intra-articular shekaru da yawa. A matsayin peptide bioregulator tare da irin wannan sakamako, Cort-g yana taka rawa zuwa wani matsayi ta hanyar daidaita amsawar kumburi da sauran hanyoyin [3].
Menene aikace-aikacen Cort-g?
1. Anti-tsufa
Jinkirta Tsarin Tsufa: A matsayin peptide anti-tsufa, Cort-g na iya daidaita maganganun kwayoyin halitta, mayar da DNA zuwa ƙaramar yanayi, ta haka rage tsufa da sake kunna takamaiman kwayoyin halitta. Tsarin tsufa yawanci yana tare da canje-canje a cikin maganganun kwayoyin halitta. Cort-g na iya jinkirta tsarin tsufa ta hanyar daidaita maganganun waɗannan kwayoyin halitta. Misali, zai iya cimma tasirin rigakafin tsufa ta hanyar kunna ayyukan telomerase, rage lalacewar danniya, ko daidaita gyare-gyaren epigenetic.
Daidaita Tsarin Halitta: Yana iya daidaita rikice-rikice na rayuwa a cikin kwakwalwa wanda ke haifar da ischemia na yau da kullum, wanda ke da fa'idodi masu mahimmanci don kiyaye lafiyar kwakwalwa da aiki [2] . Cututtukan ƙwayar cuta a cikin kwakwalwa suna da alaƙa da cututtukan neurodegenerative iri-iri da cututtukan da ke da alaƙa da tsufa. Cort-g na iya dawo da aikin rayuwa na yau da kullun ta hanyar daidaita hanyoyin rayuwa a cikin kwakwalwa, don haka kare lafiyar kwakwalwa.
1. Kariyar Neuro da Gyaran Kwakwalwa
Haɓaka Ayyukan Neuron: Cort-g na iya ƙarfafa aiki da ayyukan ƙwayoyin cuta, suna taka muhimmiyar rawa wajen farfadowa da kuma kula da aikin neuron. Nazarin ya nuna cewa zai iya inganta ci gaba da ci gaban neurons ta hanyar yin hulɗa tare da abubuwan ci gaban jijiya [4] . Wannan tsarin aikin na iya haɗawa da kunna takamaiman hanyoyin sigina, ta haka ne ke haɓaka ayyukan rayuwa da ingantaccen watsa synaptik na neurons.
Taimakawa a Farfadowar Nama na Jijiya: Cort-g ya nuna yuwuwar a cikin tsari da dawo da aiki na kyallen jijiyoyi na gefe, wanda ke taimakawa don gyara raunin jijiya. Ta hanyar daidaita abun da ke ciki da tsarin matrix extracellular, yana ba da yanayi mai dacewa don haɓaka ƙwayoyin jijiya. Matrix na extracellular yana taka muhimmiyar rawa wajen kiyaye homeostasis cell da ci gaban nama. Cort-g na iya inganta haɓakawa da gyaran kyallen jijiyoyi ta hanyar tasiri da sassa da ayyuka na matrix extracellular.
Bincike akan Cututtukan Neurodegenerative: Cort-g yana ɗaya daga cikin batutuwa masu zafi a cikin binciken cututtukan cututtukan da ke da alaƙa kamar cutar Alzheimer da cutar Parkinson. Yana taimakawa ragewa ko hana ci gaban waɗannan cututtuka. Cututtukan neurodegenerative yawanci suna da alaƙa da mutuwa da rashin aiki na ƙwayoyin cuta. Cort-g na iya rage lalacewa da mutuwar ƙwayoyin cuta ta hanyar tasirin neuroprotective, don haka jinkirta ci gaban cututtuka. Alal misali, yana iya taka rawa ta hanyar daidaita matakan neurotransmitters, haɓaka tsarin tsaro na antioxidant, ko inganta haɓakawa da bambance-bambancen ƙwayoyin jijiyoyi.
2. Haɓaka Hankali
Inganta Ƙwaƙwalwar Ƙwaƙwalwa da Hankali: Nazarin ya nuna cewa Cort-g na iya inganta ƙwaƙwalwar ajiya, hankali, da ikon tunani, haɓaka aikin fahimi. Hanyar aikinta na iya haɗawa da daidaita tsarin tsarin neurotransmitter a cikin kwakwalwa, irin su ƙara sakin ƙwayoyin cuta kamar dopamine da norepinephrine [5] . Wadannan neurotransmitters suna taka muhimmiyar rawa a cikin hanyoyin fahimta. Misali, dopamine yana da alaƙa da tsarin lada da koyo da ƙwaƙwalwa, kuma norepinephrine yana da alaƙa da hankali da faɗakarwa.
Rage Halayen Damuwa: Cort-g yana da tasirin anti-damuwa kuma yana iya taimakawa rage halayen da ke da alaƙa da tashin hankali, ta haka inganta yanayin motsin rai. A cikin gwaje-gwajen linzamin kwamfuta, Cort-g ya nuna sakamako na tsari akan halayen da suka shafi damuwa [4] . Yana iya sauƙaƙa alamun damuwa ta hanyar rinjayar da'irar jijiyoyi a cikin kwakwalwa, kamar daidaita ayyukan yankuna kamar amygdala da hippocampus.
3. Immunomodulation
Ƙarfafa Maganar Interleukin-2: Cort-g na iya tada maganganun interleukin-2, ta haka ne ke daidaita aikin rigakafi da haɓaka amsawar jiki. Interleukin-2 wani muhimmin abu ne na immunomodulatory wanda zai iya inganta haɓakawa da kunna ƙwayoyin T da haɓaka aikin rigakafi na jiki [1] . Cort-g na iya haifar da bayyanar interleukin-2 ta hanyar kunna takamaiman hanyoyin sigina, ta haka inganta garkuwar jiki.
Rage Amsoshin Taimako: Yana taimakawa wajen daidaita aikin rigakafi ta hanyar rage amsawar autoimmune kuma yana iya samun wani tasiri na tsari akan cututtuka na autoimmune. Cututtukan autoimmune suna faruwa ne ta hanyar kuskuren tsarin garkuwar jiki na kai hari ga nama. Cort-g na iya rage faruwar amsawar autoimmune ta hanyar daidaita ayyukan tsarin garkuwar jiki, ta haka ne ke taka wata rawa ta warkewa a cikin cututtukan cututtukan da ke da alaƙa.
4. Gyaran Nama da Farfaɗowa
Hanzarta Rauni farfadowa: Cort-g na iya hanzarta farfadowa bayan rauni, ciki har da raunin nama da farfadowa bayan tiyata, ta hanyar inganta farfadowar kwayar halitta. Matrix na extracellular yana da fa'idodi na musamman a cikin sabuntawa da gyara nama. Cort-g na iya inganta haɓakawa da bambance-bambancen sel ta hanyar tasiri da sassa da ayyuka na matrix extracellular, haɓaka gyaran nama da sabuntawa.
Haɓaka Farfaɗowar Jijiya: Cort-g na iya ƙarfafa farfadowar jijiyoyi kuma yana da tasiri mai kyau akan gyarawa da farfadowa na ƙwayoyin jijiya na gefe. Farfaɗowar jijiyoyi wani tsari ne mai rikitarwa wanda ya haɗa da haɓakawa, bambance-bambance, da ƙaura na ƙwayoyin jijiyoyi, da kuma ci gaban axon da samuwar synapses. Cort-g na iya inganta farfadowar jijiyoyi ta hanyar daidaita maɓalli hanyoyin sigina a cikin waɗannan matakai.
5. Lafiyar zuciya da jijiyoyin jini
Affecting Cardiovascular and Cerebrovascular Indicators: Some studies have found that Cort-g can affect certain indicators of the cardiovascular and cerebrovascular systems, although this area still requires further research. Alal misali, yana iya rinjayar alamomi kamar hawan jini, bugun zuciya, da elasticity na jijiyoyin jini (Anisimov S, 2004). Hanyar aikinta na iya haɗawa da daidaita masu watsawa, hormones, da hanyoyin sigina a cikin tsarin zuciya da jijiyoyin jini.
Daidaita Maganar Halittar Halittar Zuciya: Cort-g na iya haɓaka-daidaita-daidaita maganganun wasu kwayoyin halitta a cikin zuciya, kamar Pass1, Hsc70, Bmp2, Wnt4, Eps15, da Eps15-rs. Wadannan kwayoyin halitta suna da alaƙa da rayuwa na ƙwayoyin zuciya, da samuwar ƙwayoyin zuciya, da kuma kula da tsarin mutuwar kwayar halitta [2] . Ta hanyar daidaita maganganun kwayoyin halittar zuciya, Cort-g na iya samun tasiri mai kyau akan tsari da aikin zuciya, don haka yana taimakawa wajen kula da lafiyar zuciya.
6. Tsarin yanayi
Haɓaka Halin Ƙarfafawa: Cort-g na iya yin tasiri akan daidaita yanayi, inganta yanayin motsin rai, da rage alamun damuwa da damuwa. Tsarin aikinsa na iya kasancewa yana da alaƙa da daidaita tsarin neurotransmitter da kewayen jijiyoyi a cikin kwakwalwa [4] . Alal misali, zai iya inganta yanayin motsin rai ta hanyar ƙara yawan matakan neurotransmitters kamar serotonin da dopamine; ko kuma yana iya rage alamun damuwa da damuwa ta hanyar daidaita ayyukan yankuna kamar amygdala da hippocampus.
Maganin Adjuvant na Cututtukan Yanayi: Yana da yuwuwar ƙimar aikace-aikacen a cikin maganin alamun motsin rai / damuwa kuma ana iya amfani da shi azaman magani mai taimako. Rashin hankali cuta ce ta tabin hankali, kuma hanyoyin da ake amfani da su a halin yanzu sun haɗa da maganin ƙwayoyi, ilimin halin ɗan adam, da kuma jiyya na jiki. Cort-g za a iya amfani dashi azaman magani na adjuvant, haɗe tare da hanyoyin maganin gargajiya don inganta tasirin magani.
A ƙarshe, a matsayin tetrapeptide na roba, Cort-g yana da ƙima mara kyau a fagen ilimin halittu. Dangane da maganin tsufa, yana taimaka wa DNA komawa ƙarami ta hanyar daidaita maganganun kwayoyin halitta, yadda ya kamata ya jinkirta tsarin tsufa, kuma yana iya inganta rikice-rikice na rayuwa a cikin kwakwalwa wanda ke haifar da ischemia na kullum. A fannin ilimin kimiyyar kwakwalwa, zai iya inganta aikin neuron, wanda ke da mahimmanci ga gyaran jijiyar jijiyoyi da bincike akan cututtuka na neurodegenerative. A lokaci guda, yana iya haɓaka fahimta da kuma kawar da damuwa. Dangane da rigakafi, yana iya tada maganganun interleukin-2 da daidaita aikin rigakafi. A cikin sassan zuciya da jijiyoyin jini, ko da yake ana buƙatar ƙarin bincike, zai iya riga ya shafi alamun da suka dace da kuma daidaita kwayoyin cututtukan zuciya. Cort-g ya buɗe sabon alkibla ga lafiyar ɗan adam kuma ana tsammanin zai taka muhimmiyar rawa wajen magance cututtukan cututtukan da haɓaka ayyukan jiki.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Dokta Joseph I. Friedman ƙwararren mai bincike ne kuma ƙwararren likita wanda ke da alaƙa da manyan cibiyoyi kamar Tsarin Asibitoci na Dutsen Sinai, Makarantar Magunguna ta Icahn a Dutsen Sinai, da Cibiyar Kula da Lafiyar Mahajjata. Bincikensa ya bazu a fannoni daban-daban ciki har da ilimin halin dan Adam, Neurosciences & Neurology, Pharmacology & Pharmacy, Tsarin zuciya da jijiyoyin jini & Ilimin zuciya, da Janar & Magungunan Ciki. Ya ba da gudummawa mai mahimmanci ga fahimta da kuma kula da cututtuka na tabin hankali, cututtuka na zuciya da jijiyoyin jini, da rashin fahimta, tare da wallafe-wallafe masu yawa a cikin mujallolin da aka sake dubawa. Ayyukansa sun taimaka wajen haɓaka ilimi da hanyoyin kulawa a waɗannan fannoni. An jera Dokta Joseph I. Friedman a cikin ambaton ambaton [5].
