▎ Cort-g Kev Tshawb Fawb
Kev tshawb fawb keeb kwm ntawm Cort-g yog dab tsi?
Raws li cov khoom siv hluavtaws tetrapeptide, Cort-g pib los ntawm kev tshawb fawb tshawb fawb hauv ntau qhov chaw. Nyob rau hauv lub tshav pob ntawm neuroscience, vim yog intractability ntawm cov kab mob neurodegenerative xws li Alzheimer's kab mob thiab Parkinson's kab mob, cov kws tshawb fawb tau tshawb nrhiav cov khoom uas tuaj yeem tiv thaiv neurons thiab txhawb kev kho paj hlwb. Cort-g tau yug los hauv qhov kev tshawb nrhiav no thiab xav tias yuav pab kho cov neuron thiab ua kom cov kab mob qeeb zuj zus. Hauv kev tshawb fawb txog kev tiv thaiv kab mob, vim tias kev tiv thaiv kab mob ua rau muaj ntau yam kab mob, cov kws tshawb fawb tau tshawb nrhiav cov tshuaj me me rau kev tiv thaiv kab mob.
Cort-g tuaj yeem tswj hwm lub cev tiv thaiv kab mob, txhawb kev qhia ntawm interleukin-2, thiab txo cov lus teb autoimmune, nqa cov tswv yim tshiab rau kev kho cov kab mob tiv thaiv kab mob. Nrog rau qhov tshwm sim siab ntawm cov kab mob plawv thiab cov hlab ntsha, cov teebmeem ntawm Cort-g ntawm cov cim qhia thiab cov kab mob plawv muab cov kev taw qhia tshiab rau kev tiv thaiv thiab kho cov kab mob no. Tawm tsam cov keeb kwm yav dhau los ntawm kev nce siab hauv kev tshawb fawb los tiv thaiv kev laus vim kev laus zuj zus ntawm cov pej xeem, Cort-g tuaj yeem tswj cov noob thiab ua kom DNA ze rau lub xeev hluas, pab txhawb kev tshwm sim ntawm cov txheej txheem kev laus thiab kev ua tiav ntawm kev laus noj qab haus huv. Tsis tas li ntawd, txij li kev kho cov ntaub so ntswg thiab rov tsim dua tshiab yog qhov tseem ceeb hauv cov tshuaj, cov yam ntxwv ntawm Cort-g hauv kev txhawb nqa cell regeneration thiab stimulating paj regeneration tau qhib txoj hauv kev tshiab rau kev tshawb fawb hauv daim teb no.
Lub mechanism ntawm kev txiav txim ntawm Cort-g yog dab tsi?
1. Cov teebmeem ntawm Heterochromatin
Inducing lub Depolymerization ntawm Tag Nrho Heterochromatin: Lub peptide bioregulator Cort-g tuaj yeem ua rau muaj kev tsis sib haum xeeb thiab deheterochromatization (depolymerization) ntawm tag nrho heterochromatin. Los ntawm kev siv cov txheej txheem molecular cytogenetic, xws li kev sib txawv scanning calorimetry, tshuaj xyuas cov kev ua ntawm ribosomal noob nyob rau hauv satellite stalks ntawm acrocentric chromosome NORs, kawm cov polymorphism ntawm centromeric C-heterochromatin nyob rau hauv lub peripheral qauv, thiab soj ntsuam lub variability ntawm lymphocytes (F) kab lis kev cai los ntawm cov neeg muaj hnub nyoog 80 thiab siab dua, nws tau pom tias Cort-g muaj kev tswj hwm zoo ntawm heterochromatin [1].
Activating Ribosomal Gene Synthesis: Vim lub deheterochromatin ua kom cov satellite stalks ntawm proximal chromosomes, Cort-g activates cov txheej txheem synthesis ntawm ribosomal noob. Nyob rau tib lub sijhawm, nws tsis induce lub deheterochromatization ntawm constitutive heterochromatin nyob ib ncig ntawm lub centromere, thiab tso tawm cov inhibited noob vim lub condensation ntawm lub autosomal cheeb tsam uas tsim FH [1].
2. Cov teebmeem ntawm Neurons
Kev tswj cov hluav taws xob ua haujlwm ntawm Neurons: Cov tshuaj cortexine thiab cortexine peptides tau raug pov thawj los tswj cov hluav taws xob kev ua haujlwm ntawm cov neurons tib yam, uas yog, hloov pauv cov peev txheej so, muaj peev xwm ua tau, thiab lub zog impulse, uas yog txhais raws li kev ua kom muaj zog. Glycine kuj tseem tuaj yeem qhib cov haujlwm neuron, tab sis tsawg dua. Lub tetrapeptide Cort-g tuaj yeem ua rau hyperpolarize neurons los ntawm 2-3 mV thiab txo lawv cov kev ua haujlwm ntawm tus kheej ntawm 0.1-100 μM, qhia tias nws ua kom muaj zog (neuroprotective) nyhuv. Ntawm qhov concentration ntawm 1000 μM, Cort-g moderately depolarizes neurons (2-4 mV), thiab kev nce hauv impulse kev ua haujlwm raug kaw. Ntawm qhov concentration ntawm 10 mM, nws ua rau muaj txiaj ntsig zoo thiab thim rov qab depolarizes neurons, nce qhov zaus, thiab inhibits tiam ntawm kev ua tau zoo [1].
Kev cuam tshuam rau Ion Currents: Cort-g tuaj yeem ua rau muaj qhov loj me ntawm qhov qeeb sab nraud los ntawm 3-5% ntawm qhov concentration ntawm 0.1 μM. Tom qab tswj hwm Cort-g, tsis muaj kev nce ntxiv hauv qhov amplitude (ua kom) ntawm sab hauv sodium thiab calcium raws tau pom. Tom qab tswj hwm Cort-g ntawm qhov siab ntawm 100 μM thiab siab dua, qhov amplitude ntawm cov tam sim no tau pib qhia qhov koob tshuaj tiv thaiv thiab thim rov qab. Tom qab peptide concentration nce mus txog 10 mM, qhov inhibition tuaj yeem ncav cuag 80-90%. Ntawm lawv, inhibition ntawm sodium raws yog khaus ntau dua li cov calcium channels [1].
3. Qhov cuam tshuam rau Cardiac Gene Expression
Hloov cov Cardiac Transcriptome: Los ntawm kev tshuaj xyuas 15,247 cov ntawv sau tseg hauv lub siab ntawm 6-hli poj niam CBA nas uas tau txais kev txhaj tshuaj tas li ntawm Cort-g rau 5 hnub, nws tau pom tias piv nrog rau pawg tswj hwm, cDNA microarray hybridization ntawm lub plawv kuaj hauv pawg sim .23% ntawm kev qhia pom tias 3% ntawm cloac ntawm kev qhia. tag nrho cov clones) tau hloov pauv loj heev, thiab cov clones no tau sib tw 110 cov noob caj noob ces uas muaj nyob rau ntau pawg ua haujlwm. Qhov siab tshaj plaws nce-txoj cai thiab down-txoj cai yog +5.42 thiab -2.86 feem [2].
Kev sib piv nrog Lwm cov Peptides thiab Hormones: Sib piv cov kev hloov pauv ntawm cov kab mob plawv tshwm sim los ntawm cov peptides hluavtaws (Cort-g, Vilon, Epi) thiab pineal peptide hormone melatonin qhia txog qhov tshwm sim thiab tshwj xeeb ntawm Cort-g ntawm lub plawv gene qhia [2].
4. Lub luag haujlwm ntawm Lwm Yam
Qhov cuam tshuam rau cov paj hlwb puas ntsoog: Hauv tib neeg, Cort-g muaj cov txiaj ntsig zoo rau kev ua haujlwm thiab rov ua haujlwm ntawm cov paj hlwb puas. Nws yog ib qho hluavtaws peptide tau los ntawm kev taw qhia kev sib xyaw ua ke raws li cov amino acid tsom xam ntawm lub ntuj cerebral cortex peptide npaj Cortexin [1].
Lub luag haujlwm hauv Hip Osteoarthritis: Qee cov kev tshawb fawb tau pom tias kev txhaj tshuaj corticosteroid intra-articular tau siv ntau xyoo lawm. Raws li peptide bioregulator nrog cov txiaj ntsig zoo sib xws, Cort-g ua lub luag haujlwm rau qee yam los ntawm kev tswj hwm cov lus teb inflammatory thiab lwm txoj hauv kev [3].
Dab tsi yog cov ntawv thov ntawm Cort-g?
1. Anti-aging
Kev ncua sij hawm Kev laus: Raws li kev tiv thaiv kev laus peptide, Cort-g tuaj yeem tswj cov noob qhia, rov ua DNA rau lub xeev hluas, yog li txo qis kev laus thiab rov ua cov noob tshwj xeeb. Cov txheej txheem kev laus feem ntau yog nrog los ntawm kev hloov pauv ntawm cov noob qhia. Cort-g tuaj yeem ncua kev laus los ntawm kev tswj cov kev qhia ntawm cov noob no. Piv txwv li, nws muaj peev xwm ua tau los tiv thaiv kev laus los ntawm kev ua kom telomerase kev ua si, txo oxidative kev nyuaj siab puas tsuaj, los yog tswj kev hloov kho epigenetic.
Regulating Cellular Metabolism: Nws tuaj yeem ua rau cov kab mob metabolic hauv lub hlwb ua haujlwm los ntawm kev mob ischemia, uas muaj txiaj ntsig zoo rau kev tswj lub hlwb kev noj qab haus huv thiab kev ua haujlwm [2] . Cov kab mob metabolic hauv lub hlwb muaj feem xyuam nrog ntau yam kab mob neurodegenerative thiab cov kab mob aging. Cort-g tuaj yeem rov ua haujlwm zoo li qub los ntawm kev tswj cov txheej txheem metabolic hauv lub hlwb, yog li tiv thaiv lub hlwb kev noj qab haus huv.
1. Neuroprotection thiab Kho lub hlwb
Txhawb nqa Neuron Function: Cort-g tuaj yeem txhawb kev ua haujlwm thiab kev ua haujlwm ntawm cov neurons, ua lub luag haujlwm zoo hauv kev rov qab los thiab kev saib xyuas cov haujlwm neuron. Cov kev tshawb fawb tau pom tias nws tuaj yeem txhawb kev loj hlob thiab kev loj hlob ntawm neurons los ntawm kev cuam tshuam nrog cov paj hlwb loj hlob [4] . Cov txheej txheem ntawm kev txiav txim no tuaj yeem koom nrog kev ua kom muaj kev taw qhia tshwj xeeb, yog li txhim kho cov haujlwm metabolic thiab kev sib kis ntawm cov neurons.
Pab hauv Nerve Tissue Recovery: Cort-g tau qhia txog qhov muaj peev xwm ntawm cov txheej txheem thiab kev ua haujlwm rov qab ntawm cov paj hlwb peripheral, uas yuav pab tau rau kev kho mob ntawm cov hlab ntsha. Los ntawm kev tswj cov muaj pes tsawg leeg thiab cov qauv ntawm extracellular matrix, nws muab ib qho chaw tsim nyog rau kev loj hlob ntawm paj hlwb. Lub extracellular matrix plays lub luag haujlwm tseem ceeb hauv kev tswj hwm cell homeostasis thiab kev loj hlob ntawm cov ntaub so ntswg. Cort-g tuaj yeem txhawb kev tsim kho thiab kho cov paj hlwb los ntawm kev cuam tshuam cov khoom thiab kev ua haujlwm ntawm cov kab mob extracellular matrix.
Kev tshawb fawb txog Cov Kab Mob Neurodegenerative: Cort-g yog ib lub ntsiab lus kub hauv kev tshawb fawb txog cov kab mob neurodegenerative xws li Alzheimer's kab mob thiab Parkinson's disease. Nws pab kom qeeb lossis tiv thaiv kev loj hlob ntawm cov kab mob no. Cov kab mob neurodegenerative feem ntau muaj feem xyuam rau kev tuag thiab kev ua haujlwm tsis zoo ntawm cov neurons. Cort-g tuaj yeem txo qhov kev puas tsuaj thiab kev tuag ntawm cov neurons los ntawm nws cov nyhuv neuroprotective, yog li ncua kev loj hlob ntawm cov kab mob. Piv txwv li, nws tuaj yeem ua lub luag haujlwm los ntawm kev tswj hwm qib ntawm cov neurotransmitters, txhim kho cov kab mob antioxidant, lossis txhawb kev loj hlob thiab kev sib txawv ntawm cov kab mob neural.
2. Kev txawj ntse
Txhim Kho Kev Nco thiab Kev Txaus Siab: Cov kev tshawb fawb tau pom tias Cort-g tuaj yeem txhim kho kev nco, kev xav, thiab kev txawj ntse, txhim kho kev txawj ntse. Nws cov txheej txheem ntawm kev txiav txim yuav koom nrog kev tswj hwm cov kab mob neurotransmitter hauv lub hlwb, xws li nce kev tso tawm neurotransmitters xws li dopamine thiab norepinephrine [5] . Cov neurotransmitters no ua lub luag haujlwm tseem ceeb hauv cov txheej txheem kev paub. Piv txwv li, dopamine muaj feem xyuam rau qhov khoom plig thiab kev kawm thiab kev nco, thiab norepinephrine muaj feem xyuam rau kev mloog thiab kev ceeb toom.
Txo Tus Cwj Pwm Zoo: Cort-g muaj kev tiv thaiv kev ntxhov siab thiab tuaj yeem pab txo qis kev ntxhov siab txog tus cwj pwm, yog li txhim kho lub siab lub ntsws. Hauv kev sim nas, Cort-g tau qhia txog kev tswj hwm ntawm kev ntxhov siab txog kev coj cwj pwm [4] . Nws tuaj yeem txo cov tsos mob ntawm kev ntxhov siab los ntawm kev cuam tshuam cov neural circuits hauv lub hlwb, xws li tswj cov dej num ntawm thaj chaw xws li amygdala thiab hippocampus.
3. Immunomodulation
Txhawb Kev Tshaj Tawm ntawm Interleukin-2: Cort-g tuaj yeem txhawb nqa kev qhia ntawm interleukin-2, yog li tswj hwm kev tiv thaiv kab mob thiab txhim kho lub cev tiv thaiv kab mob. Interleukin-2 yog ib qho tseem ceeb immunomodulatory yam uas tuaj yeem txhawb kev loj hlob thiab ua kom T hlwb thiab txhim kho lub cev lub cev tiv thaiv kab mob [1] . Cort-g tuaj yeem ua rau muaj kev cuam tshuam ntawm interleukin-2 los ntawm kev ua kom cov kev taw qhia tshwj xeeb, yog li txhim kho lub cev tiv thaiv kab mob.
Txo cov lus teb autoimmune: Nws pab tswj kev tiv thaiv kab mob los ntawm kev txo cov lus teb autoimmune thiab tuaj yeem muaj qee yam kev tswj hwm ntawm cov kab mob autoimmune. Cov kab mob autoimmune yog tshwm sim los ntawm lub cev tiv thaiv kab mob ua yuam kev tawm tsam nws cov ntaub so ntswg. Cort-g tuaj yeem txo qhov tshwm sim ntawm cov lus teb autoimmune los ntawm kev tswj hwm kev ua haujlwm ntawm lub cev tiv thaiv kab mob, yog li ua si lub luag haujlwm kho mob hauv cov kab mob autoimmune.
4. Cov ntaub so ntswg kho thiab rov tsim dua tshiab
Accelerating Injury Recovery: Cort-g tuaj yeem ua kom rov qab zoo tom qab raug mob, suav nrog cov ntaub so ntswg raug mob thiab rov qab ua haujlwm tom qab phais, los ntawm kev txhawb nqa cell regeneration. Lub extracellular matrix muaj qhov tshwj xeeb zoo hauv cov ntaub so ntswg rov tsim thiab kho. Cort-g tuaj yeem txhawb kev loj hlob thiab kev sib txawv ntawm cov hlwb los ntawm kev cuam tshuam cov khoom thiab kev ua haujlwm ntawm extracellular matrix, ua kom cov ntaub so ntswg kho thiab rov tsim dua tshiab.
Txhawb Nerve Regeneration: Cort-g tuaj yeem ua rau cov paj hlwb rov tsim dua tshiab thiab muaj kev cuam tshuam zoo rau kev kho thiab rov tsim dua tshiab ntawm cov paj hlwb peripheral. Nerve regeneration yog ib txoj kev nyuaj uas cuam tshuam nrog kev loj hlob, kev sib txawv, thiab kev tsiv teb tsaws ntawm neural qia hlwb, nrog rau kev loj hlob ntawm axons thiab tsim cov synapses. Cort-g tuaj yeem txhawb kev tsim cov paj hlwb los ntawm kev tswj cov kev taw qhia tseem ceeb hauv cov txheej txheem no.
5. Mob plawv thiab Cerebrovascular Health
Kev cuam tshuam rau cov hlab plawv thiab Cerebrovascular Indicators: Qee cov kev tshawb fawb tau pom tias Cort-g tuaj yeem cuam tshuam rau qee qhov ntsuas ntawm cov hlab plawv thiab cov hlab ntsha, txawm tias thaj chaw no tseem xav tau kev tshawb fawb ntxiv. Piv txwv li, nws tuaj yeem cuam tshuam cov ntsuas xws li ntshav siab, lub plawv dhia, thiab vascular elasticity (Anisimov S, 2004). Nws cov txheej txheem ntawm kev txiav txim yuav koom nrog kev tswj cov neurotransmitters, cov tshuaj hormones, thiab cov kev taw qhia hauv cov hlab plawv thiab cerebrovascular.
Regulating Cardiac Gene Expression: Cort-g tuaj yeem txhim kho kev qhia ntawm qee cov noob hauv lub plawv, xws li Pass1, Hsc70, Bmp2, Wnt4, Eps15, thiab Eps15-rs. Cov noob no muaj feem cuam tshuam rau kev ciaj sia ntawm cov hlwb plawv, tsim cov ntaub so ntswg plawv, thiab kev tswj hwm ntawm cov txheej txheem cell tuag [2] . Los ntawm kev tswj hwm cov kab mob plawv, Cort-g tuaj yeem muaj kev cuam tshuam zoo rau cov qauv thiab kev ua haujlwm ntawm lub plawv, yog li pab tswj cov hlab plawv.
6. Kev tswj lub siab
Txhim kho lub xeev Kev xav: Cort-g tuaj yeem cuam tshuam rau kev tswj lub siab, txhim kho lub siab lub ntsws, thiab txo cov tsos mob ntawm kev nyuaj siab thiab kev ntxhov siab. Nws cov txheej txheem ntawm kev ua haujlwm yuav cuam tshuam rau kev tswj cov kab mob neurotransmitter thiab neural circuits hauv lub hlwb [4] . Piv txwv li, nws tuaj yeem txhim kho lub siab lub ntsws los ntawm kev nce qib ntawm cov neurotransmitters xws li serotonin thiab dopamine; los yog nws tuaj yeem txo cov tsos mob ntawm kev ntxhov siab thiab kev nyuaj siab los ntawm kev tswj hwm cov dej num ntawm thaj chaw xws li amygdala thiab hippocampus.
Adjuvant Treatment of Mood Disorders: Nws muaj peev xwm siv tau tus nqi hauv kev kho mob ntawm kev xav / kev nyuaj siab thiab tuaj yeem siv los ua kev kho mob ntxiv. Cov kev xav tsis zoo yog ib qho kev puas siab puas ntsws, thiab cov kev kho mob tam sim no feem ntau suav nrog kev kho tshuaj, kev kho mob hlwb, thiab kev kho lub cev. Cort-g tuaj yeem siv los ua kev kho mob ntxiv, ua ke nrog cov kev kho mob ib txwm siv los txhim kho kev kho mob.
Nyob rau hauv xaus, raws li ib tug hluavtaws tetrapeptide, Cort-g muaj ib tug tsis tshua muaj nqi nyob rau hauv lub biomedical teb. Hais txog kev tiv thaiv kev laus, nws pab DNA rov qab mus rau lub xeev hluas los ntawm kev tswj cov noob qhia, ua kom cov txheej txheem kev laus, thiab tuaj yeem txhim kho cov kab mob metabolic hauv lub hlwb los ntawm kev mob ischemia. Hauv kev ua haujlwm ntawm neuroscience, nws tuaj yeem txhawb nqa kev ua haujlwm neuron, uas yog qhov tseem ceeb rau kev kho cov hlab ntsha thiab kev tshawb fawb txog cov kab mob neurodegenerative. Nyob rau tib lub sijhawm, nws tuaj yeem txhim kho kev txawj ntse thiab txo kev ntxhov siab. Hais txog kev tiv thaiv kab mob, nws tuaj yeem txhawb kev qhia ntawm interleukin-2 thiab tswj kev tiv thaiv kab mob. Nyob rau hauv cov hlab plawv thiab cerebrovascular yam, txawm tias xav tau kev tshawb fawb ntxiv, nws tuaj yeem cuam tshuam rau cov cim qhia thiab tswj cov kab mob plawv. Cort-g tau qhib qhov kev taw qhia tshiab rau tib neeg kev noj qab haus huv thiab xav tias yuav ua lub luag haujlwm tseem ceeb hauv kev kho cov kab mob thiab kev ua kom zoo ntawm lub cev.
Hais Txog Tus Sau
Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.
Scientific Journal Author
Dr. Joseph I. Friedman yog ib tug kws tshawb fawb thiab kws kho mob koom nrog cov tsev kawm muaj koob npe xws li Mt. Sinai System of Hospitals, Icahn School of Medicine ntawm Mount Sinai, thiab Pilgrim Psychiatric Center. Nws txoj kev tshawb fawb nthuav dav thoob plaws ntau yam xws li Psychiatry, Neurosciences & Neurology, Pharmacology & Pharmacy, Cardiovascular System & Cardiology, thiab General & Internal Medicine. Nws tau ua haujlwm tseem ceeb rau kev nkag siab thiab kev kho mob ntawm kev puas siab puas ntsws, kab mob plawv, thiab kev puas siab puas ntsws, nrog ntau cov ntawv tshaj tawm hauv cov ntawv txheeb xyuas cov phooj ywg. Nws txoj haujlwm tau ua qhov tseem ceeb hauv kev nce qib kev paub thiab kev kho mob hauv cov cheeb tsam no. Dr. Joseph I. Friedman tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv pov thawj [5].
