IGF-1 LR3 1 MG

▎ IGF-1 LR3 Tsarin

▎ IGF-1 LR3 Bincike

Menene asalin bincike na IGF-1 LR3?

Bincike akan IGF-1 LR3 ya samo asali ne daga buƙatun don shawo kan ƙayyadaddun abubuwan haɓakar insulin na halitta kamar 1 (IGF-1). A matsayin babban mai kula da ci gaban kwayar halitta, bambance-bambance, da metabolism, IGF-1 na halitta yana nuna yiwuwar gyaran nama, ci gaba da nazarin ci gaba, da kuma maganin cututtuka. Koyaya, yana da babban koma baya: Rabin rayuwarsa yana ɗaukar awoyi kaɗan kawai, yana haifar da saurin sharewa a cikin vivo. Bugu da ƙari kuma, yana ɗaure tam zuwa sunadaran da ke ɗaure IGF, yana haifar da ƙarancin kaso na kyauta, nau'ikan aiki waɗanda ke gwagwarmaya don aiwatar da tasiri mai dorewa. Waɗannan iyakoki sun taƙaita ingancinsa sosai a cikin bincike na gwaji da yuwuwar aikace-aikace, korar masana kimiyya don bincika ingantattun na'urorin analogues tare da ingantaccen aiki.

Tare da ci gaba a cikin ilimin halittar kwayoyin halitta da fasahar injiniyan furotin, ƙungiyoyin bincike sun mayar da hankali kan daidaita IGF-1 don inganta kaddarorin sa. Ta hanyar zurfin bincike game da dangantakar da ke tsakanin tsarin-aiki na IGF-1, masu bincike sun gano cewa gyare-gyare a takamaiman rukunin amino acid na iya rinjayar hulɗar su tare da sunadarai masu ɗaure da masu karɓa: Sauya glutamic acid a matsayi na 3 tare da arginine da kuma ƙara 13 amino acid zuwa N-terminus yana rage kusanci ga IGF-dauri na gina jiki, yayin da yake rage nau'i-nau'i na IGF. mai karɓa. A lokaci guda, ingantaccen tsari ya tsawaita tsarin rayuwa na kwayoyin halitta a cikin vivo, a ƙarshe yana samar da IGF-1 LR3 tare da amino acid 83. Wannan ya haifar da rabin rayuwa ya tsawaita zuwa sa'o'i 20-30 kuma kusan ƙarfin ƙarfin ninki uku.

Menene tsarin aiki don IGF-1 LR3?

Yaduwar Kwayoyin Halitta da Bambance-bambance

Stimulation of Myoblast Proliferation: During fetal development, IGF-1 LR3 significantly promotes the proliferation of skeletal muscle myoblasts. For instance, studies on late-gestation lamb fetuses revealed that after one week of IGF-1 LR3 infusion, skeletal muscle myoblast proliferation rates significantly increased (P < 0.05). Wannan yana nuna IGF-1 LR3 kai tsaye yana aiki akan myoblasts don ci gaba da sake zagayowar tantanin halitta, yana ba da damar ƙarin myoblasts don shiga cikin yanayin haɓaka kuma ta haka ne ke samar da ƙarin hanyoyin salula don haɓaka ƙwayar tsoka da haɓaka ^[1].

Tasirin Ci gaban Follicular: A lokacin ilimin halittar jiki na ovarian, IGF-1 LR3 yana shiga cikin daidaita ci gaban follicular da haɓaka. A cikin samfurin superovulation na bera, haɗin gwiwar gudanarwa na IGF-1 LR3 tare da gonadotropins ya ƙara haɓaka ƙimar ovulation da haɓakar nauyin ovarian a wasu nau'ikan bera. Wannan yana nuna IGF-1 LR3 na iya yin tasiri ga maturation na follicular da ovulation ta hanyar daidaita haɓakar ƙwayoyin granulosa da bambance-bambance, ta haka yana shafar aikin haihuwa ^[2].

Tsarin Metabolism

Samun Abincin Gina Jiki da Amfani: Bayan jiko na IGF-1 LR3 a cikin ƴan rago na ƙarshen ciki, an sami raguwar ƙimar karɓar amino acid na cibiya tare da ƙananan adadin amino acid na tayin, duk da yawan juzu'in furotin na tayin. Wannan yana ba da shawarar IGF-1 LR3 na iya yin tasiri ga ɗaukar kayan abinci na tayin da tsarin amfani, yana ba da damar ingantaccen amfani da ƙarancin abinci mai gina jiki don tallafawa takamaiman haɓakar gaɓoɓin jiki maimakon haɓaka wadatar kayan abinci na tayi ta hanyar kwararar jini na placental ko haɓakar canja wurin abinci mai gina jiki ^[2].

Hoto 1 IGF-1 yana hana kumburi kuma yana haɓaka angiogenesis ta hanyar Ras / PI3K / IKK / NF-κB hanyoyin siginar don haɓaka warkar da rauni ^[3].

Hana Sirin Insulin: Jiko na IGF-1 LR3 ko saline a cikin 'yan raguna masu haihuwa na haihuwa sun bayyana rage yawan ƙwayar insulin na plasma a cikin IGF-1 LR3-infused raguna. Bugu da ƙari, ɓoyewar insulin yayin gwaje-gwajen matsawar hyperglycemic ya ragu idan aka kwatanta da sarrafawa. Wannan yana nuna IGF-1 LR3 na iya yin aiki kai tsaye akan sel-β-pancreatic don hana ƙwayar insulin. Ci gaba da karatu a kan keɓaɓɓen tsibiran tayi ya nuna cewa tsibiran daga IGF-1 LR3-infused rago sun nuna ƙarancin ƙarancin insulin don amsawa ga haɓakar glucose a cikin vitro, yana ba da shawarar IGF-1 LR3 na iya haifar da lahani na ciki a cikin β-sel na pancreatic, yana lalata aikin ɓoye insulin na al'ada ^[4,5]..

Tsarin Angiogenesis

Matsayi a cikin angiogenesis na ovarian: A cikin gwaje-gwajen al'adun follicle angiogenesis na bovine, sakamakon IGF-1 LR3 akan hanyoyin sadarwar follicle endothelial cell (EC) da kuma samar da progesterone an bincika. Sakamakon ya nuna ƙayyadaddun tasiri akan sigogin haɓakar EC amma ƙaramin haɓakar haɓakar tantanin halitta (3-5%). Sabanin haka, IGF-1 LR3 ya haifar da tasiri daban-daban akan samar da progesterone, yayin da IGF-1 antagonist antagonist picropodophyllin (PPP) ya rage mahimmancin ma'auni na ci gaban EC da ƙididdigar progesterone. Wannan yana nuna IGF-1 LR3 na iya daidaita tsarin jijiyoyin jini da samar da progesterone a cikin ƙwayoyin luteinized ta hanyar hanyar siginar mai karɓa na IGF-1, ta haka ne ke riƙe aikin ovarian da haihuwa ^[6].

Menene aikace-aikacen IGF-1 LR3?

Ci gaban Dabbobi da Bincike da Aikace-aikace

Haɓaka Girman Gaɓar Fetal: A cikin gwaje-gwaje tare da tayin ɗan rago na ƙarshen ciki, jiko na IGF-1 LR3 yana haɓaka haɓakar gabobin tayin sosai, yana haɓaka haɓakar gabobin kamar zuciya, kodan, saifa, da glandar adrenal. Wannan yana nuna IGF-1 LR3 yana taka muhimmiyar rawa wajen daidaita tsarin ci gaban gabobin tayi, yana ba da gudummawa ga zurfin fahimtar haɓakar tayin da hanyoyin haɓaka haɓaka. Yana ba da tallafi na ƙa'ida da jagora mai amfani don haɓaka aikin haifuwa na dabba da haɓaka ƙimar rayuwar zuriya ^[1].

Stimulation of Skeletal Muscle Myoblast Proliferation: Research indicates IGF-1 LR3 stimulates skeletal muscle myoblast proliferation. A cikin gwaje-gwajen tumaki na tayin, jiko na IGF-1 LR3 da alama yana haɓaka aikin haɓakar myoblasst ^[1].

Ciwon sukari da Binciken Cututtuka masu alaƙa

Ƙididdigar Tasiri akan Sigar Insulin: Gwaje-gwajen da suka haɗa da jiko na IGF-1 LR3 a cikin ƴan raguna sun nuna raguwar adadin insulin plasma na tayin. Yayin gwaje-gwajen matsawar hyperglycemic, matakan insulin a cikin IGF-1 LR3 da aka yi wa ƴan tayin sun kasance ƙasa da 66% fiye da na sarrafawa. Wannan al'amari yana nuna yiwuwar haɗin gwiwa tsakanin IGF-1 LR3 da haɓakar insulin, yana ba da mahimman bayanai don nazarin cututtukan ciwon sukari da haɓaka sabbin dabarun warkewa ^[5].

Haɗin kai tare da Ayyukan Wasan Wasanni: Bincike akan fitattun 'yan tseren Isra'ila da masu iyo sun nuna cewa IGF1 gene polymorphisms sun daidaita tare da zazzage matakan IGF1, kuma cewa IGF genetic score (IGF-GS) na sprinters yana da alaƙa da wasan motsa jiki. Elite sprinters sun baje kolin matsakaicin matsakaicin maki IGF-GS fiye da masu tseren matakin ƙasa da manyan masu ninkaya na gajeren zango. Wannan yana nuna tsarin IGF-1 na iya taka muhimmiyar rawa a cikin wasannin gudun duniya. While it remains uncertain whether IGF-GS can be used for early selection of elite sprinters, it offers new avenues for athlete selection and training interventions. Bincike na gaba zai iya ba da damar haɓaka ƙarin shirye-shiryen horo da aka yi niyya don haɓaka wasan motsa jiki ta hanyar saka idanu da kuma nazarin alamomin da ke da alaƙa da IGF-1 a cikin 'yan wasa ^[7].

Bincike a Ilimin Halittar Halittu da Magungunan asali

Binciken Ka'idojin Yadawa Kwayoyin Halitta: IGF-1 LR3 yana da damar da za ta tada yaduwar kwayar halitta. Gwaje-gwajen in vitro suna nuna tasirinta mai inganci na yaduwar kwayar halitta ta NIH 3T3. Wannan yana sanya IGF-1 LR3 kayan aiki mai mahimmanci don bincika hanyoyin ka'idojin haɓaka salon salula. Ta hanyar lura da tasirin IGF-1 LR3 akan haɓakawa a cikin layin salula daban-daban, masu bincike za su iya samun fahimta game da mahimman hanyoyin rayuwa kamar tsarin sake zagayowar tantanin halitta da hanyoyin sigina, samar da tushe na ka'idar don karatu a cikin oncology, magani mai sabuntawa, da filayen da suka danganci ^[8].

Apoptosis da Protein Metabolism Research: A cikin nazarin hydrogen peroxide-biyar C2C12 Kwayoyin, IGF-1 (ciki har da ta analog IGF-1 LR3) inganta salon salula kira gina jiki da kuma lalata ma'auni ta upregulating Pax7, myogenic regulatory dalilai (MRFs), mTOR, da P70S6K a cikin rehibiting apoptosis, rage rehibiting da MAFbguptosis. ma'auni tsakanin haɗin furotin da lalata. Wannan yana ba da gudummawa ga zurfin fahimtar rayuwa ta salula da hanyoyin mutuwa a ƙarƙashin yanayin damuwa, da kuma hanyoyin sadarwa na sarrafa furotin, suna ba da sabbin maƙasudi da hangen nesa don kula da cututtukan da ke da alaƙa ^[9].

Kammalawa

IGF-1 LR3, a matsayin analog na dogon aiki na roba na insulin-kamar girma factor 1, yana haɓaka takamaiman gabobin jikin tayin da glandar adrenal ta hanyar kunna hanyoyin sigina kamar PI3K/Akt da MAPK. Yana ƙarfafa ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar kuma da kuma haɓakar furotin mai gina jiki, yana daidaita tsarin metabolism, yana kula da lafiyar tsoka, kuma yana taimakawa wajen dawowa daga raunin da ya haifar da motsa jiki.

Game da Marubuci

Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.

Mawallafin Jaridar Kimiyya

Feng L wani mai bincike ne da ke mai da hankali kan fannin motsa jiki na motsa jiki da lafiyar zuciya. Ayyukan su na ilimi ya fi mayar da hankali kan binciken abubuwan da aka tsara na nau'o'in motsa jiki daban-daban akan ayyukan ilimin lissafi, musamman ma'amala tsakanin motsa jiki da tsarin kwayoyin jikin da ke da alaka da lafiyar tsoka da farfadowa da cututtukan zuciya. Dokta Feng sau da yawa yana ɗaukar nau'ikan nau'ikan bincike na asali da dabarun ilimin ƙwayoyin cuta don gudanar da bincike mai zurfi. An jera Feng L a cikin ma'anar ambaton [9].

▎ Abubuwan da suka dace

[1] Stremming J, Farin A, Donthi A, et al. Recombinant tumaki IGF-1 yana haɓaka takamaiman girma a cikin tumakin tayi. Iyaka a cikin Ilimin Halitta 2022; 13: 954948.DOI: 10.3389/fphys.2022.954948.

[2] Khamsi F, Roberge S, Wong J. Novel nuni na wani physiologic/pharmacologic matsayin insulin-kamar girma factor-1 a cikin ovulation a cikin berayen da mataki a kan cumulus oophorus. Endocrine 2001; 14(2): 175-180.DOI: 10.1385/ENDO:14:2:175.

[3] Zhang X, Hu F, Li J, et al. IGF-1 yana hana kumburi kuma yana haɓaka angiogenesis ta hanyar Ras / PI3K / IKK / NF-κB hanyoyin siginar don inganta warkar da rauni. Jaridar Turai na Kimiyyar Magunguna 2024; 200: 106847.DOI: 10.1016/j.ejps.2024.106847.

[4] Farin A, Stremming J, Boehmer BH, et al. Rage siginin insulin da ke motsa glucose mai motsa jiki biyo bayan jiko na 1-wk IGF-1 a cikin tumakin ciki na ƙarshen ciki ya faru ne saboda lahani na ciki na tsibiri. Jaridar Amirka na Ilimin Halitta-Endocrinology da Metabolism 2021; 320(6): E1138-E1147. DOI: 10.1152/ajpendo.00623.2020.

[5] Farin A, Stremming J, Brown LD, Rozance PJ. Ragewar fitar da insulin mai motsa glucose mai motsa jiki yayin wani mummunan jiko na IGF-1 LR3 cikin tumaki tayi baya dagewa a cikin keɓantattun tsibiran. Jaridar Ci gaban Asalin Lafiya da Cututtuka 2023; 14(3): 353-361.DOI: 10.1017/S2040 17442300009 0.

[6] Nwachukwu CU, Robinson RS, Woad KJ. Tasirin tsarin haɓaka mai kama da insulin akan luteinising angiogenesis. Haihuwa da Haihuwa 2023; 4(2).DOI: 10.1530/RAF-22-0057.

[7] Ben-Zaken S, Meckel Y, Nemet D, Eliakim A. Insulin-kamar Growth Factor Axis Genetic Score and Sports Excellence. Jaridar Ƙarfafa da Bincike na Ƙarfafawa 2021; 35(9): 2421-2426.DOI: 10.1519/JSC.0000000000004102.

[8] Mao W. High-level magana na dogon sarkar Arg ~ 3-IGF-1 a Pichia pastoris da tsarkakewa da kuma hali. Bulletin na Kwalejin Kimiyyar Kiwon Lafiyar Soja 2008. https://api.semanticscholar.org/CorpusID:88212024.

[9] Feng L, Li B, Xi Y, Cai M, Tian Z. Aerobic motsa jiki da kuma juriya motsa jiki rage skeletal tsoka atrophy ta IGF-1 / IGF-1R-PI3K / Akt hanya a cikin mice tare da myocardial infarction. Jaridar Amirka na Ilimin Halittar Halittar Halittar Halittar Halittar Halitta 2022; 322(2): C164-C176.DOI: 10.1152/ajpcell.00344.2021.

DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.  

Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.