Na Cocer Peptides 
ukwezi gushize
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Incamake
Mugihe abatuye isi basaza ku muvuduko wihuse, ubushakashatsi mu kurwanya gusaza bwabaye intego nyamukuru mu bumenyi bwubuzima. Pinealon, tripeptide ya syntetique, itanga uburyo bushya bwo gutinda gusaza no kunoza ibibazo byubuzima bijyanye nimyaka bitewe nubushobozi bwayo bwo kurwanya gusaza.
Uburyo bwibikorwa
Kurwanya Antioxydeant
Guhangayikishwa na Oxidative bifatwa nkimwe mubintu byingenzi bitera gusaza ingirabuzimafatizo no gusaza kw'ibinyabuzima. Pinealon yerekana ingaruka zirwanya antioxydeant. Nk’uko ubushakashatsi bubyerekana, pinealone ya syntetique tripeptide (Glu-Asp-Arg, ni ukuvuga Pinealon) yerekana ubushobozi bushingiye ku kigero cyo kugabanya ingaruka ziterwa na oxydeide ziterwa na selile cerebellar granule selile, neutrophile, na pheochromocytoma (PC12). Kwiyegeranya cyane kwa ROS birashobora kwangiza biomolecules selile nka ADN, proteyine, na lipide, biganisha ku mikorere mibi ya selile no gusaza. Pinealon igabanya kwirundanya kwa ROS, igabanya neza okiside itera imbaraga ziterwa na selile no gukomeza imikorere isanzwe ya selile. Mu bushakashatsi bwakozwe na vitro bwerekanye ko nyuma yo kuvurwa hamwe na Pinealon runaka, urugero rwa ROS mu ngirabuzimafatizo za PC12 rwaragabanutse ku buryo bugaragara, kandi ubushobozi bw’imikorere n’ubushobozi bwo gukwirakwiza bwongerewe ku buryo bugaragara, byerekana ko Pinealon itanga ingirabuzimafatizo zifite ubuzima bwiza bw’imbere mu guhagarika imihangayiko ya okiside, bityo bikadindiza gusaza.
Igishushanyo cya 2 Ingaruka za pinealon ku bwoko bwa ogisijeni (ROS) itagaragara mu ngirabuzimafatizo za PC12, nk'uko byapimwe mu gihe cya 1 mM hydrogen peroxide (H₂O₂).
Kugenzura ukwezi kwakagari no kuzamura ikwirakwizwa
Pinealon igira ingaruka kumikorere ya selile no gukwirakwiza selile. Ubushakashatsi bwerekana ko ingaruka zo gukingira Pinealon zijyanye no gukora ERK 1/2 hamwe nigihe cyo gutinda kwingirabuzimafatizo. Inzira ya ERK 1/2 yerekana uruhare runini mugutunganya ingirabuzimafatizo nko gukura, gukwirakwizwa, no gutandukana. Pinealon iteza imbere ingirabuzimafatizo igenda itera inzira ya ERK 1/2 yerekana inzira, ituma selile zikomeza kwiyongera no kwivugurura ubwazo. Mu bushakashatsi bwakozwe, byagaragaye ko mu ngirabuzimafatizo zugarijwe na okiside, kwiyongera kwa Pinealon byatumye habaho impinduka zikomeye mu mvugo ya poroteyine zijyanye na selile, bituma ingirabuzimafatizo zihuta cyane kuva mu kiruhuko kugera mu cyiciro cya mitoto, bityo umuvuduko w’ikwirakwizwa ry’utugari. Iri tegeko ryizunguruka rya selile no guteza imbere ikwirakwizwa rifasha kugumana imikorere isanzwe yimitsi ningingo, byishyura kugabanuka kwimibare yatewe no gusaza kwa selile no gupfa, bityo bikagera ku ngaruka zo kurwanya gusaza kurwego rwakagari.
Imikoranire na sisitemu ya endocrine
Isano na pineal gland na melatonin
Indwara ya pinusi, nk'urugingo rukomeye rwa endocrine mu mubiri w'umuntu, isohora melatonine, igira uruhare runini mu kugenga isaha y'ibinyabuzima, ukwezi gukanguka, n'imikorere ya antioxydeant, kandi ifitanye isano rya bugufi no gusaza. Pinealon ntabwo ikomoka mu buryo butaziguye, ariko imikorere yayo ifitanye isano n'imikorere ya pineine. Melatonine isohorwa na gine ya pineine ifite antioxydants ikomeye, kandi Pinealon nayo ifite ubushobozi bwo kugabanya ibibazo bya antioxydeant. Byombi birashobora kwerekana ingaruka zijyanye no gukora antioxydeant. Pinealon irashobora guhindura mu buryo butaziguye imikorere yimikorere ya gineine igenga inzira yerekana ibimenyetso byerekana inzira, bityo bikagira ingaruka kumyunyu ngugu ya melatonine n'ingaruka zayo.
Ingaruka zishobora kubaho ku zindi misemburo ya endocrine
Usibye kuba ishobora guhuza na pineine na melatonine, Pinealon irashobora no guhindura indi misemburo ya endocrine, bityo ikagira uruhare mukurwanya gusaza. Sisitemu ya endocrine yumuntu numuyoboro utoroshye aho imisemburo itandukanye ikorana kandi ikagira ingaruka. Imisemburo ikura (GH) hamwe na insuline imeze nkikura-1 (IGF-1) igira uruhare runini mukubungabunga imikurire yumubiri, metabolisme, no gusana ingirabuzimafatizo, kandi impinduka murwego rwabo zifitanye isano rya bugufi no gusaza. Pinealon irashobora kugena inzira zerekana ibimenyetso bifitanye isano no gusohora no gukora kwa GH na IGF-1, bityo bigatera imbere gukura kwingirabuzimafatizo, gusana, no kuvugurura, no gutinda gusaza. Pinealon kandi igira ingaruka ku zindi misemburo ya endocrine nka hormone ya tiroyide, igenga umuvuduko wa metabolike yumubiri kugirango igumane imikorere isanzwe ya selile kandi igere ku ngaruka zo kurwanya gusaza.
Amabwiriza ya sisitemu yubudahangarwa
Sisitemu yubudahangarwa nayo igabanuka kumikorere mugihe cyo gusaza, bigaragazwa numubare nigikorwa cyingirabuzimafatizo z'umubiri, kandi bikagabanya ubushobozi bwo guhangana nubudahangarwa bw'umubiri, bigatuma umubiri ushobora kwibasirwa cyane na virusi kandi bikanabangamira ubushobozi bwo gukuraho selile na kanseri. Pinealon irashobora kugira ingaruka zayo zo kurwanya gusaza muguhindura sisitemu yumubiri. Pinealon irashobora guteza imbere gukwirakwiza no gutandukanya ingirabuzimafatizo z'umubiri, kongera umubare wazo no kongera ubushobozi bw'umubiri bwo kurwanya indwara. Pinealon irashobora kandi kugenga imikorere yingirabuzimafatizo, ibafasha kumenya neza no kurandura virusi, selile senescent, na selile kanseri. Ubushakashatsi bwerekana ko Pinealon ishobora kongera ubushobozi bwa fagocytike ya macrophage, ikabasha gukora neza fagocytose no gukuraho bagiteri na virusi zitera. Irashobora kandi kongera ibikorwa bya cytotoxic ya lymphocytes T irwanya kanseri. Mugutunganya sisitemu yumubiri, Pinealon ifasha kugumana uburinganire bwumubiri, kugabanya kwandura indwara zitandukanye ziterwa no kudakora neza kwumubiri, bityo bikadindiza muburyo butaziguye gusaza.
Kurinda Sisitemu Nervous
Gusaza kwa sisitemu y'imitsi bifitanye isano rya bugufi no kutamenya neza imikorere n'indwara zifata ubwonko. Pinealon igira ingaruka zimwe na zimwe zo kurinda sisitemu y'imitsi. Ku rwego rwa neuronal, Pinealon irashobora kurinda neurone kwangirika muguhagarika imbaraga za okiside no kugenga ingirabuzimafatizo, bityo bikagumana imiterere isanzwe n'imikorere ya neuron. Mu bushakashatsi bwakozwe ku ngirabuzimafatizo ya cerebellar granule, Pinealon yasanze igabanya impagarara ziterwa na okiside itera urupfu kandi ikongerera ubuzima ubuzima. Pinealon igira kandi uruhare muri synthesis, kurekura, hamwe na metabolisme ya neurotransmitter, igenga kwanduza ibimenyetso byimitsi bityo bikanoza imikorere ya sisitemu. Muguhindura urwego rwa neurotransmitter nka dopamine na acetylcholine, Pinealon irashobora kongera ubushobozi bwo kwiga no kwibuka. Mu bushakashatsi bw’inyamaswa, inyamaswa zavuwe na Pinealon zagaragaje imikorere myiza mu myigire no mu gupima kwibuka, byerekana ingaruka zayo zo gukingira no gukora ku mikorere y’imitsi y’imitsi, zishobora gufasha gutinda gusaza kwa sisitemu no kwirinda indwara zifata ubwonko.
Gukoresha Pinealon murwego rwo kurwanya gusaza
Ubushakashatsi bwibanze
Mu cyiciro cyubushakashatsi bwibanze, Pinealon yakoreshejwe mubushakashatsi bwikigereranyo cyinyamanswa kugirango isuzume ingaruka zayo zo kurwanya gusaza. Mu bushakashatsi bwimbeba, dosiye zitandukanye za Pinealon zatanzwe kugirango harebwe ibipimo bifitanye isano no gusaza mu mbeba. Imbeba zavuwe na Pinealon zerekanaga umusatsi mwiza nubucucike, kongera ubushobozi bwa moteri, no kunoza imikorere yubwenge. Mu bizamini byubwenge, nkibigeragezo byamazi ya Morris, imbeba zavuwe na Pinealon zashoboye kubona urubuga rwihishe vuba, byerekana ubushobozi bwo kwiga no kwibuka. Isuzuma ry’indwara z’imbeba n’ingingo zagaragaje ko imbeba zo mu itsinda ryavuwe na Pinealon zagaragaje cyane ko kwangirika kw’ingirabuzimafatizo no gusaza mu ngingo zikomeye nk’umwijima n’impyiko, hamwe n’imikorere ya selile idahwitse kandi ikora neza. Ubu bushakashatsi bwerekana ko Pinealon igaragaza ingaruka zikomeye zo kurwanya gusaza mu buryo bw’inyamanswa, itanga inkunga ku bushakashatsi bwayo bw’ubuvuzi.
Ibishobora kuvurwa
Ukurikije ibisubizo byiza byubushakashatsi bwibanze, Pinealon yerekana uburyo bwagutse bwo gukoresha amavuriro. Mu gukumira no kuvura indwara ziterwa n'imyaka, Pinealon irashobora kugira agaciro gakomeye. Ku ndwara zifata ubwonko nk'indwara ya Alzheimer n'indwara ya Parkinson, bitewe n'ingaruka zo gukingira Pinealon kuri sisitemu y'imitsi, irashobora kuba nk'umuti ushobora kuvura indwara kugira ngo umuvuduko udatera imbere kandi utezimbere imikorere y'abarwayi ndetse n'ubushobozi bwa moteri. Mu rwego rwindwara zifata umutima, Pinealon ifasha mukurinda kwangirika no gusaza kwingirabuzimafatizo ya endoteliyale binyuze mumaganya ya antioxydeant no kugenzura imikorere ya selile, bityo bikagabanya ibyago byindwara z'umutima-dameri nka aterosklerose. Kugabanuka kumyaka kumikorere yubudahangarwa bw'umubiri, biteganijwe ko Pinealon yongera imbaraga z'umubiri mu kugenzura imikorere y’umubiri, bityo ikarinda no kuvura indwara zanduza.
Porogaramu mu Bwiza no Kuvura Uruhu
Mu bwiza no kwita ku ruhu, Pinealon nayo ifite agaciro gashoboka. Gusaza k'uruhu bigaragarira cyane cyane nk'iminkanyari yiyongereye, kugabanuka, gukama, hamwe na pigmentation. Pinealon irwanya antioxydeant ningaruka zogukwirakwiza ingirabuzimafatizo bituma iba ingirakamaro yo kurwanya gusaza kuruhu. Pinealon irashobora kugabanya kwirundanya kwa ROS mungirangingo zuruhu, kugabanya kwangirika kwa okiside itera kwangirika kwingirangingo zuruhu, ikarinda kwangirika kwa fibre ya kolagen na elastique, bityo bikagabanya imiterere yiminkanyari kandi bikagumana uruhu rworoshye. Pinealon iteza ubwiyongere no kuvugurura ingirangingo zuruhu, yihutisha gusana ingirangingo zuruhu zangiritse, kandi igahindura imiterere yuruhu no kumurika. Ubushakashatsi bwibanze bwibanze kuri Pinealon iyo bwongewe ku bicuruzwa byita ku ruhu, kandi ibisubizo byerekana ko abitabiriye gukoresha ibicuruzwa byita ku ruhu birimo Pinealon bagabanutseho ubujyakuzimu bw’iminkanyari n’umubare, ndetse no kurushaho gukomera kw’uruhu hamwe n’ubushuhe, byerekana ko Pinealon ifite ubushobozi bwo gukoresha mu bijyanye n’ubwiza no kwita ku ruhu.
Imyanzuro ishingiye ku bushakashatsi
Ingaruka Zuzuye
Ukurikije ubushakashatsi buriho, Pinealon yerekana ingaruka nziza zinyuranye mukurwanya gusaza. Kurwego rwa selire, irinda selile kwangirika kandi igakomeza imikorere isanzwe nubuzima bwayo binyuze muburyo bwinshi nka stress ya antioxydeant, kugenzura ingirabuzimafatizo, no guteza imbere ikwirakwizwa ry'utugari. Ku rwego rw’ibinyabuzima, Pinealon igira ingaruka kuri sisitemu nyinshi zingenzi zirimo endocrine, immunite, na nervice sisitemu, igera ku ngaruka zo kurwanya gusaza muguhuza imikorere yazo. Ingaruka zishobora kugenga imikorere ya pineal gland, hamwe ningaruka zayo zo kurinda sisitemu yumubiri na nervice, bigira uruhare mukubungabunga homeostasis yumubiri no kudindiza gusaza.
Umwanzuro
Nibintu bifite imiti irwanya gusaza, Pinealon yerekana uburyo butandukanye bwibikorwa mugutunganya ingirabuzimafatizo, kugenzura sisitemu ya endocrine, kugenzura sisitemu yumubiri, no kurinda imitsi ya nervice. Irerekana kandi ibishoboka mubushakashatsi bwibanze, kubishobora kuvura, no kuvura uruhu.
Inkomoko
[1] Khavinson V, Ribakova Y, Kulebiakin K, n'abandi. Pinealon yongerera imbaraga selile muguhagarika urwego rwubusa kandi igakora ibikorwa byinshi. Ubushakashatsi bwo Kuvugurura, 2011,14 (5): 535-541.DOI: 10.1089 / rej.2011.1172.
Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
