Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Txheej txheem cej luam
Raws li cov pej xeem thoob ntiaj teb muaj hnub nyoog ntawm kev nrawm nrawm, kev tshawb fawb txog kev tiv thaiv kev laus tau dhau los ua qhov tseem ceeb hauv kev tshawb fawb txog lub neej. Pinealon, ib qho hluavtaws tripeptide, muaj peev xwm tshiab rau kev ua kom qeeb ntawm kev laus thiab txhim kho hnub nyoog txog kev noj qab haus huv vim nws muaj peev xwm tiv thaiv kev laus.
Mechanism ntawm Action
Antioxidant Stress Relief
Oxidative stress yog suav tias yog ib qho ntawm cov tseem ceeb ua rau kev laus ntawm cov cellular thiab cov kab mob aging. Pinealon ua kom pom cov tshuaj tiv thaiv antioxidant kev ntxhov siab. Raws li kev tshawb fawb, cov hluavtaws tripeptide pinealone (Glu-Asp-Arg, piv txwv li, Pinealon) muaj peev xwm ua kom muaj peev xwm txo qis oxidative kev ntxhov siab vim kev puas tsuaj hauv cerebellar granule hlwb, neutrophils, thiab pheochromocytoma (PC12) hlwb. Kev sib sau ntau dhau ntawm ROS tuaj yeem ua rau cov cellular biomolecules xws li DNA, proteins, thiab lipids, ua rau cellular tsis ua haujlwm thiab kev laus. Pinealon txo ROS tsub zuj zuj, zoo mitigating oxidative kev nyuaj siab-induced cellular puas thiab tswj ib txwm cellular physiological zog. Hauv vitro thwmsim pom tias tom qab kev kho mob nrog qee qhov concentration ntawm Pinealon, ROS qib hauv PC12 hlwb tau txo qis, thiab cell viability thiab proliferation muaj peev xwm tau txhim kho, qhia tau hais tias Pinealon muab cov hlwb nrog ib puag ncig zoo dua los ntawm inhibiting oxidative kev nyuaj siab, yog li qeeb cov txheej txheem kev laus.
Daim duab 2 Qhov cuam tshuam ntawm pinealon ntawm cov kab mob hauv lub cev muaj zog (ROS) qib hauv PC12 hlwb, raws li ntsuas nyob rau hauv lub xub ntiag lossis tsis muaj 1 mM hydrogen peroxide (H₂O₂).
Cell Cycle Regulation and Proliferation Promotion
Pinealon cuam tshuam kev tswj lub voj voog ntawm tes thiab cov txheej txheem ntawm kev loj hlob ntawm tes. Kev tshawb fawb qhia tias Pinealon qhov kev tiv thaiv muaj feem cuam tshuam nrog kev ua kom ERK 1/2 thiab ncua sij hawm ntawm kev hloov pauv ntawm tes. ERK 1/2 signaling pathway plays lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm tes xws li kev loj hlob, kev loj hlob, thiab kev sib txawv. Pinealon txhawb nqa lub voj voog ntawm tes los ntawm kev ua kom lub ERK 1/2 taw qhia txoj hauv kev, ua kom cov hlwb txuas ntxiv mus ntxiv thiab rov ua dua lawv tus kheej. Hauv kev sim, nws tau pom tias hauv cov hlwb raug oxidative kev nyuaj siab, qhov sib ntxiv ntawm Pinealon tau ua rau muaj kev hloov pauv tseem ceeb hauv kev nthuav qhia ntawm cov kab mob ntawm tes-txog cov proteins, ua rau cov hlwb hloov pauv sai dua los ntawm lub sijhawm so mus rau theem mitotic, yog li ua kom cov cell proliferation. Qhov kev tswj hwm ntawm lub voj voog ntawm tes thiab kev txhawb nqa ntawm kev loj hlob tuaj yeem pab tswj kev ua haujlwm ntawm cov ntaub so ntswg thiab cov khoom nruab nrog cev, them nyiaj rau kev txo qis ntawm cov xov tooj ntawm tes los ntawm cov cellular aging thiab tuag, yog li ua tiav cov teebmeem kev laus ntawm cov cellular.
Kev cuam tshuam nrog endocrine system
Kev sib raug zoo nrog pineal caj pas thiab melatonin
Lub caj pas pineal, uas yog ib qho tseem ceeb ntawm cov kab mob endocrine hauv tib neeg lub cev, secretes melatonin, uas plays lub luag haujlwm tseem ceeb hauv kev tswj lub moos lom neeg, kev pw tsaug zog-tsim, thiab kev ua haujlwm antioxidant, thiab muaj feem cuam tshuam nrog kev laus. Pinealon tsis yog muab ncaj qha los ntawm lub caj pas pineal, tab sis nws txoj haujlwm muaj feem cuam tshuam nrog lub caj pas pineal lub luag haujlwm. Melatonin secreted los ntawm lub caj pas pineal muaj cov khoom tseem ceeb antioxidant, thiab Pinealon tseem muaj peev xwm tiv thaiv kev ntxhov siab. Ob leeg tuaj yeem pom muaj kev sib koom ua ke ntawm kev ua haujlwm antioxidant. Pinealon tuaj yeem cuam tshuam ncaj qha rau kev ua haujlwm ntawm lub caj pas pineal los ntawm kev tswj hwm txoj hauv kev hauv lub cev, yog li cuam tshuam rau melatonin secretion thiab nws cov teebmeem.
Muaj peev xwm cuam tshuam rau lwm cov tshuaj hormones endocrine
Ntxiv rau qhov nws muaj peev xwm txuas nrog lub caj pas pineal thiab melatonin, Pinealon kuj tseem tuaj yeem cuam tshuam lwm cov tshuaj endocrine, yog li koom nrog cov txheej txheem tiv thaiv kev laus. Tib neeg endocrine system yog ib qho kev sib txuas uas muaj ntau yam tshuaj hormones cuam tshuam thiab cuam tshuam ib leeg. Kev loj hlob hormone (GH) thiab insulin-zoo li kev loj hlob zoo tshaj plaws-1 (IGF-1) ua lub luag haujlwm tseem ceeb hauv kev tswj lub cev kev loj hlob, metabolism, thiab kho cellular, thiab cov kev hloov pauv hauv lawv cov qib yog cuam tshuam nrog kev laus. Pinealon tuaj yeem tswj cov kev taw qhia txog kev cuam tshuam rau kev tso tawm thiab kev ua haujlwm ntawm GH thiab IGF-1, yog li txhawb kev loj hlob ntawm tes, kho, thiab rov tsim dua tshiab, thiab ncua kev laus. Pinealon tseem cuam tshuam rau lwm cov tshuaj hormones endocrine xws li thyroid hormones, tswj lub cev metabolic tus nqi kom tswj cov cellular metabolic zog thiab ua kom muaj kev tiv thaiv kev laus.
Kev tswj hwm lub cev tiv thaiv kab mob
Lub cev tiv thaiv kab mob kuj muaj kev ua haujlwm poob qis thaum lub sijhawm laus, tshwm sim los ntawm cov lej txo thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, thiab txo qis lub cev tiv thaiv kab mob, ua rau lub cev muaj kev cuam tshuam rau cov kab mob cuam tshuam thiab cuam tshuam nws lub peev xwm los tshem tawm senescent thiab mob qog noj ntshav. Pinealon tuaj yeem siv nws cov teebmeem kev laus los ntawm kev tswj lub cev tiv thaiv kab mob. Pinealon tuaj yeem txhawb kev loj hlob thiab kev sib txawv ntawm lub cev tiv thaiv kab mob, ua kom lawv cov lej thiab txhim kho lub cev tiv thaiv kab mob. Pinealon kuj tseem tuaj yeem tswj hwm cov haujlwm ntawm lub cev tiv thaiv kab mob, ua kom lawv paub zoo dua thiab tshem tawm cov kab mob, cov hlwb hlwb, thiab cov qog nqaij hlav cancer. Kev tshawb fawb qhia tias Pinealon tuaj yeem txhim kho lub peev xwm phagocytic ntawm macrophages, ua rau lawv ua tau zoo dua phagocytose thiab tshem tawm cov kab mob invading thiab kab mob. Nws tseem tuaj yeem txhim kho cov haujlwm cytotoxic ntawm T lymphocytes tiv thaiv cov qog nqaij hlav cancer. Los ntawm kev tswj hwm lub cev tiv thaiv kab mob, Pinealon pab tswj kev tiv thaiv kab mob, txo qhov tshwm sim ntawm ntau yam kab mob tshwm sim los ntawm kev tiv thaiv kab mob, yog li tsis ncaj ncees rau kev laus.
Kev tiv thaiv ntawm Nervous System
Kev laus ntawm lub paj hlwb muaj feem cuam tshuam nrog kev paub tsis meej thiab cov kab mob neurodegenerative. Pinealon muaj qee yam kev tiv thaiv ntawm lub paj hlwb. Nyob rau theem neuronal, Pinealon tuaj yeem tiv thaiv cov neurons los ntawm kev puas tsuaj los ntawm inhibiting oxidative kev nyuaj siab thiab tswj lub voj voog ntawm tes, yog li tswj hwm qhov qub morphology thiab kev ua haujlwm ntawm neurons. Hauv kev tshawb fawb ntawm cerebellar granule hlwb, Pinealon tau pom los txo qis oxidative kev ntxhov siab vim yog cell tuag thiab nce cell ciaj sia taus. Pinealon tseem cuam tshuam cov synthesis, tso tawm, thiab cov metabolism hauv neurotransmitters, tswj cov teeb liab neural kis tau tus mob thiab yog li txhim kho lub paj hlwb. Los ntawm kev hloov kho cov theem ntawm cov neurotransmitters xws li dopamine thiab acetylcholine, Pinealon tuaj yeem txhim kho kev kawm thiab kev nco muaj peev xwm. Hauv kev sim tsiaj, cov tsiaj kho nrog Pinealon tau pom tias muaj kev ua tau zoo dua hauv kev kawm thiab kev ntsuam xyuas kev nco, qhia txog nws txoj kev tiv thaiv thiab kev txhim kho kev ua haujlwm ntawm lub paj hlwb, uas tuaj yeem pab ncua kev laus lub paj hlwb thiab tiv thaiv kab mob neurodegenerative.
Kev siv ntawm Pinealon hauv kev tiv thaiv kev laus
Cov ntawv thov kev tshawb fawb Preclinical
Hauv theem kev tshawb fawb preclinical, Pinealon tau siv rau hauv ntau qhov kev sim tsiaj txhu los ntsuas nws cov teebmeem kev laus. Hauv kev sim nas, ntau koob tshuaj Pinealon tau muab coj los soj ntsuam cov cim kev laus hauv cov nas. Cov nas kho nrog Pinealon pom cov plaub hau zoo dua qub thiab qhov ntom ntom, txhim kho lub cev muaj zog, thiab txhim kho kev txawj ntse. Hauv kev ntsuam xyuas kev txawj ntse, xws li kev sim Morris dej tshawb nrhiav, nas kho nrog Pinealon tuaj yeem nrhiav lub platform zais tau sai dua, qhia txog kev txhim kho kev kawm thiab kev nco muaj peev xwm. Kev kuaj kab mob ntawm nas cov ntaub so ntswg thiab cov kabmob tau qhia tias nas nyob rau hauv pab pawg Pinealon-kho tau pom tias txo qis cellular puas thiab kev laus ntawm cov kabmob tseem ceeb xws li daim siab thiab ob lub raum, nrog rau cov qauv cellular ntau dua thiab ua haujlwm zoo dua qub. Cov kev tshawb pom no qhia tias Pinealon qhia txog kev tiv thaiv kev laus tseem ceeb hauv cov qauv tsiaj, muab kev txhawb nqa rau nws cov kev tshawb fawb soj ntsuam ntxiv.
Muaj peev xwm kho mob daim ntawv thov Prospects
Raws li cov txiaj ntsig zoo ntawm cov kev tshawb fawb hauv tsev kho mob, Pinealon qhia tau hais tias muaj peev xwm siv tshuaj kho mob dav dav. Hauv kev tiv thaiv thiab kho cov kab mob uas muaj hnub nyoog, Pinealon tuaj yeem tuav tus nqi tseem ceeb. Rau cov kab mob neurodegenerative xws li Alzheimer's disease thiab Parkinson's disease, vim Pinealon tiv thaiv cov kab mob hauv lub paj hlwb, nws tuaj yeem ua tus neeg sawv cev kho mob kom qeeb tus kab mob thiab txhim kho cov neeg mob kev txawj ntse thiab lub cev muaj zog. Hauv kev ua haujlwm ntawm cov kab mob plawv, Pinealon pab tiv thaiv kev puas tsuaj thiab kev laus ntawm vascular endothelial hlwb los ntawm kev ntxhov siab antioxidant thiab kev tswj hwm ntawm cov cellular zog, yog li txo qhov kev pheej hmoo ntawm cov kab mob plawv xws li atherosclerosis. Rau hnub nyoog txog kev poob qis hauv lub cev tsis muaj zog, Pinealon yuav tsum txhim kho lub cev tiv thaiv los ntawm kev tswj hwm lub cev tiv thaiv kab mob, yog li tiv thaiv thiab kho cov kab mob sib kis.
Cov ntawv thov hauv Kev Zoo Nkauj thiab Kev Kho Hniav
Hauv kev zoo nkauj thiab kev tu tawv nqaij, Pinealon kuj tseem muaj peev xwm thov tus nqi. Kev laus ntawm daim tawv nqaij feem ntau manifests li wrinkles, sagging, dryness, thiab pigmentation. Pinealon's antioxidant kev nyuaj siab thiab kev loj hlob ntawm tes-txhawb cov teebmeem ua rau nws muaj txiaj ntsig los tiv thaiv kev laus rau daim tawv nqaij. Pinealon tuaj yeem txo qhov sib xyaw ntawm ROS hauv cov tawv nqaij, txo cov oxidative kev ntxhov siab vim kev puas tsuaj rau cov tawv nqaij, tiv thaiv kev degradation ntawm collagen thiab elastic fibers, yog li txo qhov tsim ntawm wrinkles thiab tswj cov tawv nqaij elasticity. Pinealon txhawb nqa kev loj hlob thiab rov ua dua tshiab ntawm cov tawv nqaij, ua kom cov tawv nqaij puas, thiab txhim kho daim tawv nqaij zoo nkauj thiab luster. Qee qhov kev tshawb fawb ua ntej tau sim Pinealon thaum ntxiv rau cov khoom tu tawv nqaij, thiab cov txiaj ntsig tau qhia tias cov neeg koom siv cov khoom siv tawv nqaij uas muaj Pinealon tau ntsib kev txo qis hauv qhov tob thiab tus lej, nrog rau kev txhim kho ntawm daim tawv nqaij firmness thiab noo noo cov ntsiab lus, qhia tias Pinealon muaj qee yam kev siv peev xwm hauv kev zoo nkauj thiab kev tu tawv nqaij.
Cov lus xaus raws li Kev Tshawb Fawb
Cov teebmeem
Raws li kev tshawb fawb uas twb muaj lawm, Pinealon qhia tau hais tias muaj txiaj ntsig zoo hauv kev tiv thaiv kev laus. Ntawm qib cellular, nws tiv thaiv cov hlwb los ntawm kev puas tsuaj thiab tswj lawv cov kev ua haujlwm ib txwm muaj thiab muaj txiaj ntsig zoo los ntawm ntau lub tswv yim xws li kev ntxhov siab antioxidant, kev tswj hwm ntawm lub voj voog ntawm tes, thiab txhawb kev loj hlob ntawm tes. Nyob rau hauv lub cev, Pinealon cuam tshuam rau ntau yam tseem ceeb xws li endocrine, lub cev tsis muaj zog, thiab lub paj hlwb, ua tiav tag nrho cov kev tiv thaiv kev laus los ntawm kev tswj hwm lawv txoj haujlwm. Nws muaj peev xwm tswj tau cov teebmeem ntawm pineal caj pas ua haujlwm, nrog rau nws cov teebmeem kev tiv thaiv ntawm lub cev thiab lub paj hlwb, pab tswj lub cev homeostasis thiab qeeb cov txheej txheem kev laus.
Xaus
Raws li cov khoom siv los tiv thaiv kev laus, Pinealon nthuav tawm ntau yam kev ua haujlwm hauv kev tswj hwm ntawm tes, kev tswj hwm kab mob endocrine, kev tiv thaiv kab mob, thiab kev tiv thaiv paj hlwb. Nws kuj tseem qhia tau tias muaj peev xwm siv tau hauv kev tshawb fawb preclinical, kev siv tshuaj kho mob, thiab kev kho tawv nqaij.
Qhov chaw
[1] Khavinson V, Ribakova Y, Kulebiakin K, et al. Pinealon ua rau kom muaj zog ntawm tes los ntawm kev tawm tsam ntawm cov dawb radical ntau ntau thiab ua kom cov txheej txheem proliferative [J]. Rejuvenation Research, 2011,14(5):535-541.DOI:10.1089/rej.2011.1172.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
