By Cocer Peptides 
1 ọnwa gara aga
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
Nchịkọta
Ka ọnụ ọgụgụ mmadụ zuru ụwa ọnụ na-eto n'ike n'ike, nyocha gbasara mgbochi ịka nká aghọwo isi ihe na-elekwasị anya na ngalaba sayensị ndụ. Pinealon, tripeptide sịntetik, na-enye ohere ọhụrụ maka ibelata usoro ịka nká na imeziwanye nsogbu ahụike metụtara afọ n'ihi ihe nwere ike ime ka ọ ghara ịka nká.
Usoro nke Omume
Enyemaka Nchegbu Antioxidant
A na-ewere nrụgide oxidative dị ka otu n'ime isi ihe na-enye aka na ịka nká cellular na ịka nká. Pinealon na-egosipụta mmetụta antioxidant na-ebelata nchekasị. Dị ka nnyocha si kwuo, sịntetik tripeptide pinealone (Glu-Asp-Arg, ie, Pinealon) na-egosiputa ikike dabere na dose iji gbochie mmebi nke nrụgide oxidative na mkpụrụ ndụ granule cerebellar, neutrophils, na pheochromocytoma (PC12). Mkpokọta ROS gabigara ókè nwere ike imebi biomolecules cellular dị ka DNA, protein, na lipids, na-eduga n'ịrụ ọrụ cellular na ịka nká. Pinealon na-ebelata mkpokọta ROS, na-ebelata nrụrụ aka nke oxidative nke mebiri emebi cellular yana idobe ọrụ physiological cellular nkịtị. Nnwale in vitro gosiri na mgbe ọgwụgwọ ya na ụfọdụ ntinye nke Pinealon gasịrị, ọkwa ROS dị na sel PC12 belatara nke ukwuu, na ikike cell na ikike ịba ụba na-abawanye nke ọma, na-egosi na Pinealon na-enye mkpụrụ ndụ ihe dị mma n'ime ime site na igbochi nrụgide oxidative, si otú ahụ na-ebelata usoro ịka nká.
Ọgụgụ 2 Mmetụta nke pinealon na ụdị oxygen intracellular reactive oxygen (ROS) na sel PC12, dịka a tụrụ na ọnụnọ ma ọ bụ enweghị 1 mM hydrogen peroxide (H₂O₂).
Usoro usoro cell na nkwalite nkwalite
Pinealon na-emetụta usoro okirikiri cell na usoro mgbasawanye cell. Nnyocha na-egosi na mmetụta nchebe nke Pinealon na-ejikọta ya na ịgbalite ERK 1/2 na oge na-egbu oge nke mgbanwe mgbanwe cell. Ụzọ akara ERK 1/2 na-arụ ọrụ nchịkwa dị mkpa na usoro cellular dị ka uto, mmụba, na ọdịiche. Pinealon na-akwalite ọganihu okirikiri cell site n'ịkwalite ụzọ akara ERK 1/2, na-eme ka mkpụrụ ndụ nwee ike ịnọgide na-amụba na ime onwe ha. N'ime nyocha, a chọpụtara na n'ime sel ndị e kpughere na nrụgide oxidative, mgbakwunye nke Pinealon mere ka mgbanwe dị ịrịba ama na nkwupụta nke protein ndị metụtara okirikiri cell, na-eme ka mkpụrụ ndụ nwee ike ịgbanwe ngwa ngwa site na oge izu ike gaa na oge mitotic, si otú ahụ na-amụba ọnụ ọgụgụ nke cell proliferation. Usoro a nke usoro okirikiri cell na nkwalite mgbasawanye na-enyere aka ịnọgide na-arụ ọrụ nkịtị nke anụ ahụ na akụkụ ahụ, na-akwụ ụgwọ maka mbelata ọnụ ọgụgụ cell nke ịka nká na ọnwụ kpatara, si otú ahụ nweta mmetụta mgbochi ịka nká na ọkwa cellular.
Mmekọrịta na usoro endocrine
Mmekọrịta na pineal gland na melatonin
Ọkpụkpụ pineal, dị ka akụkụ ahụ endocrine dị mkpa n'ime ahụ mmadụ, na-ezobe melatonin, nke na-arụ ọrụ dị mkpa n'ịhazi oge elekere ndụ, usoro ụra ụra, na ọrụ antioxidant, ma nwee njikọ chiri anya na usoro ịka nká. A naghị enweta Pinealon ozugbo site na gland pineal, mana ọrụ ya metụtara ọrụ pineal gland. Melatonin zoro ezo site na pineal gland nwere mmetụta antioxidant dị ịrịba ama, na Pinealon nwekwara ikike na-ebelata nchekasị antioxidant. Ha abụọ nwere ike igosipụta mmetụta synergistic n'ihe gbasara ọrụ antioxidant. Pinealon nwere ike imetụta ọnọdụ ọrụ nke pineal gland n'ụzọ na-edoghị anya site n'ịhazi ụzọ mgbaàmà intracellular, si otú ahụ na-emetụta secretion melatonin na mmetụta ya.
Mmetụta nwere ike na homonụ endocrine ndị ọzọ
Na mgbakwunye na njikọ ya na pineal gland na melatonin, Pinealon nwekwara ike imetụta homonụ endocrine ndị ọzọ, si otú a na-ekere òkè na usoro mgbochi ịka nká. Usoro endocrine mmadụ bụ netwọk dị mgbagwoju anya ebe homonụ dị iche iche na-emekọrịta ma na-emetụta ibe ha. Hormone na-eto eto (GH) na insulin-dị ka ihe na-eto eto-1 (IGF-1) na-arụ ọrụ dị mkpa n'ịkwado uto anụ ahụ, metabolism, na nrụzi cellular, na mgbanwe na ọkwa ha na-ejikọta ya na usoro ịka nká. Pinealon nwere ike ịhazi ụzọ mgbaàmà ndị metụtara ya ka ọ na-emetụta nzuzo nzuzo na ọrụ nke GH na IGF-1, si otú ahụ na-akwalite uto cell, nrụzi, na ịmaliteghachi, na-egbu oge usoro ịka nká. Pinealon na-emetụtakwa homonụ endocrine ndị ọzọ dị ka homonụ thyroid, na-achịkwa usoro metabolic nke anụ ahụ iji nọgide na-arụ ọrụ metabolic cellular nkịtị ma nweta mmetụta mgbochi ịka nká.
Iwu nke sistemu ahụ ji alụso ọrịa ọgụ
Usoro ahụ ji alụso ọrịa ọgụ na-enwetakwa mbelata ọrụ n'oge usoro ịka nká, gosipụtara site na ọnụ ọgụgụ na-ebelata na ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ, na ibelata ikike nzaghachi mgbochi ọrịa, na-eme ka ahụ dịkwuo mfe maka mbuso agha pathogen na imebi ikike ya ikpochapụ mkpụrụ ndụ senescent na ọrịa kansa. Pinealon nwere ike ịkpa mmetụta mgbochi ịka nká site n'ịhazi usoro ahụ ji alụso ọrịa ọgụ. Pinealon nwere ike ịkwalite mmụba na ọdịiche nke mkpụrụ ndụ na-alụso ọrịa ọgụ, na-abawanye ọnụ ọgụgụ ha na ịkwalite ikike nzaghachi nke ahụ. Pinealon nwekwara ike ịhazi ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ, na-eme ka ha nwee ike ịmata ma kpochapụ nje ndị na-akpata ọrịa, mkpụrụ ndụ sesescent, na mkpụrụ ndụ kansa. Nnyocha na-egosi na Pinealon nwere ike ịkwalite ikike phagocytic nke macrophages, na-eme ka ha nwee ike phagocytose nke ọma ma kpochapụ nje bacteria na nje ndị na-awakpo. Ọ nwekwara ike ịkwalite ọrụ cytotoxic nke T lymphocytes megide mkpụrụ ndụ kansa. Site n'ịchịkwa usoro ahụ ji alụso ọrịa ọgụ, Pinealon na-enyere aka ịnọgide na-enwe nguzozi nke usoro ahụ ji alụso ọrịa ọgụ, na-ebelata ọrịa dị iche iche nke ọrịa na-alụso ọrịa ọgụ kpatara, si otú ahụ na-ebelata usoro ịka nká n'ụzọ na-apụtaghị ìhè.
Nchedo nke sistemu ụjọ
Ịka nká nke usoro ụjọ ahụ nwere njikọ chiri anya na arụ ọrụ ụbụrụ na ọrịa neurodegenerative. Pinealon nwere mmetụta nchebe ụfọdụ na usoro ụjọ ahụ. N'ọkwa neuronal, Pinealon nwere ike ichebe neurons site na mmebi site na igbochi nrụgide oxidative na ịhazi okirikiri sel, si otú ahụ na-edobe usoro ọmụmụ na ọrụ nke neurons. N'ime ọmụmụ banyere mkpụrụ ndụ granule cerebellar, a hụrụ Pinealon iji belata ọnwụ cell na-akpata nrụgide oxidative na ịbawanye ọnụego ndụ ndụ cell. Pinealon na-emetụtakwa njikọ, ntọhapụ, na metabolism nke neurotransmitters, na-achịkwa mgbasa ozi akwara ma si otú a na-eme ka ọrụ usoro ụjọ ahụ dịkwuo mma. Site n'ịgbanwe ọkwa nke neurotransmitters dị ka dopamine na acetylcholine, Pinealon nwere ike ịkwalite ikike mmụta na ebe nchekwa. N'ime nnwale anụmanụ, anụmanụ ndị a na-emeso Pinealon gosipụtara arụmọrụ ka mma na nyocha mmụta na ebe nchekwa, na-egosi nsonaazụ nchebe ya na arụ ọrụ na sistemụ ụjọ, nke nwere ike inye aka igbu oge nke ụjọ usoro ịka nká ma gbochie ọrịa neurodegenerative.
Ngwa nke Pinealon na ngalaba mgbochi ịka nká
Ngwa nyocha nke preclinical
N'ime usoro nyocha nke izizi, etinyere Pinealon n'ọtụtụ nnwale ụdị anụmanụ iji chọpụta mmetụta mgbochi ịka nká ya. N'ime nnwale òké, a na-enye ọgwụ Pinealon dị iche iche iji hụ ihe ndị metụtara ịka nká na ụmụ oke. Ụmụ oke e ji Pinealon emeso ya gosipụtara ncha ntutu na njupụta dị mma, ikike moto na-eme ka ọ dịkwuo mma, yana ọrụ ọgụgụ isi ka mma. N'ime ule ọrụ ọgụgụ isi, dị ka nnwale maze mmiri nke Morris, ụmụ oke ejiri Pinealon emeso ya nwere ike ịchọta ikpo okwu zoro ezo ngwa ngwa, na-egosi nkwalite mmụta na ikike nchekwa. Nnyocha pathological nke anụ ahụ òké na akụkụ ahụ gosiri na ụmụ oke nọ n'òtù ndị a na-agwọ Pinealon gosipụtara n'ụzọ dị ukwuu belata mmebi cellular na ịka nká n'ime akụkụ ahụ dị mkpa dị ka imeju na akụrụ, na-enwe usoro cellular na-adịghị mma na ọrụ ndị a na-arụ ọrụ nke ọma. Nchọpụta ndị a na-egosi na Pinealon na-egosipụta mmetụta mgbochi ịka nká na ụdị anụmanụ, na-enye nkwado maka nyocha ọzọ nke ụlọ ọgwụ.
Atụmanya Ngwa nke Clinical
Dabere na nsonaazụ dị mma nke ọmụmụ izizi, Pinealon na-egosipụta atụmanya ngwa ụlọ ọgwụ buru ibu. Na mgbochi na ọgwụgwọ ọrịa ndị metụtara afọ, Pinealon nwere ike ịba uru dị ukwuu. Maka ọrịa neurodegenerative dị ka ọrịa Alzheimer na ọrịa Parkinson, n'ihi mmetụta nchebe nke Pinealon na usoro ụjọ ahụ, ọ nwere ike ịbụ onye na-agwọ ọrịa na-agwọ ọrịa iji mee ka ọrịa kwụsịlata ma melite ọrụ ọgụgụ isi nke ndị ọrịa na ikike moto. Na ngalaba nke ọrịa obi, Pinealon na-enyere aka igbochi mmebi na ịka nká nke sel endothelial vaskụla site na nrụgide antioxidant na nhazi nke ọrụ cellular, si otú ahụ belata ihe ize ndụ nke ọrịa obi dị ka atherosclerosis. Maka mbelata ọrụ sistemu ahụ ji alụso ọrịa ọgụ metụtara afọ, a na-atụ anya Pinealon ka ọ kwalite nguzogide ahụ site n'ịhazi usoro ahụ ji alụso ọrịa ọgụ, si otú a gbochie na ịgwọ ọrịa na-efe efe.
Ngwa dị n'ubi Mma na Skincare
N'ubi ịma mma na nlekọta anụ ahụ, Pinealon na-ejikwa uru ngwa nwere ike. Ịka nká nke akpụkpọ ahụ na-egosipụtakarị dị ka ụbara wrinkles, sagging, nkụ, na pigmenti. Pinealon's antioxidant stress na cell proliferation na-akwalite mmetụta na-eme ka ọ bụrụ ihe na-egbochi ịka nká nke ọma maka akpụkpọ ahụ. Pinealon nwere ike ibelata mkpokọta ROS na sel akpụkpọ ahụ, belata nrụgide oxidative na-akpata mmebi nke mkpụrụ ndụ akpụkpọ ahụ, gbochie mmebi nke collagen na eriri na-agbanwe agbanwe, si otú ahụ belata nguzobe nke wrinkles na ịnọgide na-enwe ngbanwe akpụkpọ ahụ. Pinealon na-akwalite mmụba na mmeghari nke mkpụrụ ndụ akpụkpọ ahụ, na-eme ka mmezi nke mkpụrụ ndụ akpụkpọ ahụ mebiri emebi ngwa ngwa, na-eme ka ọdịdị akpụkpọ ahụ dịkwuo mma. Ụfọdụ ọmụmụ mmalite nwalere Pinealon mgbe agbakwunyere ngwaahịa nlekọta anụ ahụ, nsonaazụ na-egosi na ndị sonyere na-eji ngwaahịa nlekọta anụ ahụ nwere Pinealon nwere mbelata omimi na ọnụ ọgụgụ wrinkle, yana mmụba akpụkpọ anụ na ọdịnaya mmiri, na-egosi na Pinealon nwere ụfọdụ ikike ngwa n'ọhịa nke ịma mma na nlekọta anụ ahụ.
Mkpebi dabere na nyocha
Mmetụta zuru oke
Dabere na nyocha dị ugbu a, Pinealon na-egosiputa mmetụta dị mma dị iche iche na mgbochi ịka nká. N'ọkwa cellular, ọ na-echebe mkpụrụ ndụ site na mmebi ma na-ejigide ọrụ nkịtị na ike ha site n'ọtụtụ usoro dị ka nrụgide antioxidant, nhazi nke usoro cell, na nkwalite mgbasawanye cell. Na ọkwa anụ ahụ, Pinealon na-emetụta ọtụtụ sistemu dị mkpa gụnyere endocrine, sistemu ahụ ji alụso ọrịa ọgụ na ụjọ, na-enweta mmetụta mgbochi ịka nká n'ozuzu ya site na ịhazi ọrụ ha. Mmetụta nchịkwa ya nwere ike ime na ọrụ pineal gland, yana mmetụta nchebe ya na usoro ahụ ji alụso ọrịa ọgụ na ụjọ, na-enye aka na-edobe homeostasis nke anụ ahụ ma na-ebelata usoro ịka nká.
Mmechi
Dị ka ihe nwere ihe na-egbochi ịka nká, Pinealon na-egosiputa usoro dị iche iche nke ime ihe na nhazi cellular, usoro usoro endocrine, usoro nchịkwa, na nchebe usoro ụjọ. Ọ na-egosipụtakwa ngwa ndị nwere ike na nyocha nke mbụ, ngwa ahụike nwere ike ime, na nlekọta anụ ahụ.
Isi mmalite
[1] Khavinson V, Ribakova Y, Kulebiakin K, et al. Pinealon na-abawanye ikike cell site na nkwụsị nke ọkwa radical n'efu na ịgbalite usoro ịgbasa [J]. Nnyocha nyochaghachi, 2011,14 (5): 535-541.DOI: 10.1089 / rej.2011.1172.
Ngwaahịa dị maka naanị nyocha:
