Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔɖeŋu bliboa
Esi xexeame katã ƒe amewo le tsitsim kabakaba la, numekuku siwo wowɔ tso tsitsi si tsi tre ɖe tsitsi ŋu ŋu va zu nu vevi aɖe si ŋu wotsia dzi ɖo le agbeŋutinunya me. Pinealon, si nye tripeptide si wowɔ, na mɔnukpɔkpɔ yeyewo be woatsɔ aɖe tsitsi ƒe dɔwɔwɔ dzi akpɔtɔ eye wòana lãmesẽnya siwo do ƒome kple tsitsi nanyo ɖe edzi le eƒe ŋutete si ate ŋu atsi tsitsi nu ta.
Dɔwɔwɔ ƒe Mɔnu
Antioxidant Nuteɖeamedzi Dzi Ðeɖe Akpɔtɔ
Wobua oxidative stress be enye nu vevi siwo nana lãmenugbagbeviwo tsina eye nugbagbeviwo tsina la dometɔ ɖeka. Pinealon ɖea antioxidant ƒe nuteɖeamedzi dzi ɖeɖe kpɔtɔ ƒe ŋusẽkpɔɖeamedzi fiana. Le numekukuwo nu la, tripeptide pinealone (Glu-Asp-Arg, si nye Pinealon) si wowɔ la ɖea ŋutete si nɔa te ɖe agbɔsɔsɔme dzi fiana be wòaxe mɔ ɖe nusiwo oxidative stress hena vɛ nu le ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo, neutrophils, kple pheochromocytoma (PC12) lãmenugbagbeviwo me. ROS ƒe ƒuƒoƒo fũ ate ŋu agblẽ nu le lãmenugbagbeviwo ƒe nugbagbeviwo abe DNA, protein, kple ami ene ŋu, si ana lãmenugbagbeviwo nawɔ dɔ nyuie o eye woatsi. Pinealon ɖea ROS ƒe ƒuƒoƒo dzi kpɔtɔna, si ɖea lãmenugbagbeviwo ƒe gbegblẽ si oxidative stress hena vɛ dzi kpɔtɔna nyuie eye wòléa lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie me ɖe asi. Dodokpɔ siwo wowɔ le vitro ɖee fia be le atikewɔwɔ kple Pinealon ƒe agbɔsɔsɔ aɖe megbe la, ROS ƒe agbɔsɔsɔ le PC12 lãmenugbagbeviwo me dzi ɖe kpɔtɔ ŋutɔ, eye lãmenugbagbeviwo ƒe agbenɔnɔ kple dzidziɖedzi ƒe ŋutete dzi ɖe edzi ŋutɔ, si ɖee fia be Pinealon naa ememe nɔnɔme si nyo wu lãmenugbagbeviwo to mɔxexe ɖe oxidative stress nu, si wɔnɛ be tsitsi ƒe ɖoɖoa dzi ɖena kpɔtɔna.
Nɔnɔmetata 2 Ŋusẽ si pinealon kpɔna ɖe lãmenugbagbeviwo me oxygen ƒomevi siwo wɔa dɔ (ROS) ƒe agbɔsɔsɔ dzi le PC12 lãmenugbagbeviwo me, abe alesi wodzidzee le 1 mM hydrogen peroxide (H2O2) ƒe anyinɔnɔ alo manɔmanɔ me ene.
Lãmenugbagbeviwo ƒe Tsitrenɔnɔ Ŋuti Ðoɖowɔwɔ Kple Wo Dodo Ðe Ŋgɔ
Pinealon kpɔa ŋusẽ ɖe lãmenugbagbeviwo ƒe tsatsam ƒe ɖoɖowɔwɔ kple lãmenugbagbeviwo ƒe dzidziɖedzi ƒe ɖoɖowo dzi. Numekukuwo ɖee fia be Pinealon ƒe ametakpɔkpɔ ƒe ŋusẽkpɔɖeamedziwo do ƒome kple ERK 1/2 ƒe dɔwɔwɔ kple lãmenugbagbeviwo ƒe tsatsam ƒe tɔtrɔ ƒe ɣeyiɣi si tsi megbe. ERK 1/2 ƒe dzesimɔ wɔa akpa vevi aɖe le ɖoɖowɔwɔ me le lãmenugbagbeviwo ƒe dɔwɔwɔ abe tsitsi, dzidziɖedzi, kple vovototodedeameme ene me. Pinealon doa lãmenugbagbeviwo ƒe tsatsam ƒe ŋgɔyiyi ɖe ŋgɔ to ERK 1/2 ƒe dzesimɔa ƒe dɔwɔwɔ me, si wɔnɛ be lãmenugbagbeviwo te ŋu yia edzi le dzidzim ɖe edzi hewɔa wo ɖokui yeyee. Le dodokpɔwo me la, wode dzesii be le lãmenugbagbevi siwo do go oxidative stress me la, Pinealon ƒe tsɔtsɔ kpe ɖe eŋu na tɔtrɔ gãwo va le protein siwo do ƒome kple lãmenugbagbeviwo ƒe tsatsam ƒe ɖeɖefia me, si wɔnɛ be lãmenugbagbeviwo te ŋu trɔna kabakaba wu tso gbɔɖemeɣia yia mitotic ƒe akpaa me, si wɔnɛ be lãmenugbagbeviwo ƒe dzidziɖedzi ƒe agbɔsɔsɔme dzina ɖe edzi. Lãmenugbagbeviwo ƒe tsatsam ƒe ɖoɖowɔwɔ sia kple woƒe dzidziɖedzi dodo ɖe ŋgɔ kpena ɖe lãmekawo kple ŋutinuwo ƒe dɔwɔwɔ nyuie ŋu, si xea fe ɖe lãmenugbagbeviwo ƒe xexlẽme dzi ɖeɖe kpɔtɔ si lãmenugbagbeviwo ƒe tsitsi kple ku hena vɛ ta, si wɔnɛ be wokpɔa ŋusẽ si tsi tre ɖe tsitsi ŋu le lãmenugbagbeviwo ƒe ɖoɖo nu.
Kadodo kple lãmenugbagbeviwo ƒe dɔwɔwɔ
Ƒomedodo si le pineal gland kple melatonin dome
Pineal gland, abe lãmenugbagbeviwo ƒe ŋutinu vevi aɖe le amegbetɔ ƒe ŋutilã me ene, ɖea melatonin, si wɔa akpa vevi aɖe le nugbagbewo ƒe gaƒoɖokui, alɔ̃dɔdɔ kple nyɔnyrɔ̃ ƒe tsatsam, kple antioxidant ƒe dɔwɔwɔwo dzi kpɔkpɔ me, eye wòdo ƒome kplikplikpli kple tsitsi ƒe ɖoɖoa. Pinealon metso pineal gland me tẽ o, gake eƒe dɔwɔwɔ do ƒome kple pineal gland ƒe dɔwɔwɔ. Melatonin si pineal gland ɖena ɖe go la ƒe antioxidant ŋutete ɖedzesiwo le esi, eye antioxidant ƒe nuteɖeamedzi dzi ɖeɖe kpɔtɔ ƒe ŋutete hã le Pinealon si. Wo ame evea ate ŋu aɖe dɔwɔwɔ aduadu afia le antioxidant ƒe dɔwɔwɔ gome. Pinealon ate ŋu akpɔ ŋusẽ ɖe pineal gland ƒe dɔwɔwɔ ƒe nɔnɔme dzi le mɔ si mele tẽ o nu to lãmenugbagbeviwo me dzesimɔwo dzi kpɔkpɔ me, si ana wòakpɔ ŋusẽ ɖe melatonin ƒe dodo kple eƒe ŋusẽkpɔɖeamedziwo dzi.
Ŋusẽ si wòate ŋu akpɔ ɖe lãmenugbagbeviwo ƒe lãmetsi bubuwo dzi
Tsɔ kpe ɖe kadodo si ate ŋu anɔ eŋu kple pineal gland kple melatonin ŋu la, Pinealon ate ŋu akpɔ ŋusẽ ɖe lãmenugbagbeviwo ƒe lãmetsi bubuwo hã dzi, si ana wòakpɔ gome le tsitsi ƒe dɔwɔwɔ me. Amegbetɔ ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nye kadodo sesẽ aɖe si me lãmetsi vovovowo wɔa dɔ le hekpɔa ŋusẽ ɖe wo nɔewo dzi le. Tsitsi ƒe lãmetsi (GH) kple insulin-like growth factor-1 (IGF-1) wɔa akpa vevi aɖe le ŋutilã ƒe tsitsi, lãmenugbagbeviwo ƒe dɔwɔwɔ, kple lãmenugbagbeviwo ɖɔɖɔɖo me, eye tɔtrɔ siwo vaa woƒe agbɔsɔsɔ me do ƒome kplikplikpli kple tsitsi ƒe ɖoɖoa. Pinealon ate ŋu aɖɔ dzesimɔ siwo do ƒome kplii ɖo be wòakpɔ ŋusẽ ɖe GH kple IGF-1 ƒe dodo kple dɔwɔwɔ dzi, si ana lãmenugbagbeviwo natsi, adzra wo ɖo, eye woagbugbɔ wo awɔ yeyee, eye wòahe tsitsi ƒe ɖoɖoa ɖe megbe. Pinealon kpɔa ŋusẽ ɖe lãmenugbagbeviwo ƒe lãmetsi bubuwo abe thyroid lãmetsiwo ene hã dzi, eɖɔa ŋutilã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo be wòalé lãmenugbagbeviwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie me ɖe asi eye wòakpɔ ŋusẽ si tsi tre ɖe tsitsi ŋu.
Dɔlélenutsiŋutete ƒe Ðoɖowɔwɔ
Dɔlélenutsiŋutete hã ƒe dɔwɔwɔ dzi ɖena kpɔtɔna le tsitsime, si dzena le dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe xexlẽme kple dɔwɔwɔ dzi ɖeɖe kpɔtɔ me, kple dɔlélenutsiŋutete ƒe dɔwɔwɔ ƒe ŋutete dzi ɖeɖe kpɔtɔ, si wɔnɛ be dɔlékuiwo ƒe amedzidzedze te ŋu xɔa ŋutilãa bɔbɔe wu eye wògblẽa nu le eƒe ŋutete be wòakɔ lãmenugbagbevi siwo tsi kple kansa ŋu. Pinealon ate ŋu awɔ eƒe ŋusẽ si tsia tsitsi nu to dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi kpɔkpɔ me. Pinealon ate ŋu ado dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme ɖe ŋgɔ, ana woƒe xexlẽme nadzi ɖe edzi eye wòana ŋutilãa ƒe dɔlélenutsiŋutete ƒe ŋutete nadzi ɖe edzi. Pinealon ate ŋu aɖɔ dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ hã ɖo, si ana woate ŋu ade dzesi dɔlékuiwo, lãmenugbagbevi siwo tsi, kple kansa lãmenugbagbeviwo nyuie wu ahaɖe wo ɖa. Numekukuwo ɖee fia be Pinealon ate ŋu ana macrophages ƒe phagocytic ŋutete nadzi ɖe edzi, si ana woate ŋu aɖu nu nyuie wu eye woaɖe dɔlékui kple dɔlékui siwo va dzea wo dzi la ɖa. Ate ŋu ana T ʋumenugbagbevi dzĩwo ƒe lãmenugbagbeviwo ƒe aɖi ƒe dɔwɔwɔ ɖe kansa lãmenugbagbeviwo ŋu hã nadzi ɖe edzi. To dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ dzi la, Pinealon kpena ɖe ame ŋu be dɔlélenutsiŋutete nada asɔ, si ɖea dɔléle vovovo siwo dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie hena vɛ dzi kpɔtɔna, si wɔnɛ be tsitsi ƒe dɔwɔwɔ dzi ɖena kpɔtɔna le mɔ si mele tẽ o nu.
Lãmetsiŋusẽ ƒe Takpɔkpɔ
Lãmetsiŋusẽ ƒe tsitsi do ƒome kplikplikpli kple susu ƒe dɔmawɔmawɔ nyuie kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie. Pinealon kpɔa ŋusẽ aɖe ɖe lãmekawo ta. Le ahɔhɔ̃mekawo ƒe ɖoɖo nu la, Pinealon ate ŋu akpɔ ahɔhɔ̃mekawo ta tso nusiwo gblẽ me to mɔxexe ɖe oxidative stress nu kple lãmenugbagbeviwo ƒe tsatsam ƒe ɖoɖowɔwɔ me, si ana ahɔhɔ̃mekawo ƒe nɔnɔme kple dɔwɔwɔ si sɔ nanɔ anyi. Le numekuku siwo wowɔ le ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ŋu me la, wokpɔe be Pinealon ɖea lãmenugbagbeviwo ƒe ku si oxidative stress hena vɛ dzi kpɔtɔna eye wòdzia lãmenugbagbeviwo ƒe agbetsitsi ɖe edzi. Pinealon kpɔa ŋusẽ ɖe ahɔhɔ̃mekawo ƒe wɔwɔme, woƒe dodo, kple woƒe lãmenugbagbeviwo ƒe dɔwɔwɔ hã dzi, eye wòɖɔa ahɔhɔ̃mekawo ƒe dzesiwo ƒe kaka ɖo eye wòtoa esia me naa lãmekawo ƒe dɔwɔwɔ nyona ɖe edzi. To asitɔtrɔ le ahɔhɔ̃mekawo abe dopamine kple acetylcholine ƒe agbɔsɔsɔ ŋu me la, Pinealon ate ŋu ana nusɔsrɔ̃ kple ŋkuɖoɖonudzi ƒe ŋutetewo nanyo ɖe edzi. Le dodokpɔ siwo wowɔ le lãwo ŋu me la, lã siwo wotsɔ Pinealon da dɔ na la ɖee fia be wowɔa dɔ nyuie wu le nusɔsrɔ̃ kple ŋkuɖoɖonudzi dodokpɔwo me, si ɖee fia be ekpɔa ŋusẽ ɖe lãmekawo dzi le ametakpɔnu kple dɔwɔwɔ me, si ate ŋu akpe ɖe lãmekawo ƒe tsitsi ŋu wòahe ɖe megbe eye wòaxe mɔ ɖe ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie nu.
Pinealon zazã le tsitsi nutsitsi ƒe akpa dzi
Numekuku siwo wozãna do ŋgɔ na dɔdamɔnu zazã
Le numekuku ƒe akpa si wowɔ do ŋgɔ na dɔdamɔnu la, wozã Pinealon le lãwo ƒe kpɔɖeŋu dodokpɔ geɖe me tsɔ da eƒe ŋusẽkpɔɖeamedzi ɖe tsitsi dzi kpɔ. Le dodokpɔ siwo wowɔ le sisiblisiwo me la, wodo Pinealon ƒe agbɔsɔsɔme vovovowo be woatsɔ alé ŋku ɖe tsitsi ŋuti dzesiwo ŋu le sisiblisiwo me. Mice siwo wotsɔ Pinealon da dɔe la ɖee fia be woƒe ɖa ƒe keklẽ kple woƒe kpekpeme nyo ɖe edzi, woƒe lãmekawo ƒe dɔwɔwɔ dzi ɖe edzi, eye woƒe susu ƒe dɔwɔwɔ nyo ɖe edzi. Le susu ƒe dɔwɔwɔ dodokpɔwo abe Morris tsi maze dodokpɔ ene me la, sisiblisi siwo wotsɔ Pinealon da dɔe te ŋu ke ɖe nuƒolanɔƒe ɣaɣla la ŋu kabakaba wu, si ɖee fia be woƒe nusɔsrɔ̃ kple ŋkuɖoɖonudzi ƒe ŋutetewo nyo ɖe edzi. Dɔléleŋutinunya me dodokpɔ siwo wowɔ le sisiblisi ƒe lãkusiwo kple ŋutinuwo ŋu ɖee fia be sisiblisi siwo le ƒuƒoƒo si wotsɔ Pinealon da dɔe me ɖe lãmenugbagbeviwo ƒe gbegblẽ kple tsitsi dzi ɖe kpɔtɔ ŋutɔ le ŋutinu veviwo abe aklã kple ayiku ene me, eye lãmenugbagbeviwo ƒe wɔwɔmewo me gblẽ wu eye wolé dɔwɔwɔ me ɖe asi nyuie wu. Nusiwo ŋu woke ɖo siawo ɖee fia be Pinealon ɖea ŋusẽ ɖedzesi siwo tsi tre ɖe tsitsi ŋu fiana le lãwo ƒe kpɔɖeŋuwo me, si na kpeɖodzi le eƒe dɔdamɔnu ŋuti numekuku bubuwo ŋu.
Mɔkpɔkpɔ Siwo Ate Ŋu Ate Ŋu Azã le Dɔnɔdzikpɔƒe
Pinealon nɔ te ɖe nu nyui siwo do tso numekuku siwo wowɔ do ŋgɔ na dɔdamɔnu zazã me dzi ɖe mɔkpɔkpɔ gbadza siwo ate ŋu anɔ dɔdamɔnu zazã me fia. Le mɔxexe ɖe tsitsi ƒe dɔlélewo nu kple wo dada me la, asixɔxɔ gã aɖe ate ŋu anɔ Pinealon ŋu. Le ahɔhɔ̃mekawo ƒe dɔlélewo abe Alzheimer ƒe dɔléle kple Parkinson ƒe dɔléle ene gome la, le Pinealon ƒe ametakpɔkpɔ ƒe ŋusẽkpɔɖeamedzi ɖe lãmekawo dzi ta la, ate ŋu anye atike si ate ŋu anye atike si ana dɔlélea nayi edzi blewu eye wòana dɔnɔwo ƒe susu ƒe dɔwɔwɔ kple woƒe dɔwɔwɔ ƒe ŋutete nanyo ɖe edzi. Le dzitodzito me dɔlélewo gome la, Pinealon kpena ɖe ame ŋu be woaxe mɔ ɖe ʋukawo me lãmenugbagbeviwo ƒe gbegblẽ kple tsitsi nu to antioxidant stress kple lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me, si wɔnɛ be dzitodzito me dɔlélewo abe ʋukawo ƒe ʋuʋu ene ƒe afɔkua dzi ɖena kpɔtɔna. Le dɔlélenutsiŋutete ƒe dɔwɔwɔ ƒe ɖiɖi si do ƒome kple tsitsi ta la, wole mɔ kpɔm be Pinealon ana ŋutilãa ƒe dɔlélenutsiŋutete nadzi ɖe edzi to dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ me, to esia me axe mɔ ɖe dɔléle siwo xɔa ame me nu ahada wo.
Dɔwɔwɔ le Atsyɔ̃ɖoɖo Kple Ŋutilãdzikpɔkpɔ ƒe Dɔwɔƒe
Le atsyɔ̃ɖoɖo kple ŋutigbalẽdzikpɔkpɔ gome la, Pinealon hã lé asixɔxɔ si ate ŋu azãe ɖe asi. Ŋutilã ƒe tsitsi dzena koŋ abe ʋuʋudedi ƒe dzidziɖedzi, eƒe ŋeŋe, eƒe ƒuƒu, kple amadede ƒe dzedzeme ene. Pinealon ƒe nuteɖeamedzi si tsia dzodzodzoetsitsi nu kple lãmenugbagbeviwo ƒe dzidziɖedzi dodo ɖe ŋgɔ na wònye nusi wɔa dɔ nyuie si tsia tsitsi nu na ŋutigbalẽa. Pinealon ateŋu aɖe ROS ƒe ƒoƒo ɖe ŋutigbalẽ ƒe lãmenugbagbeviwo me dzi akpɔtɔ, aɖe nusiwo oxidative stress hena vɛ na ŋutigbalẽ ƒe lãmenugbagbeviwo dzi akpɔtɔ, axe mɔ ɖe collagen kple elastic fibers ƒe gbegblẽ nu, si ana wòaɖe ɖa ƒe wɔwɔme dzi akpɔtɔ eye ŋutigbalẽa nate ŋu alé ɖe te. Pinealon doa ŋutigbalẽmenugbagbeviwo ƒe dzidziɖedzi kple woƒe yeyewɔwɔ ɖe ŋgɔ, enaa ŋutigbalẽmenugbagbevi siwo gblẽ la ɖɔɖɔɖo kabakaba, eye wònaa ŋutigbalẽ ƒe nɔnɔme kple keklẽ nyona ɖe edzi. Numekuku gbãtɔ aɖewo do Pinealon kpɔ ne wotsɔe kpe ɖe ŋutigbalẽtikewo ŋu, eye emetsonuwo ɖee fia be gomekpɔla siwo zã ŋutigbalẽlétike siwo me Pinealon le la kpɔ flitete ƒe goglome kple xexlẽme dzi ɖeɖe kpɔtɔ, kpakple ŋutigbalẽ ƒe sesẽme kple tsi ƒe agbɔsɔsɔ si nyo ɖe edzi, si ɖee fia be ŋutete aɖewo le Pinealon zazã ŋu le atsyɔ̃ɖoɖo kple ŋutigbalẽdzikpɔkpɔ ƒe akpa dzi.
Nyataƒoƒo Siwo Wotu Ðe Numekuku Dzi
Ŋusẽkpɔɖeamedzi Siwo Katã
Pinealon nɔ te ɖe numekuku siwo li dzi ɖe ŋusẽkpɔɖeamedzi nyui siwo le go geɖe me fia le tsitsi nutsitsi me. Le lãmenugbagbeviwo ƒe ɖoɖo nu la, ekpɔa lãmenugbagbeviwo ta tso nusiwo gblẽ me eye wòléa woƒe dɔwɔwɔ kple ŋusẽ si sɔ me ɖe asi to mɔnu vovovowo abe antioxidant stress, lãmenugbagbeviwo ƒe tsatsam ƒe ɖoɖowɔwɔ, kple lãmenugbagbeviwo ƒe dzidziɖedzi dodo ɖe ŋgɔ ene dzi. Le nugbagbewo ƒe ɖoɖo nu la, Pinealon kpɔa ŋusẽ ɖe ɖoɖo vevi geɖewo dzi siwo dometɔ aɖewoe nye lãmenugbagbeviwo, dɔlélenutsiŋutete, kple lãmekawo, eye wòkpɔa ŋusẽ blibo si tsi tre ɖe tsitsi ŋu to woƒe dɔwɔwɔwo dzi kpɔkpɔ me. Eƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe pineal gland ƒe dɔwɔwɔ dzi, kpakple eƒe ametakpɔkpɔ ƒe ŋusẽkpɔɖeamedzi ɖe dɔlélenutsiŋutete kple lãmekawo dzi, kpena ɖe ŋutilã ƒe homeostasis ŋu eye wòɖea tsitsi ƒe dɔwɔwɔ dzi kpɔtɔna.
Nyanuwuwuw
Esi Pinealon nye nusi tsia tsitsi nu ta la, eɖea dɔwɔwɔ ƒe mɔnu vovovowo fiana le lãmenugbagbeviwo ƒe ɖoɖowɔwɔ, lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ, dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ, kple lãmekawo takpɔkpɔ me. Eɖe alesi woate ŋu azãe le numekuku siwo wowɔ do ŋgɔ na dɔdamɔnu, dɔdamɔnu siwo woate ŋu azã, kple ŋutigbalẽdzikpɔkpɔ hã fia.
Dzɔtsoƒewo
[1] Khavinson V, Ribakova Y, Kulebiakin K, kple ame bubuwo. Pinealon dzia lãmenugbagbeviwo ƒe agbenɔnɔ ɖe edzi to free radical ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ kple dzidziɖedzi ƒe dɔwɔwɔwo wɔwɔ me[J]. Gbugbɔgadzɔ ƒe Numekuku, 2011, 14 (5): 535-541.DOI: 10.1089 / rej.2011.1172.
Adzɔnu si li na numekuku zazã ɖeɖeko:
