▎ DSIP Numekuku
Nukae nye numekuku si wowɔ le DSIP ŋu?
Le ƒe 1970-awo me la, alɔ̃dɔdɔ ŋuti numekukuwo dzi ɖe edzi, eye dzɔdzɔmeŋutinunyalawo di vevie be yewoase alɔ̃dɔdɔ ƒe ɖoɖowɔwɔ ƒe nya ɣaɣlawo gɔme. Le ƒe 1977 me la, Switzerlandtɔ atikeŋutinunyala Schönenberg kple eƒe ƒuƒoƒoa ke ɖe DSIP ŋu le vo me esime wonɔ nu srɔ̃m tso avugbɔ̃ewo ƒe alɔ̃dɔdɔ ŋu. Enye nusi menye peptide o si me amino acid enyi le, si wowɔna le hypothalamus kple pituitary gland me. Le ɣeyiɣi sia me la, wowɔ ŋgɔyiyi ɖedzesiwo le peptide dzɔdzɔmeŋutinunya me. Amerikatɔ dzɔdzɔmeŋutinunyala Kastin kple Hollandtɔ dzɔdzɔmeŋutinunyala de Wied do nukpɔsusu si nye be peptidewo ate ŋu atso ʋu kple ahɔhɔ̃ ƒe mɔxenu la ɖa, si ɖo gɔmeɖoanyi na numekuku siwo woawɔ emegbe le DSIP ŋu. Le nyateƒe me la, ʋu kple ahɔhɔ̃ ƒe mɔxenu kpɔa ahɔhɔ̃a ta vevie, eye nu akpa gãtɔ me yiyi sesẽna. Ne DSIP ate ŋu atso mɔxenu sia la, akpɔ ŋusẽ gã aɖe ɖe akpa si wòwɔna le ahɔhɔ̃a ƒe alɔ̃dɔdɔ dzi kpɔkpɔ ƒe mɔ̃a me dzi.
Numekuku siwo wowɔ emegbe ɖee fia be menye ahɔhɔ̃a ƒe akpa aɖewo koŋ koe DSIP le o, ke boŋ le limbic system hã me le nɔnɔme siwo le ablɔɖe me alo esiwo wobla me, kpakple le gotagome ŋutinu vovovowo, lãkusiwo, kple ŋutilã me tsiwo hã me. Le kpɔɖeŋu me, le pituitary gland me la, enɔa teƒe ɖeka kple peptide vovovowo kple non-peptide domenɔlawo abe adrenocorticotropic hormone ene. Le dɔgbo ƒe lãmenugbagbeviwo kple dɔgbo me la, enɔa anyi ɖekae kple glucagon. Mama sia si kaka ɖe teƒe geɖe la ɖee fia be DSIP ate ŋu awɔ dɔ vovovowo eye wòsesẽ. Le gɔmedzedzea me la, wobua DSIP be enye alɔ̃dɔdɔ ƒe peptide. Esi numekukuwo le goglom ɖe edzi ta la, wokpɔe be menye alɔ̃dɔdɔ koe wòkpɔa ŋusẽ ɖe ŋutilã dzi o. Numekuku aɖewo ɖee fia be ate ŋu awɔ akpa aɖe le nuteɖeamedzi ƒe ŋuɖoɖo kple vevesese ƒe dzedzeme me, eye nɔnɔme siwo ate ŋu anɔ esi be wòaɖe dzimaɖitsitsi dzi akpɔtɔ eye wòaɖe vevesese dzi akpɔtɔ, gake egahiã kokoko be woatsɔ numekuku geɖe aɖo kpe ŋusẽkpɔɖeamedzi siawo dzi.
Nukae nye DSIP ƒe dɔwɔwɔ ƒe mɔnu?
Alɔ̃dɔdɔ kple ŋudzɔnɔnɔ ƒe ɖoɖowɔwɔ
Ŋusẽkpɔkpɔ ɖe alɔ̃dɔdɔ kple ŋudzɔnɔnɔ ƒe tsatsam dzi: Numekuku geɖe ɖee fia be DSIP kpɔa ŋusẽ gã aɖe ɖe alɔ̃dɔdɔ kple ŋudzɔnɔnɔ dzi le ɖoɖowɔwɔ me. Le kpɔɖeŋu me. Wokpɔe be DSIP ɖea alɔ̃dɔdɔ ƒe amedzidzedze dzi kpɔtɔna, enaa ŋkeke me dɔwɔnawo, ŋudzɔnɔnɔ, kple dɔwɔwɔ dzina ɖe edzi [1] . DSIP te alɔ̃dɔdɔ ƒe tsatsam ɖe to eye wòna ŋku ƒe ʋuʋu kabakaba (REM) ƒe alɔ̃dɔdɔ dzi ɖe edzi. Nusiwo do tso eme ɖee fia be ŋusẽkpɔɖeamedzi siawo tso DSIP si doa ŋusẽ circadian rhythm kple ultradian rhythm gbɔ. DSIP ate ŋu ado ŋutilã ƒe dɔwɔwɔ ƒe mɔnu siwo wozãna le dzadzraɖo ɖe gota gome ŋu si do ƒome kple alɔ̃dɔdɔ ƒe gɔmedzedze ɖe ŋgɔ.
Alɔ̃dɔdɔ ƒe ɖoɖo dzi kpɔkpɔ: Menye ɖeko DSIP kpɔa ŋusẽ ɖe alɔ̃dɔdɔ ƒe ɖoɖo kple ɣeyiɣi didi dzi ko o, ke ekpɔa ŋusẽ ɖe alɔ̃dɔdɔ ƒe wɔwɔme hã dzi. Ate ŋu ana REM alɔ̃dɔdɔ nanyo ɖe edzi, si fia akpa vevi si wòwɔna le alɔ̃dɔdɔ ƒe akpa vovovowo dzi kpɔkpɔ me.
Lãmetsiŋusẽ ƒe ŋusẽkpɔɖeamedziwo
Ŋusẽ si wòkpɔna ɖe dzoxɔxɔ ƒe ɖoɖowɔwɔ, dzi ƒe tsotso, ʋu ƒe sisi, vevesese ƒe dzidzenu, kple ʋumenugbagbeviɣidɔ ƒe dɔwɔwɔ dzi: Tsɔ kpe ɖe alɔ̃dɔdɔ dodo ɖe ŋgɔ le nɔnɔme tɔxɛ aɖewo me le lãwo me ŋu la, DSIP kpɔa ŋusẽ vovovowo ɖe ŋutilã dzi. Le kpɔɖeŋu me, DSIP ate ŋu akpɔ ŋusẽ ɖe dzoxɔxɔ ƒe ɖoɖowɔwɔ, dzi ƒe tsotso, ʋu ƒe sisi, vevesese ƒe dzidzenu, kple ʋumenugbagbeviɣidɔ ƒe dɔwɔwɔ dzi [2] . DSIP ƒe ŋusẽkpɔɖeamedzi siawo nɔ te ɖe ɣeyiɣi ƒe didime ƒe tsatsam dzi, eye ŋusẽkpɔɖeamedzi aɖewo dzena hafi ahɔhɔ̃mekawo alo nuwɔna ƒe alɔ̃dɔdɔ ƒe dzesiwo dzena. Esia fia be DSIP ate ŋu adze ŋutilã ƒe dɔwɔwɔ gɔme le gotagome dzadzraɖo me hafi alɔ̃dɔdɔ nadze egɔme.
Antioxidant ƒe ŋusẽkpɔɖeamedzi
Numekukuwo ɖee fia be exogenous DSIP (100μg/kg ŋutilã ƒe kpekpeme, wodoe ŋkeke 5 tsiã ɖe enu) le ŋutigbalẽ te le sisiblisi siwo xɔ ɣleti 2 - 24 me ate ŋu axe mɔ nyuie na oxidative damage of lipids kple malondialdehyde ƒe ƒoƒo ɖe sisiblisi siwo xɔ ƒe vovovowo ƒe lãmenugbagbeviwo kple plasma me [4] . DSIP ƒe dɔlékuiwutike sẽŋu aɖe le esi, si wokpɔna to dɔlékuiwutike takpɔkpɔ ƒe mɔnu vovovo siwo le lãmenugbagbeviwo me le lãmenugbagbeviwo me kple lãmenugbagbeviwo dome tsiwo me. DSIP kpɔa ŋusẽ ɖe superoxide dismutase, catalase, kple ceruloplasmin ƒe dɔwɔwɔ dzi si doa ŋusẽ ame, eye wòkpɔa ŋusẽ ɖe antioxidants siwo menye enzyme o abe urea kple uric acid ene ƒe agbɔsɔsɔ dzi. Ne nugbagbeviwo le tsitsim le ŋutilã me la, woaxe mɔ ɖe antioxidant takpɔkpɔ ƒe mɔnuwo nu, esime DSIP ate ŋu adzi antioxidant takpɔkpɔ ƒe ɖoɖo si le lãmekawo kple ʋu me ƒe ŋutete ɖe edzi, vevietɔ to enzymatic antioxidant system ƒe akpawo dodo ɖe ŋgɔ me, vevietɔ le ame ɖekaɖekawo ƒe tsitsi ƒe akpa si kplɔe ɖo me.
Nukae nye DSIP ƒe dɔwɔwɔwo?
Alɔ̃madɔmadɔ ƒe atikewɔwɔ
Le numekuku aɖe me la, wowɔ DSIP-tike na dɔnɔ siwo alɔ̃madɔmadɔ. Nusiwo do tso eme ɖee fia be DSIP dodo zi ɖeka le agbɔsɔsɔ si nye 25nmol/kg ŋutilã ƒe kpekpeme me hafi adɔ alɔ̃ ate ŋu adɔ alɔ̃ nyuie wu. Ne wodoe enuenu ɖee fia be alɔ̃dɔdɔ ƒe nɔnɔme va sɔ le edodo zi ene megbe. Dodo ɖe lãme na ame enuenu le ŋdi me, tsɔ kpe ɖe ŋkeke me dɔwɔna siwo dzi ɖe edzi ŋu la, egakpɔa ŋusẽ nyui ɖe zã me alɔ̃dɔdɔ dzi vevie kokoko, gake atike si wodona zi eve gbesiagbe ƒe ŋusẽkpɔɖeamedzi menyo o. Le alɔ̃madɔmadɔ si ahɔhɔ̃medɔléle siwo me agbe mele o hena vɛ gome la, DSIP ƒe agbɔsɔsɔ gbogbo aɖe wɔa dɔ nyuie [1] ..
Atikewɔwɔ na alɔ̃dɔdɔ ƒe dɔléle
Wodo DSIP na ŋutsu aɖe si xɔ ƒe 35 si ŋu alɔ̃madɔmadɔ le enuenu le numekuku aɖe me. Woda DSIP ƒe ŋusẽkpɔɖeamedzi ɖe ŋudzɔnɔnɔ kple alɔ̃dɔdɔ dzi kpɔ to ame ŋutɔ ƒe nyatakakawo gbɔgblɔ, dɔwɔwɔ ƒe dodokpɔwo, alɔ̃dɔdɔ ƒe ɣeyiɣi didi dodokpɔ geɖe, kple zã bliboa ƒe alɔ̃dɔdɔ ƒe dodokpɔ me. Nusiwo do tso eme ɖee fia be DSIP ɖe alɔ̃dɔdɔ ƒe amedzidzedze dzi kpɔtɔ, ena ŋkeke me dɔwɔnawo, ŋudzɔnɔnɔ, kple dɔwɔwɔ dzi ɖe edzi. DSIP te alɔ̃dɔdɔ ƒe ɣeyiɣia ɖe to eye wòna REM alɔ̃dɔdɔ nyo ɖe edzi. Numekukua me tsonu ɖee fia be ŋusẽkpɔɖeamedzi siawo tso DSIP si tea gbe ɖe circadian rhythm kple ultradian rhythm dzi gbɔ [1]..
Ahanono kple opiate zazã ƒe asiɖeɖe le ame ŋu ƒe dɔlélewo dada
Dɔdamɔnu ƒe ŋusẽkpɔɖeamedzi: Wonɔ te ɖe lãwo ŋuti numekuku me tsonu dzi, si fia be morphine, aha sesẽ, pentobarbital, kple DSIP dodo tẽ ɖe bulboreticular formation-midbrain-thalamus recruitment system me ate ŋu ana ƒutsotsoe blewu kple ƒutsotsoe gbogbo aɖewo nadɔ alɔ̃, eye woate ŋu atrɔ ŋusẽkpɔɖeamedzi sia to naloxone dzi. Wosusu be DSIP ƒe agonistic dɔwɔwɔ le opioid xɔlawo dzi eye ateŋu anye nusi ŋu asixɔxɔ le le atike si nana ame ƒe asiɖeɖe le eŋu ƒe dɔlélewo dada me[3]. Esi wodo DSIP ɖe ʋuka me hena dɔnɔ 107 siwo woxɔ ɖe kɔdzi siwo ƒe ahanono (n = 47) alo opiate (n = 60) ƒe asiɖeɖe le ahanono ƒe dzesiwo dada vɔ megbe la, atikewɔnyawo me dzodzro siwo ɖɔktawo kple dɔnɔdzikpɔlawo wɔ ɖee fia be opiate kple ahanono zu numame na ame 97% kple 87% ƒe dɔdamɔnu ƒe dzesiwo kple dzesiwo bu alo nyo ɖe edzi ŋutɔ le DSIP megbe dodo nɛ, eye dzimaɖitsitsi ƒe dzesiwo dzi ɖeɖe kpɔtɔ nɔ blewu vie. Opiate zazã ƒe dzesi siwo nɔa anyi didi wu eye wòhiã be woado DSIP geɖe wu [3] ..
Dɔnɔ kawoe DSIP ate ŋu ana kpeɖeŋutɔ ƒe ŋusẽkpɔɖeamedziwo na?
Dɔnɔ siwo ŋu alɔ̃dɔdɔ ƒe kuxiwo le: DSIP ate ŋu ana alɔ̃dɔdɔ ahaɖɔe ɖo. Le dɔnɔ siwo ŋu alɔ̃madɔmadɔ le, siwo dome alɔ̃dɔdɔ sesẽna na, alɔ̃dɔdɔ bɔbɔe, kple nyɔnyrɔ̃ bɔbɔe hã le gome la, ate ŋu akpe ɖe wo ŋu woadɔ alɔ̃ nyuie wu, adidi alɔ̃dɔdɔ ƒe ɣeyiɣi ɖe edzi, eye wòakpe ɖe wo ŋu woadɔ alɔ̃ kabakaba eye woanɔ alɔ̃ dɔm nyuie wu. Tsɔ kpe ɖe eŋu la, le amesiwo ƒe alɔ̃dɔdɔ ƒe tsɔtsɔme me gblẽ le jet lag, shift work, kple bubuawo ta gome la, DSIP ate ŋu akpe ɖe wo ŋu hã be woatrɔ asi le alɔ̃dɔdɔ ƒe tsatsam ŋu eye wòagbugbɔ alɔ̃dɔdɔ ƒe ɖoɖo si sɔ la aɖo anyi.
Dɔnɔ siwo ŋu lãmekawo ƒe dɔléle le: Zi geɖe la, alɔ̃madɔmadɔ kple lãmekawo ƒe dɔwɔwɔ si mesɔ o kpena ɖe lãmekawo ƒe dɔléle aɖewo abe Parkinson ƒe dɔléle kple Alzheimer ƒe dɔléle ene ŋu. Tsɔ kpe ɖe alɔ̃dɔdɔ ƒe nyonyo ŋu la, DSIP ate ŋu akpɔ ŋusẽ aɖe si akpɔ lãmekawo ƒe lãmenugbagbeviwo ta hã, si akpe ɖe ame ŋu wòaɖe lãmekawo ƒe dɔlélewo ƒe dzesi aɖewo dzi akpɔtɔ eye wòana dɔnɔwo ƒe agbenɔnɔ nanyo ɖe edzi. Le kpɔɖeŋu me, le Parkinson-dɔlélawo gome la, alɔ̃dɔdɔ nyuie ate ŋu akpe ɖe ame ŋu be ɖeɖiteameŋu le ŋkeke me kple ʋuʋu ƒe kuxiwo dzi naɖe akpɔtɔ.
Dɔnɔ siwo ŋu nuteɖeamedzi ƒe dɔlélewo le: Zi geɖe la, alɔ̃dɔdɔ ƒe kuxiwo nɔa ame siwo le nuteɖeamedzi si nɔa anyi didi, abe dɔnɔ siwo ŋu tagbɔ kple susumedɔlélewo abe dzimaɖitsitsi ƒe kuxiwo kple blanuiléle ene le, eye woƒe ŋutilã nɔa nuteɖeamedzi si nɔa anyi didi me. DSIP ate ŋu aɖɔ ŋutilãa ƒe nuteɖeamedzi ƒe ŋuɖoɖo ɖo to alɔ̃dɔdɔ ƒe ɖoɖowɔwɔ me, si akpe ɖe ame ŋu wòaɖe seselelãme ƒe dzesiwo abe dzimaɖitsitsi kple blanuiléle ene dzi akpɔtɔ eye wòana dɔnɔwo ƒe nɔnɔme bliboa nanyo ɖe edzi. Le ɣeyiɣi ma ke me la, le ŋutilã ƒe dɔwɔwɔ ƒe kuxi aɖewo siwo nuteɖeamedzi hena vɛ, abe nuɖuɖumeŋusẽ ƒe kuxiwo kple dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ ene gome la, DSIP ate ŋu awɔ kpeɖeŋutɔ ƒe akpa aɖe hã to alɔ̃dɔdɔ ƒe nyonyo kple nuteɖeamedzi ƒe ŋuɖoɖo dzi wɔwɔ me.
Le nyataƒoƒo me la, DSIP wɔa akpa vevi aɖe le alɔ̃dɔdɔ ƒe ɖoɖowɔwɔ me. Ate ŋu ana alɔ̃madɔmadɔlélawo ƒe alɔ̃dɔdɔ ƒe nyonyome nanyo ɖe edzi nyuie eye wòana woƒe alɔ̃dɔdɔ ƒe ɣeyiɣi nadidi ɖe edzi. Le dɔnɔ siwo ŋu alɔ̃dɔdɔ le gome la, ate ŋu aɖe alɔ̃dɔdɔ ƒe amedzidzedze dzi akpɔtɔ eye wòana ŋkeke me dɔwɔnawo kple ŋudzɔnɔnɔ nanyo ɖe edzi.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Schneider-Helmert D nye numekula xɔŋkɔ aɖe le alɔ̃dɔdɔ ƒe kuxiwo kple atikewɔwɔ siwo do ƒome kplii ŋu. wotsɔ eƒe dɔa do ƒome kple dɔwɔƒe xɔŋkɔ vovovowo abe kirschgarten vevesesenutsitike, vevesesenutsitike, vevesesenutsitike kirschgarten, med ctr mariastein, amsterdam yunivɛsiti, tagbɔdɔléle klinik kanton aargau, kantonsspital aarau ag (ksa), tagbɔdɔléle clin, tagbɔdɔléle klin konigsfelden, tagbɔdɔléle klin kt aargau, kple tagbɔdɔlélawo klin rt aargau ƒe ŋkɔ. eƒe numekukua ku ɖe ahɔhɔ̃ŋutinunya & ahɔhɔ̃ŋutinunya, tagbɔdɔléle, atikewɔwɔ bliboa & ememe, atikeŋutinunya & atikeŋutinunya, kple susuŋutinunya ŋu koŋ. ewɔ akpa vevi aɖe le alɔ̃madɔmadɔ kple alɔ̃dɔdɔ ƒe dɔléle bubuwo gɔmesese kple wo dada me, eye wòtsɔ ɖe le ŋusẽ si dsip (delta-sleep-inducing-peptide) kpɔna ɖe amegbetɔ ƒe alɔ̃dɔdɔ dzi me vevie.
Eƒe numekukuwo ku nu me tso dsip ƒe susuŋudɔwɔwɔ ƒe nɔnɔme siwo wɔa dɔ vovovowo ŋu wu akpa si wòwɔna le dzɔdzɔme alɔ̃dɔdɔ hehe vɛ me, si me ŋusẽ si wòkpɔna ɖe amegbetɔ ƒe alɔ̃dɔdɔ si tɔtɔ dzi kple ŋutete si le esi be wòana alɔ̃dɔdɔ ƒe nyonyome nanyo ɖe edzi le alɔ̃madɔmadɔlélawo me hã le. hekpe ɖe eŋu la, eku nu me le ŋudzɔnɔnɔ ƒe dzidzenu siwo wozãna le susu me kple esiwo ŋu woate ŋu akpɔ nu le le amesiwo sɔ kple alɔ̃madɔmadɔ dome, kpakple alɔ̃madɔmadɔ si me dzesi aɖeke mele o ƒe nukpɔsusu ŋu. wota eƒe dɔa ɖe agbalẽ vovovowo me, siwo dometɔ aɖewoe nye 'alɔ̃dɔdɔ,' 'eur neurol,' 'experientia,' kple 'neuropsychobiology,' kpakple bubuawo. Woŋlɔ Schneider-Helmert D ƒe ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [1].
