Research bwa DSIP Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na DSIP?
Mu myaka ya za 70, habaye ubushakashatsi mu bitotsi, kandi abahanga bashishikajwe no gusobanura amayobera yo kugenzura ibitotsi. Mu 1977, umuhanga mu bya shimi wo mu Busuwisi Schönenberg nitsinda rye bavumbuye ku buryo butunguranye DSIP ubwo bigaga uburyo ibitotsi by’inkwavu. Ni peptide itari igizwe na acide amine icyenda, ikorerwa muri hypothalamus na gland ya pitoito. Muri kiriya gihe, intambwe igaragara yatewe muri siyanse ya peptide. Umuhanga w’umunyamerika Kastin n’umuhanga w’Ubuholandi de Wied batanze igitekerezo kivuga ko peptide ishobora kurenga inzitizi y’amaraso n’ubwonko, igashyiraho urufatiro rw’ubushakashatsi bwakurikiyeho kuri DSIP. N'ubundi kandi, ubwonko burinzwe cyane n'inzitizi y'amaraso n'ubwonko, kandi ibintu byinshi biragoye kubyinjira. Niba DSIP ishobora kurenga iyi nzitizi, bizagira ingaruka cyane kubikorwa byayo muburyo bwo kugenzura ibitotsi byubwonko.
Ubushakashatsi bwakurikiyeho bwerekanye ko DSIP itabaho mu bice bimwe na bimwe by’ubwonko gusa ahubwo no muri sisitemu ya limbic muburyo bwisanzuye cyangwa buboshye, ndetse no mubice bitandukanye bya periferique, tissue, na fluid umubiri. Kurugero, muri glande ya pitoito, ifatanyirizwa hamwe na peptide zitandukanye hamwe nabunzi badafite peptide nka hormone adrenocorticotropique. Mu ngirabuzimafatizo zo mu nda na pancreas, zibana na glucagon. Ikwirakwizwa ryinshi ryerekana ko DSIP ishobora kuba ifite imirimo itandukanye kandi igoye. Ku ikubitiro, DSIP yafatwaga nka peptide yo gusinzira. Hamwe n’ubushakashatsi bwimbitse, byagaragaye ko ingaruka zayo ku mubiri zitagarukira gusa ku gusinzira. Ubushakashatsi bumwe bwerekanye ko bushobora kugira uruhare mugukemura ibibazo no kumva ububabare, kandi bukaba bufite ibimenyetso biranga kugabanya amaganya no kugabanya ububabare, ariko izi ngaruka ziracyakeneye kugenzurwa nubushakashatsi bwinshi.
Ni ubuhe buryo bwo gukora bwa DSIP?
Kugena ibitotsi no gukanguka
Guhindura ibitotsi no gukanguka: Ubushakashatsi butari buke bwerekanye ko DSIP igira ingaruka zikomeye kubitotsi no kubyuka. Kurugero, mubushakashatsi bwakozwe, umurwayi wa narcolepsy wumugabo wimyaka 35 yatewe inshuro nyinshi na DSIP, hanyuma asuzumwa binyuze muri raporo yonyine, ibizamini byakozwe, ibizamini byinshi byo gutinda gusinzira, hamwe na polysomnografiya ijoro ryose. Byagaragaye ko DSIP yagabanije inshuro nyinshi ibitotsi, kongera ibikorwa byo ku manywa, kuba maso, no gukora [1] . DSIP yagabanije gusinzira kandi byongera umuvuduko ukabije w'amaso (REM). Ibisubizo byerekana ko izo ngaruka ziterwa na DSIP izamura injyana ya circadian na rhythm ya ultradian. DSIP irashobora guteza imbere uburyo bwa physiologique yo gutegura periferique ijyanye no gusinzira.
Kugenga imiterere y'ibitotsi: DSIP ntabwo igira ingaruka gusa ku nshuro n'ibihe byo gusinzira ahubwo inagira ingaruka ku miterere y'ibitotsi. Irashobora kongera ibitotsi bya REM, byerekana uruhare rwayo mugutunganya ibyiciro bitandukanye byo gusinzira.
Ingaruka z'umubiri
Ingaruka kuri thermoregulation, umuvuduko wumutima, umuvuduko wamaraso, kurenga ububabare, hamwe na lymphokine: Usibye guteza imbere ibitotsi mubihe byihariye byinyamaswa, DSIP igira ingaruka zitandukanye zumubiri. Kurugero, DSIP irashobora kugira ingaruka kuri thermoregulation, umuvuduko wumutima, umuvuduko wamaraso, kurenga ububabare, hamwe na lymphokine [2] . Izi ngaruka za DSIP ziterwa nigitekerezo cyizunguruka cyizunguruka, kandi ingaruka zimwe zigaragara mbere yikimenyetso cyibitotsi cyangwa imyitwarire. Ibi birerekana ko DSIP ishobora gutangiza uburyo bwa physiologique bwo gutegura periferique mbere yo gusinzira.
Ingaruka ya Antioxydeant
Ubushakashatsi bwerekanye ko inshinge ziterwa na DSIP zidasanzwe (uburemere bwumubiri 100μg / kg, zatewe muminsi 5 ikurikiranye) ku mbeba zifite amezi 2 - 24 zishobora gukumira neza kwangiza okiside ya lipide no kwirundanya kwa malondialdehyde mumyanya na plasma yimbeba zimyaka itandukanye [4] . DSIP ifite antioxydants ikomeye, igerwaho mugukoresha uburyo butandukanye bwo kurinda antioxyde de antogiside mu mazi yo mu nda no mu mitsi. DSIP igira ingaruka zikomeye kubikorwa bya superoxide disutase, catalase, na ceruloplasmin, kandi ikagira ingaruka kumitekerereze ya antioxydants idafite imisemburo nka urea na aside uric. Hamwe no gusaza kwa physiologique yibinyabuzima, uburyo bwo kurinda antioxydeant buzabuzwa, mugihe DSIP ishobora kongera ubushobozi bwa sisitemu yo gukingira antogiside ya endogenous mu mitsi no mu maraso, cyane cyane mu gukangurira ibice bigize sisitemu ya antioxydants ya enzymatique, cyane cyane mu cyiciro cya nyuma cy’iterambere ry’umuntu ku giti cye.
Ni ubuhe buryo bukoreshwa na DSIP?
Umuti wo kudasinzira
Mu bushakashatsi bwakozwe, kuvura inshinge DSIP byakorewe abarwayi badasinzira. Ibisubizo byerekanye ko inshinge imwe ya DSIP ku gipimo cya 25nmol / kg ibiro byumubiri mbere yo gusinzira bishobora kunoza ibitotsi. Ubuyobozi bwagiye busubiramo bwerekanye ko ibitotsi bisanzwe nyuma yubuyobozi bune. Gutera inshinge nyinshi mugitondo, usibye kongera ibikorwa byo kumanywa, byagize ingaruka zikomeye kubitotsi bya nijoro, ariko ingaruka zo kunywa inshuro ebyiri kumunsi ntabwo zari nziza. Mu gihe kudasinzira biterwa n'indwara zo mu bwonko, urugero rwa DSIP rwakiriye neza [1].
Kuvura ibiyobyabwenge
Umurwayi wa narcolepsy wumugabo wimyaka 35 yatewe inshuro nyinshi na DSIP mubushakashatsi. Ingaruka za DSIP mukanguka no gusinzira zasuzumwe binyuze muri raporo yonyine, ibizamini byo gukora, ibizamini byinshi byo gutinda gusinzira, hamwe na polysomnografiya ijoro ryose. Ibisubizo byerekanaga ko DSIP yagabanije inshuro yibitotsi, kongera ibikorwa kumanywa, kuba maso, no gukora. DSIP yagabanije igihe cyo gusinzira kandi yongera ibitotsi bya REM. Ibisubizo byubushakashatsi byerekana ko izo ngaruka ziterwa na DSIP ishimangira injyana ya circadian na rhythm ya ultradian [1].
Kuvura inzoga hamwe na syndromes yo gukuramo
Ingaruka zo kuvura Clinical: Ukurikije ibyavuye mu bushakashatsi bw’inyamaswa, ni ukuvuga, gutera mu buryo butaziguye morphine, inzoga, pentobarbital, na DSIP muri sisitemu yo gushaka abakozi ba bulboreticular-midbrain-thalamus sisitemu yo kwinjiza abakozi irashobora gutuma ibitotsi bitinda kandi n’umubare munini wa spindle, kandi izo ngaruka zishobora guhindurwa na naloxone. Biravugwa ko DSIP ifite ibikorwa bya agonistic kuri reseptor ya opioid kandi ishobora kuba ingirakamaro mukuvura syndromes yo kubikuramo [3]. Nyuma yo gutera inshinge DSIP yo kuvura abarwayi 107 bari mu bitaro bafite inzoga (n = 47) cyangwa ibimenyetso byo kwikuramo (n = 60), isuzuma ry’amavuriro ryakozwe n’abaganga n’abaforomo ryerekanye ko 97% na 87% by’abasinzi b’ibiyobyabwenge n’inzoga, byagaragaye ko ibimenyetso by’ibimenyetso by’ibimenyetso byacitse cyangwa byateye imbere cyane nyuma y’ubuyobozi bwa DSIP, kandi kugabanya ibimenyetso by’amaganya byari bitinze. Abanywa ibiyobyabwenge barwaye ibimenyetso byigihe kirekire kandi basabye inshinge nyinshi za DSIP [3].
Ni abahe barwayi DSIP bashobora gutanga ingaruka zingirakamaro kuri?
Abarwayi bafite ikibazo cyo gusinzira: DSIP irashobora gutera no kugenzura ibitotsi. Ku barwayi bafite ikibazo cyo kudasinzira, harimo abafite ikibazo cyo gusinzira, gusinzira byoroheje, no kubyuka byoroshye, birashobora gufasha kunoza ibitotsi, kongera igihe cyo gusinzira, no kubafasha gusinzira vuba no gukomeza gusinzira neza. Byongeye kandi, kubantu bafite injyana yo gusinzira ihungabana kubera gutinda kwindege, akazi ko guhinduranya, nibindi, DSIP irashobora kandi gufasha guhindura ukwezi gusinzira no kugarura ibitotsi bisanzwe.
Abarwayi bafite uburwayi bwa sisitemu: Indwara zimwe na zimwe zifata imitsi nk'indwara ya Parkinson n'indwara ya Alzheimer akenshi ziherekezwa no kubura ibitotsi n'imikorere idasanzwe y'imitsi. Usibye kunoza ibitotsi, DSIP irashobora kandi kugira ingaruka zimwe na zimwe zo kurinda ingirabuzimafatizo, zifasha kugabanya ibimenyetso bimwe na bimwe byindwara zifata imitsi no kuzamura imibereho y’abarwayi. Kurugero, mubarwayi ba Parkinson, kunoza ibitotsi bishobora gufasha kugabanya umunaniro wumunsi no guhungabana.
Abarwayi bafite indwara ziterwa no guhangayika: Abantu bafite ibibazo by'igihe kirekire, nk'abarwayi bafite uburwayi bwo mu mutwe no mu mutwe nko guhungabana no kwiheba, bakunze kugira ibibazo byo gusinzira kandi imibiri yabo ikaba ihangayitse cyane. DSIP irashobora kugenga imyitwarire yumubiri muguhindura ibitotsi, ifasha kugabanya ibimenyetso byamarangamutima nko guhangayika no kwiheba no kuzamura imiterere rusange yabarwayi. Muri icyo gihe, kubibazo bimwe na bimwe byimikorere yumubiri iterwa no guhangayika, nkindwara zifungura igifu no kugabanuka kwimikorere yumubiri, DSIP irashobora kandi kugira uruhare runini mugutezimbere ibitotsi no kugenzura igisubizo.
Mu gusoza, DSIP igira uruhare runini murwego rwo kugenzura ibitotsi. Irashobora kuzamura neza ibitotsi byabarwayi badasinzira kandi ikongera igihe cyo gusinzira. Ku barwayi ba narcolepsy, irashobora kugabanya inshuro nyinshi ibitotsi no kunoza ibikorwa byo kumanywa no kuba maso.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Schneider-Helmert D numushakashatsi ukomeye mubijyanye no kubura ibitotsi no kuvura bijyanye. umurimo we wahujwe n’ibigo bitandukanye bizwi nka kirschgarten ububabare bw’ubuvuzi, ivuriro ry’ububabare, ivuriro ry’ububabare kirschgarten, med ctr mariastein, kaminuza ya amsterdam, indwara zo mu mutwe klinik kanton aargau, kantonsspital aarau ag (ksa), ivuriro ry’indwara zo mu mutwe, indwara zo mu mutwe. ubushakashatsi bwe bwibanze cyane cyane kuri neurosciences & neurology, psychiatry, ubuvuzi rusange & imbere, farumasi & farumasi, na psychologiya. yagize uruhare runini mu gusobanukirwa no kuvura kudasinzira nizindi ndwara ziterwa no gusinzira, ashishikajwe cyane ningaruka za dsip (delta-ibitotsi-bitera-peptide) ku bitotsi byabantu.
Ubushakashatsi bwe bwakoze ubushakashatsi ku mikorere myinshi ya psychophysiologique ya dsip irenze uruhare rwayo mu gutera ibitotsi bisanzwe, harimo n’ingaruka zayo ku gusinzira kw’abantu ndetse n’ubushobozi bwayo mu kuzamura ireme ry’ibitotsi. Byongeye kandi, yakoze ubushakashatsi ku ngamba zifatika kandi zifatika zo gukanguka mu bisanzwe no kudasinzira, ndetse n'igitekerezo cyo kudasinzira neza. ibikorwa bye byasohotse mubinyamakuru bitandukanye byamasomo, harimo 'ibitotsi, ' 'eur neurol, ' 'uburambe, ' na 'neuropsychobiology, ' nibindi. Schneider-Helmert D yanditse kurutonde rwerekana [1].
