▎ DSIP Nnyocha
Kedu ihe ndabere nyocha nke DSIP?
N'afọ ndị 1970, enwere ọganihu na nyocha ụra, ndị ọkà mmụta sayensị chọsiri ike ịchọpụta ihe omimi nke ụkpụrụ ụra. Na 1977, onye Switzerland chemist Schönenberg na ndị otu ya chọtara DSIP na mberede mgbe ha na-amụ usoro ihi ụra nke oke bekee. Ọ bụ ihe na-abụghị peptide mejupụtara amino acid itoolu, nke a na-emepụta na hypothalamus na pituitary gland. N'ime oge a, enwere nnukwu ọganihu na sayensị peptide. Onye ọkà mmụta sayensị America bụ Kastin na onye ọkà mmụta sayensị Dutch de Wied tụpụtara echiche na peptides nwere ike ịgafe mgbochi ụbụrụ ọbara, na-atọ ntọala maka nyocha na-esote na DSIP. A sị ka e kwuwe, ihe mgbochi ụbụrụ nke ọbara na-echebe ụbụrụ nke ọma, ọtụtụ ihe na-esikwa ike ịbanye. Ọ bụrụ na DSIP nwere ike ịgafe ihe mgbochi a, ọ ga-emetụta oke ọrụ ya na usoro nhazi ụra nke ụbụrụ.
Nnyocha ndị sochirinụ achọpụtala na DSIP adịghị adị ọ bụghị nanị n'akụkụ ụfọdụ nke ụbụrụ kamakwa na usoro limbic n'ụdị n'efu ma ọ bụ nke a na-ekekọta, yana n'ụdị akụkụ ahụ dị iche iche, anụ ahụ, na mmiri ahụ. Dịka ọmụmaatụ, na pituitary gland, a na-ejikọta ya na ụdị peptides dị iche iche na ndị na-eme ihe na-abụghị peptide dị ka hormone adrenocorticotropic. N'ime sel nzuzo nke eriri afọ na pancreas, ọ na-ejikọta ya na glucagon. Nkesa zuru ebe niile na-egosi na DSIP nwere ike ịnwe ọrụ dị iche iche na mgbagwoju anya. Na mbụ, a na-ewere DSIP dị ka peptide ụra. Site na omimi nke nyocha, a chọpụtala na mmetụta ya na ahụ abụghị nanị ụra. Ụfọdụ ọmụmụ egosila na ọ nwere ike na-ekere òkè na nzaghachi nrụgide na nghọta mgbu, ma nwee àgwà ndị nwere ike ime ka nchekasị na ibelata ihe mgbu, ma mmetụta ndị a ka kwesịrị ikwenye site na nyocha ndị ọzọ.
Gịnị bụ usoro omume nke DSIP?
Iwu nke ụra na ịmụrụ anya
Na-emetụta ụra na ịmụ anya okirikiri: Ọtụtụ nchọpụta egosila na DSIP nwere mmetụta nchịkwa dị ukwuu na ụra na ịmụrụ anya. Dịka ọmụmaatụ, n'ime ọmụmụ ihe, a na-agbanye onye ọrịa narcolepsy nwoke dị afọ 35 ugboro ugboro na DSIP, a na-enyocha ya site na akụkọ onwe ya, ule arụmọrụ, ọtụtụ ule nkwụsị ụra, na polysomnography abalị niile. Achọpụtara na DSIP belatara ugboro ole mwakpo ụra, ịba ụba ọrụ ụbọchị, ịmụrụ anya, na arụmọrụ [1] . DSIP kpachiri okirikiri ihi ụra wee kwalite mmegharị anya ngwa ngwa (REM) ụra. Nsonaazụ na-egosi na mmetụta ndị a bụ n'ihi DSIP na-eme ka ụda okirikiri na ultradian rhythm dịkwuo elu. DSIP nwere ike ịkwalite usoro physiological nke nkwadebe mpụta nke metụtara mmalite ụra.
Ịchịkwa usoro ihi ụra: DSIP abụghị naanị na-emetụta ugboro na oge ụra mana ọ nwekwara mmetụta na nhazi ụra. Ọ nwere ike ịkwalite ụra REM, na-egosi ọrụ dị mkpa ọ na-arụ n'ịhazi ọkwa dị iche iche nke ụra.
Mmetụta anụ ahụ
Mmetụta na thermoregulation, ọnụ ọgụgụ obi, ọbara mgbali elu, ọnụ ụzọ mgbu, na usoro lymphokine: Na mgbakwunye na ịkwalite ụra n'okpuru ọnọdụ ụfọdụ na anụmanụ, DSIP nwere mmetụta dịgasị iche iche nke physiological. Dịka ọmụmaatụ, DSIP nwere ike imetụta thermoregulation, ọnụ ọgụgụ obi, ọbara mgbali elu, ọnụ ụzọ mgbu, na usoro lymphokine [2] . Mmetụta ndị a nke DSIP na-adabere na okirikiri okirikiri okirikiri, na mmetụta ụfọdụ na-apụta n'ihu ihe ịrịba ama nke ụra akwara ma ọ bụ omume. Nke a na-egosi na DSIP nwere ike ibido usoro physiological nke nkwadebe n'akụkụ tupu ụra amalite.
Mmetụta antioxidant
Nnyocha achọpụtala na ntụtụ subcutaneous nke exogenous DSIP (100μg/kg arọ ahụ, ịgbanye maka ụbọchị 5 n'usoro) n'ime oke dị afọ 2 - ọnwa 24 nwere ike igbochi mmebi oxidative nke lipids na mkpokọta malondialdehyde na anụ ahụ na plasma nke oke dị iche iche [4] . DSIP nwere mmetụta antioxidant siri ike, nke a na-enweta site na ịgbalite usoro nchebe antioxidant dị iche iche na mmiri intracellular na intercellular. DSIP nwere mmetụta na-akpali akpali na ọrụ nke superoxide dismutase, catalase, na ceruloplasmin, ma na-emetụta mkpokọta nke antioxidants na-abụghị enzymatic dị ka urea na uric acid. Site na ịka nká physiological nke ihe ndị dị ndụ, a ga-egbochi usoro nchebe antioxidant, ebe DSIP nwere ike ịbawanye ikike nke usoro nchebe antioxidant endogenous na anụ ahụ na ọbara, tumadi site na-akpali akpali nke akụkụ nke enzymatic antioxidant usoro, karịsịa na ikpeazụ ogbo nke onye.
Kedu ihe bụ ngwa DSIP?
Ọgwụgwọ ehighi ura
N'ime ọmụmụ ihe, a na-eme ọgwụgwọ injection DSIP na ndị ọrịa na-adịghị ehi ụra nke ọma. Nsonaazụ gosiri na otu ịgba ọgwụ DSIP na dose nke 25nmol/kg arọ ahụ tupu ụra nwere ike ime ka ụra dịkwuo mma. Nlekọta ugboro ugboro gosiri na usoro ụra na-edozi ahụ mgbe nchịkwa anọ gasịrị. Ịgba ogwu ugboro ugboro n'ụtụtụ, na mgbakwunye na ịba ụba nke ọrụ ehihie, ka nwere mmetụta dị mma na ụra abalị, ma mmetụta nke doses ugboro abụọ kwa ụbọchị adịghị mma. N'ihe banyere ehighị ụra nke ọma nke ọrịa ụbụrụ ụbụrụ na-akpata, nnukwu doses nke DSIP nabatara nke ọma [1].
Ọgwụgwọ nke narcolepsy
A gbanyere onye ọrịa narcolepsy nwoke dị afọ 35 ugboro ugboro na DSIP n'ime ọmụmụ ihe. A tụlere mmetụta DSIP na ịmụrụ anya na ihi ụra site na mkpesa nke onwe, ule arụmọrụ, ọtụtụ ule latency ụra, na polysomnography abalị niile. Nsonaazụ gosiri na DSIP belatara ugboro ọgụ nke ụra, ịba ụba ọrụ ụbọchị, ịmụrụ anya, na ịrụ ọrụ. DSIP chịkọbara oge ụra ma kwalite ụra REM. Nsonaazụ ọmụmụ na-egosi na mmetụta ndị a bụ n'ihi DSIP na-emesi ike na okirikiri circadian na ultradian rhythm [1].
Ọgwụgwọ nke mmanya na opiate withdrawal syndromes
Mmetụta ọgwụgwọ ụlọ ọgwụ: Dabere na nsonaazụ nke ọmụmụ anụmanụ, ya bụ, injection ozugbo nke morphine, mmanya, pentobarbital, na DSIP n'ime usoro nchịkọta bulboreticular-midbrain-thalamus nwere ike ime ka ụra na-adịghị ngwa ngwa na ọnụ ọgụgụ dị ukwuu nke ebili mmiri spindle, na naloxone nwere ike gbanwee mmetụta a. A na-eche na DSIP nwere ọrụ agonistic na ndị na-anabata opioid ma nwee ike ịba uru na ọgwụgwọ nke ọrịa nkwụsị [3]. Mgbe ịgba ọgwụ mgbochi nke DSIP maka ọgwụgwọ nke ndị ọrịa 107 n'ụlọ ọgwụ na-aṅụ mmanya (n = 47) ma ọ bụ opiate (n = 60) nkwụsị mgbaàmà, nyocha ụlọ ọgwụ nke ndị dọkịta na ndị nọọsụ gosiri na 97% na 87% nke opiate na ndị na-aṅụ mmanya na-aba n'anya, n'otu n'otu, nwere mgbaàmà ụlọ ọgwụ ha na ihe ịrịba ama na-apụ n'anya ma ọ bụ na-emeziwanye ma jiri nwayọọ nwayọọ nchịkwa nke DSIP. Ndị na-eri ahụ opiate nwere mgbaàmà ụlọ ọgwụ na-adịte aka ma chọkwuru injections DSIP [3].
Kedu ndị ọrịa DSIP nwere ike ịnye mmetụta adjuvant maka?
Ndị ọrịa nwere nsogbu ihi ụra: DSIP nwere ike ịkpalite ma mezie ụra. Maka ndị ọrịa nwere nsogbu ehighị ụra nke ọma, gụnyere ndị ọ na-esiri ike ihi ụra, ihi ụra dị mfe, na ịmụrụ anya nke ọma, ọ nwere ike inye aka melite ogo ihi ụra, gbatịkwuo oge ihi ụra, ma nyere ha aka ịrahụ ụra ngwa ngwa ma nọgide na-ehi ụra nke ọma. Na mgbakwunye, maka ndị mmadụ na-akụghasị ụda ihi ụra ha n'ihi ụgbọ elu jet lag, ọrụ mgbanwe, wdg, DSIP nwekwara ike inye aka gbanwee usoro ụra ma weghachite usoro ụra nkịtị.
Ndị ọrịa nwere ọrịa sistemu ụjọ: Ụfọdụ ọrịa sistemu ụjọ dịka ọrịa Parkinson na ọrịa Alzheimer na-esokarị nsogbu ihi ụra na arụrụ ọrụ akwara. Na mgbakwunye na imeziwanye ụra, DSIP nwekwara ike inwe mmetụta nchebe ụfọdụ na mkpụrụ ndụ akwara, na-enyere aka ịkwụsị ụfọdụ mgbaàmà nke ọrịa usoro ụjọ ahụ ma melite ogo ndụ nke ndị ọrịa. Dịka ọmụmaatụ, na ndị ọrịa ọrịa Parkinson, imeziwanye ụra nwere ike inye aka belata ike ọgwụgwụ ụbọchị na nsogbu mmegharị.
Ndị na-arịa ọrịa na-akpata nchekasị: Ndị mmadụ nọ n'okpuru nrụgide ogologo oge, dị ka ndị nwere ọrịa uche na nke uche dị ka nsogbu nchekasị na ịda mbà n'obi, na-enwekarị nsogbu ụra na ahụ ha nọ n'ọnọdụ nrụgide na-adịghị ala ala. DSIP nwere ike ịhazi nzaghachi nrụgide ahụ site n'ịhazi ụra, na-enyere aka ịkwụsị mgbaàmà mmetụta uche dị ka nchekasị na ịda mbà n'obi na imeziwanye ọnọdụ ndị ọrịa n'ozuzu ya. N'otu oge ahụ, maka ụfọdụ nsogbu arụ ọrụ anụ ahụ kpatara nrụgide, dị ka nsogbu mgbaze na mbelata ọrụ mgbochi, DSIP nwekwara ike rụọ ọrụ ụfọdụ nkwalite nkwalite site n'ịkwalite ụra na ịhazi nzaghachi nrụgide.
N'ikpeazụ, DSIP na-arụ ọrụ dị mkpa na nhazi nhazi ụra. Ọ nwere ike melite ogo ihi ụra nke ndị ọrịa ehighị ụra nke ọma na ịgbatị oge ụra ha. Maka ndị na-arịa ọrịa narcolepsy, ọ nwere ike ibelata ugboro ọgụ nke ụra ma melite ọrụ ụbọchị na ịmụrụ anya.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Schneider-Helmert D bụ onye nchọpụta ama ama n'ihe gbasara nsogbu ihi ụra na ọgwụgwọ ndị metụtara ya. Ejikọtala ọrụ ya na ụlọ ọrụ dị iche iche a ma ama dị ka kirschgarten pain clin, pain clin, pain clin kirschgarten, med ctr mariastein, mahadum nke amsterdam, psychiatrie klinik kanton aargau, kantonsspital aarau ag (ksa), psychiat clin, psychiat klin kopsychifelatden. klin rt argau. nyocha ya lekwasịrị anya na neurosciences & akwara ozi, psychiatry, izugbe & ọgwụ ime, ọgwụ na ọgwụ na ọgwụ, na akparamaagwa. o meela nnukwu enyemaka na nghọta na ọgwụgwọ nke ehighi ura na nsogbu ndị ọzọ metụtara ihi ụra, na-enwe mmasị pụrụ iche na mmetụta nke dsip (delta-sleep-inducing-peptide) na ụra mmadụ.
Ọmụmụ ihe ya enyochala njirimara psychophysiological multifunctional nke disip karịrị ọrụ ya n'ịkwalite ụra eke, gụnyere mmetụta ọ na-enwe na ụra mmadụ na-akpaghasị ya na ikike ọ nwere ime ka ụra dịkwuo mma na ndị na-ehi ụra. Ọzọkwa, ọ enyochala usoro ebumnuche na ebumnuche nke ịmụrụ anya n'etiti ndị nkịtị na ndị ehighị ụra nke ọma, yana echiche nke ehighị ụra nke ọma asymptomatic. Ebipụtala ọrụ ya n'akwụkwọ akụkọ agụmakwụkwọ dị iche iche, gụnyere 'ụra,' ' eur neurol, ' experientia, ' na ' neuropsychobiology,' n'etiti ndị ọzọ. Edepụtara Schneider-Helmert D n'akwụkwọ ntụaka [1].
