▎ DSIP Binciken
Menene asalin bincike na DSIP?
A cikin 1970s, an sami bunƙasa a cikin binciken barci, kuma masana kimiyya sun ɗokin gano asirin ƙa'idodin barci. A cikin 1977, masanin ilmin sunadarai na Swiss Schönenberg da tawagarsa sun gano DSIP da gangan yayin da suke nazarin yanayin barci na zomaye. Ba peptide ne wanda ya ƙunshi amino acid tara, wanda aka samar a cikin hypothalamus da glandan pituitary. A wannan lokacin, an sami gagarumin ci gaba a kimiyyar peptide. Masanin kimiyar Amurka Kastin da masanin kimiya dan kasar Holland de Wied sun gabatar da ra'ayin cewa peptides na iya ketare shingen kwakwalwar jini, tare da aza harsashin bincike na gaba akan DSIP. Bayan haka, kwakwalwar tana da kariya sosai ta hanyar shingen jini-kwakwalwa, kuma yawancin abubuwan suna da wahalar shiga. Idan DSIP zai iya ƙetare wannan shinge, zai yi tasiri sosai a cikin tsarin tsarin barci na kwakwalwa.
Nazarin da suka biyo baya sun gano cewa DSIP yana wanzuwa ba kawai a cikin takamaiman wurare na kwakwalwa ba har ma a cikin tsarin limbic a cikin nau'i na kyauta ko ɗaure, da kuma a cikin nau'o'in gabobin jiki, kyallen takarda, da ruwan jiki. Misali, a cikin glandar pituitary, an haɗa shi tare da nau'ikan peptides da masu shiga tsakani marasa peptide kamar hormone adrenocorticotropic. A cikin sel secretory na hanji da pancreas, yana rayuwa tare da glucagon. Wannan yaɗuwar rarraba yana nuna cewa DSIP na iya samun ayyuka iri-iri da hadaddun. Da farko, ana ɗaukar DSIP azaman peptide barci. Tare da zurfafa bincike, an gano cewa tasirinsa a jiki bai iyakance ga barci ba. Wasu nazarin sun nuna cewa yana iya taka rawa a cikin amsawar damuwa da jin zafi, kuma yana da halayen halayen da za su iya kawar da damuwa da rage ciwo, amma waɗannan tasirin har yanzu suna buƙatar tabbatar da su ta hanyar ƙarin bincike.
Menene tsarin aikin DSIP?
Tsarin bacci da farkawa
Tasirin sake zagayowar barci da farkawa: Yawancin bincike sun nuna cewa DSIP yana da tasiri mai mahimmanci akan barci da farkawa. Alal misali, a cikin binciken, an yi wa majiyyacin narcolepsy mai shekaru 35 allura akai-akai tare da DSIP, kuma an kimanta shi ta hanyar rahoton kai, gwaje-gwajen aiki, gwaje-gwajen jinkirin barci da yawa, da kuma polysomnography na dare. An gano cewa DSIP ya rage yawan hare-haren barci, ƙara yawan aiki na rana, faɗakarwa, da aiki [1] . DSIP ya matsa yanayin bacci da haɓaka saurin motsin ido (REM) barci. Sakamakon ya nuna cewa waɗannan tasirin sun kasance saboda DSIP yana haɓaka rhythm na circadian da ultradian rhythm. DSIP na iya haɓaka hanyoyin ilimin lissafin jiki na shirye-shiryen gefe masu alaƙa da fara bacci.
Daidaita tsarin barci: DSIP ba wai kawai yana rinjayar mita da tsawon lokacin barci ba amma kuma yana da tasiri akan tsarin barci. Yana iya haɓaka barcin REM, yana nuna muhimmiyar rawar da yake takawa wajen daidaita matakan barci daban-daban.
Tasirin jiki
Abubuwan da ke haifar da thermoregulation, bugun zuciya, hawan jini, bakin zafi, da tsarin lymphokine: Bugu da ƙari ga inganta barci a ƙarƙashin ƙayyadaddun yanayi a cikin dabbobi, DSIP yana da nau'o'in tasirin ilimin lissafi. Alal misali, DSIP na iya rinjayar thermoregulation, bugun zuciya, hawan jini, ƙananan zafi, da tsarin lymphokine [2] . Waɗannan tasirin DSIP sun dogara ne akan zagayowar zagayowar zagayowar circadian, kuma wasu tasirin suna bayyana a gaban alamun baccin jijiya ko ɗabi'a. Wannan yana nuna cewa DSIP na iya ƙaddamar da hanyoyin physiological na shirye-shirye na gefe kafin fara barci.
Antioxidant sakamako
Nazarin ya gano cewa allurar subcutaneous na exogenous DSIP (100μg / kg nauyin jiki, allura don kwanaki 5 a jere) a cikin berayen da ke da shekaru 2 - 24 watanni na iya hana lalacewar oxidative na lipids da kuma tarin malondialdehyde a cikin kyallen takarda da plasma na berayen shekaru daban-daban [4] . DSIP yana da tasiri mai ƙarfi na antioxidant, wanda aka samu ta hanyar kunna hanyoyin kariya na ƙwayoyin cuta daban-daban a cikin ruwaye na cikin salula da na salula. DSIP yana da tasiri mai ban sha'awa akan ayyukan superoxide dismutase, catalase, da ceruloplasmin, kuma yana rinjayar yawan abubuwan antioxidants marasa enzymatic kamar urea da uric acid. Tare da tsufa na physiological na kwayoyin halitta, hanyoyin kariya na antioxidant za a hana su, yayin da DSIP na iya ƙara ƙarfin tsarin kariyar antioxidant na endogenous a cikin kyallen takarda da jini, musamman ta hanyar ƙarfafa abubuwan da ke cikin tsarin antioxidant enzymatic, musamman a cikin mataki na gaba na ci gaban mutum.
Menene aikace-aikacen DSIP?
Maganin rashin barci
A cikin binciken, an gudanar da maganin allura na DSIP akan marasa lafiya marasa barci. Sakamakon ya nuna cewa allurar DSIP guda ɗaya a nauyin nauyin 25nmol/kg kafin barci zai iya inganta barci. Gudanar da maimaitawa ya nuna cewa tsarin barci ya daidaita bayan gwamnatoci hudu. Maimaita allura da safe, ban da haɓaka ayyukan rana, har yanzu yana da tasiri mai ƙarfi akan barcin dare, amma tasirin shan sau biyu a rana bai yi kyau ba. A lokuta na rashin barci da cututtukan kwakwalwar kwayoyin halitta ke haifar da su, yawancin allurai na DSIP sun amsa da kyau [1].
Maganin narcolepsy
An yi wa wani majiyyacin narcolepsy mai shekaru 35 allurar akai-akai tare da DSIP a cikin wani bincike. An kimanta tasirin DSIP akan farkawa da barci ta hanyar rahoton kai, gwaje-gwajen aiki, gwaje-gwajen jinkirin barci da yawa, da polysomnography na dare duka. Sakamakon ya nuna cewa DSIP ya rage yawan hare-haren barci, ƙara yawan ayyukan rana, faɗakarwa, da aiki. DSIP ya matsa lokacin barci da haɓaka barcin REM. Sakamakon binciken ya nuna cewa waɗannan tasirin sun faru ne saboda DSIP da ke jaddada rhythm na circadian da ultradian rhythm [1].
Maganin barasa da opiate withdrawal syndromes
Tasirin maganin asibiti: Dangane da sakamakon binciken dabba, wato, allurar kai tsaye na morphine, barasa, pentobarbital, da DSIP a cikin tsarin samar da aikin bulboreticular-midbrain-thalamus na iya haifar da jinkirin bacci da yawan igiyoyin igiya, kuma wannan tasirin naloxone na iya juyawa. Ana hasashe cewa DSIP yana da aikin agonist akan masu karɓar opioid kuma yana iya zama mai mahimmanci a cikin maganin cututtukan cirewa[3]. Bayan allura na DSIP na ciki don maganin 107 marasa lafiya na asibiti tare da barasa (n = 47) ko opiate (n = 60) bayyanar cututtuka na janyewa, ƙididdigar asibiti ta likitoci da ma'aikatan jinya sun nuna cewa 97% da 87% na opiate da barasa masu shan barasa, bi da bi, sun sami alamun bayyanar cututtuka da alamun sun ɓace ko kuma ingantawa da jinkirin jinkirin gudanarwa na DSIP. Masu shaye-shaye na opiate suna da alamun asibiti na dindindin kuma suna buƙatar ƙarin alluran DSIP [3].
Wadanne marasa lafiya ne DSIP za su iya ba da tasirin adjuvant don?
Marasa lafiya da matsalar barci: DSIP na iya jawowa da daidaita barci. Ga marasa lafiya da rashin barci, ciki har da waɗanda ke da wahalar yin barci, barci mai sauƙi, da sauƙi ta tashi, yana iya taimakawa wajen inganta yanayin barci, tsawaita lokacin barci, da kuma taimaka musu su yi barci da sauri da kuma kula da barci mai kyau. Bugu da ƙari, ga mutanen da yanayin barci ya rushe saboda lag na jet, aikin motsi, da dai sauransu, DSIP na iya taimakawa wajen daidaita yanayin barci da mayar da yanayin barci na yau da kullum.
Marasa lafiya da cututtukan tsarin jijiya: Wasu cututtukan jijiyoyi irin su cutar Parkinson da cutar Alzheimer galibi suna tare da matsalar barci da ayyukan jijiya mara kyau. Bugu da ƙari, inganta barci, DSIP na iya samun wani tasiri mai kariya a kan ƙwayoyin jijiya, yana taimakawa wajen sauƙaƙa wasu alamun cututtuka na tsarin jin tsoro da inganta rayuwar marasa lafiya. Misali, a cikin majinyatan cutar Parkinson, inganta bacci na iya taimakawa wajen rage gajiyar rana da matsalar motsi.
Marasa lafiya da cututtukan da ke da alaƙa da damuwa: Mutanen da ke cikin damuwa na dogon lokaci, kamar marasa lafiya da cututtukan tunani da tunani kamar rikicewar damuwa da damuwa, galibi suna fuskantar matsalar barci kuma jikinsu yana cikin yanayi na matsananciyar damuwa. DSIP na iya daidaita martanin damuwa na jiki ta hanyar daidaita barci, taimakawa wajen kawar da alamun motsin rai kamar damuwa da damuwa da inganta yanayin marasa lafiya gaba ɗaya. A lokaci guda, don wasu cututtuka na aikin jiki da ke haifar da damuwa, irin su cututtuka na narkewa da kuma rage aikin rigakafi, DSIP na iya taka wata rawar ingantawa ta hanyar inganta barci da daidaita amsawar damuwa.
A ƙarshe, DSIP yana taka muhimmiyar rawa a fagen ka'idojin barci. Yana iya inganta ingancin barcin marasa lafiya da rashin barci yadda ya kamata da kuma tsawaita lokacin barci. Ga marasa lafiyar narcolepsy, zai iya rage yawan hare-haren barci da inganta ayyukan rana da faɗakarwa.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Schneider-Helmert D fitaccen mai bincike ne a fagen fama da matsalar barci da kuma magunguna masu alaƙa. aikinsa yana da alaƙa da manyan cibiyoyi daban-daban kamar su kirschgarten pain clin, jin zafi, jin zafi clin kirschgarten, med ctr mariastein, jami'ar amsterdam, psychiatrie klinik kanton aargau, kantonsspital aarau ag (ksa), psychiat clin, psychiat psychiat, psychiatden klin kopsychifelatden klin rt argau. bincikensa da farko ya mayar da hankali ne akan neurosciences & Neurology, psychiatry, general & ciki magani, pharmacology & kantin magani, da kuma ilimin halin dan Adam. ya bayar da gudunmawa sosai wajen fahimta da magance matsalar rashin barci da sauran matsalolin da suka shafi barci, tare da sha'awar illar dsip (delta-sleep-inducing-peptide) akan barcin dan adam.
Nazarin nasa sun binciki kaddarorin psychophysiological multifunctional na disip fiye da rawar da yake takawa wajen haifar da barcin dabi'a, gami da tasirinsa akan rikicewar barcin ɗan adam da yuwuwar sa wajen inganta ingancin bacci a cikin marasa bacci. Bugu da ƙari, ya binciki ma'auni da ma'auni na haƙiƙa na farkawa tsakanin al'ada da rashin barci, da kuma manufar rashin barci mai asymptomatic. An buga aikinsa a cikin mujallu na ilimi daban-daban, ciki har da 'barci,' ' eur neurol,' ' gwaninta,' da 'neuropsychobiology,' da sauransu. An jera Schneider-Helmert D a cikin ambaton ambaton [1].
