Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ �e) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔɖeŋu bliboa
Esi amewo le tsitsim kabakaba le egbegbe hadomegbenɔnɔ me ta la, dɔléle siwo do ƒome kple dɔgbo ƒe dɔwɔwɔ, abe suklidɔ ƒomevi evelia kple suklidɔ ƒe dɔmawɔmawɔ nyuie ene, va le dzedzem geɖe wu. Pancragen, si nye tetrapeptide, xɔ ŋkɔ ŋutɔ le ƒe ʋɛ siwo va yi me le dɔgboa ƒe lãmesẽ ŋuti numekuku me.
Nɔnɔmetata 1 Pancragen ƒe atikewo ƒe wɔwɔme.
Pancragen ƒe Dɔwɔɖoɖowo ƒe Ŋusẽkpɔɖeamedzi ɖe Dɔgbo ƒe Dɔlélenutsitsi ƒe Dɔwɔwɔ Dzi
Glucose ƒe Ðoɖowɔwɔ
Le numekuku siwo wowɔ le rhesus boso tsitsiwo ŋu me la, wokpɔe be le sukli ƒe agbɔsɔsɔme si wozãna ɖaa dodo vɔ megbe la, sukli ƒe 'bu' ƒe agbɔsɔsɔ le lã tsitsiwo me ne wotsɔe sɔ kple lã viwo, si fia be sukli ƒe ɖeɖeɖa ƒe ŋutete dzi ɖe kpɔtɔ. Gake esi wodo Pancragen na rhesus boso tsitsiwo to lãmeka me atike (50 μg/lã/ŋkeke hena ŋkeke 10) dzi la, sukli ƒe 'bu' ƒe agbɔsɔsɔ dzi ɖe edzi ŋutɔ. Esia ɖee fia be Pancragen ate ŋu ana ŋutilãa ƒe sukli ƒe asitɔtrɔ ƒe ŋutete nadzi ɖe edzi, si ana sukli si le ʋu me naɖe kabakaba eye wòana sukli ƒe agbɔsɔsɔ si le ʋu me nali ke. Dɔwɔwɔ ƒe mɔnu sia do ƒome kple Pancragen ƒe dɔgbo ƒe lãmenugbagbeviwo ƒe ɖoɖowɔwɔ, elabena ate ŋu aʋã insulin ƒe dodo alo ana insulin ƒe seselelãme nadzi ɖe edzi, si ana sukli ƒe xɔxlɔ̃ kple eŋudɔwɔwɔ nadzi ɖe edzi eye wòana sukli ƒe agbɔsɔsɔ le ʋu me naɖiɖi.
Insulin kple C-peptide ƒe agbɔsɔsɔ dzi kpɔkpɔ
Numekukua ɖee fia hã be le sukli dodo vɔ megbe la, insulin kple C-peptide ƒe agbɔsɔsɔ si sɔ gbɔ wu (aɖabaƒoƒo 5 kple 15 le sukli dodo vɔ megbe) sɔ gbɔ wu le lã tsitsiwo me wu lã suewo. Esia ɖee fia be insulin ƒe dodo le lã tsitsiwo me mesɔ o. Pancragen zazã nana plasma insulin kple C-peptide ƒe ʋuʋu si sɔ la gaɖoa wo me. C-peptide dona le molar agbɔsɔsɔme si sɔ me kple insulin, eye tɔtrɔ siwo vaa eƒe agbɔsɔsɔ me ɖea dɔgboa ƒe β-lãmenugbagbeviwo ƒe dɔwɔwɔ fiana. Pancragen gbugbɔa insulin kple C-peptide ƒe agbɔsɔsɔ si sɔ la ɖoa anyi, si fia be eƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi nyui ɖe dɔgboa ƒe β-lãmenugbagbeviwo ƒe dɔwɔwɔ dzi, si kpena ɖe ame ŋu be insulin ƒe dodo ƒe ɣeyiɣi si sɔ la nanɔ anyi. Esia le vevie ŋutɔ be sukli ƒe agbɔsɔsɔ le ʋu me nali ke eye wòana sukli ƒe asitɔtrɔ le ŋutilãa me le mɔ nyuitɔ nu.
Pancragen kple Glucose ƒe Mɔɖeɖe ɖe Dɔléle Ŋu si Gblẽna ƒe Nyonyome
Lãwo Dodokpɔ Metsonuwo
Wozã rhesus boso tsitsi enyi siwo le lãmesẽ me le atikewɔnyawo me siwo xɔ ƒe 20–25 abe numekukua me tɔwo ene. siwo dometɔ 5 wodo Pancragen (0.05 mg/lã/ŋkeke, wodoe ɖe lãmeka me, hena ŋkeke 10), eye wodo suklidɔlékuiwutike si wozãna zi geɖe si nye glimepiride (4 mg/lã/ŋkeke, nono, hena ŋkeke 10) na 4. Pancragen kple glimepiride siaa ɖe boso tsitsiwo ƒe ʋumesukli ƒe agbɔsɔsɔ si le ʋu me dzi kpɔtɔ. Menye ɖeko Pancragen ɖea sukli si le ʋu me dzi kpɔtɔna ko o, ke enaa insulin kple C-peptide ƒe agbɔsɔsɔ hã gaɖoa nɔnɔme si sɔ me, si ɖee fia be eɖea ŋusẽ si gbugbɔna ɖoa sukli ƒe mɔɖeɖe ɖe nu ŋu ƒe gbegblẽ le lã tsitsiwo me ŋu. Pancragen ɖea viɖe tɔxɛwo fiana le suklidɔ ƒe mɔɖeɖe ɖe nu ŋu ƒe gbegblẽ me, elabena menye ɖeko wòɖea sukli ƒe agbɔsɔsɔ si le ʋu me dzi kpɔtɔna ko o, ke vevietɔ wu la, ekpɔa nusi gbɔ wòtso gbɔ to dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me, si wɔnɛ be ŋutilãa ƒe ŋutete be wòado dzi le sukli me.
Nusiwo ate ŋu agblẽ le ame ŋu le dɔdamɔnu me
Suklidɔ ƒe dɔmawɔmawɔ nyuie nye suklidɔ ƒomevi evelia ƒe afɔɖeɖe si do ŋgɔ na suklidɔ, eye ne womekpɔ egbɔ o la, ate ŋu ava zu suklidɔ bɔbɔe. Ŋutete si le Pancragen si be wòana suklidɔ ƒe mɔɖeɖe ɖe nu ŋu nanyo ɖe edzi le lã tsitsiwo me na gɔmesese yeyewo va le suklidɔ ƒomevi evelia nu tsitsi kple edada ŋu. Le ame ɖekaɖeka siwo le suklidɔ ƒe dɔmawɔmawɔ nyuie ƒe afɔɖeɖea me, vevietɔ ame tsitsiwo gome la, Pancragen ate ŋu anye nudede eme si le dedie eye wòwɔa dɔ nyuie be wòahe suklidɔ ƒe ŋgɔyiyi ɖe megbe alo axe mɔ ɖe enu.
Pancragen ƒe Ŋusẽkpɔɖeamedzi Dodo Ðe Dɔgboa ƒe Lãmenugbagbeviwo ƒe Vovototodedeameme Dzi
Lãmenugbagbeviwo ƒe Vovototodedeameme Dzesiwo Ƒe Ðeɖefia Ŋuti Ðoɖowɔwɔ
Numekukuwo ɖee fia be ne dɔgboa me lãmenugbagbeviwo le tsitsim la, vovototodedeameme ƒe dzesiwo ƒe ɖeɖefia dzi ɖena kpɔtɔna. Ke hã, Pancragen ateŋu aʋã dɔgbo ƒe vovototodedeameme ƒe nusiwo (abe PDX1 kple PTFLA) kple ƒukpo me lãmenugbagbeviwo ƒe dzesiwo (PDX1, PAX6, PAX4, FOXA2, kple NKX2.2) ƒe ɖeɖefia le 'sɔhɛ' kple 'ame tsitsi' dekɔnuwo siaa me. Nu siawo siwo ɖea vovototodedeameme fiana la le vevie ŋutɔ na dɔgboa ƒe lãmenugbagbeviwo ƒe vovototodedeameme kple woƒe dɔwɔwɔ nyuie. PDX1 nye dɔgbo ƒe tsitsi kple dɔgbo ƒe β-lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔla vevi aɖe, eye eƒe ɖeɖefia si dzi ɖe edzi kpena ɖe dɔgboa ƒe β-lãmenugbagbeviwo ƒe vovototodedeameme kple dɔwɔwɔ ƒe hayahaya ŋu dodo ɖe ŋgɔ. Pancragen doa dɔgboa ƒe lãmenugbagbeviwo ƒe vovototodedeameme ɖe ŋgɔ va zu lãmenugbagbevi siwo wɔa dɔ nyuie to vovototodedeameme ƒe dzesi siawo ƒe ɖeɖefia dzi ɖeɖe kpɔtɔ me.
Vovototodedeameme ƒe Mɔnu kple Lãmesẽ ƒe Gɔmesese
Pancragen nana dɔgboa ƒe ƒukpo kple acinar lãmenugbagbeviwo ƒe vovototodedeameme, si nye mɔnu vevi siwo gbɔ eƒe suklidɔ kple dɔdzẽ ƒe ŋusẽkpɔɖeamedzi tso la dometɔ ɖeka. To lãmenugbagbeviwo ƒe vovototodedeameme dodo ɖe ŋgɔ me la, Pancragen kpena ɖe ame ŋu be dɔgboa ƒe lãkusiwo ƒe wɔwɔme kple dɔwɔwɔ nanɔ blibo, enaa dɔgboa ƒe ŋutete be wòaɖɔ sukli ƒe agbɔsɔsɔ le ʋu me ɖo, eye wòɖea dɔdzẽ ƒe nugbegblẽ le dɔgboa ƒe lãkusiwo ŋu dzi kpɔtɔna. Dɔgbo ƒe lãmenugbagbeviwo ƒe vovototodedeameme dodo ɖe ŋgɔ sia naa atikewɔwɔ ƒe taɖodzinu si ate ŋu anɔ dɔlékui siwo do ƒome kple dɔgbo abe suklidɔ kple dɔgbo ƒe dɔléle ene dada.
Pancragen ƒe Zazã ƒe Ŋutete le Ame Tsitsiwo Me
Dɔgbo ƒe Dɔmawɔmawɔ nyuie si Do Ƒome Kple Ƒe Siwo Tsi Ƒe Ƒe Gbɔkpɔkpɔ
Le egbegbe hadomegbenɔnɔ ƒe amewo ƒe xexlẽme ƒe ɖoɖo nu la, ame tsitsiwo ƒe dzidziɖedzi ɖedzesi nye nu vevi siwo na suklidɔ ƒomevi eve ƒe dɔnɔwo ƒe xexlẽme le dzidzim ɖe edzi eye suklidɔ ƒe mɔɖeɖe ɖe nu ŋu ƒe gbɔdzɔgbɔdzɔ le dzidzim ɖe edzi la dometɔ ɖeka. Dɔ nyui siwo Pancragen kpɔna ɖe dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi le lãvi tsitsi siwo menye amegbetɔwo o me ɖee fia be woate ŋu azãe le mɔ gbadza nu le ame tsitsiwo dome. Ate ŋu aɖɔ dɔgboa ƒe dɔmawɔmawɔ nyuie si tso tsitsi gbɔ le ame tsitsiwo me ɖo nyuie ahawɔe wòanyo ɖe edzi, si akpe ɖe wo ŋu be sukli ƒe agbɔsɔsɔ si le ʋu me kple dɔgboa ƒe dɔwɔwɔ nyuie nanɔ anyi.
Nyanuwuwuw
Kpuie ko la, Pancragen ɖe ŋusẽkpɔɖeamedzi nyui vovovowo fia le dɔgboa ƒe lãmesẽnyawo gome. Ate ŋu aɖɔ dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo, ana sukli ƒe agbɔsɔsɔ le ʋu me kple insulin kple C-peptide ƒe dodo ƒe ɖoɖowo nanyo ɖe edzi nyuie; ekpɔa ŋusẽ nyui ɖe suklidɔ ƒe mɔɖeɖe ɖe nu ŋu ƒe gbegblẽ dzi gbugbɔgaɖoanyi, si naa mɔnu yeyewo hena mɔxexe ɖe suklidɔ ƒomevi evelia nu kple edada; to dɔgboa ƒe lãmenugbagbeviwo ƒe vovototodedeameme dodo ɖe ŋgɔ me la, enaa dɔgboa ƒe lãmenugbagbeviwo ƒe wɔwɔme kple dɔwɔwɔ nɔa te, eye wòwɔa akpa vevi aɖe le dɔlélewo abe suklidɔ kple dɔgbo ƒe dɔléle ene dada me.
Dzɔtsoƒewo
[1] Goncharova N. D., Ivanova L. G., Oganyan T. E., kple ame bubuwo. [Suklidɔ ƒe mɔɖeɖe ɖe nu ŋu ƒe gbegblẽ ɖɔɖɔɖo to tetrapeptide (Pancragen) zazã me le rhesus boso tsitsiwo me][J]. Ŋgɔyiyi le Amegãkukuŋutinunya me, 2015,28(3):579-585.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Xɔ&db=pubmed&dopt=Abstract&list_uids=28509500&query_hl=1
[2] Goncharova N. D., Ivanova L. G., Oganian T. E., kple ame bubuwo. [Ŋusẽ si tetrapeptide pancragen kpɔna ɖe dɔgboa ƒe dɔwɔwɔ le lãmenugbagbeviwo me le boso tsitsiwo me][J]. Ŋgɔyiyi le Amegãkukuŋutinunya me, 2014,27 (4): 662-667.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Xɔ&db=pubmed&dopt=Abstract&list_uids=25946840&query_hl=1
[3] Khavinson V, Durnova A. O., Polyakova V. O., kple ame bubuwo. Dɔ si pancragen wɔna ɖe dɔgboa ƒe lãmenugbagbeviwo ƒe vovototodedeameme dzi le woƒe tsitsi me[J]. Bulletin of dodokpɔ nugbagbeŋutinunya kple atikewɔwɔ, 2013, 154 (4): 501-504.DOI: 10.1007 / s10517-013-1987-6.
Adzɔnu si li na numekuku zazã ɖeɖeko:
