By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
Dubawa
Tare da haɓaka tsufa na yawan jama'a a cikin al'ummar zamani, cututtuka masu alaƙa da aikin pancreatic, irin su nau'in ciwon sukari na 2 da rashin haƙuri na glucose, sun zama sananne. Pancragen, tetrapeptide, ya sami kulawa sosai a cikin 'yan shekarun nan a fannin binciken lafiyar pancreatic.
Hoto 1 Tsarin sinadaran Pancragen.
Tasirin Ka'idoji na Pancragen akan Ayyukan Endocrine na Pancreatic
Tsarin glucose
A cikin binciken da aka yi kan tsofaffin birai na rhesus, an gano cewa bayan gudanar da daidaitaccen kashi na glucose, 'bacewar' adadin glucose ya ragu a cikin tsofaffin dabbobi idan aka kwatanta da kananan dabbobi, wanda ke nuna rage yawan damar glucose. Koyaya, lokacin da aka yiwa tsofaffin birai rhesus na Pancragen ta hanyar allurar ciki (50 μg/dabba/rana tsawon kwanaki 10), “bacewar” adadin glucose ya karu sosai. Wannan yana nuna cewa Pancragen na iya haɓaka ƙarfin metabolism na jiki don glucose, inganta saurin kawar da glucose na jini da kiyaye matakan glucose na jini. Wannan tsarin aikin yana da alaƙa da tsarin Pancragen na ƙwayoyin endocrin na pancreatic, saboda yana iya haɓaka haɓakar insulin ko haɓaka haɓakar insulin, ta haka ƙara ɗaukar nama na gefe da amfani da glucose da rage matakan glucose na jini.
Tsarin insulin da matakan C-peptide
Har ila yau, binciken ya nuna cewa bayan gudanar da glucose, mafi girman matakan insulin da C-peptide (minti 5 da 15 bayan allurar glucose) sun fi girma a cikin tsofaffin dabbobi fiye da kananan dabbobi. Wannan yana nuna cewa tsarin samar da insulin a cikin dabbobin da suka tsufa ba su da kyau. Amfani da Pancragen yana dawo da insulin plasma na al'ada da C-peptide kinetics. Ana ɓoye C-peptide daidai gwargwado daidai gwargwado tare da insulin, kuma canje-canje a matakan sa yana nuna aikin ƙwayoyin β-pancreatic. Pancragen yana dawo da insulin na al'ada da matakan C-peptide, yana nuna ingantaccen tasirin sa akan aikin β-cell na pancreatic, wanda ke taimakawa kiyaye haɓakar ƙwayar insulin ta al'ada. Wannan yana da mahimmanci don daidaita matakan glucose na jini da kuma tabbatar da metabolism na glucose na yau da kullun a cikin jiki.
Pancragen da Inganta Rashin Haƙurin Glucose
Sakamakon Gwajin Dabbobi
An yi amfani da birai rhesus tsofaffi tsofaffi masu lafiya guda tara masu shekaru 20-25 a matsayin batutuwan karatu. daga cikinsu an yi wa 5 allura tare da Pancragen (0.05 mg / dabba / rana, allurar intramuscular, na tsawon kwanaki 10), kuma 4 an gudanar da glimepiride na maganin ciwon sukari da aka saba amfani da shi (4 mg / dabba / rana, maganin baka, na kwanaki 10). Dukansu Pancragen da glimepiride sun rage matakan glucose na jini na basal na birai. Pancragen ba wai kawai rage glucose na jini ba ne, amma kuma yana mayar da insulin da matakan C-peptide zuwa al'ada, yana nuna tasirin farfadowa akan rashin haƙuri na glucose a cikin dabbobin da suka tsufa. Pancragen yana ba da fa'idodi na musamman don haɓaka ƙarancin haƙuri na glucose, saboda ba wai kawai yana rage matakan glucose na jini bane amma mafi mahimmanci yana magance tushen tushen ta hanyar daidaita ayyukan endocrine na pancreatic, ta haka yana haɓaka ikon jiki don jurewar glucose.
Abubuwan da ake iya haifarwa na asibiti
Rashin haƙuri na glucose shine matakin prediabetic na nau'in ciwon sukari na 2, kuma idan ba a magance shi ba, yana iya ci gaba zuwa ciwon sukari cikin sauƙi. Ƙarfin Pancragen don inganta haƙurin glucose a cikin dabbobin da suka tsufa yana ba da sababbin fahimta don rigakafi da maganin ciwon sukari na 2. Ga mutanen da ke cikin matakin haƙuri na glucose mai rauni, musamman tsofaffi, Pancragen na iya zama amintaccen saƙo mai inganci don jinkirta ko hana ci gaban ciwon sukari.
Haɓaka Tasirin Pancragen akan Bambancin Kwayoyin Kwayoyin Pancreatic
Ka'idar Bayyana Alamomin Bambance-bambancen Kwayoyin Halitta
Bincike ya nuna cewa yayin da ƙwayoyin pancreatic suka tsufa, bayyanar alamun bambance-bambance suna raguwa. Duk da haka, Pancragen na iya tada bayyanar da abubuwan banbance-banbancen pancreatic (irin su PDX1 da PTFLA) da alamomin kwayar halitta (PDX1, PAX6, PAX4, FOXA2, da NKX2.2) a cikin al'adun 'matasa' da 'shekaru' duka. Wadannan abubuwan bambance-bambancen suna da mahimmanci don bambance-bambancen al'ada da kuma kula da aikin ƙwayoyin pancreatic. PDX1 shine maɓalli mai mahimmanci na ci gaban pancreatic da aikin β-cell na pancreatic, kuma ƙara yawan maganganunsa yana taimakawa wajen haɓaka bambance-bambance da aikin farfadowa na β-cell na pancreatic. Pancragen yana haɓaka bambance-bambancen ƙwayoyin pancreatic zuwa sel masu aiki na yau da kullun ta hanyar haɓaka maganganun waɗannan alamomin bambance-bambance.
Tsarin Bambance-Bambance da Tasirin Lafiya
Pancragen yana haifar da bambance-bambancen tsibirin pancreatic da ƙwayoyin acinar, wani tsari wanda shine ɗayan mahimman hanyoyin da ke ƙarƙashin tasirin cutar ciwon sukari da cututtukan kumburi. Ta hanyar haɓaka bambance-bambancen tantanin halitta, Pancragen yana taimakawa kiyaye tsari da amincin aikin nama na pancreatic, yana haɓaka ikon ƙwayar ƙwayar cuta don daidaita matakan glucose na jini, kuma yana rage lalacewar kumburin nama na pancreatic. Wannan haɓakar bambance-bambancen cell na pancreatic yana ba da kyakkyawar manufa ta warkewa don magance cututtukan da ke da alaƙa kamar ciwon sukari da pancreatitis.
Yiwuwar Aikace-aikacen Pancragen a cikin Yawan Tsofaffi
Magance Rashin Ciwon Ciwon Ciwon Shekaru
A cikin tsarin al'umma na zamani, haɓakar yawan tsofaffi shine ɗayan dalilan farko na haɓakar adadin marasa lafiya da ke da nau'in ciwon sukari na 2 da rashin haƙuri na glucose. Kyakkyawan sakamako na Pancragen akan aikin endocrine na pancreatic a cikin tsofaffi waɗanda ba na ɗan adam ba suna ba da shawarar yuwuwar aikace-aikacen sa a cikin yawan tsofaffi. Yana iya daidaitawa yadda ya kamata da kuma inganta aikin aikin pancreatic na shekaru a cikin tsofaffi, yana taimaka musu su kula da matakan glucose na jini na al'ada da aikin pancreatic.
Kammalawa
A taƙaice, Pancragen ya nuna sakamako masu kyau masu yawa a fagen lafiyar pancreatic. Yana iya daidaita aikin endocrine na pancreatic, yadda ya kamata inganta matakan glucose na jini da tsarin ɓoyewar insulin da C-peptide; yana da sakamako mai kyau na farfadowa akan rashin haƙuri na glucose, yana ba da sababbin dabaru don rigakafi da maganin ciwon sukari na 2; ta hanyar haɓaka bambance-bambancen cell na pancreatic, yana kiyaye zaman lafiyar tsarin nama na pancreatic da aiki, yana taka muhimmiyar rawa wajen magance cututtuka irin su ciwon sukari da pancreatitis.
Sources
[1] Goncharova ND, Ivanova LG, Oganyan TE, et al. [gyara rashin haƙuri na glucose ta amfani da tetrapeptide (Pancragen) a cikin tsohuwar birai rhesus na mata [J]. Ci gaba a Gerontology, 2015,28(3):579-585.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=28509500&query_hl
[2] Goncharova ND, Ivanova LG, Oganian T É, et al. [Tasirin tetrapeptide pancragen akan aikin endocrine na pancreas a cikin tsoffin birai] [J]. Ci gaba a Gerontology, 2014,27(4): 662-667.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=25946840&query_hl
[3] Khavinson V, Durnova AO, Polyakova VO, et al. Tasirin pancragen akan bambance-bambancen ƙwayoyin pancreatic yayin tsufa [J]. Bulletin na Kwayoyin Gwaji da Magunguna, 2013,154(4):501-504.DOI:10.1007/s10517-013-1987-6.
Samfura akwai don amfani da bincike kawai:
