Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Txheej txheem cej luam
Nrog rau kev loj hlob sai ntawm cov pej xeem hauv lub neej niaj hnub no, cov kab mob cuam tshuam nrog kev ua haujlwm ntawm pancreatic, xws li hom 2 mob ntshav qab zib mellitus thiab cov piam thaj tsis txaus siab, tau dhau los ua qhov tseem ceeb. Pancragen, tetrapeptide, tau txais kev saib xyuas tseem ceeb hauv xyoo tas los no hauv kev tshawb fawb txog kev noj qab haus huv ntawm tus txiav.
Daim duab 1 Cov qauv tshuaj ntawm Pancragen.
Kev tswj hwm cov txiaj ntsig ntawm Pancragen ntawm Pancreatic Endocrine Function
Glucose Regulation
Hauv kev tshawb fawb txog cov neeg laus rhesus liab, nws tau pom tias tom qab kev tswj hwm tus qauv koob tshuaj ntawm cov piam thaj, qhov ' ploj mus' tus nqi ntawm cov piam thaj qis dua hauv cov tsiaj laus piv rau cov tsiaj hluas, qhia tias muaj peev xwm txo cov piam thaj. Txawm li cas los xij, thaum cov neeg laus rhesus liab tau muab Pancragen los ntawm kev txhaj tshuaj intramuscular (50 μg / tsiaj / hnub rau 10 hnub), qhov 'tso tseg' tus nqi ntawm cov piam thaj tau nce ntxiv. Qhov no qhia tau hais tias Pancragen tuaj yeem txhim kho lub cev muaj peev xwm metabolic rau cov piam thaj, txhawb kev tshem tawm cov ntshav qabzib sai thiab tswj cov ntshav qabzib kom ruaj khov. Cov txheej txheem ntawm kev ua haujlwm no cuam tshuam nrog Pancragen txoj cai tswj hwm ntawm pancreatic endocrine hlwb, vim nws tuaj yeem ua rau cov tshuaj insulin tso tawm lossis txhim kho insulin rhiab heev, yog li nce cov ntaub so ntswg peripheral thiab siv cov piam thaj thiab txo cov ntshav qabzib.
Kev tswj hwm ntawm insulin thiab C-peptide qib
Txoj kev tshawb no tseem qhia tau hais tias tom qab kev tswj hwm cov piam thaj, cov qib siab ntawm insulin thiab C-peptide (5 thiab 15 feeb tom qab txhaj cov piam thaj) tau siab dua hauv cov tsiaj laus dua li cov tsiaj hluas. Qhov no qhia tau hais tias cov qauv kev tso tawm insulin hauv cov tsiaj muaj hnub nyoog yog qhov txawv txav. Kev siv Pancragen kho cov ntshav plasma insulin thiab C-peptide kinetics. C-peptide tau tso tawm hauv qhov sib npaug ntawm cov molar nrog insulin, thiab cov kev hloov pauv hauv nws cov qib qhia txog kev ua haujlwm ntawm pancreatic β-hlwb. Pancragen rov qab kho cov tshuaj insulin ib txwm thiab C-peptide, qhia txog nws txoj kev tswj hwm zoo ntawm pancreatic beta-cell muaj nuj nqi, uas pab tswj cov tshuaj insulin li qub. Qhov no yog qhov tseem ceeb rau stabilizing cov ntshav qabzib thiab ua kom cov piam thaj metabolism hauv lub cev.
Pancragen thiab Kev Txhim Kho ntawm Impaired Glucose Tolerance
Cov txiaj ntsig kev sim tsiaj
Cuaj qhov chaw kho mob noj qab haus huv cov poj niam rhesus liab hnub nyoog 20-25 xyoo tau siv los ua kev kawm. Ntawm cov 5 tau txhaj tshuaj Pancragen (0.05 mg / tsiaj / hnub, txhaj tshuaj intramuscular, rau 10 hnub), thiab 4 tau muab cov tshuaj tiv thaiv mob ntshav qab zib ntau glimepiride (4 mg / tsiaj / hnub, kev tswj qhov ncauj, rau 10 hnub). Pancragen thiab glimepiride txo qis cov ntshav qabzib hauv cov ntshav ntawm cov laus liab. Pancragen tsis tsuas yog txo cov ntshav qabzib, tab sis kuj tseem rov qab kho cov tshuaj insulin thiab C-peptide mus rau qhov qub, ua kom pom kev rov ua haujlwm ntawm cov piam thaj hauv cov tsiaj muaj hnub nyoog. Pancragen nthuav tawm cov txiaj ntsig tshwj xeeb hauv kev txhim kho cov piam thaj tsis txaus siab, vim nws tsis tsuas yog txo cov ntshav qabzib tab sis tseem ceeb dua qhov cuam tshuam los ntawm kev tswj hwm pancreatic endocrine muaj nuj nqi, yog li txhim kho lub cev muaj peev xwm zam cov piam thaj.
Muaj feem cuam tshuam txog kev kho mob
Impaired qabzib kam rau ua yog qhov prediabetic theem ntawm ntshav qab zib hom 2, thiab yog tias tsis kho, nws tuaj yeem ua rau mob ntshav qab zib tau yooj yim. Pancragen lub peev xwm los txhim kho cov piam thaj hauv cov tsiaj muaj hnub nyoog muaj kev nkag siab tshiab rau kev tiv thaiv thiab kho mob ntshav qab zib hom 2. Rau cov tib neeg nyob rau theem tsis muaj qabzib siab ntev, tshwj xeeb tshaj yog cov neeg laus, Pancragen tuaj yeem ua haujlwm nyab xeeb thiab muaj txiaj ntsig zoo los ncua lossis tiv thaiv kev mob ntshav qab zib.
Kev txhawb nqa cov nyhuv ntawm Pancragen ntawm Pancreatic Cell Differentiation
Kev cai ntawm kev nthuav qhia ntawm Cell Differentiation Markers
Kev tshawb fawb tau pom tias thaum lub hnub nyoog ntawm cov qog pancreatic, qhov qhia txog kev sib txawv ntawm cov cim txo qis. Txawm li cas los xij, Pancragen tuaj yeem txhawb nqa qhov kev qhia ntawm pancreatic sib txawv (xws li PDX1 thiab PTFLA) thiab islet cell markers (PDX1, PAX6, PAX4, FOXA2, thiab NKX2.2) hauv ob qho tib si ' hluas' thiab ' laus' kab lis kev cai. Cov yam ntxwv sib txawv no yog qhov tseem ceeb rau kev sib txawv ntawm ib txwm thiab kev ua haujlwm ntawm cov kab mob pancreatic. PDX1 yog tus tswj hwm tseem ceeb ntawm kev txhim kho pancreatic thiab pancreatic β-cell muaj nuj nqi, thiab nws cov lus qhia ntxiv pab txhawb kev sib txawv thiab kev ua haujlwm rov qab ntawm pancreatic β-cells. Pancragen txhawb kev sib txawv ntawm cov hlwb pancreatic rau hauv cov hlwb ua haujlwm zoo los ntawm kev txhawb nqa kev qhia ntawm cov cim sib txawv.
Differentiation Mechanism thiab Health Implications
Pancragen induces qhov sib txawv ntawm pancreatic islet thiab acinar hlwb, ib txheej txheem uas yog ib qho ntawm cov txheej txheem tseem ceeb hauv qab nws cov tshuaj tiv thaiv kab mob ntshav qab zib thiab tshuaj tiv thaiv. Los ntawm kev txhawb nqa kev sib txawv ntawm tes, Pancragen pab tswj cov txheej txheem thiab kev ua haujlwm zoo ntawm cov ntaub so ntswg pancreatic, txhim kho pancreatic muaj peev xwm tswj cov ntshav qabzib, thiab txo qis kev puas tsuaj rau pancreatic nqaij. Qhov kev txhawb nqa ntawm pancreatic cell sib txawv muab lub hom phiaj kho mob rau kev kho cov kab mob pancreatic xws li ntshav qab zib thiab pancreatitis.
Daim ntawv thov muaj peev xwm ntawm Pancragen hauv cov neeg laus
Hais txog Hnub Nyoog Txog Kev Ua Haujlwm Pancreatic Dysfunction
Hauv cov txheej txheem niaj hnub hauv zej zog, kev nce ntxiv hauv cov neeg laus yog ib qho ntawm cov laj thawj tseem ceeb rau cov neeg mob ntshav qab zib hom 2 thiab cov piam thaj tsis txaus siab. Cov txiaj ntsig zoo ntawm Pancragen ntawm pancreatic endocrine muaj nuj nqi hauv cov neeg laus uas tsis yog tib neeg primates qhia nws txoj kev siv dav hauv cov neeg laus. Nws tuaj yeem tswj hwm thiab txhim kho lub hnub nyoog ntsig txog pancreatic dysfunction hauv cov neeg laus, pab lawv tswj cov ntshav qabzib thiab ua haujlwm ntawm pancreatic.
Xaus
Hauv cov ntsiab lus, Pancragen tau pom muaj ntau yam txiaj ntsig zoo hauv kev noj qab haus huv ntawm pancreatic. Nws tuaj yeem tswj hwm pancreatic endocrine muaj nuj nqi, txhim kho cov ntshav qabzib zoo thiab cov qauv tso tawm ntawm insulin thiab C-peptide; nws muaj cov txiaj ntsig zoo rov qab los ntawm cov piam thaj tsis txaus siab, muab cov tswv yim tshiab rau kev tiv thaiv thiab kho mob ntshav qab zib hom 2; los ntawm kev txhawb nqa kev sib txawv ntawm tes ntawm pancreatic, nws tswj kev ruaj ntseg ntawm pancreatic cov qauv thiab kev ua haujlwm, ua lub luag haujlwm tseem ceeb hauv kev kho cov kab mob xws li ntshav qab zib thiab pancreatitis.
Qhov chaw
[1] Goncharova ND, Ivanova LG, Oganyan TE, et al. [Kev kho cov piam thaj tsis txaus siab siv tetrapeptide (Pancragen) hauv cov poj niam laus rhesus liab] [J]. Advances in Gerontology, 2015,28(3):579-585.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=28509500&query_hl=1
[2] Goncharova ND, Ivanova LG, Oganian T É, et al. [Kev cuam tshuam ntawm tetrapeptide pancragen ntawm endocrine kev ua haujlwm ntawm pancreas hauv cov laus liab [J]. Advances in Gerontology, 2014,27(4):662-667.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=25946840&query_hl=1
[3] Khavinson V, Durnova AO, Polyakova VO, et al. Cov teebmeem ntawm pancragen ntawm kev sib txawv ntawm cov hlwb pancreatic thaum lawv laus [J]. Bulletin of Experimental Biology and Medicine, 2013,154(4):501-504.DOI:10.1007/s10517-013-1987-6.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
