Bya Cocer Peptides 
omwezi gumu emabega
EBINTU BYONNNA N’AMAWULIRE GW’EBINTU EBIweereddwa KU MUTINDO GUNO BIKOZESEBWA KU KUSASANYA AMAWULIRE N’EBIKOLWA BY’OKUSOMESA.
Ebintu ebiweereddwa ku mukutu guno bigendereddwamu kunoonyereza mu kisenge (in vitro research) byokka. Okunoonyereza mu vitro (Olulattini: *mu ndabirwamu*, ekitegeeza mu bikozesebwa mu ndabirwamu) kukolebwa ebweru w’omubiri gw’omuntu. Ebintu bino si bya ddagala, tebikkiriziddwa kitongole kya Amerika ekivunaanyizibwa ku by’emmere n’eddagala (FDA), era tebirina kukozesebwa kuziyiza, kujjanjaba oba kuwonya mbeera yonna ya bujjanjabi, bulwadde oba bulwadde. Kikugirwa nnyo mu mateeka okuyingiza ebintu bino mu mubiri gw’omuntu oba ebisolo mu ngeri yonna.
Okutwalira awamu
Olw’okukaddiwa amangu kw’abantu mu bantu ab’omulembe guno, endwadde ezikwata ku nkola y’olubuto, gamba nga sukaali ow’ekika eky’okubiri n’okulemererwa okugumira glucose, zeeyongedde okweyoleka. Pancragen, tetrapeptide, efunye okufaayo okunene mu myaka egiyise mu by’okunoonyereza ku bulamu bw’olubuto.
Ekifaananyi 1 Ensengekera y’eddagala lya Pancragen.
Ebikolwa by’okulungamya ebya Pancragen ku nkola ya Pancreatic Endocrine
Okulungamya ku Glucose
Mu kunoonyereza ku nkimye za rhesus enkadde, kyazuulibwa nti oluvannyuma lw'okuweebwa ddoozi ya glucose eya bulijjo, omuwendo gwa 'okubula' ogwa glucose gwali wansi mu bisolo ebikadde bw'ogeraageranya n'ebisolo ebito, ekiraga nti obusobozi bw'okugogola glucose bukendedde. Wabula enkima za rhesus enkadde bwe zaaweebwa Pancragen nga ziyita mu mpiso mu binywa (50 μg/ekisolo/olunaku okumala ennaku 10), omuwendo gwa 'okubula' ogwa glucose gweyongera nnyo. Kino kiraga nti Pancragen esobola okutumbula obusobozi bw’omubiri mu kukyusa glucose, okutumbula okulongoosa amangu glucose mu musaayi n’okukuuma emiwendo gya glucose mu musaayi nga gitebenkedde. Enkola eno ey’okukola ekwatagana n’okulungamya kwa Pancragen obutoffaali bw’omu lubuto, kubanga esobola okusitula okufulumya insulini oba okutumbula okuwuliziganya kwa insulini, bwe kityo n’eyongera okuyingiza n’okukozesa glucose mu bitundu by’omubiri eby’okumpi n’okukendeeza ku muwendo gwa glucose mu musaayi.
Okulungamya emiwendo gya insulini ne C-peptide
Okunoonyereza kuno era kwalaga nti oluvannyuma lw’okuweebwa glucose, emiwendo gya insulini ne C-peptide egy’oku ntikko (eddakiika 5 ne 15 oluvannyuma lw’okukuba empiso ya glucose) gyali mingi mu bisolo ebikadde okusinga mu bisolo ebito. Kino kiraga nti enkola y’okufulumya insulini mu bisolo ebikadde si ya bulijjo. Okukozesa Pancragen kuzzaawo insulini mu plasma eya bulijjo ne C-peptide kinetics. C-peptide efulumizibwa mu bungi obw’enkanankana mu molar ne insulin, era enkyukakyuka mu miwendo gyayo ziraga enkola y’obutoffaali bwa β obw’olubuto. Pancragen ezzaawo emiwendo gya insulini ne C-peptide egya bulijjo, ekiraga enkola yaayo ennungi ey’okulungamya ku nkola ya β-cell z’olubuto, ekiyamba okukuuma ennyimba eza bulijjo ez’okufulumya insulini. Kino kikulu nnyo mu kutebenkeza emiwendo gya glucose mu musaayi n’okukakasa nti glucose ekyukakyuka mu mubiri mu ngeri eya bulijjo.
Pancragen n’okulongoosa mu kugumira glucose okukosebwa
Ebivudde mu kugezesa ebisolo
Enkima enkazi enkazi eza rhesus mwenda ezirina obulamu obulungi mu bujjanjabi obw’emyaka 20–25 zaakozesebwa ng’abanoonyereza. ku bano 5 baafukibwa Pancragen (0.05 mg/ekisolo/olunaku, empiso mu binywa, okumala ennaku 10), ate 4 ne baweebwa eddagala eritera okukozesebwa eriweweeza ku ssukaali erya glimepiride (4 mg/ekisolo/olunaku, okuweebwa mu kamwa, okumala ennaku 10). Pancragen ne glimepiride byombi byakendeeza ku mutindo gwa glucose mu musaayi ogw’omusingi ogw’enkima enkadde. Pancragen tekoma ku kukendeeza glucose mu musaayi, wabula era ezzaawo emiwendo gya insulin ne C-peptide mu mbeera eya bulijjo, ekiraga nti ekola ku kuzzaawo okugumira glucose okukosebwa mu bisolo ebikadde. Pancragen eraga ebirungi eby’enjawulo mu kulongoosa okugumira glucose okukosebwa, kubanga tekoma ku kukendeeza ku miwendo gya glucose mu musaayi wabula ekisinga obukulu ekola ku kikolo ekivaako omubiri ng’etereeza enkola y’endwadde z’omu lubuto, bwe kityo n’eyongera ku busobozi bw’omubiri okugumira glucose.
Ebiyinza okuvaamu mu bujjanjabi
Okulemererwa okugumira glucose gwe mutendera ogusooka okukwatibwa ssukaali ow’ekika eky’okubiri, era singa tegukolebwako, kyangu okugenda mu maaso n’afuuka ssukaali. Obusobozi bwa Pancragen okulongoosa okugumira glucose mu bisolo ebikadde buwa amagezi amapya ku kuziyiza n’okujjanjaba ssukaali ow’ekika eky’okubiri. Ku bantu ssekinnoomu abali mu mutendera gw‟okugumira glucose okukosebwa naddala abakadde, Pancragen eyinza okukola ng‟okuyingira mu nsonga okutali kwa bulabe era okulungi okulwawo oba okuziyiza okukulaakulana okutuuka ku ssukaali.
Okutumbula Enkola ya Pancragen ku Njawulo y’obutoffaali bw’olubuto
Okulungamya okwolesebwa kw’obubonero bw’enjawulo mu butoffaali
Okunoonyereza kulaga nti obutoffaali bw’olubuto bwe bukaddiwa, okwolesebwa kw’obubonero obw’enjawulo kukendeera. Naye, Pancragen esobola okusitula okwolesebwa kw'ensonga z'enjawulo z'olubuto (nga PDX1 ne PTFLA) n'obubonero bw'obutoffaali bw'ebizinga (PDX1, PAX6, PAX4, FOXA2, ne NKX2.2) mu buwangwa bwombi 'abato' ne 'emyaka'. Ensonga zino ez’enjawulo nkulu nnyo mu njawulo eya bulijjo n’okulabirira obutoffaali bw’olubuto mu nkola. PDX1 ye regulator enkulu ey’enkula y’olubuto n’enkola ya β-cell z’olubuto, era okweyongera kwayo okwolesebwa kuyamba okutumbula okwawukana n’okuddamu okukola kw’obutoffaali bwa β-obutoffaali bw’olubuto. Pancragen etumbula okwawukana kw’obutoffaali bw’olubuto mu butoffaali obukola obwa bulijjo nga etereeza okwolesebwa kw’obubonero buno obw’enjawulo.
Enkola y’Okwawula n’Ebikwata ku bulamu
Pancragen ereeta okwawukana kw’obutoffaali bw’ekizinga ky’olubuto n’obutaffaali bwa acinar, enkola eno y’emu ku nkola enkulu ezisibukako ebikolwa byayo eby’okulwanyisa ssukaali n’okuzimba. Nga etumbula enjawulo y’obutoffaali, Pancragen eyamba okukuuma obulungi ensengekera n’enkola y’ebitundu by’olubuto, eyongera ku busobozi bw’olubuto okutereeza emiwendo gya glucose mu musaayi, n’okukendeeza ku kwonooneka kw’okuzimba kw’ebitundu by’olubuto. Okutumbula kuno okwawukana kw’obutoffaali bw’olubuto kuwa ekigendererwa eky’obujjanjabi ekiyinza okujjanjaba endwadde ezikwatagana n’olubuto nga sukaali n’obulwadde bw’olubuto.
Obusobozi bw’okukozesa Pancragen mu bantu abakadde
Okukola ku buzibu bw’olubuto obuva ku myaka
Mu nsengeka y‟abantu mu bantu ab‟omulembe guno, okweyongera okw‟amaanyi mu muwendo gw‟abakadde y‟emu ku nsonga enkulu eziviiriddeko omuwendo gw‟abalwadde ba ssukaali ow‟ekika eky‟okubiri okweyongera n‟okulemererwa okugumira glucose. Ebirungi ebiva mu Pancragen ku nkola y’endocrine y’olubuto mu bimera ebikadde ebitali bantu biraga obusobozi bwayo obw’okukozesebwa mu bungi mu bantu abakadde. Kisobola bulungi okulung’amya n’okulongoosa obuzibu bw’olubuto obuva ku myaka mu bakadde, ne kibayamba okukuuma omutindo gwa glucose mu musaayi ogwa bulijjo n’enkola y’olubuto.
Mu bufunzi
Mu bufunze, Pancragen eraga ebirungi eby’enjawulo mu by’obulamu bw’olubuto. Kisobola okulung’amya enkola y’endwadde z’omu lubuto, okulongoosa obulungi emiwendo gya glucose mu musaayi n’engeri y’okufulumya insulini ne C-peptide; kirina ekikolwa ekirungi eky’okuzzaawo ku kulemererwa okugumira glucose, okuwa obukodyo obupya obw’okuziyiza n’okujjanjaba ssukaali ow’ekika eky’okubiri; nga etumbula okwawukana kw’obutoffaali bw’olubuto, ekuuma obutebenkevu bw’ensengeka n’enkola y’ebitundu by’olubuto, nga kikola kinene mu kujjanjaba endwadde nga sukaali n’obulwadde bw’olubuto.
Ensonda
[1] Goncharova ND, Ivanova LG, Oganyan T. E., n’abalala. [Okutereeza okugumira glucose okukosebwa nga tukozesa tetrapeptide (Pancragen) mu nkimye enkazi enkadde eza rhesus][J]. Enkulaakulana mu by’obukadde, 2015,28(3):579-585.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Ggyawo&db=pubmed&dopt=Abstract&list_uids=28509500&query_hl=1
[2] Goncharova ND, Ivanova LG, Oganian T É, n’abalala. [Enkosa ya tetrapeptide pancragen ku nkola y’endocrine ey’olubuto mu nkimye enkadde][J]. Enkulaakulana mu by’obukadde, 2014,27(4):662-667.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Ggyawo&db=pubmed&dopt=Abstract&list_uids=25946840&query_hl=1
[3] Khavinson V, Durnova AO, Polyakova V. O., n’abalala. Ebikolwa bya pancragen ku njawulo y’obutoffaali bw’olubuto mu kiseera ky’okukaddiwa kwabwo[J]. Bulletin y'okugezesa ebiramu n'obusawo, 2013,154 (4): 501-504.DOI: 10.1007 / s10517-013-1987-6.
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