By Cocer Peptides 
1 ọnwa gara aga
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
Nchịkọta
Site na ịka nká nke ndị mmadụ na ọha mmadụ nke oge a, ọrịa ndị metụtara ọrụ pancreatic, dị ka ụdị ọrịa shuga 2 na enweghị nnabata glucose, na-apụtawanye ìhè. Pancragen, tetrapeptide, enwetala nlebara anya dị ukwuu n'afọ ndị na-adịbeghị anya na ngalaba nyocha ahụike nke pancreatic.
Ọgụgụ 1 Ọdịdị kemịkalụ nke Pancragen.
Mmetụta nchịkwa nke Pancragen na arụ ọrụ Endocrine Pancreatic
Iwu glucose
N'ime ọmụmụ banyere enwe rhesus agadi, achọpụtara na mgbe nchịkwa nke glucose kwesịrị ekwesị, 'ọdịdị' nke glucose dị ala na anụ ndị agadi ma e jiri ya tụnyere ụmụ anụmanụ na-eto eto, na-egosi mbelata ikike mkpochapụ glucose. Otú ọ dị, mgbe a na-enye enwe ndị agadi rhesus Pancragen site na ntụtụ intramuscular (50 μg/anụmanụ kwa ụbọchị maka ụbọchị 10), ọnụ ọgụgụ glucose 'mpụpụ' abawanyela nke ukwuu. Nke a na-egosi na Pancragen nwere ike ịkwalite ikike metabolic nke anụ ahụ maka glucose, na-akwalite mkpochapụ nke glucose ọbara ngwa ngwa ma na-edobe ọkwa glucose ọbara kwụsiri ike. Usoro a na-emetụta usoro Pancragen nke mkpụrụ ndụ endocrine nke pancreatic, n'ihi na ọ nwere ike kpalite insulin secretion ma ọ bụ mee ka mmetụta insulin dịkwuo elu, si otú ahụ na-abawanye nnabata anụ ahụ na iji glucose na-ebelata ọkwa glucose ọbara.
Nhazi nke insulin na ọkwa C-peptide
Ọmụmụ ihe ahụ gosikwara na mgbe nchịkwa glucose gasịrị, ọkwa kachasị elu nke insulin na C-peptide (nkeji 5 na 15 mgbe ịgbanye glucose gasịrị) dị elu karịa ụmụ anụmanụ ndị na-eto eto. Nke a na-egosi na usoro mmepụta insulin n'ime anụmanụ merela agadi adịghị mma. Ojiji nke Pancragen na-eweghachi insulin plasma nkịtị na C-peptide kinetics. A na-ezobe C-peptide n'otu nha nha molar yana insulin, mgbanwe na ọkwa ya na-egosipụta ọrụ nke mkpụrụ ndụ β-pancreatic. Pancragen na-eweghachi insulin nkịtị na ọkwa C-peptide nkịtị, na-egosi mmetụta nchịkwa ya dị mma na ọrụ β-cell pancreatic, nke na-enyere aka ịnọgide na-enwe usoro nzuzo insulin nkịtị. Nke a dị oke mkpa maka mbelata ọkwa glucose ọbara na ịgba mbọ hụ na metabolism nke glucose nkịtị n'ime ahụ.
Pancragen na Mmelite nke nnabata glucose na-adịghị mma
Nsonaazụ nnwale anụmanụ
Enwere ụmụ nwanyị rhesus agadi agadi nwere ahụike ahụike ahụike dị afọ 20-25 dị ka ihe ọmụmụ. 5 n'ime ya ka a gbanyere Pancragen (0.05 mg / anụmanụ / ụbọchị, ịgba ọgwụ intramuscular, maka ụbọchị 10), na 4 ka a na-enye ọgwụ antidiabetic glimepiride (4 mg / anụmanụ / ụbọchị, nchịkwa ọnụ, maka ụbọchị 10). Ma Pancragen na glimepiride belatara ọkwa glucose ọbara basal nke enwe agadi. Pancragen abụghị naanị na-ebelata glucose ọbara, kamakwa na-eweghachi insulin na C-peptide n'ọkwa dị mma, na-egosipụta mmetụta mweghachi na nnabata glucose na-adịghị mma na anụmanụ merela agadi. Pancragen na-egosipụta uru pụrụ iche n'ịkwalite nnabata glucose na-adịghị mma, n'ihi na ọ bụghị naanị na-ebelata ọkwa glucose ọbara mana nke ka mkpa na-ekwu maka isi ihe kpatara ya site na ịhazi ọrụ endocrine nke pancreas, si otú a na-eme ka ahụ ahụ nwee ike ịnagide glucose.
Mmetụta ụlọ ọgwụ nwere ike ime
Enweghi ike nnabata glucose bụ ụdị ọrịa shuga nke ụdị nke abụọ, ma ọ bụrụ na edozighị ya, ọ nwere ike ịga n'ihu ruo ọrịa shuga. Ike Pancragen imeziwanye nnabata glucose n'ime anụmanụ meworo agadi na-enye nghọta ọhụrụ maka mgbochi na ọgwụgwọ ụdị ọrịa shuga 2. Maka ndị mmadụ n'otu n'otu nọ na ọkwa nnabata glucose na-adịghị mma, ọkachasị ndị agadi, Pancragen nwere ike bụrụ ihe enyemaka dị mma ma dị mma iji gbuo oge ma ọ bụ gbochie ọganihu na ọrịa shuga.
Mmetụta Pancragen na-akwalite ọdịiche dị na cell pancreatic
Iwu nke nkwupụta nke ihe nrịbama dị iche iche cell
Nnyocha egosiwo na ka mkpụrụ ndụ pancreatic na-aka nká, ngosipụta nke ihe nrịbama dị iche na-ebelata. Agbanyeghị, Pancragen nwere ike kpalite ngosipụta nke ihe dị iche iche nke pancreatic (dịka PDX1 na PTFLA) na akara mkpụrụ ndụ islet (PDX1, PAX6, PAX4, FOXA2, na NKX2.2) na ma 'nwatakịrị' na 'omenala'. Ihe ndị a dị iche iche dị oké mkpa maka ịdị iche nke nkịtị na ịrụ ọrụ nke mkpụrụ ndụ pancreatic. PDX1 bụ isi ihe na-achịkwa mmepe nke pancreatic na ọrụ β-cell pancreatic, yana mmụba ya na-enyere aka ịkwalite ọdịiche na mgbake ọrụ nke mkpụrụ ndụ β-pancreatic. Pancragen na-akwalite ọdịiche nke mkpụrụ ndụ pancreatic n'ime sel arụ ọrụ nkịtị site n'ịkwalite nkwupụta nke ihe nrịbama ndị a.
Usoro dị iche iche na mmetụta ahụike
Pancragen na-ebute ọdịiche dị n'etiti islet pancreatic na sel acinar, usoro nke bụ otu n'ime isi ihe na-akpata ọrịa shuga na mgbochi mkpali. Site n'ịkwalite ọdịiche dị n'etiti cell, Pancragen na-enyere aka ịnọgide na-enwe nguzozi na arụ ọrụ nke anụ ahụ pancreatic, na-eme ka pancreas nwee ike ịhazi ọkwa glucose ọbara, ma na-ebelata mkpali mmebi nke anụ ahụ pancreatic. Usoro a na-enye ohere maka ọgwụgwọ nke ọrịa pancreatic dị ka ọrịa shuga na ọrịa pancreatitis.
Enwere ike itinye Pancragen n'ime ọha mmadụ
Na-agwa arụrụ ọrụ pancreatic metụtara afọ
N'ime usoro ọha mmadụ nke oge a, mmụba dị ukwuu na ndị agadi bụ otu n'ime isi ihe kpatara ọnụ ọgụgụ ndị ọrịa na-arị elu nke ụdị ọrịa shuga 2 na enweghị nnabata glucose. Mmetụta dị mma nke Pancragen na ọrụ endocrine nke pancreatic na ndị agadi na-abụghị mmadụ primates na-atụ aro ike itinye ya na ndị agadi. Ọ nwere ike ịhazi nke ọma ma melite arụmọrụ pancreatic metụtara afọ na ndị agadi, na-enyere ha aka ịnọgide na-enwe ọkwa glucose ọbara nkịtị na ọrụ pancreatic.
Mmechi
Na nchịkọta, Pancragen egosila ọtụtụ mmetụta dị mma na ngalaba ahụike nke pancreatic. Ọ nwere ike ịhazi ọrụ endocrine nke pancreatic, na-emeziwanye ọkwa glucose ọbara nke ọma na usoro nzuzo nke insulin na C-peptide; ọ nwere mmetụta mweghachi dị mma na nnabata glucose na-adịghị mma, na-enye usoro ọhụrụ maka mgbochi na ọgwụgwọ nke ụdị ọrịa shuga 2; site n'ịkwalite ọdịiche dị n'etiti cell pancreatic, ọ na-ejigide nkwụsi ike nke nhazi anụ ahụ na ọrụ pancreatic, na-ekere òkè dị mkpa na ọgwụgwọ ọrịa ndị dị ka ọrịa shuga na pancreatitis.
Isi mmalite
[1] Goncharova ND, Ivanova LG, Oganyan TE, et al. [Ndozi nke nnabata glucose na-adịghị mma site na iji tetrapeptide (Pancragen) na enwe rhesus ochie [J]. Ọganihu na Gerontology, 2015,28(3):579-585.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=28509500&query_hl
[2] Goncharova ND, Ivanova LG, Oganian T É, et al. [Mmetụta nke tetrapeptide pancragen na ọrụ endocrine nke pancreas na enwe ochie]. Ọganihu na Gerontology, 2014,27(4):662-667.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=25946840&query_hl
[3] Khavinson V, Durnova AO, Polyakova VO, et al. Mmetụta nke pancragen na ọdịiche nke mkpụrụ ndụ pancreatic n'oge ha na-aka nká [J]. Akwụkwọ akụkọ nke ihe omumu ihe omumu na ogwu, 2013,154(4):501-504.DOI:10.1007/s10517-013-1987-6.
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