Na Cocer Peptides 
ukwezi gushize
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Incamake
Hamwe no gusaza kwabaturage mu mibereho ya none, indwara zijyanye n'imikorere ya pancreatic, nka diyabete yo mu bwoko bwa 2 no kutihanganira glucose, byagaragaye cyane. Pancragen, tetrapeptide, yitabiriwe cyane mumyaka yashize mubijyanye nubushakashatsi bwubuzima bwa pancreatic.
Igishushanyo 1 Imiterere yimiti ya Pancragen.
Ingaruka Zigenga za Pancragen kumikorere ya pancreatic Endocrine
Glucose
Mu bushakashatsi bwakozwe ku nguge zishaje za rhesus, byagaragaye ko nyuma yo gutanga igipimo gisanzwe cya glucose, igipimo cya 'kubura ' cya glucose cyaragabanutse ku nyamaswa zishaje ugereranije n’inyamaswa zikiri nto, byerekana ko ubushobozi bwo gukuraho glucose bwagabanutse. Ariko, mugihe inguge za rhesus zishaje zahawe Pancragen hakoreshejwe inshinge (50 μg / inyamaswa / kumunsi iminsi 10), igipimo cya 'kubura ' cya glucose cyariyongereye cyane. Ibi byerekana ko Pancragen ishobora kongera imbaraga za metabolike yumubiri wa glucose, igateza imbere glucose yamaraso kandi ikagumana urugero rwa glucose rwamaraso. Ubu buryo bwo gukora bufitanye isano no kugenzura Pancragen kugenga ingirabuzimafatizo ya endocrine, kuko ishobora gutera insuline gusohora cyangwa kongera insuline, bityo bikongerera umubiri gufata no gukoresha glucose no kugabanya urugero rwa glucose.
Kugena urwego rwa insuline na C-peptide
Ubushakashatsi bwerekanye kandi ko nyuma y’ubuyobozi bwa glucose, urugero rwa insuline na C-peptide (iminota 5 na 15 nyuma yo guterwa glucose) rwabaye rwinshi mu nyamaswa zishaje kuruta iz’inyamaswa zikiri nto. Ibi byerekana ko uburyo bwo gusohora insuline mu nyamaswa zishaje bidasanzwe. Gukoresha Pancragen bigarura plasma isanzwe insuline na C-peptide kinetics. C-peptide irekurwa muburyo bungana na insuline, kandi impinduka murwego rwazo zigaragaza imikorere ya pancreatic β-selile. Pancragen igarura insuline zisanzwe na C-peptide, byerekana ingaruka nziza zogukora kumikorere ya pancreatic β-selile, ifasha kugumana injyana isanzwe ya insuline. Ibi nibyingenzi muguhindura glucose yamaraso no kwemeza glucose metabolism mumubiri.
Pancragen no Gutezimbere Kworoherwa kwa Glucose
Ibisubizo by'inyamaswa
Inkende icyenda zifite ubuzima bwiza bw’inguge rhesus inguge zifite hagati yimyaka 20-25 zikoreshwa nkamasomo. muri bo 5 batewe na Pancragen (0,05 mg / inyamaswa / umunsi, inshinge zo mu nda, mu minsi 10), naho 4 baterwa imiti isanzwe ikoreshwa na glimepiride (4 mg / inyamaswa / umunsi, ubuyobozi bwo mu kanwa, iminsi 10). Pancragen na glimepiride byombi byagabanije glucose yamaraso yibanze yinguge zishaje. Pancragen ntabwo igabanya glucose yamaraso gusa, ahubwo inagarura urugero rwa insuline na C-peptide kurwego rusanzwe, byerekana ingaruka zo kugarura ingaruka mbi zo kwihanganira glucose mubikoko byashaje. Pancragen igaragaza ibyiza byihariye mugutezimbere glucose yihanganira, kuko itagabanya gusa glucose yamaraso ahubwo ikanakemura cyane cyane intandaro yo kugenzura imikorere ya pancreatic endocrine, bityo bikazamura ubushobozi bwumubiri kwihanganira glucose.
Ingaruka zishobora kuvurwa
Kwihanganira glucose kwihanganira ni intambwe ya diyabete yo mu bwoko bwa 2, kandi iyo idakemuwe, irashobora gutera diyabete byoroshye. Ubushobozi bwa Pancragen bwo kunoza glucose kwihanganira inyamaswa zishaje zitanga ubumenyi bushya bwo kwirinda no kuvura diyabete yo mu bwoko bwa 2. Ku bantu bari mu cyiciro cyo kwihanganira glucose, cyane cyane abasaza, Pancragen irashobora kuba uburyo bwiza kandi bwiza bwo gutinza cyangwa gukumira indwara ya diyabete.
Ingaruka zo Guteza Imbere Pancragen Kubitandukanya Utugingo ngengabuzima
Amabwiriza yo Kugaragaza Ibimenyetso Bitandukanya Akagari
Ubushakashatsi bwerekanye ko uko selile pancreatic selile igenda isaza, imvugo yerekana itandukaniro igabanuka. Nyamara, Pancragen irashobora gushimangira imvugo yibintu bitandukanya pancreatic (nka PDX1 na PTFLA) hamwe nibimenyetso bya selile (PDX1, PAX6, PAX4, FOXA2, na NKX2.2) mumico yombi 'muto ' na 'abasaza '. Ibi bintu byo gutandukanya nibyingenzi muburyo butandukanye bwo gutandukanya no gufata neza imikorere ya selile pancreatic selile. PDX1 ningingo nyamukuru igenga iterambere rya pancreatic hamwe na pancreatic β-selile imikorere, kandi imvugo yayo yiyongera ifasha guteza imbere gutandukanya no gukira kwimikorere ya pancreatic β-selile. Pancragen iteza imbere uturemangingo twa pancreatic selile mumikorere isanzwe ikora muguhuza imvugo yibimenyetso bitandukanye.
Uburyo bwo Gutandukanya hamwe nubuzima bwiza
Pancragen itera itandukaniro ryizinga rya pancreatic islet na selile acinar, inzira nimwe muburyo bwingenzi bushingiye ku ngaruka zayo zo kurwanya diyabete no kurwanya inflammatory. Mugutezimbere gutandukanya selile, Pancragen ifasha kugumana ubusugire bwimiterere nimikorere yumubiri wa pancreatic, byongera ubushobozi bwurwungano ngogozi rwo kugenzura urugero rwa glucose yamaraso, kandi bikagabanya kwangirika kwingirangingo. Iterambere ryimikorere itandukanye ya pancreatic selile itanga intego yo kuvura yo kuvura indwara ziterwa na pancreatic nka diabete na pancreatitis.
Gusaba Ubushobozi bwa Pancragen mubantu bakuze
Gukemura Imyaka Ijyanye na Pancreatic Imikorere mibi
Mu miterere y’imibereho y’abaturage igezweho, ubwiyongere bukabije bw’abaturage bageze mu za bukuru ni imwe mu mpamvu z’ibanze zitera ubwiyongere bw’abarwayi bafite diyabete yo mu bwoko bwa 2 no kutihanganira glucose. Ingaruka nziza za Pancragen kumikorere ya pancreatic endocrine mumikorere yabasaza batari abantu berekana ko ishobora gukoreshwa mubantu bageze mu zabukuru. Irashobora gutunganya neza no kunoza imikorere idahwitse yatewe no gusaza kubasaza, ibafasha kugumana urugero rwamaraso glucose mumikorere n'imikorere ya pancreatic.
Umwanzuro
Muri make, Pancragen yerekanye ingaruka nziza zitandukanye mubice byubuzima bwurwagashya. Irashobora kugenga imikorere ya pancreatic endocrine, igatezimbere neza glucose yamaraso hamwe nuburyo bwo gusohora kwa insuline na C-peptide; igira ingaruka nziza zo kugarura kwihanganira glucose yangiritse, itanga ingamba nshya zo gukumira no kuvura diyabete yo mu bwoko bwa 2; mugutezimbere gutandukanya selile pancreatic selile, ikomeza ituze ryimiterere yimikorere yimikorere ya pancreatic tissue, ikora, igira uruhare runini mukuvura indwara nka diyabete na pancreatite.
Inkomoko
[1] Goncharova ND, Ivanova LG, Oganyan TE, n'abandi. [Gukosora kwihanganira glucose yangiritse ukoresheje tetrapeptide (Pancragen) mu nguge za rhesus zishaje] [J]. Iterambere muri Gerontologiya, 2015,28 (3): 579-585. Http: //www.ncbi.nlm.nih.gov/entrez/query.fcgi?
[2] Goncharova ND, Ivanova LG, Oganian T É, n'abandi. [Ingaruka za tetrapeptide pancragen ku mikorere ya endocrine ya pancreas mu nguge zishaje] [J]. Iterambere muri Gerontologiya, 2014,27 (4): 662-667. Http:
[3] Khavinson V, Durnova AO, Polyakova VO, n'abandi. Ingaruka za pancragen ku gutandukanya ingirangingo za pancreatic mugihe zishaje [J]. Amatangazo y’ibinyabuzima n’ubuvuzi, 2013,154 (4): 501-504.DOI: 10.1007 / s10517-013-1987-6.
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