By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
Dubawa
Glutathione, wanda kuma aka sani da glutathione, wani muhimmin fili ne wanda ya yadu a cikin halittu masu rai. Yana da tripeptide wanda ya ƙunshi glutamic acid, cysteine, da glycine. Ana iya samun shi a cikin dabbobi masu shayarwa, tsirrai, da ƙwayoyin ƙwayoyin cuta masu yawa, inda yake taka rawar da ba dole ba a cikin sel. Glutathione an san shi da 'Master Antioxidant' saboda kaddarorinsa na antioxidant. Wannan lakabin ya samo asali ne daga babban taro a cikin sel da ikonsa na yin aiki tare da sauran antioxidants don haɓaka tasirin antioxidant.
Hoto 1 Haɗin gwiwar aikin enzymes antioxidant superoxide dismutase, catalase, da glutathione peroxidase.
Ayyuka
Share radicals free da kuma kare kwayoyin halitta da mitochondria: Free radicals su ne sosai amsawa kwayoyin halitta a lokacin salon salula metabolism. Matsakaicin radicals masu yawa na iya haifar da lalatawar oxidative da peroxidative ga sel da mitochondria. Glutathione yana amsawa tare da radicals kyauta ta hanyar rukunin sulfhydryl (-SH), yana canza su zuwa wasu abubuwa masu tsayayye, don haka yana hana radicals kyauta daga hare-haren sel da mitochondria da kiyaye tsarin al'ada da aikin sel. Lokacin da aka fallasa ƙwayoyin sel zuwa abubuwan motsa jiki na waje irin su ultraviolet radiation ko radiation, ana samar da adadi mai yawa na free radicals. Glutathione na iya hanzarta amsawa don kawar da waɗannan radicals na kyauta, rage haɗarin lalacewar salula.
Shiga cikin ma'auni na rayuwa: A cikin ƙwayoyin cuta, glutathione yana shiga cikin halayen redox yayin metabolism. Ta hanyar halayen enzymatic, yana kiyaye daidaito a cikin jiki. Wannan ma'auni yana ba da damar ƙwayoyin cuta kai tsaye ko a kaikaice su tsayayya da canje-canje daban-daban da suka haifar da abubuwan muhalli da nasu metabolism yayin girma, irin su high oxygen matakan, high osmotic matsa lamba, kwayoyi, da karfe ions. Lokacin da kwayoyin cuta ke cikin yanayi mai yawan iskar oxygen, suna samar da nau'in iskar oxygen mai yawa (ROS). Glutathione na iya rage ROS ta hanyar jerin halayen, ba da damar ƙwayoyin cuta su rayu a cikin irin waɗannan wurare.
Detoxification: Glutathione na iya ɗaure da gubobi, ƙarfe masu nauyi, da sauran abubuwa masu cutarwa a cikin sel, canza su zuwa abubuwan da ba su da guba ko ƙarancin guba da haɓaka fitar su daga jiki. Karkashin damuwa mai nauyi na ƙarfe, matakan glutathione a cikin ƙwayoyin shuka suna ƙaruwa. Yana samar da hadaddiyar giyar tare da karafa masu nauyi, yana rage gubarsu zuwa kwayoyin halitta. Glutathione kuma yana iya ɗaure tare da abubuwa masu guba na electrophilic don hana lalacewar mahimman kwayoyin halitta a cikin sel (kamar sunadarai da acid nucleic), ta haka ne ke kare sel daga guba.
Haɓaka rigakafi: Glutathione shima yana taka muhimmiyar rawa a cikin tsarin rigakafi. Yana iya daidaita aikin ƙwayoyin rigakafi, haɓaka ayyukansu, kuma ta haka yana inganta aikin garkuwar jiki. Zai iya rinjayar haɓakawa da bambance-bambancen T lymphocytes da B lymphocytes, yana ba da damar tsarin rigakafi don gane da kuma kawar da ƙwayoyin cuta na kasashen waje, da kuma taimakawa jiki wajen tsayayya da cututtuka da cututtuka.
Aikace-aikace
Kariyar Hanta: Hanta wata mahimmanci ce ta detoxification a cikin jikin mutum kuma tana da saurin lalacewa daga abubuwa masu cutarwa daban-daban yayin tafiyar matakai na rayuwa. Glutathione yana haɓaka aikin detoxification na hanta kuma yana inganta gyaran gyare-gyare da sake farfado da ƙwayoyin hanta. A asibiti, ana amfani da ita don magance cututtuka daban-daban masu tsanani da kuma na yau da kullum, irin su ciwon hanta na barasa da raunin hanta da miyagun ƙwayoyi ya haifar. Don lalacewar hanta da ke haifar da barasa ta hanyar amfani da barasa na dogon lokaci, glutathione na iya rage lalacewar hanta ta hanyar lalata radicals kyauta, don haka inganta alamun aikin hanta.
Maganin Ciwon Cutar Endocrine: Aiki na yau da kullun na tsarin endocrin yana da mahimmanci don kiyaye daidaiton ilimin lissafi a jikin ɗan adam. Glutathione na iya daidaita tsarin kira, ɓoyewa, da kuma metabolism na hormones a cikin tsarin endocrin, don haka yana yin tasiri mai tasiri akan cututtuka da ke da alaka da cututtuka na endocrine. Alal misali, a wasu cututtuka na thyroid, glutathione na iya tsara yanayin redox a cikin kwayoyin thyroid, ta haka ne ya rinjayi kira da sakin hormones na thyroid da inganta yanayin.
Magungunan Adjuvant don ciwace-ciwacen daji: Kwayoyin Tumor suna samar da adadi mai yawa na free radicals yayin girma da haɓaka. Bugu da ƙari, magungunan chemotherapy da radiation far da aka yi amfani da su wajen maganin ciwon daji na iya ƙara yawan damuwa a cikin jiki. Ana iya amfani da Glutathione azaman maganin haɗin gwiwa don rage lalacewar da chemotherapy da radiotherapy ke haifarwa ga sel na al'ada, ta haka inganta rayuwar marasa lafiya. Yana iya kawar da radicals kyauta, rage lalata danniya ga kyallen takarda na yau da kullun, da haɓaka ƙwayar ƙwayar cuta ga magungunan chemotherapy ta hanyar daidaita hanyoyin siginar ciki, ta haka inganta ingantaccen magani.
Fatar fata da kulawa: Glutathione na iya hana ayyukan tyrosinase, rage haɓakar melanin, da cimma tasirin fata. Abubuwan da ke cikin antioxidant na iya kawar da radicals kyauta a cikin sel fata, jinkirta tsufa na fata, da rage bayyanar wrinkles da aibobi na shekaru. Yawancin fararen fata da kayan shafawa na rigakafin tsufa sun ƙunshi abubuwan glutathione.
Gyaran Fatar da ta lalace: Fatar da aka fallasa ga haskoki na UV, gurɓataccen muhalli, da sauran abubuwan na iya ɗaukar lalacewa. Glutathione yana inganta gyare-gyare da sabunta ƙwayoyin fata masu lalacewa, yana ƙarfafa aikin shinge na fata, kuma yana inganta lafiyar fata gaba ɗaya. Don fata mai ƙonewa ko rashin lafiyan fata, samfuran kula da fata masu ɗauke da glutathione na iya taimakawa rage alamun bayyanar cututtuka da hanzarta dawo da fata.
Kammalawa
A taƙaice, glutathione, tare da ƙarfinsa na antioxidant mai ƙarfi da ayyuka masu mahimmanci a cikin jiki, yana taka muhimmiyar rawa a fannoni daban-daban, gami da magani.
Sources
[1] Jomova K, Alomar SY, Alwasel SH, et al. Layukan da yawa na kariyar antioxidant daga damuwa na oxidative: enzymes antioxidant, nanomaterials tare da ayyuka masu kama da enzyme da yawa, da ƙananan antioxidants masu nauyi-nauyi [J]. Archives of Toxicology, 2024,98(5):1323-1367.DOI:10.1007/s00204-024-03696-4.
[2] Ivanov A A. Babi na 8 - Matsayin glutathione wajen haɓaka haɓakar haɓakar ƙarfe a cikin tsire-tsire[M]//Hasanuzzaman M, Prasad MN V. Handbook of Bioremediation. Ilimin Jarida, 2021: 115-152. doi.org/10.1016/B978-0-12-819382-2.00008-9.
[3] Perjesi P. Glutathione: Biosynthesis, Ayyuka da Abubuwan Halittu [M]. 2019. ISBN: 978-1-53614-740-7.
[4] Sarvananda, Premarathna A D. Magunguna da kayan magani na glutathione: Bayanin Bayani, 2019[C]. https://api.semanticscholar.org/CorpusID:199640213.
Samfura akwai don amfani da bincike kawai:
