Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Txheej txheem cej luam
Glutathione, tseem hu ua glutathione, yog ib qho tseem ceeb ntawm cov khoom muaj sia nyob. Nws yog ib qho tripeptide uas muaj glutamic acid, cysteine, thiab glycine. Nws tuaj yeem pom muaj nyob rau hauv cov tsiaj txhu, cov nroj tsuag, thiab ntau cov kab mob microbial, uas nws ua lub luag haujlwm tseem ceeb hauv cov hlwb. Glutathione hu ua 'Master Antioxidant' vim nws cov khoom muaj zog antioxidant. Lub npe no stems los ntawm nws siab concentration nyob rau hauv lub hlwb thiab nws muaj peev xwm ua hauj lwm synergistically nrog rau lwm yam antioxidants los txhim kho lawv cov teebmeem antioxidant.
Daim duab 1 Concerted kev txiav txim ntawm antioxidant enzymes superoxide dismutase, catalase, thiab glutathione peroxidase.
Muaj nuj nqi
Clearing dawb radicals thiab tiv thaiv hlwb thiab mitochondria: Dawb radicals yog heev reactive molecules tsim thaum lub sij hawm cellular metabolism. Cov dawb radicals ntau dhau tuaj yeem ua rau oxidative thiab peroxidative puas tsuaj rau cov hlwb thiab mitochondria. Glutathione reacts nrog dawb radicals los ntawm nws pab pawg sulfhydryl (-SH), hloov mus rau hauv cov khoom ruaj khov, yog li tiv thaiv dawb radicals los ntawm kev tawm tsam cov hlwb thiab mitochondria thiab tswj cov qauv thiab kev ua haujlwm ntawm cov hlwb. Thaum cov hlwb raug rau sab nraud stimuli xws li hluav taws xob ultraviolet lossis hluav taws xob, ntau cov dawb radicals raug tsim. Glutathione tuaj yeem teb sai sai los tshem tawm cov dawb radicals, txo kev pheej hmoo ntawm cellular puas.
Kev koom tes hauv metabolic tshuav nyiaj li cas: Hauv cov kab mob, glutathione koom nrog cov tshuaj tiv thaiv redox thaum lub sij hawm metabolism. Los ntawm cov tshuaj tiv thaiv enzymatic, nws tswj kev sib npaug hauv lub cev. Qhov kev sib npaug no ua rau cov kab mob ncaj qha lossis tsis ncaj qha tiv thaiv ntau yam kev hloov pauv los ntawm ib puag ncig thiab lawv cov metabolism hauv kev loj hlob, xws li cov pa oxygen siab, siab osmotic siab, tshuaj, thiab hlau ions. Thaum cov kab mob nyob hauv qhov chaw muaj pa oxygen ntau, lawv tsim cov pa oxygen ntau ntau (ROS). Glutathione tuaj yeem txo ROS los ntawm ntau cov tshuaj tiv thaiv, ua kom cov kab mob muaj sia nyob hauv qhov chaw zoo li no.
Detoxification: Glutathione tuaj yeem khi nrog cov co toxins, cov hlau hnyav, thiab lwm yam teeb meem hauv cov hlwb, hloov lawv mus rau hauv cov tshuaj tsis muaj tshuaj lom lossis tsis muaj tshuaj lom thiab txhawb nqa lawv tawm ntawm lub cev. Nyob rau hauv cov hlau hnyav hnyav, qib glutathione hauv cov nroj tsuag nce. Nws tsim complexes nrog hnyav hlau, txo lawv toxicity rau cog hlwb. Glutathione tseem tuaj yeem khi nrog cov tshuaj lom electrophilic los tiv thaiv kev puas tsuaj rau cov biomolecules tseem ceeb hauv cov hlwb (xws li cov proteins thiab nucleic acids), yog li tiv thaiv cov hlwb los ntawm toxicity.
Txhim khu kev tiv thaiv: Glutathione kuj ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob. Nws tuaj yeem tswj hwm kev ua haujlwm ntawm lub cev tiv thaiv kab mob, txhim kho lawv cov haujlwm, thiab yog li txhim kho lub cev tiv thaiv kab mob. Nws tuaj yeem cuam tshuam rau kev loj hlob thiab kev sib txawv ntawm T lymphocytes thiab B lymphocytes, ua rau lub cev tiv thaiv kab mob kom paub zoo dua thiab tshem tawm cov kab mob txawv teb chaws, thiab pab lub cev tiv thaiv kab mob thiab kab mob.
Daim ntawv thov
Kev Tiv Thaiv Daim Siab: Lub siab yog ib qho tseem ceeb detoxification lub cev hauv tib neeg lub cev thiab muaj kev cuam tshuam rau kev puas tsuaj los ntawm ntau yam teeb meem thaum lub sij hawm metabolic. Glutathione txhim kho lub siab lub siab ua haujlwm detoxification thiab txhawb kev kho thiab rov tsim dua tshiab ntawm daim siab. Clinically, nws yog feem ntau siv los kho ntau yam kab mob siab thiab mob ntev, xws li kab mob siab cawv thiab yeeb tshuaj vim raug mob siab. Rau kev haus dej cawv hauv daim siab puas tsuaj los ntawm kev haus cawv mus ntev, glutathione tuaj yeem txo oxidative kev nyuaj siab rau lub siab los ntawm kev tshem tawm cov dawb radicals, yog li txhim kho daim siab ua haujlwm.
Kev kho mob ntawm cov kab mob endocrine: Kev ua haujlwm ib txwm ntawm cov kab mob endocrine yog qhov tseem ceeb rau kev tswj hwm lub cev sib npaug hauv tib neeg lub cev. Glutathione tuaj yeem tswj cov synthesis, secretion, thiab cov metabolism hauv cov tshuaj hormones hauv endocrine system, yog li ua rau muaj txiaj ntsig zoo rau cov kab mob ntsig txog endocrine. Piv txwv li, hauv qee cov thyroid kab mob, glutathione tuaj yeem tswj hwm lub xeev redox hauv cov thyroid hlwb, yog li cuam tshuam rau kev sib txuas thiab tso tawm cov thyroid hormones thiab txhim kho tus mob.
Adjuvant therapy rau cov qog nqaij hlav: qog hlwb tsim cov dawb radicals loj thaum lub sij hawm loj hlob thiab kev loj hlob. Tsis tas li ntawd, cov tshuaj chemotherapy thiab kev kho hluav taws xob siv hauv kev kho mob qog tuaj yeem ua rau muaj kev ntxhov siab oxidative hauv lub cev. Glutathione tuaj yeem siv los ua kev kho mob ntxiv kom txo tau qhov kev puas tsuaj los ntawm kev siv tshuaj khomob thiab kev kho mob hluav taws xob rau cov hlwb li qub, yog li txhim kho cov neeg mob lub neej zoo. Nws tuaj yeem tshem tawm cov dawb radicals, txo oxidative kev nyuaj siab puas tsuaj rau cov ntaub so ntswg ib txwm, thiab txhim kho cov qog hlwb rhiab heev rau cov tshuaj kho mob los ntawm kev tswj cov kab mob hauv lub cev, yog li txhim kho kev kho mob.
Cov tawv nqaij ntxuav hniav dawb thiab saib xyuas: Glutathione tuaj yeem tiv thaiv kev ua haujlwm tyrosinase, txo melanin synthesis, thiab ua tiav cov teebmeem ntawm daim tawv nqaij. Nws cov khoom antioxidant tuaj yeem tshem tawm cov dawb radicals hauv daim tawv nqaij, ncua kev laus ntawm daim tawv nqaij, thiab txo qhov pom ntawm wrinkles thiab hnub nyoog me ntsis. Ntau cov tawv nqaij ntxuav hniav dawb thiab tiv thaiv kev laus cov tshuaj pleev ib ce muaj glutathione Cheebtsam.
Kho daim tawv nqaij puas: daim tawv nqaij raug UV rays, ib puag ncig muaj kuab paug, thiab lwm yam yuav pab txhawb kev puas tsuaj. Glutathione txhawb kev kho thiab rov tsim dua tshiab ntawm cov tawv nqaij puas, ntxiv dag zog rau daim tawv nqaij ua haujlwm, thiab txhim kho tag nrho cov tawv nqaij noj qab haus huv. Rau cov tawv nqaij tawv nqaij los yog ua xua, cov khoom tu tawv nqaij uas muaj glutathione tuaj yeem pab txo cov tsos mob thiab ua kom tawv nqaij rov qab.
Xaus
Hauv cov ntsiab lus, glutathione, nrog nws lub peev xwm antioxidant muaj zog thiab ntau lub luag haujlwm tseem ceeb hauv lub cev, ua lub luag haujlwm tseem ceeb hauv ntau yam, suav nrog tshuaj.
Qhov chaw
[1] Jomova K, Alomar SY, Alwasel SH, et al. Ob peb kab ntawm kev tiv thaiv antioxidant tiv thaiv oxidative kev nyuaj siab: antioxidant enzymes, nanomaterials nrog ntau yam enzyme-mimicking kev ua ub no, thiab qis-molecular-yuag antioxidants [J]. Archives of Toxicology, 2024,98(5):1323-1367.DOI:10.1007/s00204-024-03696-4.
[2] Ivanov A. Tshooj 8 - Lub luag haujlwm ntawm glutathione hauv kev txhim kho hlau hyperaccumulation hauv cov nroj tsuag[M]//Hasanuzzaman M, Prasad MN V. Phau ntawv ntawm Bioremediation. Ntawv Xov Xwm, 2021: 115-152. https://doi.org/10.1016/B978-0-12-819382-2.00008-9.
[3] Perjesi P. Glutathione: Biosynthesis, Functions and Biological Implications [M]. 2019. ISBN: 978-1-53614-740-7, ib.
[4] Sarvananda, Premarathna A D. Pharmaceutical and medicinal properties of glutathione: An Overview, 2019[C]. https://api.semanticscholar.org/CorpusID:199640213.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
