▎ Kɔnlutɛni ɲinini
Chonluten ye mun ye?
Kɔnlutɛni ye pepitiri biyoregulatɛri ye min bɛ bɔ kosɛbɛ fogonfogon la, a bɛ ni ɲɛnamaya kɛcogo caman ye minnu bɛ se ka kɛ ani a kɛcogo nafaw.
Chonluten ka ɲininiw kɛcogo ye mun ye?
1. Sɛgɛsɛgɛli Macro Background (Sɛgɛsɛgɛli min kɛra peptides bioactifs kan
Kabini san kɛmɛ 20nan na, ni dɔnniyaw yiriwara teliya la i n’a fɔ fɛnɲɛnamaw ka ɲɛnamayako ni ɲɛnamayako, dɔnnikɛlaw ye sɛgɛsɛgɛli kuncɛlenw kɛ fɛnɲɛnama suguya caman jɔcogo n’u baarakɛcogo kan fɛnɲɛnamaw kɔnɔ. Protéines, i n’a fɔ ɲɛnamaya baara kɛbagaw kunbabaw, pepitiriw sinsinni surun minnu bɛ dilan u kɔnɔfɛnw fɛ - asidi aminikiw, a jirala ko kunnafoni nafamaw bɛ sɔrɔ ɲɛnamayako la ani farikoloɲɛnajɛ baara suguya caman bɛ u la. Ɲɛnamaya taabolo jɔnjɔn caman na i n’a fɔ selilɛriw ka taamasiɲɛw, farikoloɲɛnajɛw labɛnni, ani farikolo tangacogo, a ka c’a la, pepitiri surunw jɔyɔrɔ ka bon kosɛbɛ. O faamuyali in ye diɲɛ ɲininikɛla jɛkuluw bila ka u sen don kosɛbɛ pepitiri surunw sɛgɛsɛgɛli la minnu bɛ baara kɛrɛnkɛrɛnnenw kɛ ka bɔ fɛnɲɛnama suguya caman na, k’u jigi da fɛn kuraw kan ka na ni fɛn kuraw ye baara caman na i n’a fɔ furakɛli, dumuniko dɔnniya, ani sɛnɛ. Sɛgɛsɛgɛli minnu bɛ Kɛ Chonluten kan, olu bɛ Kɛ o ko in de kan tigitigi.
2. Fɛɛrɛ min bɛ sɔrɔ Chonluten sɔrɔli la Bronchus kɔnɔ
Baganw ka farikolo yɔrɔ caman ka sɛgɛsɛgɛliw cɛma, ninakilidegunw ka fiɲɛbɔlan ye dɔnnikɛlaw hakili kɛrɛnkɛrɛnnen sama. I n’a fɔ gazi ka don fogonfogon la ani ka bɔ sira nafama ye, fogonfogon ɲɛgɛnɛsira bɛ ɲɔgɔn sɔrɔ kɛnɛma lamini na, wa a jɔyɔrɔ ka bon banakisɛw ka binkanni kunbɛnni na ani ka ninakiliyɔrɔ kɔnɔna sigida sabatili sabati.
Ni an bɛ farikolo ta fan fɛ, fogonfogon ɲɛgɛnɛsiraw bɛ kura ye tuma bɛɛ ani ka dilan, wa u bɛ se ka fɛnɲɛnamafagalan suguya caman bɔ walasa ka sigida farikolo tangacogo ni funu jaabiw labɛn, o kɔrɔ ye ko a ka ca a la ko pepitiri surunw bɛ yen minnu ka baara kɛrɛnkɛrɛnnenw bɛ o farikolo yɔrɔ in na. Ka da o kan, ɲininikɛlaw ye fiɲɛbɔlan ta k’a kɛ ɲininiw dondaw ye, ka baara kɛ ni molekiyɔmu biologi ni biyokimisi fɛɛrɛ kɔrɔw ye walasa ka ɲinini kuncɛlenw kɛ fiɲɛbɔlanw bɔlenw kan. Kɔlɔsili ni sɛgɛsɛgɛli kuntaalajanw kɛlen kɔ, Chonluten labanna ka sɔrɔ ka ɲɛ. Nin sɔrɔli in tɛ dɔrɔn ka taamasiyɛn kuraw di walasa ka fiɲɛbɔlan farikololabɛncogo faamuyali jugu sɔrɔ, nka a bɛ jusigilan fana sigi senkan walasa ka Kɔnlutɛni tali ɲinini nataw kɛ ninakilibanaw kunbɛnni n’u furakɛli la ani kɛnɛyako wɛrɛw la minnu bɛ tali kɛ o la.
Chonluten ka baarakɛcogo ye mun ye?
1. Labɛnni nɔ min bɛ funu kan
Tumu Nekɔrɔsi Facteur (TNF) sɔrɔli balili .
Tripeptide Chonluten bɛ se ka tumor necrosis factor (TNF) sɔrɔli bali monositiw fɛ a kɛlen kɔ ka banakisɛw ka lipopolysaccharide (LPS) sɔrɔ , TNF hakɛ dɔgɔman bɔli bɛ tali kɛ TNF muɲuni fɛɛrɛ la, o min bɛ dɛmɛ ka funu jaabi dɔgɔya.
Kɛrɛnkɛrɛnnenya la, Kɔnlutɛni bɛ se ka nɔ bila jeninida jirali la walima farikolojɔli baara la min bɛ tali kɛ TNF bɔli la monositɛriw la taamasiɲɛ sira kɛrɛnkɛrɛnnen dɔ fɛ walima molekiyɔmuw ka jɛɲɔgɔnya fɛ, o bɛ dɔ bɔ TNF dilanni ni a bɔli la.
Sitokiniw (cytokines pro-inflammatoires) jirali balili
Khavinson Peptides duuru bɛɛ (Kɔnluten fana sen bɛ o la) bɛ se ka TNF ni pro-inflammatory interleukin-6 (IL-6) sitokiniw jirali bali THP-1 selilɛriw la minnu danfaralen don laban na, LPS ye lawuli minnu O b’a jira ko Kɔnlutɛni jɔyɔrɔ ka bon banakisɛfagalanw balili la funu jaabi la.
Fɛɛrɛ min bɛ se ka kɛ, o ye ko Chonluten bɛ LPS sirili bali selilɛri sanfɛla minɛbagaw la walima ka jiginɛ taamasiɲɛw cili sira labɛn, o la, a bɛ dɔ bɔ sitokiniw bɔli la minnu bɛ banakisɛw dɛmɛ.
Ka dɔ bɔ selilɛriw ka nɔrɔli la
Ni THP1 selilɛriw furakɛra ni Chonluten ye endoteliyali selilɛriw (HUVEC) layini dɔ kan minnu bɛ baara kɛ ni LPS ye selilu nɔrɔli dɔgɔyara kɔlɔsira , Kɔnɔnatumuw nɔrɔli ye farikolojɔli fɛɛrɛ ye min bɛ kɛ ka caya, wa ni Chonluten ye selilu nɔrɔli dɔgɔya, o bɛ se ka dɛmɛ ka funu jaabi nɔgɔya.
O bɛ se ka kɛ bawo Chonluten bɛ selilu sanfɛla mɔlikuluw jiracogo walima u baara Changer, o bɛ nɔ bila seliluw ni ɲɔgɔn cɛ walima selilu ni matiriyali cɛ.
2. Sariyasunba nɔ min bɛ sɔrɔ banakisɛw caya taabolo la
Tirosini fosifɔriyali caya
I n’a fɔ Khavinson Peptide tɔw, Chonluten bɛ se ka dɔ fara tirosini fosforilasi kan mitogène-activée cytoplasmique kinases [1] . O b’a jira ko Chonluten bɛ se ka taamasiɲɛw sira kolomaw labɛn selilu caya taabolo la. Tirosini fosforilasi ye taamasiɲɛw cili fɛɛrɛ nafama dɔ ye selilɛri kɔnɔ, min bɛ se ka farikolojɔlifɛn suguya caman baara walima ka u bali, o la, a bɛ nɔ bila selilu caya, u danfara ani u ka ɲɛnamaya la. Kɔnlutɛni bɛ se ka dɔ fara sitoplasma kinaziw ka tirosini fosforilasi kan, a kɛtɔ ka kinase walima fosfatazi kɛrɛnkɛrɛnnenw ka baara labɛn, o kɔfɛ, a bɛ se ka nɔ bila selilu cayacogo la.
3. Jɔrɔ min bɛ kɔnɔbara basigilen na
Sɛgɛsɛgɛli dɔ kɛra muso 14 kan minnu furakɛra ni Kɔnlutɛni ye (a bɛ se ka kɛ ko a ni Kɔnlutɛni bɛ tali kɛ ɲɔgɔn na) ani muso 9 minnu furakɛra ni Kɔnlunɛti ye, a jirala ko ni a sɔrɔla ni nukilila magnɛti rezɔn (NMR) ye, furakɛli waati la, fura fila bɛɛ bɛ se ka kɔnɔbara nɔgɔ caman sɛmɛntiya ka bɔ ɔrimɔni suguya la (E suguya) min bɛ a to cɛya ka taa porojɛsitɛri suguya la (G suguya) min bɛ cɛya jiginni bali kɔnɔmaya waati. O bεε bε bεn muso 74% ma minnu bε Konlutεn kulu la ani 64% la minnu bε Konlutεn kulu la [2] ..
Chonluten kɛcogo ye mun ye?
Fogonfogonlabana basigilen (EPOC) ni sɔgɔsɔgɔninjɛ furakɛli : Kɔnlutɛni bɛ furakɛli seko jira ninakilibanaw la i n’a fɔ fogonfogonlabana basigilen ni sɔgɔsɔgɔninjɛ. Kɔlɔsiliw y’a jira ko a bɛ se ka dɔ bɔ funu na [1] . Funu ye fɛnba ye min bɛ Ɲɛgɛnɛsiraw ni sɔgɔsɔgɔninjɛ banakisɛw sɔrɔ. Ni a bɛ dɔ bɔ funu jaabi la, Chonluten bɛ se ka bana taamasiɲɛw nɔgɔya i n’a fɔ fiɲɛbɔyɔrɔw kirinni ani ninakilidegun. O waati kelen na, nin pepitiri-kolɛki in bɛ se ka fogonfogon yɔrɔw dilancogo ni u labɛncogo kura fana sabati. Fogonfogon yɔrɔw tiɲɛni bɛna kɛ sababu ye ka ninakili baara dɔgɔya, wa Chonluten ka dilancogo bɛ se ka fogonfogonw jɔcogo n’u baara ɲɛ, o la, ninakili baara bɛ bonya.
Kɔnɔbara basigilen joginni dilancogo : Kɔnlutɛni bɛ seko jira kɔnɔbara basigilen joginni dilancogo la. A bɛ se ka jeninida jiracogo ɲɛnabɔ min bɛ tali kɛ farikolo tangalanw na (i n’a fɔ superoxide dismutase) [1] . Oksidan kunbɛncogo min bɛ kɔnɔbara la, o nafa ka bon kosɛbɛ kɔnɔbara tangacogo la ka bɔ oksidan degun tiɲɛni na. Chonluten ka ɲɛnabɔli nɔ bɛ se ka dɛmɛ ka farikolo tangalan balancogo segin a cogo kɔrɔ la ani ka oksidan degun tiɲɛni dɔgɔya kɔnɔbara basigilen na. Ka fara o kan, nin pepitiri complexe in bɛ se fana ka selilɛriw labɛn kokura ani ka kɔnɔbara basigilen joginni dilancogo teliya.
Kuncɛli la, Chonluten bɛ furakɛli nafaw jira minnu bɛ se ka kɛ funu kɛlɛli, farikolo yɔrɔw dilancogo ani farikolo tangacogo ɲɛnabɔli siratigɛ la.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Francesco Avolio ye kalanfa ye min ni G. d’Annunzio Iniwɛrisite bɛ Chieti-Pescara, kɛrɛnkɛrɛnnenya la, kalansobaw ni seko ni dɔnko kalanso (Ctr Adv Studies & Technol) kɔnɔ. A ka ɲininiw ɲɛsinnen bɛ dɔnniyako caman ma, i n’a fɔ ɲinini ni furakɛli kɛcogo kɔrɔbɔli, Biochimie & Molecular Biology, Physiology, Immunology, ani Endocrinology & Diabetes. Inivɛrisite ɲinini jɛkulu dɔ kɔnɔ, a bɛ dɛmɛ don baarada in ka sinsin dɔnniya dɔnniya ni kokuradonni ɲɛtaa kan. Francesco Avolio tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [1].
