▎ Kev Tshawb Fawb Chonluten
Chonluten yog dab tsi?
Chonluten yog peptide bioregulator feem ntau muab los ntawm cov ntaub so ntswg bronchial, muaj ntau yam kev ua ub no thiab cov txiaj ntsig ntawm daim ntawv thov.
Kev tshawb fawb keeb kwm ntawm Chonluten yog dab tsi?
1. Macro keeb kwm ntawm kev tshawb fawb ntawm Bioactive Peptides
Txij li thaum xyoo pua 20th, nrog rau kev loj hlob sai ntawm kev qhuab qhia xws li molecular biology thiab biochemistry, cov kws tshawb fawb tau tshawb nrhiav qhov tob ntawm cov qauv thiab kev ua haujlwm ntawm ntau yam molecules hauv cov kab mob muaj sia. Proteins, raws li lub ntsiab bearers ntawm lub neej kev ua ub no, lub luv luv peptide sequences tsim los ntawm lawv cov constituent units - amino acids tau pom muaj nplua nuj cov ntaub ntawv lom neeg thiab muaj ntau yam physiological kev ua ub no. Hauv ntau cov txheej txheem tseem ceeb hauv lub neej xws li kev qhia xov tooj ntawm tes, kev tswj hwm cov metabolism, thiab kev tiv thaiv kab mob, cov peptides luv luv feem ntau ua lub luag haujlwm tseem ceeb. Qhov kev nkag siab no tau ua rau cov pab pawg tshawb fawb thoob ntiaj teb kom nquag koom nrog kev tshawb fawb ntawm kev khawb cov peptides luv luv nrog cov haujlwm tshwj xeeb los ntawm ntau cov ntaub so ntswg, vam tias yuav coj cov kev hloov tshiab rau ntau yam xws li tshuaj, khoom noj khoom haus science, thiab kev ua liaj ua teb. Kev tshawb fawb ntawm Chonluten yog ua tiav tawm tsam qhov teeb meem no.
2. Lub Sij Hawm Rau Kev Tshawb Nrhiav Chonluten hauv Bronchus
Ntawm cov kev tshawb fawb ntawm ntau cov tsiaj cov ntaub so ntswg, lub bronchus ntawm lub pa system tau attracted tshwj xeeb mloog ntawm cov kws tshawb fawb. Raws li ib qho tseem ceeb channel rau cov roj nkag mus thiab tawm hauv lub ntsws, cov ntaub so ntswg mucosal ntawm lub bronchus ncaj qha mus rau sab nraud ib puag ncig thiab plays lub luag hauj lwm tseem ceeb hauv kev tiv thaiv kev cuam tshuam ntawm cov kab mob thiab tswj kev ruaj ntseg ntawm ib puag ncig sab hauv ntawm lub ntsws.
Los ntawm qhov kev xav ntawm lub cev, cov hlwb epithelial ntawm lub bronchial mucosa yog tas li txuas ntxiv thiab kho, thiab tuaj yeem tso tawm ntau yam bioactive tshuaj los tswj cov kev tiv thaiv hauv zos thiab cov lus teb inflammatory, uas txhais tau hais tias muaj qhov tshwm sim siab ntawm qhov muaj nyob ntawm luv peptides nrog cov haujlwm tshwj xeeb hauv cov ntaub so ntswg. Raws li qhov no, pab pawg tshawb fawb tau coj cov bronchus los ua qhov chaw nkag rau kev tshawb fawb thiab siv cov thev naus laus zis molecular biology thiab biochemistry technologies los ua qhov kev tshawb fawb tob txog kev rho tawm ntawm cov ntaub so ntswg bronchial. Tom qab kev soj ntsuam mus sij hawm ntev thiab kev soj ntsuam, Chonluten tau tshawb pom tiav. Qhov kev tshawb pom no tsis yog tsuas yog muab cov ntsiab lus tshiab rau kev nkag siab tob txog kev tswj hwm lub cev ntawm lub bronchus tab sis kuj yog lub hauv paus rau kev tshawb nrhiav tom ntej ntawm kev siv Chonluten hauv kev tiv thaiv thiab kho cov kab mob ua pa thiab lwm yam kev noj qab haus huv.
Lub mechanism ntawm kev txiav txim ntawm Chonluten yog dab tsi?
1. Kev tswj xyuas qhov ua rau mob
Inhibiting the Production of Tumor Necrosis Factor (TNF)
Tripeptide Chonluten tuaj yeem tiv thaiv kev tsim cov qog necrosis (TNF) los ntawm monocytes tom qab raug rau cov kab mob pro-inflammatory lipopolysaccharide (LPS) [1] . Kev tso tawm ntawm cov qib qis ntawm TNF muaj feem xyuam rau cov txheej txheem ntawm TNF kam rau ua, uas yuav pab txo qis cov lus teb inflammatory.
Tshwj xeeb, Chonluten tuaj yeem cuam tshuam rau cov noob caj noob ces lossis kev ua haujlwm ntawm cov protein uas cuam tshuam nrog TNF ntau lawm hauv monocytes los ntawm qee qhov kev taw qhia tshwj xeeb lossis kev sib cuam tshuam molecular, yog li txo cov synthesis thiab tso tawm ntawm TNF.
inhibiting kev nthuav qhia ntawm Pro-inflammatory Cytokines
Tag nrho tsib Khavinson Peptides (xws li Chonluten) tuaj yeem cuam tshuam qhov kev qhia ntawm TNF thiab pro-inflammatory interleukin-6 (IL-6) cytokines hauv terminally sib txawv THP-1 hlwb txhawb los ntawm LPS [1] . Qhov no qhia tau hais tias Chonluten muaj lub luag haujlwm dav hauv inhibiting pro-inflammatory cytokines hauv cov lus teb inflammatory.
Cov txheej txheem ua tau yog tias Chonluten cuam tshuam nrog kev khi ntawm LPS rau ntawm tes saum npoo receptors lossis tswj cov kab hluav taws xob qis qis, yog li txo qis kev tsim cov cytokines pro-inflammatory.
Txo Cell Adhesion
Los ntawm culturing THP1 hlwb kho nrog Chonluten ntawm ib txheej ntawm endothelial hlwb (HUVECs) qhib los ntawm LPS, ib tug txo nyob rau hauv cell adhesion tau pom [1] . Cell adhesion yog ib qho kev tiv thaiv kev tiv thaiv kab mob, thiab txo qis ntawm cell adhesion los ntawm Chonluten tuaj yeem pab daws cov kab mob inflammatory.
Qhov no tej zaum yuav yog vim Chonluten hloov cov kev qhia los yog kev ua ntawm cell nto molecules, yog li cuam tshuam rau kev sib cuam tshuam ntawm cov hlwb los yog ntawm cov hlwb thiab matrix.
2. Kev tswj kom muaj txiaj ntsig rau txoj kev loj hlob
Txhim kho Tyrosine Phosphorylation
Zoo li lwm yam Khavinson Peptides, Chonluten tuaj yeem nce tyrosine phosphorylation ntawm mitogen-activated cytoplasmic kinases [1] . Qhov no qhia tau hais tias Chonluten tuaj yeem tswj hwm txoj kev taw qhia tseem ceeb hauv txoj kev loj hlob ntawm tes. Tyrosine phosphorylation yog ib qho ntawm cov txheej txheem tseem ceeb ntawm cov teeb liab intracellular transduction, uas tuaj yeem qhib lossis cuam tshuam cov haujlwm ntawm ntau cov proteins, yog li cuam tshuam rau cell proliferation, sib txawv, thiab ciaj sia taus. Chonluten tuaj yeem ua rau tyrosine phosphorylation ntawm cytoplasmic kinases los ntawm kev tswj hwm cov haujlwm ntawm cov kinases lossis phosphatase, thiab tom qab ntawd cuam tshuam rau cov qauv kev loj hlob ntawm tes.
3. Lub luag hauj lwm hauv Cervical Mucus
Hauv kev tshawb fawb ntawm 14 tus poj niam kho nrog Conluten (tejzaum nws muaj feem xyuam rau Chonluten) thiab 9 tus poj niam kho nrog Conlunett, nws tau pom tias kuaj pom los ntawm nuclear magnetic resonance (NMR), thaum lub sij hawm kho, ob qho tshuaj tuaj yeem hloov lub ncauj tsev menyuam los ntawm hom tshuaj estrogen (hom E) uas tso cai rau phev tsiv teb tsaws mus rau hom kev tiv thaiv kab mob progesterone. Qhov kev hloov pauv no tshwm sim hauv 74% ntawm cov poj niam hauv pawg Conluten thiab 64% ntawm cov poj niam hauv pawg Conlunett [2].
Dab tsi yog cov ntawv thov ntawm Chonluten?
Kev Kho Mob Mob Hlwb Obstructive Pulmonary Disease (COPD) thiab Asthma: Chonluten qhia tau tias muaj peev xwm kho tau hauv cov kab mob ua pa xws li mob ntsws obstructive pulmonary thiab hawb pob. Cov kev tshawb fawb tau pom tias nws tuaj yeem txo qhov mob [1] . Kev mob ntsws yog ib qho tseem ceeb hauv cov kab mob COPD thiab mob hawb pob. Los ntawm kev txo cov lus teb inflammatory, Chonluten tuaj yeem txo cov tsos mob xws li mob ntsws stenosis thiab dyspnea. Nyob rau tib lub sijhawm, qhov peptide complex tseem tuaj yeem txhawb kev kho thiab rov tsim dua tshiab ntawm lub ntsws. Kev puas tsuaj rau lub ntsws yuav ua rau muaj kev poob qis hauv kev ua pa, thiab kho cov nyhuv ntawm Chonluten tuaj yeem txhim kho cov qauv thiab kev ua haujlwm ntawm lub ntsws, yog li txhim kho kev ua pa.
Kho ntawm Gastric Mucosal Injury: Chonluten qhia tau hais tias muaj peev xwm nyob rau hauv kev kho ntawm gastric mucosal raug mob. Nws tuaj yeem tswj hwm cov noob qhia ntsig txog cov enzymes antioxidant (xws li superoxide dismutase) [1] . Cov tshuaj tiv thaiv antioxidant hauv lub plab mucosa yog qhov tseem ceeb rau kev tiv thaiv cov ntaub so ntswg los ntawm kev puas tsuaj oxidative kev nyuaj siab. Cov kev tswj hwm ntawm Chonluten tuaj yeem pab kho qhov sib npaug ntawm cov tshuaj tiv thaiv antioxidant thiab txo qhov kev puas tsuaj ntawm oxidative kev nyuaj siab rau lub plab mucosa. Tsis tas li ntawd, qhov no peptide complex tseem tuaj yeem txhawb kev tsim kho ntawm tes thiab ua kom cov txheej txheem kho mob plab hnyuv.
Hauv kev xaus, Chonluten qhia tau tias muaj peev xwm siv tshuaj kho mob qhov tseem ceeb hauv kev tiv thaiv kab mob, kho cov ntaub so ntswg, thiab kev tiv thaiv kab mob.
Hais Txog Tus Sau
Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.
Scientific Journal Author
Francesco Avolio yog ib qho kev kawm cuam tshuam nrog G. d'Annunzio University of Chieti-Pescara, tshwj xeeb hauv Center for Advanced Studies thiab Technology (Ctr Adv Studies & Technol). Nws cov kev tshawb fawb nyiam nthuav dav ntau yam kev qhuab qhia, suav nrog Kev Tshawb Fawb & Kev Tshawb Fawb Tshuaj, Biochemistry & Molecular Biology, Physiology, Immunology, thiab Endocrinology & Metabolism. Raws li ib feem ntawm lub tsev kawm ntawv tshawb fawb zej zog, nws pab txhawb rau lub tsev kawm ntawv tsom mus rau kev nce qib kev paub txog kev tshawb fawb thiab kev tsim kho tshiab. Francesco Avolio tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv pov thawj [1].
