ChonlutenResearch Ubushakashatsi bwa
Chonluten ni iki?
Chonluten ni peptide bioregulator ikomoka cyane cyane mubice bya bronchial, ifite ibikorwa byinshi byibinyabuzima nibiciro byagaciro.
Ni ubuhe bushakashatsi bwakozwe na Chonluten?
1. Imiterere ya Macro yubushakashatsi kuri Bioactive Peptides
Kuva mu kinyejana cya 20, hamwe n’iterambere ryihuse rya disipuline nka biyolojiya y’ibinyabuzima na biohimiya, abahanga bakoze ubushakashatsi bwimbitse ku miterere n’imikorere ya molekile zitandukanye mu binyabuzima. Poroteyine, nk’ingenzi mu bikorwa by’ubuzima, urutonde rwa peptide ngufi rwakozwe n’ibice biyigize - aside amine yasanze irimo amakuru y’ibinyabuzima kandi ifite ibikorwa bitandukanye bya physiologiya. Mubikorwa byinshi byingenzi byubuzima nkibimenyetso bya selile, kugenzura metabolike, hamwe nigisubizo cyumubiri, peptide ngufi akenshi igira uruhare rukomeye. Uku gusobanukirwa kwatumye amatsinda yubushakashatsi ku isi agira uruhare rugaragara mu bushakashatsi bwo gucukura peptide ngufi n’imirimo yihariye ituruka ku binyabuzima bitandukanye by’ibinyabuzima, yizera ko bizazana impinduka nshya mu bice byinshi nk’ubuvuzi, ubumenyi bw’ibiribwa, n’ubuhinzi. Ubushakashatsi kuri Chonluten bukorwa neza neza ninyuma.
2. Amahirwe yo kuvumbura Chonluten muri Bronchus
Mu bushakashatsi bwakozwe ku nyama nyinshi z’inyamaswa, bronchus ya sisitemu yubuhumekero yakwegereye cyane abahanga. Numuyoboro wingenzi wa gaze yinjira no gusohoka mu bihaha, ingirangingo ya mucosal ya bronchus ihura neza n’ibidukikije kandi ikagira uruhare runini mu kurwanya igitero cya virusi no kubungabunga umutekano w’imbere mu myanya y'ubuhumekero.
Urebye kuri physiologique, selile epithelale ya mucosa ya bronchial mucosa ihora ivugururwa kandi igasanwa, kandi irashobora gusohora ibintu bitandukanye bioaktike kugirango igabanye ubudahangarwa bwaho hamwe nibisubizo byokongoka, bivuze ko hari amahirwe menshi yo kubaho kwa peptide ngufi zifite imirimo yihariye muriyi nyama. Hashingiwe kuri ibi, itsinda ry’ubushakashatsi ryafashe bronchus nk'aho ryinjira mu bushakashatsi kandi rikoresha ibinyabuzima bigezweho bya biologiya na tekinoloji y’ibinyabuzima kugira ngo bikore ubushakashatsi bwimbitse ku bivamo ingirangingo. Nyuma yigihe kirekire cyo kwitegereza no gusesengura, Chonluten yaje kuvumburwa neza. Ubu buvumbuzi ntabwo butanga ibimenyetso bishya gusa kugirango dusobanukirwe byimazeyo uburyo bwo kugenzura imikorere ya bronchus ahubwo binashyiraho urufatiro rwubushakashatsi bwakurikiyeho bwakoreshejwe Chonluten mukurinda no kuvura indwara zubuhumekero nizindi nzego zubuzima bijyanye.
Ni ubuhe buryo bwo gukora bwa Chonluten?
1. Ingaruka Zigenga Kumuriro
Kubuza umusaruro wa Tumor Necrosis Factor (TNF)
Tripeptide Chonluten irashobora kubuza kubyara ikibyimba cya nérosose (TNF) na monocytes nyuma yo guhura na bagiteri yitwa lipopolysaccharide (LPS) itera indwara . Isohora ryurwego ruto rwa TNF rifitanye isano nuburyo bwo kwihanganira TNF, bufasha kugabanya igisubizo cyakongejwe.
By'umwihariko, Chonluten irashobora kugira ingaruka ku mvugo ya gene cyangwa ibikorwa bya poroteyine bijyanye n'umusaruro wa TNF muri monocytes binyuze mu nzira runaka yerekana ibimenyetso cyangwa imikoranire ya molekile, bityo bikagabanya synthesis no kurekura TNF.
Kubuza Kugaragaza Pro-inflammatory Cytokines
Peptide zose uko ari eshanu za Khavinson (harimo na Chonluten) zirashobora kubuza imvugo ya TNF na por-inflammatory interleukin-6 (IL-6) cytokine mu ngirabuzimafatizo zitandukanye za THP-1 zatewe imbaraga na LPS [1] . Ibi byerekana ko Chonluten ifite uruhare runini muguhagarika cytokine ziterwa no gutwika.
Uburyo bushoboka ni uko Chonluten ibangamira guhuza LPS no kwakirwa hejuru yimikorere ya selile cyangwa igenga inzira yohereza ibimenyetso byamanuka, bityo bikagabanya umusaruro wa cytokine itera umuriro.
Kugabanya Akagari
Mu gutsimbataza selile THP1 zavuwe na Chonluten kurwego rwingirabuzimafatizo (HUVECs) zakozwe na LPS, hagaragaye kugabanuka kwingirabuzimafatizo [1] . Gufata ingirabuzimafatizo ni uburyo busanzwe bwo gutwika, kandi kugabanuka kwa selile na Chonluten birashobora gufasha kugabanya igisubizo cyakongejwe.
Ibi birashobora kuba kubera ko Chonluten ihindura imvugo cyangwa ibikorwa bya selile ya selile, bityo bikagira ingaruka kumikoranire hagati ya selile cyangwa hagati ya selile na matrix.
2. Ingaruka zigenga uburyo bwo gukwirakwiza
Kongera Tososine Fosifora
Kimwe nizindi Peptide ya Khavinson, Chonluten irashobora kongera fosifori ya tirozine ya mitogen ikoreshwa na cytoplasmeque kinase [1] . Ibi byerekana ko Chonluten ishobora kugenzura inzira nyamukuru yerekana inzira yo gukwirakwiza selile. Tososine fosifora ni bumwe mu buryo bw'ingenzi bwo kwanduza ibimenyetso byo mu nda, bishobora gukora cyangwa guhagarika ibikorwa bya poroteyine zitandukanye, bityo bikagira ingaruka ku ikwirakwizwa ry'uturemangingo, gutandukana, no kubaho. Chonluten irashobora kongera fosifori ya tyrosine ya cytoplasmeque kinase muguhuza ibikorwa bya kinase yihariye cyangwa fosifata, hanyuma bikagira ingaruka muburyo bwo gukwirakwiza selile.
3. Uruhare muri nyababyeyi
Mu bushakashatsi bwakozwe ku bagore 14 bavuwe na Conluten (bishoboka ko bufitanye isano na Chonluten) n’abagore 9 bavuwe na Conlunett, byagaragaye ko byagaragaye ko byatewe na magnetiki resonance (NMR), mu gihe cyo kuvura, imiti yombi ishobora guhindura ururenda rw’inkondo y'umura ruva mu bwoko bwa estrogene (ubwoko bwa E) butuma intanga zinjira mu bwoko bwa progesterone (ubwoko bwa G) bubuza kwimuka kw'intanga mu gihe cyo gutera intanga. Ihinduka ryabaye muri 74% by'abagore bari mu itsinda rya Conluten na 64% by'abagore bo mu itsinda rya Conlunett [2].
Ni ubuhe buryo bukoreshwa na Chonluten?
Kuvura indwara zidakira zidakira (COPD) na asima: Chonluten yerekana ubushobozi bwo kuvura indwara zubuhumekero nkindwara zidakira zifata ibihaha na asima. Ubushakashatsi bwerekanye ko bushobora kugabanya gucana [1] . Gutwika nikintu cyingenzi mubitera COPD na asima. Mugabanye igisubizo kibabaza, Chonluten irashobora kugabanya ibimenyetso nka stenosis de airway na dyspnea. Muri icyo gihe, iyi peptide irashobora kandi guteza imbere gusana no kuvugurura ingirangingo. Kwangirika kw'imitsi y'ibihaha bizatuma igabanuka ry'imikorere y'ubuhumekero, kandi ingaruka zo gusana Chonluten zirashobora kunoza imiterere n'imikorere y'ibihaha, bityo bikazamura imikorere y'ubuhumekero.
Gusana ibikomere bya Gastrici: Chonluten yerekana ubushobozi mugukosora ibikomere byo munda. Irashobora kugenga imvugo ya gene ijyanye na enzymes za antioxydeant (nka superoxide dismutase) [1] . Uburyo bwo kwirinda antioxydeant muri mucosa yo mu gifu ni ingenzi mu kurinda ingirangingo zo mu nda kwangirika kwa okiside. Ingaruka igenga Chonluten irashobora gufasha kugarura uburinganire bwokwirinda antioxydeant no kugabanya kwangirika kwingutu ya okiside kuri mucosa gastric. Byongeye kandi, iyi peptide irashobora kandi guteza imbere ingirabuzimafatizo no kwihutisha gusana ibikomere byo mu gifu.
Mu gusoza, Chonluten yerekana indangagaciro zishobora gukoreshwa mubuvuzi murwego rwo kurwanya indwara, gusana ingirabuzimafatizo, no kugenzura indwara.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Francesco Avolio ni umunyeshuri ufitanye isano na kaminuza ya G. d'Annunzio ya Chieti-Pescara, cyane cyane mu kigo cy’ubushakashatsi n’ikoranabuhanga (Ctr Adv Studies & Technol). Ibyifuzo bye mubushakashatsi bikubiyemo ubumenyi bwinshi bwa siyanse, harimo Ubushakashatsi & Ubushakashatsi bwubuvuzi, Ibinyabuzima na Molecular Biologiya, Physiology, Immunology, na Endocrinology & Metabolism. Mu rwego rw’umuryango w’ubushakashatsi muri kaminuza, agira uruhare mu kigo cyibanda ku guteza imbere ubumenyi bwa siyansi no guhanga udushya. Francesco Avolio yanditse kurutonde rwerekana [1].
