▎ Chonluten Research
Kedu ihe bụ Chonluten?
Chonluten bụ peptide bioregulator nke sitere na anụ ahụ nke bronchi, nwere ọtụtụ ihe omume ndụ yana ụkpụrụ ngwa.
Kedu ihe bụ ndabere nyocha nke Chonluten?
1. The Macro Background of Research on Bioactive Peptides
Kemgbe narị afọ nke 20, site na mmepe ngwa ngwa nke usoro mmụta dị ka ihe ndị dị ndụ na biochemistry, ndị ọkà mmụta sayensị emewo nyocha miri emi nke nhazi na ọrụ nke ụmụ irighiri ihe dị iche iche n'ime ihe ndị dị ndụ. Protein, dị ka ndị bụ isi na-ebu ihe omume ndụ, obere peptide usoro kpụrụ site na ngalaba mejupụtara ha - amino asịd nwere ọgaranya ozi ndu na nwere dị iche iche physiological omume. N'ọtụtụ usoro ndụ ndị dị mkpa dị ka akara cell, usoro metabolic, na nzaghachi mgbochi, peptides mkpụmkpụ na-arụkarị ọrụ dị mkpa. Nghọta a emeela ka ndị otu nyocha zuru ụwa ọnụ na-arụsi ọrụ ike na nyocha nke igwupụta peptides dị mkpirikpi nwere ọrụ pụrụ iche sitere na anụ ahụ dị iche iche dị ndụ, na-atụ anya iweta mgbanwe ọhụrụ n'ọtụtụ mpaghara dị ka ọgwụ, sayensị nri, na ọrụ ugbo. A na-eme nyocha nke Chonluten kpọmkwem megide ndabere a.
2. Ohere maka Nchọpụta Chonluten na Bronchus
N'ime nchọpụta nke ọtụtụ anụ ahụ anụmanụ, bronchus nke usoro iku ume adọtawo mmasị pụrụ iche nke ndị ọkà mmụta sayensị. Dị ka ọwa dị mkpa maka gas ịbanye na ịpụ na ngụgụ, anụ ahụ mucosal nke bronchus na-akpọtụrụ gburugburu ebe dịpụrụ adịpụ ma na-arụ ọrụ dị mkpa n'iguzogide mwakpo nke nje na ịnọgide na-enwe nkwụsi ike nke gburugburu ebe obibi nke akụkụ iku ume.
Site na physiology, mkpụrụ ndụ epithelial nke bronchial mucosa na-emeghachi mgbe niile ma na-edozi ya, ma nwee ike izobe ihe dị iche iche nke bioactive iji mezie mgbochi mpaghara na nzaghachi mkpali, nke pụtara na enwere ohere dị elu nke ịdị adị nke peptides dị mkpụmkpụ nwere ọrụ pụrụ iche na anụ ahụ a. Dabere na nke a, ndị otu nyocha ahụ weere bronchus dị ka ebe ntinye maka nyocha ma jiri nkà mmụta ihe omimi dị elu na teknụzụ biochemistry mee nchọpụta miri emi na mpụta nke anụ ahụ bronchial. Mgbe nyocha na nyocha nyocha ogologo oge gasịrị, Chonluten mechara chọpụta nke ọma. Nchọpụta a abụghị nanị na-enye ihe ngosi ọhụrụ maka nghọta miri emi nke usoro nhazi usoro physiological nke bronchus ma na-atọkwa ntọala maka nyocha ndị na-esote nke ngwa Chonluten na mgbochi na ọgwụgwọ nke ọrịa iku ume na mpaghara ahụike ndị ọzọ metụtara ya.
Kedu ihe bụ usoro ọrụ nke Chonluten?
1. Mmetụta nchịkwa na mbufụt
Na-egbochi mmepụta nke Tumor Necrosis Factor (TNF)
Chonluten tripeptide nwere ike igbochi mmepụta nke tumor necrosis factor (TNF) site na monocytes mgbe ekpughere ya na pro-inflammatory bacterial lipopolysaccharide (LPS) [1] . Ntọhapụ nke ọkwa dị ala nke TNF metụtara usoro nke nnabata TNF, nke na-enyere aka belata nzaghachi mkpali.
Kpọmkwem, Chonluten nwere ike imetụta okwu mkpụrụ ndụ ihe nketa ma ọ bụ ọrụ protein metụtara mmepụta TNF na monocytes site na ụfọdụ ụzọ mgbaàmà ma ọ bụ mmekọrịta molecular, si otú ahụ belata njikọ na ntọhapụ nke TNF.
Na-egbochi nkwupụta nke Cytokines Pro-inflammatory
Ihe ise ọ bụla nke Khavinson Peptides (gụnyere Chonluten) nwere ike igbochi okwu nke TNF na pro-inflammatory interleukin-6 (IL-6) cytokines na mkpụrụ ndụ THP-1 dị iche iche nke LPS [1] kpaliri . Nke a na-egosi na Chonluten nwere oke ọrụ na-egbochi cytokines pro-inflammatory na nzaghachi mkpali.
Usoro nwere ike ime bụ na Chonluten na-egbochi njikọ nke LPS na ndị na-anabata ihe n'elu cell ma ọ bụ na-achịkwa ụzọ ntụgharị mgbaàmà nke ala, si otú a na-ebelata mmepụta nke cytokines pro-inflammatory.
Na-ebelata njikọ cell
Site n'ịmepụta mkpụrụ ndụ THP1 nke a na-emeso ya na Chonluten na oyi akwa nke mkpụrụ ndụ endothelial (HUVECs) nke LPS na-arụ ọrụ, a na-ahụ mbelata nke ntanye cell [1] . Adhesion cell bụ ihe na-ahụkarị pro-inflammatory, na mbelata cell adhesion site Chonluten nwere ike inye aka belata nzaghachi mkpali.
Nke a nwere ike ịbụ n'ihi na Chonluten na-agbanwe okwu ma ọ bụ ọrụ nke mkpụrụ ndụ elu cell, si otú ahụ na-emetụta mmekọrịta dị n'etiti sel ma ọ bụ n'etiti sel na matriks.
2. Mmetụta nchịkwa na usoro mgbasawanye
Na-abawanye Tyrosine phosphorylation
Dị ka ndị ọzọ Khavinson Peptides, Chonluten nwere ike ịbawanye tyrosine phosphorylation nke mitogen-activated cytoplasmic kinases [1] . Nke a na-egosi na Chonluten nwere ike ịhazi ụzọ mgbaàmà igodo na usoro mgbasawanye cell. Tyrosine phosphorylation bụ otu n'ime usoro dị mkpa nke ntụgharị mgbaàmà intracellular, nke nwere ike ịmegharị ma ọ bụ gbochie ọrụ nke protein dị iche iche, si otú ahụ na-emetụta mmụba cell, ọdịiche, na nlanarị. Chonluten nwere ike ịbawanye tyrosine phosphorylation nke cytoplasmic kinases site n'ịhazi ọrụ nke kinase ma ọ bụ phosphatases kpọmkwem, wee metụta usoro mgbasawanye cell.
3. Ọrụ na Cervical Mucus
N'ime nnyocha nke ụmụ nwanyị 14 na-emeso Conluten (ikekwe metụtara Chonluten) na ụmụ nwanyị 9 mesoro Conlunett, achọpụtara na achọpụtara ya site na resonance magnetik nuklia (NMR), n'oge oge ọgwụgwọ, ọgwụ abụọ ahụ nwere ike gbanwee ụbụrụ cervical site na ụdị estrogen (ụdị E) nke na-enye ohere ịkwaga spam na ụdị progesterone (ụdị G) nke na-egbochi ịkwaga n'oge ọpụpụ. Mgbanwe a mere na 74% nke ụmụ nwanyị nọ na Conluten na 64% nke ụmụ nwanyị nọ na Conlunett [2].
Kedu ihe bụ ngwa nke Chonluten?
Ọgwụgwọ nke Ọrịa Na-egbochi Ọrịa Pulmonary Na-adịghị Ala Ala (COPD) na Asthma: Chonluten na-egosi ike ọgwụgwọ na ọrịa iku ume dị ka ọrịa na-adịghị ala ala obstructive pulmonary na asthma. Nnyocha egosiwo na ọ nwere ike ibelata mbufụt [1] . Mbufụt bụ isi ihe na-akpata ọrịa COPD na ụkwara ume ọkụ. Site na ibelata nzaghachi mkpali, Chonluten nwere ike belata mgbaàmà dị ka stenosis ikuku na dyspnea. N'otu oge ahụ, mgbagwoju peptide a nwekwara ike ịkwalite nrụzi na ịmaliteghachi anụ ahụ ngụgụ. Mmebi nke anụ ahụ ngụgụ ga-eduga n'ịdalata ọrụ iku ume, na nrụzi nke Chonluten nwere ike melite nhazi na ọrụ nke ngụgụ, si otú ahụ na-eme ka ọrụ iku ume dịkwuo elu.
Mmezi nke mmerụ ahụ Mucosal Gastric: Chonluten na-egosi ike na nrụzi nke mmerụ ahụ mucosal gastric. Ọ nwere ike ịhazi okwu mkpụrụ ndụ ihe nketa metụtara enzymes antioxidant (dị ka superoxide dismutase) [1] . Usoro nchebe antioxidant dị na mucosa gastric dị oké mkpa maka ichebe anụ ahụ gastric site na mmebi nrụgide oxidative. Mmetụta nchịkwa nke Chonluten nwere ike inye aka weghachite nguzozi nke usoro nchebe antioxidant ma belata mmebi nke nrụgide oxidative na mucosa gastric. Tụkwasị na nke a, mgbagwoju peptide a nwekwara ike ịkwalite nrụpụta cell ma mee ka usoro nrụzi nke mmerụ ahụ mucosal dị ngwa ngwa.
N'ikpeazụ, Chonluten na-egosiputa ụkpụrụ ngwa ngwa ụlọ ọgwụ nwere ike ime n'ọhịa nke mgbochi mbufụt, nrụzi anụ ahụ, na nchịkwa mgbochi.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Francesco Avolio bụ agụmakwụkwọ metụtara G. d'Annunzio University of Chieti-Pescara, kpọmkwem n'ime Center for Advanced Studies and Technology (Ctr Adv Studies & Technol). Ihe gbasara nyocha ya gbasara ọtụtụ usoro sayensị, gụnyere Research & Experimental Medicine, Biochemistry & Molecular Biology, Physiology, Immunology, and Endocrinology & Metabolism. Dị ka akụkụ nke obodo nyocha nke mahadum, ọ na-enye aka na ụlọ ọrụ ahụ na-elekwasị anya na ịkwalite ihe ọmụma sayensị na ihe ọhụrụ. Edepụtara Francesco Avolio na ntụaka nke ntụaka [1].
