▎ Chonluten Ŋuti Numekuku
Nukae nye Chonluten?
Chonluten nye peptide bioregulator si woɖe tso aɖuɖɔtoe me lãkusiwo me koŋ, si si nugbagbeŋusẽ ƒe dɔwɔwɔ geɖe siwo ate ŋu adzɔ kple dɔwɔwɔ ƒe asixɔxɔwo le esi.
Nukae nye numekuku si wowɔ le Chonluten ŋu?
1. Numekuku le Bioactive Peptides ŋu ƒe Macro Background
Tso ƒe alafa 20 lia me, esi nusɔsrɔ̃wo abe molecule biology kple biochemistry ene va le ŋgɔ yim kabakaba ta la, dzɔdzɔmeŋutinunyalawo ku nu me tsitotsito le molecule vovovo siwo le nu gbagbewo me ƒe wɔwɔme kple dɔwɔwɔ ŋu. Proteinwo, abe agbe ƒe dɔwɔnawo tsɔla vevitɔwo ene la, peptide ƒe ɖoɖo kpui siwo woƒe akpa siwo le wo me - amino acidwo wɔ la, wokpɔe be nugbagbe ŋuti nyatakaka gbogbo aɖewo le wo me eye ŋutilã ƒe dɔwɔwɔ vovovowo le wo si. Le agbemenu vevi geɖe abe lãmenugbagbeviwo ƒe dzesiwo, lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie, kple dɔlélenutsiŋutete ƒe dɔwɔwɔ me la, zi geɖe la, peptide kpuiwo wɔa akpa vevi aɖe. Gɔmesese sia na xexeame katã ƒe numekulawo ƒo wo ɖokui ɖe numekuku si ku ɖe peptide kpui siwo wɔa dɔ tɔxɛwo tso nugbagbeviwo ƒe lãkusi vovovowo me kuku me vevie, kple mɔkpɔkpɔ be yewoahe tɔtrɔ yeyewo vɛ le dɔ vovovowo abe atikewɔwɔ, nuɖuɖuŋutinunya, kple agbledede ene me. Wowɔ numekuku le Chonluten ŋu le nɔnɔme sia me tututu.
2. Mɔnukpɔkpɔ si Li Be Woake Ðe Chonluten Ŋu le Aɖuɖɔtoe me
Le numekuku siwo wowɔ le lãwo ƒe lãkusi gbogbo aɖewo ŋu dome la, gbɔgbɔtsixe ƒe aɖuɖɔtoea he dzɔdzɔmeŋutinunyalawo ƒe susu etɔxɛe. Esi wònye mɔ vevi aɖe si dzi gas tona gena ɖe lãkusiwo me hedoa go ta la, aɖuɖɔtoea ƒe lãkusi doa ka kple gotagome nutoa me tẽ eye wòwɔa akpa vevi aɖe le tsitretsitsi ɖe dɔlékuiwo ƒe amedzidzedze ŋu kple gbɔgbɔtsixe ƒe nuto si le eme ƒe liƒo me.
Le ŋutilãŋutinunya ƒe nukpɔsusu nu la, wowɔa aɖuɖɔtoe me lãmenugbagbevi siwo le lãkusi me yeyee ɣesiaɣi eye wodzraa wo ɖo, eye woate ŋu aɖe nu vovovo siwo wɔa dɔ le nugbagbewo me ɖa be woatsɔ aɖɔ teƒea ƒe dɔlélenutsiŋutete kple dɔdzẽ ƒe ŋuɖoɖowo ɖo, si fia be kakaɖedzi gã aɖe li be peptide kpui siwo wɔa dɔ tɔxɛwo nanɔ lãkusi sia me. Numekulawo nɔ te ɖe esia dzi tsɔ aɖuɖɔtoea be enye afisi woage ɖo le numekuku me eye wozã molecule biology kple biochemistry mɔ̃ɖaŋununya deŋgɔwo tsɔ wɔ numekuku deto tso aɖuɖɔtoe me lãkusiwo me. Le dodokpɔ me ŋkuléleɖenuŋu kple numekuku ɣeyiɣi didi megbe la, wova ke ɖe Chonluten ŋu dzidzedzetɔe mlɔeba. Menye ɖeko nusi ŋu woke ɖo sia na kpeɖodzi yeyewo hena aɖuɖɔtoe ƒe ŋutilã ƒe ɖoɖowɔwɔ ƒe mɔnu gɔmesese deto ko o, ke eɖo gɔmeɖoanyi hã na numekuku siwo woawɔ emegbe le Chonluten zazã le mɔxexe ɖe gbɔgbɔmedɔlélewo nu kple wo dada kple lãmesẽnya bubu siwo do ƒome kplii me.
Nukae nye Chonluten ƒe dɔwɔwɔ ƒe mɔnu?
1. Ŋusẽkpɔɖeamedzi si Ðoɖowɔɖiwo Kpɔna Ðe Dzoxɔxɔ Dzi
Mɔxexe Ðe Tumor Necrosis Factor (TNF) ƒe Dɔwɔwɔ Nu .
Tripeptide Chonluten ateŋu axe mɔ na tumor necrosis factor (TNF) ƒe wɔwɔ to monocytes dzi le pro-inflammatory bacterial lipopolysaccharide (LPS) zazã vɔ megbe [1] . TNF ƒe agbɔsɔsɔ si bɔbɔ ƒe dodo do ƒome kple alesi TNF te ŋu nɔa te ɖe enu, si kpena ɖe ame ŋu be dɔdzẽ ƒe ŋuɖoɖo dzi ɖena kpɔtɔna.
Etɔxɛe la, Chonluten ate ŋu akpɔ ŋusẽ ɖe domenyiŋusẽfianu ƒe ɖeɖefia alo protein ƒe dɔwɔwɔ si do ƒome kple TNF wɔwɔ le monocytes me to dzesimɔ aɖe koŋ alo molecule ƒe kadodo dzi, si ana TNF ƒe wɔwɔme kple eƒe dodo dzi naɖe akpɔtɔ.
Mɔxexe Ðe Pro-inflammatory Cytokines ƒe Nyaɖeɖefia Nu
Khavinson Peptides atɔ̃awo katã (Chonluten hã le eme) ate ŋu axe mɔ ɖe TNF kple pro-inflammatory interleukin-6 (IL-6) cytokines ƒe ɖeɖefia nu le THP-1 lãmenugbagbevi siwo to vovo le nuwuwu si LPS ʋãna me [1] . Esia ɖee fia be Chonluten wɔa akpa gã aɖe le mɔxexe ɖe dɔlékuiwutike siwo doa alɔ dɔlékuiwo nu le dɔdzẽ ƒe ŋuɖoɖo me.
Mɔnu si ate ŋu awɔe nye be Chonluten doa kplamatse LPS ƒe kadodo kple lãmenugbagbeviwo ƒe anyime xɔlawo alo ɖɔa dzesiwo ƒe tɔtrɔmɔ si le anyime la ɖo, si wɔnɛ be pro-inflammatory cytokines ƒe wɔwɔ dzi ɖena kpɔtɔna.
Lãmenugbagbeviwo ƒe Kpekpeɖeŋunana Dzi Ðeɖe Akpɔtɔ
To THP1 lãmenugbagbevi siwo wotsɔ Chonluten da dɔe ƒe agbledede ɖe lãmenugbagbevi siwo le lãkusi me (HUVECs) siwo LPS wɔ dɔ dzi ƒe ƒuƒoƒo aɖe dzi la, wokpɔ lãmenugbagbeviwo ƒe ƒoƒo ɖe wo nɔewo ŋu dzi ɖeɖe kpɔtɔ [1] . Lãmenugbagbeviwo ƒe ƒoƒo ɖe wo nɔewo ŋu nye mɔnu si bɔ si doa alɔ dɔdzẽ, eye lãmenugbagbeviwo ƒe ƒoƒo ɖe wo nɔewo ŋu dzi ɖeɖe kpɔtɔ to Chonluten dzi ate ŋu akpe ɖe ame ŋu be dɔdzẽ ƒe ŋuɖoɖoa dzi naɖe akpɔtɔ.
Esia ate ŋu atso esi Chonluten trɔa lãmenugbagbeviwo ƒe anyime moleculewo ƒe ɖeɖefia alo dɔwɔwɔ, si wɔnɛ be wòkpɔa ŋusẽ ɖe lãmenugbagbeviwo dome alo lãmenugbagbeviwo kple matriki dome kadodo dzi.
2. Dɔwɔnawo ƒe Ŋusẽkpɔɖeamedzi ɖe Aʋawɔnuwo ƒe Adziɖedzi ƒe Dɔwɔna Dzi
Tyrosine ƒe Phosphorylation ƒe dzidziɖedzi
Abe Khavinson Peptides bubuwo ene la, Chonluten ateŋu adzi tyrosine phosphorylation ɖe edzi le mitogen-activated cytoplasmic kinases me [1] . Esia ɖee fia be Chonluten ate ŋu aɖɔ dzesimɔ vevi si le lãmenugbagbeviwo ƒe dzidziɖedzi ƒe ɖoɖoa me ɖo. Tyrosine phosphorylation nye lãmenugbagbeviwo me dzesiwo ƒe tɔtrɔ ƒe mɔnu veviwo dometɔ ɖeka, si ate ŋu ana protein vovovowo nawɔ dɔ alo axe mɔ ɖe woƒe dɔwɔwɔ nu, si ana wòakpɔ ŋusẽ ɖe lãmenugbagbeviwo ƒe dzidziɖedzi, vovototodedeameme, kple agbetsitsi dzi. Chonluten ate ŋu ana tyrosine phosphorylation nadzi ɖe edzi le cytoplasmic kinases me to kinase alo phosphatases tɔxɛwo ƒe dɔwɔwɔ dzi kpɔkpɔ me, eye emegbe wòakpɔ ŋusẽ ɖe lãmenugbagbeviwo ƒe dzidziɖedzi ƒe ɖoɖo dzi.
3. Akpa si wòwɔna le Vidzidɔ me Ʋuʋudedi me
Le numekuku aɖe si wowɔ le nyɔnu 14 siwo wotsɔ Conluten da dɔe (si anya do ƒome kple Chonluten) kple nyɔnu 9 siwo wotsɔ Conlunett da dɔe ŋu me la, wokpɔe be ne wotsɔ nuklia magnetic resonance (NMR) de dzesii, le atikewɔwɔ ƒe ɣeyiɣia me la, atike eveawo siaa ate ŋu atrɔ vidzidɔ ƒe ʋuʋudedi tso estrogen ƒomevi (ƒomevi E) si ɖea mɔ na tsinyenye ƒe ʋuʋu yi progesterone ƒomevi (ƒomevi G) si xea mɔ na tsinyenye ƒe ʋuʋu le fufɔɣi. Tɔtrɔ sia dzɔ le nyɔnu siwo le Conluten ƒuƒoƒoa me ƒe 74% kple nyɔnu siwo le Conlunett ƒuƒoƒoa me ƒe 64% me [2]..
Nukae nye Chonluten ƒe dɔwɔwɔ?
Aklãdɔléle si xea mɔ na dɔléle (COPD) kple Asrã ƒe Atikewɔwɔ: Chonluten ɖea atikewɔwɔ ƒe ŋutete fiana le gbɔgbɔmedɔlélewo abe aklãdɔléle si xea mɔ na dɔléle si nɔa anyi didi kple asrã ene me. Numekukuwo ɖee fia be ate ŋu aɖe dɔdzẽ dzi akpɔtɔ [1] . Dzoxɔxɔ nye nu vevi aɖe si nana COPD kple asrãdɔ dzɔna. To dɔdzẽ ƒe ŋuɖoɖo dzi ɖeɖe kpɔtɔ me la, Chonluten ate ŋu aɖe dzesiwo abe yaƒoƒomɔ̃ ƒe ʋuʋu kple gbɔgbɔtsixetsixe ene dzi akpɔtɔ. Le ɣeyiɣi ma ke me la, peptide complex sia ate ŋu ado lãkusiwo ɖɔɖɔɖo kple wo gbugbɔgawɔ hã ɖe ŋgɔ. Nusiwo gblẽ le lãkusiwo ŋu ana gbɔgbɔtsixe ƒe dɔwɔwɔ dzi naɖe akpɔtɔ, eye Chonluten ƒe ɖɔɖɔɖo ƒe ŋusẽkpɔɖeamedzi ate ŋu ana lãkusiwo ƒe wɔwɔme kple dɔwɔwɔ nanyo ɖe edzi, si ana gbɔgbɔtsixe ƒe dɔwɔwɔ nanyo ɖe edzi.
Gastric Mucosal Injury Dzadzraɖo: Chonluten ɖea ŋutete fiana le gastric mucosal injury dzadzraɖo me. Ate ŋu aɖɔ domenyiŋusẽfianu ƒe ɖeɖefia si do ƒome kple antioxidant enzymes (abe superoxide dismutase ene) ɖo [1] . Antioxidant takpɔnu si le dɔgboa ƒe lãkusi me le vevie ŋutɔ na dɔgboa ƒe lãkusi takpɔkpɔ tso oxidative stress ƒe nugbegblẽ me. Chonluten ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ate ŋu akpe ɖe ame ŋu be antioxidant defense mechanism la nagada asɔ eye wòaɖe oxidative stress ƒe nugbegblẽ le dɔgboa ƒe lãkusi ŋu dzi akpɔtɔ. Tsɔ kpe ɖe eŋu la, peptide complex sia ate ŋu ado lãmenugbagbeviwo ƒe gbugbɔgadzɔ hã ɖe ŋgɔ eye wòana dɔgboa ƒe abi si woxɔ la ɖɔɖɔɖo kabakaba.
Le nyataƒoƒo me la, Chonluten ɖe asixɔxɔ siwo woate ŋu azã le atikewɔnyawo me le dɔlékuiwutike, lãmenugbagbeviwo ɖɔɖɔɖo, kple dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ ƒe akpawo me fia.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Francesco Avolio nye agbalẽnyala si do ƒome kple G. d’Annunzio Yunivɛsiti si le Chieti-Pescara, vevietɔ le Nusɔsrɔ̃ Deŋgɔwo Kple Mɔ̃ɖaŋununya Dɔwɔƒe (Ctr Adv Studies & Technol) me. Eƒe numekuku ƒe didiwo ku ɖe dzɔdzɔmeŋutinunya me nu vovovowo ŋu, siwo dometɔ aɖewoe nye Numekuku & Dodokpɔ ƒe Atikewɔwɔ, Biochemistry & Molecular Biology, Physiology, Immunology, kple Endocrinology & Metabolism. Abe yunivɛsitia ƒe numekukuhabɔbɔa ƒe akpa aɖe ene la, ewɔa akpa aɖe le dɔwɔƒea ƒe susu tsɔtsɔ ɖe dzɔdzɔmeŋutinunya me sidzedze kple nu yeyewo dodo ɖe ŋgɔ ŋu. Woŋlɔ Francesco Avolio ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [1].
