▎ Binciken Chonluten
Menene Chonluten?
Chonluten shine peptide bioregulator wanda aka samo shi daga kyallen takarda, yana da yuwuwar ayyukan ilimin halitta da ƙimar aikace-aikace.
Menene asalin bincike na Chonluten?
1. Tarihin Macro na Bincike akan Bioactive Peptides
Tun daga karni na 20, tare da saurin bunkasuwar fannonin ilimi kamar ilmin kwayoyin halitta da ilmin halitta, masana kimiyya sun gudanar da zurfafa bincike kan tsari da ayyukan kwayoyin halitta daban-daban a cikin halittu masu rai. Sunadaran, a matsayin manyan masu gudanar da ayyukan rayuwa, gajerun jerin peptide da aka kafa ta raka'o'in su - amino acid an gano suna ƙunshe da wadataccen bayanan ilimin halitta kuma suna da ayyuka daban-daban na physiological. A yawancin hanyoyin rayuwa masu mahimmanci kamar siginar tantanin halitta, ƙa'idodin rayuwa, da martanin rigakafi, gajeriyar peptides galibi suna taka muhimmiyar rawa. Wannan fahimtar ta sa ƙungiyoyin bincike na duniya su himmatu wajen gudanar da bincike na tono gajerun peptides tare da ayyuka na musamman daga nau'ikan ƙwayoyin halitta daban-daban, suna fatan kawo sabbin sauye-sauye zuwa fagage da yawa kamar magani, kimiyyar abinci, da aikin gona. Ana gudanar da bincike kan Chonluten daidai da wannan bayanan.
2. Damar Gano Chonluten a cikin Bronchus
Daga cikin nazarin ƙwayoyin dabbobi masu yawa, ƙwayar ƙwayar ƙwayar ƙwayar cuta ta numfashi ta jawo hankalin masana kimiyya na musamman. A matsayin muhimmiyar tashar gas don shiga da fita daga cikin huhu, ƙwayar mucosal na bronchus kai tsaye yana hulɗa da yanayin waje kuma yana taka muhimmiyar rawa wajen tsayayya da mamayewa na ƙwayoyin cuta da kuma kiyaye kwanciyar hankali na yanayin ciki na numfashi.
Daga hangen nesa na ilimin lissafi, sel epithelial na mucosa na bronchial suna sabuntawa akai-akai kuma ana gyara su, kuma suna iya ɓoye abubuwa daban-daban na bioactive don daidaita rigakafi na gida da martani mai kumburi, wanda ke nufin cewa akwai yuwuwar kasancewar gajerun peptides tare da ayyuka na musamman a cikin wannan nama. Bisa ga wannan, ƙungiyar masu binciken sun ɗauki bronchus a matsayin hanyar shiga don bincike kuma sun yi amfani da ci gaban ilimin kwayoyin halitta da fasahar kwayoyin halitta don gudanar da bincike mai zurfi game da tsantsa na kyallen takarda. Bayan dogon nazari da nazari na gwaji, an sami nasarar gano Chonluten a ƙarshe. Wannan binciken ba wai kawai yana ba da sabbin alamu ba don zurfin fahimtar tsarin tsarin tsarin ilimin halittar jiki na bronchus amma kuma ya kafa harsashin bincike na gaba na aikace-aikacen Chonluten a cikin rigakafi da magance cututtukan numfashi da sauran fannonin kiwon lafiya masu alaƙa.
Menene tsarin aikin Chonluten?
1. Tasirin Ka'idoji akan Kumburi
Hana Samar da Tumor Necrosis Factor (TNF)
Chonluten na tripeptide zai iya hana samar da ƙwayar necrosis factor (TNF) ta monocytes bayan bayyanar da kwayoyin lipopolysaccharide pro-inflammatory (LPS) [1] . Sakin ƙananan matakan TNF yana da alaƙa da tsarin juriya na TNF, wanda ke taimakawa wajen rage amsawar kumburi.
Musamman, Chonluten na iya rinjayar maganganun kwayoyin halitta ko aikin furotin da ke da alaƙa da samar da TNF a cikin monocytes ta hanyar takamaiman hanyar sigina ko hulɗar kwayoyin halitta, ta haka ne rage haɗuwa da sakin TNF.
Hana Bayyanawar Cytokines mai kumburi
Dukkanin Peptides guda biyar na Khavinson (ciki har da Chonluten) na iya hana bayyanar TNF da pro-inflammatory interleukin-6 (IL-6) cytokines a cikin sel THP-1 da aka bambanta da LPS [1] . Wannan yana nuna cewa Chonluten yana da rawar da ya dace wajen hana cytokines masu kumburi a cikin amsawar kumburi.
Hanyar da za ta yiwu ita ce Chonluten yana tsoma baki tare da ɗaurin LPS zuwa masu karɓa na sararin samaniya ko kuma ya tsara hanyar watsa siginar da ke ƙasa, don haka rage samar da cytokines masu kumburi.
Rage Manne Kwayoyin Halitta
Ta hanyar haɓaka ƙwayoyin THP1 da aka bi da su tare da Chonluten a kan wani Layer na sel na endothelial (HUVECs) wanda LPS ke kunnawa, an lura da raguwar adhesion cell [1] . Ƙwaƙwalwar ƙwayar ƙwayar cuta ita ce hanyar da za ta iya haifar da kumburi, kuma rage ƙwayar ƙwayar ƙwayar cuta ta Chonluten na iya taimakawa wajen rage amsawar kumburi.
Wannan yana iya zama saboda Chonluten yana canza magana ko aiki na kwayoyin saman sel, ta haka yana shafar hulɗar tsakanin sel ko tsakanin sel da matrix.
2. Tasirin Ka'idoji akan Tsarin Yaduwa
Ƙara Tyrosine Phosphorylation
Kamar sauran Khavinson Peptides, Chonluten na iya ƙara tyrosine phosphorylation na mitogen-activated cytoplasmic kinases [1] . Wannan yana nuna cewa Chonluten zai iya tsara hanyar siginar maɓalli a cikin tsarin yaduwar kwayar halitta. Tyrosine phosphorylation yana daya daga cikin mahimman hanyoyin watsa siginar intracellular, wanda zai iya kunna ko hana ayyukan sunadarai daban-daban, don haka ya shafi yaduwar kwayar halitta, bambanta, da kuma rayuwa. Chonluten na iya ƙara tyrosine phosphorylation na cytoplasmic kinases ta hanyar daidaita ayyukan kinases na musamman ko phosphatases, sa'an nan kuma ya shafi tsarin yaduwar kwayar halitta.
3. Rawar da ke cikin Ciwon mahaifa
A cikin binciken da aka yi wa mata 14 da aka yi wa Conluten (wataƙila suna da alaƙa da Chonluten) da mata 9 da aka bi da su tare da Conlunett, an gano cewa an gano ta hanyar haɓakar maganadisu ta nukiliya (NMR), a lokacin lokacin jiyya, duka magungunan biyu na iya canza ƙwayar mahaifa daga nau'in estrogen (nau'in E) wanda ke ba da izinin ƙaurawar maniyyi zuwa nau'in progesterone (nau'in G) wanda ke hana ƙaura a lokacin ƙaura. Wannan canjin ya faru a cikin kashi 74% na matan da ke cikin rukunin Conluten da kashi 64% na matan da ke cikin rukunin Conlunett [2].
Menene aikace-aikacen Chonluten?
Maganin Cutar Cutar Cutar Cutar Cutar Cutar Cutar Cutar (COPD) da Asthma: Chonluten yana nuna yiwuwar warkewa a cikin cututtukan numfashi kamar na yau da kullun na toshewar huhu da asma. Nazarin ya nuna cewa yana iya rage kumburi [1] . Kumburi shine babban mahimmanci a cikin pathogenesis na COPD da asma. Ta hanyar rage amsawar kumburi, Chonluten na iya sauƙaƙa alamun bayyanar cututtuka irin su stenosis na iska da dyspnea. A lokaci guda, wannan hadaddun peptide kuma na iya haɓaka gyare-gyare da sake haɓaka ƙwayoyin huhu. Lalacewar kyallen huhu zai haifar da raguwar aikin numfashi, kuma sakamakon gyara na Chonluten zai iya inganta tsari da aikin huhu, don haka inganta aikin numfashi.
Gyaran Rauni na Mucosal Gastric: Chonluten yana nuna yiwuwar gyara raunin mucosal na ciki. Yana iya daidaita maganganun jinsin da ke da alaƙa da enzymes antioxidant (kamar superoxide dismutase) [1] . Tsarin kariya na antioxidant a cikin mucosa na ciki yana da mahimmanci don kare nama na ciki daga lalacewar danniya. Sakamakon tsari na Chonluten zai iya taimakawa wajen dawo da ma'auni na tsarin kare kariya na antioxidant da rage lalacewar danniya na oxidative ga mucosa na ciki. Bugu da ƙari, wannan hadaddun peptide kuma zai iya inganta farfadowar tantanin halitta da kuma hanzarta aiwatar da gyaran gyare-gyare na raunin mucosal na ciki.
A ƙarshe, Chonluten yana nuna ƙimar aikace-aikacen asibiti mai yuwuwa a cikin fagagen rigakafin kumburi, gyaran nama, da tsarin rigakafi.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Francesco Avolio malami ne mai alaƙa da Jami'ar G. d'Annunzio na Chieti-Pescara, musamman a cikin Cibiyar Nazarin Ci gaba da Fasaha (Ctr Adv Studies & Technol). Bukatun bincikensa sun mamaye fannonin kimiyya da yawa, gami da Bincike & Magungunan Gwaji, Biochemistry & Biology Molecular, Physiology, Immunology, da Endocrinology & Metabolism. A matsayinsa na jama'ar bincike na jami'a, yana ba da gudummawa ga ci gaba da mayar da hankali kan ci gaban ilimin kimiyya da kirkire-kirkire. An jera Francesco Avolio a cikin ambaton ambaton [1].
