SS31 miligaramu 10

▎ SS-31 Jatebɔcogo

Sɔrɔyɔrɔ: PubChem

A kɛcogo: RXKF Formula molekilɛri: C 32H 49N 9O5 Molecules girinya: 639,8g/mol CAS nimɔrɔ: 736992-21-5 PubChem ka CID: 11764719. Bamako, Mali Kɔrɔɲɔgɔnmaw: Elamipretide

▎ SS-31 Sɛgɛsɛgɛli

SS-31 ka ɲininiw kɛcogo ye mun ye?

SS-31 ye tetarapɛtidi ye min bɛ se ka ji la, katiyɔni kasadiman, min ɲɛsinnen bɛ mitokondriyaw ma (Sabbah HN, 2022). A ka kemikaliya jɔcogo kɛrɛnkɛrɛnnen b’a To a bɛ Se ka Dòn nɔgɔya la ani k’a Sìgi waati dɔɔnin mitokondriyaw kɔnɔna na. Kɛrɛnkɛrɛnnenya la, a bɛ se ka siri karidiyolipini la, o min ye mitokondriyaw kɔnɔna yɔrɔba dɔ ye, o la, a bɛ a nɔ bila ka mitokondriyaw ka baara ɲɛ.

O kemikoro danfaralen in bɛ jusigilan di a kɛcogo ma bana suguya caman furakɛli la. Bana caman bɛ tali kɛ mitokondriyaw ka baarakɛbaliya la, i n’a fɔ Barth ka bana, dusukun tantanni, farikolojidɛsɛbanaw, a ɲɔgɔnnaw Mitokondriyaw jɔyɔrɔ ka bon kosɛbɛ selilɛriw ka fanga sɔrɔli la, oksidan degunw labɛnni na, ani fɛn wɛrɛw. Ni mitokondriyaw ka baara tiɲɛna, o bɛ se ka kɛ sababu ye ka gɛlɛyaw lase mɔgɔ ma i n’a fɔ farikolo fanga dɔgɔyali, oksidan degun caya, ani farikolojidɛsɛ, o minnu bɛ bana suguya caman bila mɔgɔ la.

SS-31 ɲinini n’a yiriwali kun ye ka nin bana ninnu laɲini minnu bɛ sɔrɔ mitokondriyaw fɛ, ka bana taamasiɲɛw nɔgɔya ni mitokondriyaw ka baara ɲɛnabɔli ye ani ka banabagatɔw ka ɲɛnamaya kɛcogo n’u ka ɲɛnamaya kɛcogo ɲɛ. Ni ɲinini kunbabaw bɛ senna mitokondriyaw ka ɲɛnamayako kan, mɔgɔw y’a dɔn dɔɔnin dɔɔnin ko mitokondriyaw nafa ka bon banaw sɔrɔli n’u yiriwali la.

Ɲininikɛlaw y’a ye ko mitokondriyaw ka baarakɛbaliya bɛ tali kɛ bana suguya caman ka banakisɛfagalanw ka baarakɛcogo la. Misali la, farikolojidɛsɛbanaw la, ko dɔw bɛ yen i n’a fɔ senfagabana mitokondriyaw baarakɛbaliya, senfagabana basigilen, farikolojɔli dumuni bagalenw dalajɛli, ani ^apoptose senfagabana Sani a ka don kɛnɛyaso ɲininiw na, SS-31 ye sɛgɛsɛgɛli caman kɛ ka kɔn kɛnɛyaso ɲɛ. O ɲininiw tun bɛ kɛ ni kɔrɔbɔliw ye minnu kɛra selilɛriw misaliw ni baganw ka misaliw kan walasa ka fura in lakanani, a nafa ani a furakɛcogo jateminɛ. Misali la, Barth ka bana sɛgɛsɛgɛli la, SS-31 y’a jira ko a bɛ se ka mitokondriyaw ka biyoenerji ni u cogoya ɲɛ ka taa a fɛ joona selilɛriw la minnu bɛ se ka kɛ sababu ye ka banakisɛ caman ^sɔrɔ.

Sɛgɛsɛgɛli minnu kɛra farikolojidɛsɛbanaw kan, SS-31 ye farikolo tangacogo jira baganw ka misali caman na, i n’a fɔ ka mitokondriyaw ninakili fanga bonya, ka farikolojidɛsɛ bali, ani ka farikolojɔlifɛn toxicw ^bali dalajɛli SS-31 sen bɛ kɛnɛyaso sɛgɛsɛgɛli caman na kaban minnu bɛ bana suguya wɛrɛw ɲɛfɔ.

Dusukun tantanni furakɛli la, sɛgɛsɛgɛli dɔ kɛra min kɛra ni mɔgɔw ye, min kɛra ni furakisɛ ye, o y’a jira ko SS-31 pikiri kelen kɛli farati tɛ, wa a bɛ muɲu kosɛbɛ, wa SS-31 hakɛ caman bɛ se ka kɔnɔbara kiniyanfan hakɛ ɲɛ, o bɛ a jɔyɔrɔ dɛmɛ min bɛ se ka kɛ dusukun tantanni furakɛli ^la.

SS-31 ka baara kɛcogo kɛrɛnkɛrɛnnenw ye jumɛnw ye bana suguya wɛrɛw la?

1. Baara kɛcogo joli-sira-funu ni joli-sira-funu-kɔlɔsili modɛli la

Joginni ischemie-reperfusion (IRI) min bɛ sɔrɔ joli-sira-funu ni joli-sira-funu (REBOA) fɛ, o misali la, mitokondriyaw tiɲɛni jɔyɔrɔ ka bon kosɛbɛ. SS-31 bɛ se ka dɔ bɔ kristalɛji ɲinini na ani ka sugunɛ ni dusukun lakana. Kɛrɛnkɛrɛnnenya la, a bɛ se ka kɛrɛyatinini, troponin ani interleukin-6 hakɛ dɔgɔya joli la, nka a tɛ nɔ bila laktati hakɛ laban na joli la. SS-31 bɛ se ka IRI nɔgɔya ni mitokondriyaw lakanani ye, ka furakɛli sira kura da mɔgɔw ye minnu bɛ IRI tɔɔrɔ joli bɔlen kɔfɛ ^{[4] .}.

2. Baara kɛcogo Barth ka bana na

Barth ka bana ye bana ye min man teli ka sɔrɔ X ni ɲɔgɔn cɛ, a bɛ sɔrɔ dusukunnabana, kolotugudaw fanga dɔgɔyali, bonya kɔtigɛbaliya ani neutropenie cyclique. SS-31 ye tetarapɛtidi ye min bɛ se ka ji la, katiyɔni kasadiman, min ɲɛsinnen bɛ mitokondriyaw ma, a bɛ se ka don mitokondriyaw kɔkanna ɲɛgɛnɛsira la ka siri karidiyolipini na. A bɛ selilɛriw ka kɛnɛya sabati a kɛtɔ ka fanga sɔrɔli ɲɛ ani ka oksizɛni suguya minnu bɛ se ka baara kɛ, olu sɔrɔli damatɛmɛni bali, o la, o bɛ dɔ bɔ oksidan degun na. Barth ka banakisɛfagalanw ni bana wɛrɛw minnu bɛ tali kɛ jamu la, minnu bɛ sɔrɔ denmisɛnninw ka dusukunnabana fɛ, SS-31 bɛ se ka mitokondriyaw ka biyoenerji ni u cogoya ɲɛ joona. Kalan caman jaabiw bɛ SS-31 tali dɛmɛ i n’a fɔ furakɛli min bɛ se ka kɛ banabagatɔw ma minnu bɛ ni Barth ka bana ye, kɛrɛnkɛrɛnnenya la dusukunnabana sɔrɔla yɔrɔ minnu naⁿⁱ .

3. A kɛcogo sugunɛbaralabana min bɛ wele ko autosomal dominant polycystic kidney disease (ADPKD) .

A jatera ko kɔnɔmaya bɛ kurukuruw taabolo juguya sugunɛbaralabana min bɛ wele ko autosomal dominant polycystic kidney disease (ADPKD) la. Nka, tolvaptan, fura kelenpe min dabɔra FDA fɛ balikuw ka ADPKD kama, o man ɲi ADPKD banabagatɔ kɔnɔmaw ma ka da a kan a bɛ se ka tiɲɛni kɛ den na. SS-31 ye tetarapɛtidi ye min bɛ mitokondriyaw tanga, a jirala ko a bɛ sugunɛbana taabolo ɲɛ Pkd1RC/RC sogo kɔnɔmaw la, ka sɔrɔ ka ERK1/2 fosforilasi dɔgɔya ani ka mitokondriyaw ka supercomplexes (mitokondriyaw supercomplexes) sɔrɔli ɲɛ. Ka fara o kan, SS-31 bɛ se ka denso ni sinji tigɛ, ka denmisɛnninw ka sugunɛbaralabana jugumanba ɲɛnabɔ, k’a sɔrɔ a ma kɔlɔsi teratojeni walima nɔ jugu si la. Nin ɲinini minnu kɛra ka kɔn kɛnɛyaso ɲɛ, olu bɛ SS-31 ka kɛnɛyako sɛgɛsɛgɛliw dɛmɛ minnu bɛ se ka kɛ ^{[5] .}.

4. Baara kɛcogo dusukun tantanni na

Dusukun tantanni (HF) la, a dɔnna ko fɛn juguw bɛ kɛ mitokondriyaw la. SS-31 bɛ nɔ ɲuman bila hadamaden dusukun tantanni baara mitokondriyaw ni supercomplex baarakɛcogo la. A bɛ se ka dɔ fara oksizɛni bɔli kan kosɛbɛ, complexe I ni complex IV baarakɛcogo, ani complex IV baara min bɛ tali kɛ supercomplexes la hadamaden dusukun mitokondriyaw fanga dɔgɔyalenw na, o bɛ hadamaden mitokondriyaw baarakɛbaliya ɲɛ ^kosɛbɛ.

Denmisɛn minnu bɛ ni dusukunnabana bangenen ye min bɛ sɔrɔ kɔnɔbara kelen na (SV CHD), kɛnɛyaso taamasiɲɛ minnu bɛ dusukun cili la, olu b’a jira ko mitokondriyaw ka baarakɛbaliya bɛ u la. SS-31 ye pentapeptide ye min bɛ karidiyolipini laɲini min bɛ se ka mitokondriyaw supercomplexes (complex I, III, IV) ka jɛɲɔgɔnya ɲɛ. SV CHD bɛ denmisɛn minnu na, olu dusukun na, SS-31 bɛ se ka complexe I baara kɛcogo ɲɛ ani ka ninakili hakɛ maksimali (MR), o b’a jira ko a bɛ a nɔ jira kosɛbɛ ni mitokondriyaw ka supercomplexes (mitokondriyaw supercomplexes ^{) ɲɛnabɔli ye}.

5. Baara kɛcogo sukarodunbana na

Jabɛti suguya 2 sosow ka db/db misali la, sukarodunbana (DKD) bɛ tali kɛ sugunɛ ni dusukun superoxyde hakɛ dɔgɔyali la. Mitokondriyaw tangalan SS-31 (a bɛ fɔ fana ko MTP-131, SS-31, walima Bendavia) bɛ se ka farikolojɔli dumuni, sugunɛ H2O2, ani glomerular mesangial matrix dalajɛli bali kosɛbɛ db/db sogow la, ani ka sugunɛbilenni superoxyde sɔrɔli hakɛ mara pewu o sogo ninnu na. SS-31 bɛ se fana ka sugunɛbilenni lizokaridiyolipini bɛɛ lajɛlen ni lizokaridiyolipini kulu fitinin kunbabaw dɔgɔya db/db sogow la, ani ka lizokaridiyolipini asilitransfɛrazi 1 jiracogo lakana farikolo la, superoxyde hakɛ bɛ kɛ ni karidiyolipini (cardiolipin remodeling) labɛnni ye ^{[8] .}.

Ja min bɛ kɛ ni hakilina ye, o bɛ elamipretide ka farikolo lakanani nɔw lajɛ senfagabana mitokondriyaw jogoɲini kan.

Soso:PubMed ^{[1] Ɲɛjirali dɔw.}

SS-31 baarakɛcogo minnu bɛ tali kɛ o la, olu ye mun ye?

Dusukun tantanni Barth ka bana la : Barth ka bana ye bana ye min man teli ka sɔrɔ ani a bɛ se ka mɔgɔ ka ɲɛnamaya bila farati la, min bɛ sɔrɔ dusukunnabana fɛ, kolotugudaw fanga dɔgɔyali, bonya kɔtigɛbaliya ani neutropenie cyclique. Banabagatɔw ka saya farati ka bon denmisɛnninya la, wa u ka teli ka dusukunnabana sɔrɔ min bɛ taa ni farikolo tangacogo fanga dɔgɔyali juguman ye. SS-31 bɛ gɛlɛyaw ni cogoyaw bɛɛ jira dusukunnabana furakɛli la banabagatɔw la minnu bɛ ni Barth ka bana ye. Kalan caman jaabiw b’a jira ko a bɛ se ka kɛ furakɛli ye banabagatɔw ma minnu bɛ ni Barth ka bana ye, kɛrɛnkɛrɛnnenya la ni dusukunnabana sɔrɔla. A bɛ se ka nɔ banbali bila dusukun tantanni taabolo la ani ka dɔɔni dɔɔni ani a jɔcogo la, a bɛ se ka kinibolo kiniyanfan dɛsɛlen in labɛncogo kura kɔsegin diɲɛ, selilɛri ani molekiyɔmu hakɛw ^la.

Dusukunnabana bangenen min bɛ sɔrɔ kɔnɔbara kelen na: 

Dusukunnabana bangenenw de ye bangekɔlɔsi fɛɛrɛw ye minnu ka teli ka kɛ bangekɔlɔsi fɛɛrɛw la, wa dusukunnabana jugumanba min bɛ sɔrɔ kɔnɔbara kelen na, o de ye den dusukun cili taamasiɲɛba ye, furakɛli suguya damadɔw bɛ sɔrɔ sisan. A jirala ko mitokondriyaw ka baarakɛbaliya bɛ denmisɛnniw dusukun na minnu bɛ ni dusukunnabana bangenen ye min bɛ sɔrɔ kɔnɔbara kelen fɛ, wa pepitiri SS-31 min ɲɛsinnen bɛ mitokondriyaw ma, o bɛ se ka dusukun mitokondriyaw baara ɲɛ. Sɛgɛsɛgɛli wɛrɛw ka kan ka kɛ fura in seko kan ka dusukun tantanni baara ɲɛ ani ka mɔgɔ cili taabolo bila kɔfɛ ^{[7] .}.

Leber ka ɲɛkisɛbanakisɛ ciyɛntalen: 

Sɛgɛsɛgɛli dɔ ye SS-31 tali farikolo yɔrɔ la, a lakanani, a muɲuni ani a nafa jateminɛ banabagatɔw furakɛli la minnu bɛ ni Leber ka ɲɛnaminibana ciyɛntalen ye. Jateminɛw y’a jira ko SS-31 tun bɛ muɲu kosɛbɛ, nka a ma se ɲɛnayeli nafa laban fɔlɔ la. Nka, ɲɛnayeli baara jateminɛni da wulilen janya waati la ani kɔfɛ sɛgɛsɛgɛli y’a jira ko ɲɛtaa bɛ dusu don mɔgɔ kɔnɔ cɛmancɛ ɲɛnayeli yɔrɔ cɛmancɛ la, o min bɛ ɲinini wɛrɛw ^wajibiya.

Ɲɛkisɛ-banakisɛ min bɛ mɔgɔ tɔɔrɔ: 

A jirala ko SS-31 (MTP-131), n’o ye tetarapɛtidi ye min ɲɛsinnen bɛ mitokondriyaw ma, n’a bɛ tali kɛ mitokondriyaw la, n’a bɛ kɛ ni etanercept ye, n’o bɛ kɛ ni tumor necrosis factor inhibitor etanercept ye, o bɛ se ka kɛ ɲɛda tangalan ye ɲɛda ɲɛgɛnɛsiraw la, ɲɛkisɛw tiɲɛni kɔfɛ sosow la. Etanercept walima MTP-131 min bɛ kɛ farikolo jukɔrɔ o dɔrɔn n’u faralen ɲɔgɔn kan, olu bɛɛ bɛ se ka dɔ fara ɲɛda ɲɛkisɛw ka ɲɛnamaya hakɛ kan, nka jɛɲɔgɔnya nɔ si ma ye ni u kɛra ɲɔgɔn fɛ^, .

Kɔkolo jogin : SS-31 (SS-31) ye pepitiri katiyɔni kasadiman kura ye min bɛ se ka joli ni kunsɛmɛ sira tigɛ hɔrɔnya la. Kɔlɔsiliw y’a jira ko SS-31 bɛ baarakɛcogo kɛnɛya sabati kɔkolo jogin kɔfɛ, a kɛtɔ ka cPLA2-mediated autophagic damage bali, ka dɔ fara lizozomu membrane permeability bali, ani ka piroptosis bali, wa a bɛ se ka kɛ kɛnɛyaso ^la.

Farikoloɲɛnajɛ ni hakiliɲagami: 

Sogo kɔrɔbaw la, lipopolysaccharide bɛ se ka farikolo funu ni farikolo funu bila mɔgɔ la, ani SS-31 bɛ se ka kɛ furakɛli la. Kɔlɔsiliw y’a jira ko ni hipokampus neuroinflammation balili tɛ se ka dɔ bɔ funu jaabi dɔrɔn na hippocampe kɔnɔ, nka a bɛ se ka hakili ka baarakɛcogo jɛɲɔgɔnya fana ɲɛ hipocampus ni yɔrɔw la. Furakɛli fɔlɔ min bɛ kɛ ni SS-31 ye, o bɛ nɔ banbali bila lipopolisaccharide ka farikolojidɛsɛ nɔ na ^{[12] .}.

Sugunɛbilenni min bɛ kɛ ni otosomali dominant polycystique ye: 

A jatera ko kɔnɔmaya bɛ kurukuruw taabolo juguya sugunɛbaralabana min bɛ wele ko autosomal dominant polycystic kidney disease. A jirala ko tetarapɛtidi SS-31 min bɛ mitokondriyaw tanga, o bɛ se ka sugunɛbana taabolo ɲɛ Pkd1^{RC/RC} sogo kɔnɔmaw la, ka sɔrɔ ka ERK1/2 fosforilasi dɔgɔya ani ka mitokondriyaw ka supercomplexes (mitokondriyaw supercomplexes) sɔrɔli ɲɛ. SS-31 bɛ se ka denso ni sinji tigɛ, ka denmisɛnninw ka sugunɛbaralabana jugumanba ɲɛnabɔ ka sɔrɔ a ma kɔlɔsi teratojeni walima a jugumanba la ^{[5] .}.

Bana minnu bɛ farikolojidɛsɛ furakɛ: 

SS-31 ye tetarapɛtidi fitinin ye min ɲɛsinnen bɛ mitokondriyaw ma, min ye furakɛli nɔ ni lakana jira bana suguya caman na minnu bɛ tali kɛ mitokondriyaw la. Banakisɛfagalanw na, SS-31 bɛ se ka mitokondriyaw ninakili fanga bonya, ka senfagabana mitokondriyaw ka biyojenisi baara kɛ ni mitokondriyaw ka biyojenizi ɲɛnabɔbagaw ni translocator factors ye, ka mitokondriyaw ka ɲɔgɔn sɔrɔcogo ɲɛ, ka mitokondriyaw farali bali, ka mitofaji caya, ka senfagabana oksidan degun dɔgɔya, ka senfagabana funu, ani ka farikolojidɛsɛ furakisɛw dalajɛli bali apoptose, ani ka senfagabana ɲɛnamaya siraw bonya. O la, SS-31 bɛ se ka farikolojidɛsɛbanaw ka taa ɲɛ ni a bɛ mitokondriyaw ninakili, ka biyojenɛsi, fusion ani senfagabana ɲɛnamaya siraw sabati, ka fara mitokondriyaw ka farali, oksidan degun, senfagabana, farikolojɔli dumuni baga dalajɛli, ani senfagabana apoptose ^bali.

Sarkopeni : A jirala ko dɔgɔkun 8 furakɛli ni SS-31 ye, o bɛ se ka fɛn dɔ kɔsegin fɛn dɔ la min bɛ sɔrɔ si hakɛ fɛ farikolojɔli fosforilasi la soso muso kɔrɔbaw kolotugudaw la, o bɛ bɛn ni kolotugudaw baara ɲɛnabɔli ye ani fɛn caman yeli ye farikolojɔli dumuniw S-glutathionylation ^la.

I n’a fɔ fura min ɲɛsinnen bɛ mitokondriyaw ma, SS-31 bɛ fɛɛrɛ kura di mitokondriyaw ka banaw furakɛli la. Ni a ye mitokondriyaw sigicogo n’u baara lakana, a ye nafa jira kɛnɛyaso la banaw la i n’a fɔ LHON ani Barth ka bana, kɛrɛnkɛrɛnnenya la, a bɛ nafa caman jira ɲɛkisɛw ka bana jugumanba la. A bɛ furakɛli kɛ bana suguya caman na minnu bɛ sɔrɔ mitokondriyaw ka baarakɛbaliya fɛ, i n’a fɔ dusukun tantanni ni farikolojidɛsɛbanaw, wa a bɛ se ka bana taamasiɲɛw lajɔ ani ka bana in taabolo bila kɔfɛ.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Daneshgar N ye dɔnnikɛla ŋana ye kalanko siratigɛ la, wa a ka kalanko baara ni Iowa Iniwɛrisite ani Oregon Etazini Iniwɛrisite cɛsirilen don kosɛbɛ. A ka ɲininiw ka bon ani u ka dun, u bɛ baara caman Kɛ i n’a fɔ mɔgɔkɔrɔbaw ni mɔgɔkɔrɔbaw ka kɛnɛyako, dusukun ni jolisiraw ni dusukunnakow, biyokimisi ni molekiyɔmuw ka ɲɛnamayako, selilɛriw ka ɲɛnamayako, ani kansɛri furakɛli. Mɔgɔkɔrɔbaw ni mɔgɔkɔrɔbaw ka kɛnɛyako siratigɛ la, Daneshgar N cɛsirilen don ka kɔrɔya kɛcogo ɲɛnamaw sɛgɛsɛgɛ ani ka fɛɛrɛ ɲumanw tigɛ banaw la minnu bɛ sɔrɔ kɔrɔya fɛ, a jigi b’a kan ka mɔgɔkɔrɔbaw ka ɲɛnamaya kɛcogo n’u ka kɛnɛya hakɛ ɲɛ ɲininiw sababu fɛ.

Dusukun ni jolisiraw ni dusukunnakow siratigɛ la, a bɛ ɲininibaw kɛ dusukunnabanaw sɔrɔcogo, u sɛgɛsɛgɛli fɛɛrɛw ani u furakɛli fɛɛrɛw kan, o bɛ kɛ sababu ye ka dusukunnabanaw kunbɛnni n’u furakɛ. Biyokimisi ni molekiyɔmu biologi siratigɛ la, a b’a sinsin biyomolekuliw jɔcogo, u baaracogo ani u ka ɲɔgɔnfaamu kan, ka ɲɛnamaya baara gundo jira molekiyɔmu siratigɛ la ani ka hakilinata basigi di banaw faamuyali n’u furakɛli ma. Kɔnɔnatumuw ka ɲɛnamayako siratigɛ la, Daneshgar N bɛ a sinsin seliluw jɔcogo, u baarakɛcogo ani u ka ɲɛnamaya kɛcogo sariyaw kan, ka taabolo jɔnjɔnw sɛgɛsɛgɛ i n’a fɔ selilu taamasiɲɛw cili ani selilɛriw ka taamacogo ɲɛnabɔli, o bɛ taamasiyɛn nafamaw di banaw selilɛriw ka baarakɛcogo kalanni ma. Kansɛri furakɛli siratigɛ la, a cɛsirilen don ɲininiw la minnu bɛ kɛ tumuw sɔrɔli n’u yiriwali fɛɛrɛw kan, ka fara tumuw sɛgɛsɛgɛli n’u furakɛli kan, ka tumuw dɔnni taamasiɲɛw sɛgɛsɛgɛ joona ani furakɛli laɲini kura minnu bɛ kɛ tumuw kan, o bɛ jigiya kura lase tumu banabagatɔw ma. Daneshgar N tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [5].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Nhu N. T., Xiao S., Liu Y., ani a ɲɔgɔnnaw. Tetarapɛtidi Elamipretide fitinin min ɲɛsinnen bɛ mitokondriyaw ma, o ka farikolo lakanani nɔw hakiliɲagami na[J]. Dancɛw ni hakiliɲagami dɔnniya jɛlen ye, 2022,15.DOI:10.3389/fnint.2021.747901.

[2] Sabbah H N. Elamipretide for Barth syndrome cardiomyopathy: kuran sira dɛsɛlen jɔli dɔɔni dɔɔni[J]. Dusukun tantanni lajɛw, 2022,27(5):1911-1923.DOI:10.1007/s10741-021-10177-8.

[3] Daubert M. A., Yow E., Dunn G., ani mɔgɔ wɛrɛw. Peptide kura min bɛ mitokondriyaw laɲini dusukun tantanni furakɛli la Elamipretide ka sɛgɛsɛgɛli kɛcogo la min kɛra ni furakisɛ ye[J]. Circulation-Dusukun tantanni, 2017,10(12).DOI:10.1161/CIRCHEARTFAILURE.117.004389.

[4] Patel N, Johnson M. A., Vapniarsky N, ani a ɲɔgɔnnaw. Elamipretide bɛ joli-sira-funu-sɔgɔsɔgɔninjɛ nɔgɔya donsokɛ ka joli-sira-funu modɛli la[J]. Dɔnniya kunnafoniw, 2023,13(1).DOI:10.1038/s41598-023-31374-5.

[5] Daneshgar N, Liang P, Lan R. S., ani mɔgɔ wɛrɛw. Elamipretide furakɛli kɔnɔmaya waati bɛ sugunɛbaralabana polisisitiki ɲɛtaa nɔgɔya denba ni den bangenen sogow la minnu ka PKD1 fɛn falen bɛ u la[J]. Sugunɛ diɲɛ kɔnɔ, 2022,101(5):906-911.DOI:10.1016/j.kint.2021.12.006.

[6] Chatfield KC, Sparagna G. C., Chau S., ani a ɲɔgɔnnaw. Elamipretide bɛ Mitokondriyaw ka baara ɲɛ hadamaden dusukun na min bɛ dɛsɛ[J]. Jacc-Basic ka bamanankan baarakɛcogo dɔnniya, 2019,4(2):147-157.DOI:10.1016/j.jacbts.2018.12.005.

[7] Garsiya A, Jonscher R, Sparagna G, ani mɔgɔ wɛrɛw. Elamipretide bɛ dusukun mitokondriyaw baara ɲɛ ka taa a fɛ denmisɛnniw na minnu dusukunnabana bɛ u la[J]. Dusukun tantanni gafe, 2023,29(4):661.

[8] Miyamoto S, Zhang G, Hall D, ani mɔgɔ wɛrɛw. Mitokondriyaw ka superoxyde hakɛ seginni ni elamipretide (MTP-131) ye, o bɛ db/db sogow tanga sukarodunbana sugunɛbana ka taa ɲɛ.[J]. Ɲɛnamaya kɛcogo ɲuman gafe, 2020,295(21):7249-7260.DOI:10.1074/jbc.RA119.011110.

[9] Karanjia R, Coupland S. G., Garsia M., ani mɔgɔ wɛrɛw. Elamipretide (MTP-131) Ɲɛkisɛ fura min bɛ kɛ ɲɛda la walasa ka Leber ka ɲɛkisɛw furakɛcogo ciyɛntalen furakɛ[J]. Ɲɛdɔgɔtɔrɔso sɛgɛsɛgɛli & ɲɛnayeli dɔnniya, 2019,60(9).

[10] Tse B. C., Dvoriantchikova G., Tao W., ani mɔgɔ wɛrɛw. Furakɛli min ɲɛsinnen bɛ mitokondriyaw ma ni elamipretide (MTP-131) ye, o ye dɛmɛ ye min bɛ kɛ ka tumo necrosis factor inhibition (tumu necrosis factor inhibition) kɛ ɲɛda-la-banakisɛ jugumanba la sigida jugumanba la[J]. Ɲɛ ɲinini kɔlɔsili, 2020,199.DOI:10.1016/j.exer.2020.108178.

[11] Zhang H, Chen Y, Li F, ani mɔgɔ wɛrɛw. Elamipretide bɛ piroptose nɔgɔya kɔkolo joginlen na ni bɔnɛ ye, a kɛtɔ ka cPLA2-induite lysosomal membrane permeabilization bali[J]. Journal of neuroinflammation, 2023,20(1).DOI:10.1186/s12974-023-02690-4.

[12] Liu Y, Fu H, Wu Y, ani a ɲɔgɔnnaw. Elamipretide (SS-31) bɛ baarakɛcogo ɲɛ ka taa a fɛ Hippocampus ni yɔrɔ wɛrɛw la minnu bɛ tali kɛ a la, ka tugu farikolojidɛsɛ kuntaalajan kɔfɛ min bɛ sɔrɔ Lipopolysaccharide fɛ wulu kɔrɔbaw la[J]. Danyɔrɔw kɔrɔya hakililata la, 2021,13.DOI:10.3389/fnagi.2021.600484.

[13] Campbell M. D., Martin-Perez M., Egertson J. D., ani a ɲɔgɔnnaw. Elamipretide nɔ minnu bɛ kolotugudaw fosifoporotɛyɔmu la soso musoman kɔrɔbaw la[J]. Geroscience, 2022,44(6):2913-2924.DOI:10.1007/s11357-022-00679-0. Bamako, Mali.

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Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.