|
1kits (Ebipipa 10) .
| Omuwendo: | |
|---|---|
▎ ya Epitalon Enzimba
Ensibuko: PubChem |
Omutendera: Ala-Glu-Asp-Gly Ensengekera ya molekyu: C 14H 22N 4O9 Obuzito bwa molekyu: 390.35 g/mol Ennamba ya CAS: 307297-39-8 Ekitabo kya PubChem CID: 219042 Ebigambo ebifaanagana: Epithalon |
▎ Epitalon Okunoonyereza kwa
Epitalon y’akola mu kunoonyereza kuliwa?
Mu myaka gya 1980, ekibinja ky’abanoonyereza okuva mu Russia nga bakulemberwa Vladimir Khavinson baasooka okuzuula Epitalon1 [1] . Epitalon ye peptide ennyimpi ekoleddwa nga erimu amino asidi nnya: alanine, glutamic acid, aspartic acid, ne glycine. Okusengejja kwayo kwesigamiziddwa ku peptide epithalamion ey’obutonde eggyibwa mu nseke ya pineal. Epitalon kirowoozebwa nti erina ebikolwa ebiziyiza obuwuka obuleeta obulwadde okugeraageranyizibwa ku bya melatonin era eyinza okuba n’omugaso ogw’okwongera ku bulamu [2] . Abanoonyereza bakizudde nti Epitalon esobola okusitula emirimu gya telomerase. Telomerase ye enzyme esobola okukuuma n’okugaziya telomeres ku nkomerero za chromosomes. Abantu bwe bakaddiwa, telomeres zikendeera, ekikwatagana n’endwadde eziva ku myaka n’obulamu obutono. Nga esitula emirimu gya telomerase, Epitalon eyinza okuyamba okugaziya telomeres, bwe kityo n’ekendeeza ku nkola y’okukaddiwa n’okuziyiza endwadde ezeekuusa ku kukaddiwa [1] . Okunoonyereza okumu kulaga nti Epitalon eyinza okwenyigira mu kulungamya okwolesebwa kw’obuzaale bwa CCL11 ne HMGB1 era n’ekola ng’ekola ng’ekola ku kwolesebwa kw’obuzaale buno. Mu kiseera kye kimu, dipeptide vilon (Lys-Glu) ne tetrapeptide Epitalon (Ala-Glu-Asp-Gly) ziyinza okukola ebikolwa byabwe eby’okulwanyisa okukaddiwa nga ziziyiza obuzaale buno. Okugatta awamu, Epitalon ne vilon bimanyiddwa okulungamya okulaga kw’obuzaale n’okusengejja obutoffaali, okutumbula okukendeeza ku kufa n’okukendeeza ku nkula y’endwadde mu bakadde [3] . Mu kiseera kino, okunoonyereza ku Epitalon okusinga kwesigamye ku mutendera gw’okugezesa ebisolo, era obulungi bwayo obw’ekiseera ekiwanvu n’obukuumi mu bantu tebinnaba kutegeerekeka mu bujjuvu. Wadde ng’okunoonyereza okumu ku bisolo kutuuse ku bivuddemu ebizzaamu amaanyi, gamba nga mu biwuka, Epitalon ekwatagana n’obulamu obuwanvu n’obulamu obulungi, okukozesebwa kw’ebivuddemu bino mu bantu kukyakwetaagisa okwongera okunoonyereza [1]..
Enkola ki ey’okukola kwa Epitalon mu kisaawe ky’okulwanyisa okukaddiwa?
Okukendeeza ku mutindo gw’ebika bya oxygen ebikola:
Ebika bya oxygen ebikola (ROS) bikola kinene mu nkola y’okukaddiwa kw’enkwaso. ROS eyitiridde ejja kuleeta okwonooneka kw’enkwaso (oxidative damage), okukosa omutindo gwazo n’obusobozi bwazo obw’okukula. Okunoonyereza kulaga nti Epitalon esobola okukendeeza ku sipiidi y’okukutukakutuka kw’obutoffaali obuyitibwa oocytes obuva ku kukaddiwa n’ebirimu ebika bya oxygen ebikola mu butoffaali [2] . Ng’ekirungo ekiziyiza obuwuka obuleeta obulwadde, Epitalon esobola okumalawo ROS mu butoffaali n’okukendeeza ku kwonooneka kwayo eri enkwaso. Okusingira ddala, kiyinza okutuukibwako mu ngeri bbiri zino wammanga: Esooka, okusenya butereevu ROS. Epitalon eyinza okuba n’obusobozi okukola butereevu ne ROS n’agikyusa mu bintu ebitali bya bulabe. Ekyokubiri, okutumbula emirimu gy’enziyiza eziziyiza obuwuka obuleeta obulwadde. Epitalon eyinza okusitula emirimu gy’enziyiza eziziyiza obuwuka obuleeta obulwadde mu butoffaali, nga superoxide dismutase (SOD), catalase (CAT), n’ebirala Enziyiza zino zisobola okuyamba okusaanyawo ROS n’okukuuma bbalansi ya redox mu butoffaali.
Okulongoosa enkola ya mitochondrial:
Mitochondria zikola kinene mu nkyukakyuka y’amasoboza n’okuwangaala kw’obutoffaali bw’enkwaso. Nga enkwaso zikaddiwa, enkola ya mitochondria ejja kukendeera mpolampola, nga yeeyolekera ng’okukendeera mu busobozi bw’oluwuzi lwa mitochondrial n’okukendeera mu muwendo gwa kkopi ya DNA ya mitochondrial. Epitalon esobola okwongera ku busobozi bw’oluwuzi lwa mitochondrial n’omuwendo gwa copy ya DNA ya mitochondrial [2] . Kino kiyamba okulongoosa amaanyi g’enkwaso n’okukuuma emirimu gya bulijjo egy’omubiri egy’obutoffaali. Enkola entongole ey’okukola eyinza okuli: Ekisooka, okwongera ku busobozi bw’oluwuzi lwa mitochondrial. Okukuuma obusobozi bw’oluwuzi lwa mitochondria kikulu nnyo ku nkola eya bulijjo eya mitochondria. Epitalon eyinza okwongera ku busobozi bw’oluwuzi lwa mitochondria nga etereeza emikutu gya ion oba okutambuza obutoffaali ku luwuzi lwa mitochondria, okutumbula obusobozi bw’okukola amaanyi ga mitochondria. Ekyokubiri, okwongera ku muwendo gwa kkopi za DNA ya mitochondrial. Okwongera ku muwendo gwa kkopi ya DNA ya mitochondria kiyinza okulongoosa obusobozi bw’okusengejja mitochondria n’okuwa amaanyi amangi eri obutoffaali. Epitalon eyinza okwongera ku muwendo gwa kkopi za DNA ya mitochondrial nga etumbula okukoppa kwa DNA ya mitochondrial oba okukendeeza ku kuvunda kwayo.
Okukendeeza ku nkula ya spindle etali ya bulijjo n’exocytosis etali ya bulijjo ey’obutundutundu bw’omubiri (cortical granules):
Mu kiseera ky’okukaddiwa kw’enkwaso, emigerageranyo gy’enkula y’enkwaso etali ya bulijjo n’ensengekera y’obutoffaali obutali bwa bulijjo ey’obutundutundu bw’omubiri (cortical granules) gijja kweyongera, ekijja okukosa obusobozi bw’okuzaala n’okukula kw’embuto z’enkwaso. Epitalon esobola okukendeeza ku migerageranyo gy’enkula ya spindle etali ya bulijjo n’exocytosis etali ya bulijjo ey’obutundutundu bw’omubiri (cortical granules) [2] . Kino kiyinza okuba nga kiva ku nkola y’okulungamya eya Epitalon ku kutebenkera kw’amagumba g’obutoffaali n’oluwuzi lw’obutoffaali: Ekisooka, okutebenkeza ensengekera ya spindle. Ekiwujjo (spindle) nsengekera nkulu mu nkola y’okugabanya obutoffaali, era enkula yaakyo etali ya bulijjo ejja kuleeta okwawukana kwa chromosome okutali kwa bulijjo era ekose enkula y’enkwaso. Epitalon eyinza okutebenkeza ensengekera ya spindle nga etereeza polymerization ne depolymerization ya tubulin, okukendeeza ku kubeerawo kw’enkula etali ya bulijjo. Ekyokubiri, okukuuma obutebenkevu bw’obutundutundu obuyitibwa cortical granules. Cortical granules zikola kinene mu nkola y’okuzaala enkwaso. Epitalon eyinza okukuuma obutebenkevu bw’obutundutundu bw’omubiri (cortical granules) nga etereeza okuyita kw’oluwuzi lw’obutoffaali oba obubonero bwa calcium ion, okukendeeza ku kubeerawo kw’obusimu obuyitibwa exocytosis obutali bwa bulijjo.
Okukendeeza ku bubonero bwa apoptosis:
Mu kiseera ky’okukaddiwa kw’enkwaso, obubonero bwa apoptosis bujja kweyongera, ekivaamu okufa kw’obutoffaali. Epitalon esobola okukendeeza ku muwendo omulungi ogw’okusiiga Annexin V n’amaanyi g’okumasamasa ga γH2AX mu nkwaso ezikaddiye mu vitro [2] . Kino kiraga nti Epitalon esobola okukendeeza ku apoptosis y’enkwaso. Enkola entongole eyinza okuli: Ekisooka, okuziyiza ekkubo ly’obubonero bwa apoptosis. Epitalon eyinza okuziyiza okutambuza obubonero bwa apoptosis nga etereeza obutoffaali obukulu mu kkubo ly’obubonero bwa apoptosis, nga puloteyini z’amaka ga Bcl-2 ne puloteyini z’amaka ga caspase, n’okukendeeza ku kufa kw’obutoffaali. Ekyokubiri, okukuuma obutebenkevu bw’ensengekera y’obutonde (genomic stability). γH2AX kye kimu ku biraga nti DNA eyonoonese. Epitalon eyinza okukuuma obutebenkevu bwa genomic nga ekendeeza ku kwonooneka kwa DNA n’okukendeeza ku bubonero bwa apoptosis.
Epitalon yakuuma obulungi bwa spindle obwa bulijjo n’okusaasaana kwa CGs.
Ensibuko:PubMed [2] .
Engeri ki entongole Epitalon gy’ekola mu kujjanjaba endwadde z’obusimu?
Okulungamya enkola y’abaserikale b’omubiri:
Okunoonyereza kulaga nti Epitalon esobola okukosa abaserikale b’omubiri mu mbeba mu mbeera ez’enjawulo ez’okunyigirizibwa. Mu maaso g’okunyigirizibwa kw’okukyusakyusa okusitula abaserikale b’omubiri n’okunyigirizibwa okugatta obusimu obuziyiza endwadde, Epitalon esobola okwongera ku mirimu gy’okukula kw’obutoffaali bwa thymocytes [4] . Kino kitegeeza nti Epitalon eyinza okutumbula obusobozi bw’omubiri okuziyiza endwadde z’obusimu ng’etereeza abaserikale b’omubiri. Okukula kw’obutoffaali obuyitibwa thymocytes kukwatagana nnyo n’enkola y’abaserikale b’omubiri, era abaserikale b’omubiri bakola kinene mu kubaawo n’okukula kw’endwadde z’obusimu. Ng’ekyokulabirako, endwadde ezimu ezikendeeza ku busimu ziyinza okuba nga zeekuusa ku kukola oba obutakola bulungi kw’abaserikale b’omubiri mu ngeri etaali ya bulijjo. Ekikolwa kya Epitalon ekitumbula ku kweyongera kw’obutoffaali obuyitibwa thymocytes kiyinza okuyamba okukuuma bbalansi y’abaserikale b’omubiri, bwe kityo ne kikendeeza ku bubonero bw’endwadde z’obusimu.
Enkola ku kkubo ly’okukyusa obubonero:
Epitalon erina ekikolwa eky’okulungamya ku kkubo ly’okukyusa obubonero bwa interleukin-1β (IL-1β). Okusingira ddala, Epitalon esobola okwongera ku synergistic effect ya IL-1β n’okukosa emirimu gy’enziyiza enkulu mu ceramide signal transduction ekkubo mu cerebral cortex membrane, okuge membrane neutral sphingomyelinase (nSMase) [4] . IL-1β ye cytokine enkulu eyenyigira mu nkola ez’enjawulo ez’omubiri n’endwadde. Mu ndwadde ezikendeera kw’obusimu, okwolesebwa okutali kwa bulijjo okwa IL-1β kuyinza okuvaako okuzimba obusimu n’okwonooneka kw’obusimu. Nga etereeza ekkubo ly’okukyusa obubonero bwa IL-1β, Epitalon eyinza okukendeeza ku kuzimba kw’obusimu n’okukuuma obusimu obutafuna kwonooneka. Okugatta ku ekyo, enkyukakyuka mu nkola ya nSMase nazo zeekuusa ku ndwadde ezikendeeza ku busimu. Okulungamya emirimu gya nSMase nga Epitalon kuyinza okuyamba okukuuma enkola eya bulijjo ey’obutoffaali bw’obusimu.Mu kumaliriza, engeri Epitalon gy’ekola mu kujjanjaba endwadde z’obusimu eyinza okuzingiramu okulungamya abaserikale b’omubiri n’okulungamya ekkubo ly’okukyusa obubonero. Wabula okunoonyereza okuliwo kati ku Epitalon mu kujjanjaba endwadde z’obusimu kukyali mu mutendera ogusookerwako, era okunoonyereza okulala kwetaagibwa okukakasa obulungi bwayo n’obukuumi bwayo.
Enkulaakulana y’okunoonyereza eya Epitalon
Enkosa ku mutindo gw’enkwaso
Okulwawo okukaddiwa kw’enkwaso:
Okunoonyereza mu kugezesa mu vitro kuzudde nti Epitalon esobola okukendeeza ku mutindo gw’ebika bya oxygen ebikola mu butoffaali (ROS) mu nkwaso z’ebibe ezikaddiye oluvannyuma lw’okuggyamu eggi. Oluvannyuma lw’ekiseera, obusobozi bw’enkula y’enkwaso bujja kukendeera mpolampola oluvannyuma lw’okufulumya eggi mu vivo oba mu vitro. Nga peptide ennyimpi ey’obutonde, Epitalon ekola okufaananako ne melatonin era nga ye antioxidant ennungi, ekiyinza okuba n’omugaso ogw’okwongera ku bulamu. Obujjanjabi ne Epitalon bwakendeeza nnyo ku mirundi gy’obulema mu spindle n’okusaasaana okutali kwa bulijjo okw’obutundutundu bw’omubiri (cortical granules) mu ssaawa 12 n’essaawa 24 ez’okukaddiwa, era mu kiseera kye kimu ne kyongera ku busobozi bw’olususu lw’emitochondrial n’omuwendo gw’okukoppa DNA ya mitochondrial, bwe kityo ne kikendeeza ku apoptosis y’enkwaso mu ssaawa 24 ez’okukaddiwa mu vitro. Ebivudde mu kunoonyereza kuno biraga nti Epitalon esobola okulwawo enkola y’okukaddiwa kw’enkwaso mu vitro ng’etereeza emirimu gya mitochondria n’emiwendo gya ROS [2]..
Okulongoosa omutindo gw’enkwaso:
Okwongera 0.1 mM ya Epitalon mu kifo eky’okukuza mu kisenge ekitali kya bulijjo kiyinza okukendeeza ku sipiidi y’okukutuka kw’obutoffaali mu bitundu by’omubiri ebiyitibwa parthenogenetic activation of oocytes ekiva ku kukaddiwa mu vitro oluvannyuma lw’okuggyamu eggi, okukendeeza ku migerageranyo gy’enkula ya spindle etali ya bulijjo n’exocytosis etali ya bulijjo eya cortical granules, okwongera ku mitochondrial membrane potential n’omuwendo gwa mitochondrial DNA, n’okukendeeza ku positive omutindo gw’okusiiga Annexin V n’amaanyi g’okumasamasa ga γH2AX mu nkwaso ezikaddiye mu vitro. Kino kiraga nti Epitalon esobola okulongoosa obuzibu bw’ebitundu by’omubiri mu kiseera ky’okukaddiwa mu kisenge ky’enkwaso (in vitro aging process) n’okulongoosa omutindo gw’enkwaso (Xue Yue).
Enkosa ku njawulo y’obutoffaali bw’obusimu
Okunoonyereza kuzudde nti AEDG peptide (Epitalon) esobola okwongera ku kusengejja obubonero bw’enjawulo mu busimu mu butoffaali obusibuka mu bitundu by’omubiri ebiyitibwa gingival mesenchymal stem cells z’omuntu, nga Nestin, GAP43, β Tubulin III, ne Doublecortin. Enkola z’okugezesa molekyu ziraga nti Epitalon esinga kwesiba ku H1/6 ne H1/3 histones, ekiyinza okuba emu ku nkola ez’okwongera ku kuwandiika kw’obuzaale buno obw’enjawulo mu busimu [5]..
Enkola y’okulungamya ku nkola y’obusimu
Okulungamya emirimu gy’obusimu:
Okuyita mu kunoonyereza ku nvunza, kizuuliddwa nti okufuyira Epitalon mu nnyindo (2 ng) kuyinza okukola ennyo emirimu gy’obusimu bw’omubiri gw’obwongo bw’envunza mu ddakiika ntono, era emirundi gy’okukuba amasasi egy’obusimu gyeyongera emirundi 2 - 2.5 [6] . Mu bimu ku bikwata, eby’okuddamu ebizibu ebirimu emitendera egiwerako nabyo byalabibwa. Okweyongera kw’emirimu egy’okwekolako egy’obusimu obuyitibwa neurons nga Epitalon kiva ku mirundi mingi egya yuniti ezikola edda n’okwetaba kw’obutoffaali obwali busirise emabegako. Waakiri omutendera ogusooka ogw’ekikolwa kya Epitalon guyinza okunnyonnyolwa olw’engeri peptide eno gy’ekwata obutereevu ku butoffaali bw’ekitundu ky’omubiri ekiyitibwa motor cortex.
Ekikolwa eky’okukuuma situleesi:
Epitalon erina ekikolwa eky’okukuuma situleesi ku mbeba ezikwatibwa embeera za situleesi ez’enjawulo. Okugezesa kulaga nti Epitalon ayongera ku mirimu gy’okukula kw’obutoffaali obuyitibwa thymocytes. Ka kibe nti eyongezebwa wansi w’okunyigirizibwa okw’okukyusakyusa okusitula abaserikale oba okuziyizibwa wansi w’okunyigirizibwa okugatta obusimu obuziyiza endwadde, Epitalon esobola okukola omulimu gw’okulungamya (Vladimir Kh Khavinson, 2002). Mu kiseera kye kimu, Epitalon era esobola okwongera ku synergistic effect ya interleukin-1β (IL-1β) era erina impact ku nkyukakyuka mu mirimu gya sphingomyelinase (nSMase) mu cerebral cortex membrane ereetebwa stress. Kino kiraga nti Epitalon erina ekikolwa eky’okukuuma situleesi ku ddaala ly’okukyusa obubonero bwa IL-1β mu kkubo lya sphingomyelin ne ku ddaala ly’okukula kw’obutoffaali obugendereddwamu mu bitundu by’obusimu.
Enkosa ku nkola y’endocrine y’ebisolo ebitali bantu:
Mu nkimye za rhesus enkadde, Epitalon esobola okukendeeza ku muwendo gwa glucose ne insulin mu musingi n’okwongera ku muwendo gwa melatonin ogw’ekiro ogwa basal. Mu kiseera kye kimu, Epitalon esobola okukendeeza ku kitundu wansi w'enkulungo y'okuddamu kwa glucose mu plasma, okwongera ku kigero kya 'okubula' kwa glucose, n'okuzza enkola ya insulini mu plasma eya bulijjo mu kuddamu okuweebwa glucose. Kino kiraga nti Epitalon nsonga esuubiza okuzzaawo obutakola bulungi bwa endocrine obuva ku myaka mu primates [7]..
Okusobola okukozesebwa kwa Epitalon mu kujjanjaba endwadde z’obusimu
Obulwadde bwa Alzheimer: Obulwadde bwa Alzheimer bulwadde bwa bulijjo obukendeeza ku busimu, okusinga bumanyiddwa olw’okukendeera kw’enkola y’okutegeera n’okubulwa okujjukira. Okunoonyereza okuliwo kati kulaga nti obulwadde bwa Alzheimer bukwatagana n’okukosa enjawulo y’obusimu. Omuwendo gw’obutoffaali obusibuka mu busimu mu bwongo bw’abalwadde b’obulwadde bwa Alzheimer gukendeera, era n’obusobozi bwabwo obw’okwawula nabwo buziyizibwa. Epitalon eyinza okutumbula okukula n’okwawukana kw’obutoffaali obusibuka mu busimu, okwongera ku muwendo gw’obusimu obuyitibwa neurons, n’okulongoosa enkola y’okutegeera kw’abalwadde b’obulwadde bwa Alzheimer. Okugatta ku ekyo, Epitalon era eyinza okulung’amya okufulumya kw’obusimu obutambuza obusimu, okulongoosa okujjukira n’okuyiga kw’abalwadde b’obulwadde bwa Alzheimer [8]..
Obulwadde bwa Parkinson: Obulwadde bwa Parkinson bulwadde obukendeeza ku busimu obusinga okumanyibwa olw’obuzibu bw’enkola y’emirimu. Ekintu kyayo ekikulu eky’obulwadde kwe kufiirwa obusimu obuyitibwa dopaminergic neurons mu substantia nigra. Enkola z’obujjanjabi eziriwo kati okusinga zikendeeza ku bubonero nga zigatta ku dopamine oba okuziyiza okuvunda kwa dopamine, naye enkola zino teziyinza kuyimiriza kukula kw’obulwadde. Okusimbuliza obutoffaali obusibuka mu busimu (neural stem cell transplantation) nkola eyinza okujjanjaba, naye ensibuko n’obusobozi bw’okwawula obutoffaali obusibuka mu busimu bukyali kizibu. Epitalon eyinza okutumbula okukula n’okwawukana kw’obutoffaali obusibuka mu busimu, okwongera ku muwendo gw’obusimu obukola dopaminergic, n’okulongoosa enkola y’enkola y’emirimu gy’abalwadde b’obulwadde bwa Parkinson [8]..
Stroke n’obuvune ku bwongo: Sstroke bulwadde bwa bulijjo obw’emisuwa gy’obwongo, era ekisinga okuvaamu kwe kufa kw’obusimu obuyitibwa neurons n’obusimu obutakola bulungi. Obuvune ku bwongo era buyinza okuvaako obusimu obuyitibwa neurons okufiirwa n’obutakola bulungi. Obutoffaali obusibuka mu busimu bukola kinene mu kuddaabiriza n’okuddamu okukola oluvannyuma lw’okusannyalala n’okulumwa obwongo. Epitalon eyinza okutumbula okukula n’okwawukana kw’obutoffaali obusibuka mu busimu, okwongera ku muwendo gw’obusimu, n’okulongoosa enkola y’obusimu bw’abalwadde ba stroke n’obuvune ku bwongo [8]..
Mu kumaliriza, nga tetrapeptide ey’obutonde, enkola enkulu ey’okulwanyisa okukaddiwa eya Epitalon eri mu kukola kw’okwolesebwa kw’obuzaale bwa telomerase reverse transcriptase subunit (TERT), okugaziya obuwanvu bwa telomeres n’okukuuma emirimu gya telomerase, bwe kityo n’eyingira mu nkola enkulu ey’okukaddiwa kw’obutoffaali. Amakulu gaayo gali mu kusooka okutegeera okuyingira mu nsonga z’okulwanyisa okukaddiwa okuva mu ndowooza y’ebiramu bya telomere, okumenyawo ekkomo ly’ebirungo ebiziyiza obuwuka eby’ennono ebigenderera ebirungo ebiziyiza obuwuka zokka, n’okuwa ekigendererwa ekipya eky’okulwawo endwadde ezeekuusa ku myaka ng’obulwadde bwa Alzheimer n’endwadde z’emisuwa. Newankubadde obukuumi bwayo obw’ekiseera ekiwanvu (naddala obulabe bwa kookolo) bukyalina okukakasibwa mu kugezesebwa okw’omutendera III, ng’enkola y’okunoonyereza n’okukulaakulanya eddagala erisooka eriziyiza okukaddiwa ery’ekika kya telomerase activator, eraga enkyukakyuka ey’amaanyi mu kuyingira mu nsonga z’okukaddiwa okuva ku kulongoosa obubonero okutuuka ku kulungamya enkola ya molekyu era kisuubirwa okutumbula okwongezaayo obulamu bw’omuntu.
Ebikwata ku Muwandiisi
Ebintu ebyogeddwako waggulu byonna binoonyerezeddwako, birongooseddwa era ne bikung’aanyizibwa kkampuni ya Cocer Peptides.
Omuwandiisi w’ekitabo kya Scientific Journal Vladimir Khavinson mukugu mu by’obutonde omututumufu mu Russia era omukugu mu kunoonyereza ku bikwata ku biramu ebiyitibwa peptide bioregulator. Ye Dayirekita w’ekitongole kya St. Petersburg Institute of Bioregulation and Gerontology era mmemba mu ttendekero ly’ebyobujjanjabi erya Russia. Khavinson akoze kinene mu mulimu gw'okunoonyereza ku kukaddiwa era awandiise ebitabo bingi mu bitabo ebimanyiddwa nga 'Molecular Biology of Aging' ne 'Journal of Anti-Aging Medicine'. Omulimu gwe okusinga gussa essira ku kukola n’okukozesa peptide bioregulators okulwanyisa endwadde ezeekuusa ku myaka n’okulongoosa obulamu. Okunoonyereza kwa Khavinson kubadde kwa maanyi mu by’obukadde, nga kuwa amagezi amapya n’enkola z’obujjanjabi ku kukaddiwa okulamu. Vladimir Khavinson awandiikiddwa mu kiwandiiko ekijuliziddwa [5].
