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1kits （10Ibikoresho）
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CagrilintideStructure Imiterere ya
Inkomoko: PubChem |
Urukurikirane: Pyr-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP CAS: 1415456-99-3 Inzira: C 174H 269N 45O 52S.2 MW 4409 g / mol |
Research Ubushakashatsi bwa Cagrilintide
Ni ubuhe bushakashatsi bwakozwe na Cagrilintide?
Cagrilintide ni amyline ebyiri na calcitonine reseptor agonist (DACRA) yakozwe ishingiye kumiterere ya amylin. Amylin isohorwa na pancreatic islet β selile kandi ikorana na insuline kugirango ikore imirimo itandukanye. Irashobora gutera ibyiyumvo byo guhaga no kugabanya gufata ibiryo, cyane cyane mugukora reseptors mukarere ka postrema munsi yumushinga wa kane. Ibimenyetso by'imitsi byanduzwa imbere yimbere binyuze muri nucleus yinzira yonyine kandi birashobora no kwanduzwa mukarere ka hypothalamic hamwe nandi matsinda ya kirimbuzi binyuze muri nucleus ya parabrachial, bityo bigashimisha ikigo gihaza kandi bikabuza gufata ibiryo [1] . Amylin irashobora kandi kugenga glucose homeostasis mukurinda gusohora kwa insuline na glucagon kugirango ikomeze glucose yamaraso [2] . Muburyo bukubiyemo harimo ingaruka itaziguye ku kirwa cya pancreatic islet α selile no kugenzura mu buryo butaziguye ururenda rwa glucagon binyuze mu bimenyetso by'imitsi muri hypothalamus. Ku barwayi bafite metabolisme, gusenya β selile bituma igabanuka rya amyline. Amylin agira uruhare mu kugena glucose homeostasis mu kubuza gusiba gastrica no kubyara hepatike glucose nyuma yo kugabanuka, kugabanya ihindagurika ryamaraso ya glucose nyuma yinyuma. Irashobora kandi gutinza ubusa gastrica, ikabuza gastrointestinal peristalsis, kongera igihe cyo gutura ibiryo, kandi ikarinda kwiyongera gukabije kwamaraso glucose. Nyamara, igice gito cyubuzima bwa amylin karemano igabanya ikoreshwa ryayo. Nubwo pramlintide iboneka nkumuti wongeyeho, bisaba inshinge eshatu kumunsi, ntibyoroshye kandi bikavamo kutubahiriza nabi [3] . Kugira ngo iki kibazo gikemuke, Cagrilintide yatejwe imbere. Ubushakashatsi niterambere ryayo bishingiye ku gusobanukirwa byimbitse kumikorere ya physiologique ya amyline karemano, igamije kwigana uburyo bwayo bwibikorwa mugihe hagamijwe kunoza imiterere n’imikorere myinshi yibiyobyabwenge kugirango bikemure ivuriro.
Cagrilintide ni iki?
Cagrilintide nigitabo kimaze igihe kinini kigereranya amylin igereranya kandi ifite imbaraga nyinshi, imaze kwerekana imbaraga zambere mukuvura umubyibuho ukabije na metabolism. Yashizwemo amavuta kandi ifite imiterere ihamye kandi ikora igihe kirekire [3] . Amylin arekurwa hamwe na insuline na selile pancreatic β selile kandi bigatera kumva uhaze ukora mukarere ka homeostatike kandi kunezeza ubwonko. Nkikigereranyo, Cagrilintide irashobora kwigana izi ngaruka, itera guhaga kugirango ifashe kugenzura ibiro byumubiri. Muri icyo gihe, nka amyline ebyiri na calcitonine reseptor agonist (DACRA), ikomoka mu mugongo wa amylin kandi ifite uburyo bwihariye mu kugenzura metabolike.
Imiterere yuburyo bwa Cagrinlintide
Inkomoko: Byatangajwe [3]
Nibihe bikorwa bifitanye isano na Cagrilintide?
Mu bigeragezo bivura, Cagrilintide yageze ku musaruro mwiza mu kugabanya ibiro. Kurugero, muri multicenter, idahwitse, impumyi ebyiri, igenzurwa na platbo, kandi igereranya igereranya Icyiciro cya 2 ikigereranyo cyo gushakisha ikigereranyo, ugereranije nitsinda rya placebo, impuzandengo yikigereranyo cyo kugabanya ibiro kuva kuri buri tsinda rya dose ya Cagrilintide (0.3 - 4.5 mg) (6.0% - 10.8%) yari hejuru kurenza iyo mumatsinda ya placebo (3.0%). Kugabanuka ibiro mu itsinda rya 4.5 mg nabyo byari byinshi kuruta ibyo mu itsinda rya liraglutide 3.0 mg (10.8% na 9.0%), byerekana ko bishobora kuba uburyo bwiza bwo gucunga ibiro [4] . Cagrilintide ifite uburyo butandukanye ariko bujyanye nibikorwa ugereranije na GLP-1 reseptor agonist semaglutide. Semaglutid igabanya ubushake bwo kurya, ikongera imisemburo ya insuline, kandi igatinda gusohora gastrica ikora kuri reseptor ya GLP-1 muri hypothalamus, naho Cagrilintide ikomeza kugabanya ubushake bwo gukora reseptor ya amylin. Gukoresha hamwe byombi birashobora gutanga ingaruka zidasanzwe, byongera cyane kugabanya ibiro [5] . Urebye umubyibuho ukabije, ubu buryo bwo kuvura ni ingamba zifatika kandi zifatika.
Ku barwayi bafite metabolism yo mu bwoko bwa 2, Cagrilintide yerekanye kandi ubushobozi bwiza bwo kugenzura amaraso glucose. Ubuvuzi bwa Clinical bwerekanye ko bufite umutekano muke no kuvura umubyibuho ukabije hamwe na metabolism yo mu bwoko bwa 2. Kurugero, mugupima kwa kliniki y’abarwayi bafite metabolism yo mu bwoko bwa 2, gukoresha hamwe na Cagrilintide hamwe na GLP-1 reseptor agonist semaglutide byagaragaje neza glucose yamaraso no kugabanya ibiro [6] . Urundi rubanza kandi rwerekanye ko rwihanganirwa n’umutekano rwiza iyo rukoreshejwe rwonyine cyangwa rufatanije na semaglutide [6] , kubera ko imiti ihagaze neza ifitanye isano no kwihanganira umutekano.
Byongeye kandi, Cagrilintide yihanganiye neza mubigeragezo byamavuriro. Mu cyiciro cya 2 cyo gushakisha ibipimo, ibipimo byo guhagarika burundu muri buri tsinda rivura byari bisa, ahanini bitewe nibintu bibi. Nyamara, ibintu byakunze kugaragara nabi ni indwara zo munda no gutera inshinge, kandi ibyinshi muri byo byari byoroheje kandi bitagereranywa. Mu igeragezwa ryateganijwe, rigenzurwa Icyiciro cya 1b, kuvura hamwe na Cagrilintide na 2,4 mg semaglutide nabyo byagaragaje kwihanganira umutekano n'umutekano [7] . Ibigeragezo binini kandi birebire birakenewe mugihe kizaza kugirango dusuzume byimazeyo imikorere numutekano byubu buvuzi hamwe.
Cagrilintide izana ibyiringiro bishya byo kuvura umubyibuho ukabije hamwe na metabolism yo mu bwoko bwa 2. Itanga uburyo bushya bwo kuvura abarwayi bafite umubyibuho ukabije, cyane cyane abatitabira neza uburyo bwo kubaho kandi ntibakwiriye kubagwa ibibari. Uburyo bwihariye bwibikorwa bitanga ibitekerezo nuburyo bushya bwo kuvura umubyibuho ukabije, kandi birashobora kugira ibyiza byinshi kuruta imiti igabanya ibiro (D'Ascanio AM, 2024). Ikibazo cyatsinzwe cyo gukoresha Cagrilintide na semaglutide (CagriSema) cyerekana ko kuvura intego nyinshi ari ingamba zifatika zo kunoza uburyo bwo kuvura umubyibuho ukabije [6] . Iyi moderi itanga paradizo nshya yo gucunga umubyibuho ukabije kandi ikanazana iterambere rikomeye kubarwayi bafite metabolism yo mu bwoko bwa 2.
Mu gusoza, nkigitabo gishya cyerekana amylin igereranya, Cagrilintide ifite amahirwe menshi yo kugabanya ibiro no kurwanya glucose yamaraso. Ikora inzira yerekana ibimenyetso byuzuye yigana ibikorwa bya amylin kandi igenga metabolisme nka agoniste ya reseptor ebyiri. Igeragezwa rya Clinical ryerekanye ko Cagrilintide, yonyine cyangwa ifatanije na semaglutide, ishobora kugabanya cyane ibiro byumubiri kandi irihanganirwa. Byongeye kandi, yerekanye kandi ubushobozi bwiza bwo kugenzura amaraso glucose ku barwayi bafite metabolism yo mu bwoko bwa 2, itanga uburyo bushya bwo kuvura umubyibuho ukabije na metabolisme, kuzuza icyuho mu buryo bwo kuvura buriho, cyane cyane ku barwayi batitabira neza ibikorwa by’ubuzima kandi bidakwiriye kubagwa. Ingamba zayo zo kuvura intego nyinshi zitanga ibitekerezo bishya byo gucunga indwara ziterwa na metabolike.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Dr. DCW Lau ni umwarimu mu ishuri ry'ubuvuzi rya Cumming, kaminuza ya Calgary, muri Kanada. Ibyifuzo bye mubushakashatsi bikubiyemo endocrinology na metabolism, ubuvuzi rusange n’imbere, sisitemu yumutima nimiyoboro yumutima, umutima rusange, ubuzima rusange bwibidukikije ndetse nubuzima bwakazi, ndetse na onkologiya. Afite kandi imyanya muri serivisi z'ubuzima za Alberta (AHS) na Umubyibuho ukabije muri Kanada kandi akora mu kigo cy’ubushakashatsi cya Julia McFarlane. Dr. Lau afite ubunararibonye mu bijyanye na metabolism n'ubushakashatsi bw'umubyibuho ukabije, hamwe n'ibikorwa bye byasohotse mu binyamakuru byigisha nk'ikinyamakuru cyo muri Kanada cyitwa Metabolism. Muganga DCW yanditse kurutonde rwerekana [4].
